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1. 发明申请

US20090312576A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF 审中-公开
标题翻译：制备3-（氨基）-3-环丙基甲基-2-羟基丙酰胺或其盐的方法和中间体
公开(公告)号：US20090312576A1
公开(公告)日：2009-12-17
申请号：US12543275
申请日：2009-08-18
申请人： Minzhang Chen , Michael D. Green , Fucheng Zhang
发明人： Minzhang Chen , Michael D. Green , Fucheng Zhang
IPC分类号： C07C233/16
CPC分类号： C07C271/16 , C07C237/14 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译：在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。

2. 发明授权

US06992220B2 Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof 失效
公开(公告)号：US06992220B2
公开(公告)日：2006-01-31
申请号：US10867601
申请日：2004-06-15
申请人： Minzhang Chen , Michael D. Green , Fucheng Zhang
发明人： Minzhang Chen , Michael D. Green , Fucheng Zhang
IPC分类号： C07C233/05 , C07C271/14
CPC分类号： C07C271/16 , C07C237/14 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.

3. 发明授权

US07595419B2 Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof 失效
标题翻译：用于制备3-（氨基）-3-环丁基甲基-2-羟基 - 丙酰胺或其盐的方法和中间体
公开(公告)号：US07595419B2
公开(公告)日：2009-09-29
申请号：US11236447
申请日：2005-09-27
申请人： Minzhang Chen , Michael D. Green , Fucheng Zhang
发明人： Minzhang Chen , Michael D. Green , Fucheng Zhang
IPC分类号： C07C271/14
CPC分类号： C07C271/16 , C07C237/14 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译：在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。

4. 发明授权

US07326795B2 Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl 失效
标题翻译：制备（1R，2S，5S）-3-氮杂双环[3,1,0]己烷-2-甲酰胺，N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3 - [（2S）-2 - [[[1,1-二甲基乙基]氨基]羰基氨基] -3,3-二甲基-1-氧代丁基] -6,6-二甲基
公开(公告)号：US07326795B2
公开(公告)日：2008-02-05
申请号：US10867600
申请日：2004-06-15
申请人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
发明人： Anantha Sudhakar , Vilas Dahanukar , Ilia A. Zavialov , Cecilia Orr , Hoa N. Nguyen , Juergen Weber , Ingyu Jeon , Minzhang Chen , Michael D. Green , George S. Wong , Jeonghan Park , Tetsuo Iwama
IPC分类号： C07D209/52 , C07C233/08
CPC分类号： C07K5/0202 , C07C271/22 , C07C2601/04
摘要： In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
摘要翻译：在一个实施方案中，本申请涉及制备式I化合物的方法以及在制备式I化合物的方法中制备的某些中间体化合物。

5. 发明申请

US20120142914A1 EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 有权
公开(公告)号：US20120142914A1
公开(公告)日：2012-06-07
申请号：US13370768
申请日：2012-02-10
申请人： Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人： Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-Iong Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号： C07D413/12 , C07D307/92 , C07D405/08 , C07D317/72 , C07C269/06
CPC分类号： C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

6. 发明授权

US4817091A Fault-tolerant multiprocessor system 失效
标题翻译：容错多处理器系统
公开(公告)号：US4817091A
公开(公告)日：1989-03-28
申请号：US52094
申请日：1987-05-19
申请人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
发明人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
IPC分类号： G06F11/18 , G06F1/26 , G06F5/06 , G06F7/78 , G06F9/46 , G06F9/52 , G06F11/00 , G06F11/10 , G06F11/16 , G06F11/20 , G06F12/08 , G06F12/10 , G06F12/12 , G06F12/14 , G06F13/00 , G06F13/12 , G06F13/20 , G06F13/28 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173
CPC分类号： G06F7/78 , G06F11/10 , G06F11/1044 , G06F11/2007 , G06F11/2015 , G06F11/2023 , G06F11/2035 , G06F11/2043 , G06F11/2097 , G06F12/08 , G06F12/14 , G06F12/1458 , G06F13/122 , G06F13/20 , G06F13/287 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G06F5/06
摘要： In a multiprocessor system interconnected by a bus structure that provides communication and information transfers between the processor modules of the system, each processor broadcasts a central message to all the other processors of the system on a periodic basis. A processor module not receiving the control message from a sending processor module will assume the sending processor module has failed, and operate to take over the task of the failed processor module.
摘要翻译：在通过提供系统的处理器模块之间的通信和信息传输的总线结构互连的多处理器系统中，每个处理器周期性地向系统的所有其他处理器广播中央消息。没有从发送处理器模块接收控制消息的处理器模块将假定发送处理器模块已经失败，并且操作以接管故障处理器模块的任务。

7. 发明授权

US4807116A Interprocessor communication 失效
标题翻译：处理器间通信
公开(公告)号：US4807116A
公开(公告)日：1989-02-21
申请号：US52095
申请日：1987-05-18
申请人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
发明人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
IPC分类号： G06F11/18 , G06F1/26 , G06F5/06 , G06F7/78 , G06F9/46 , G06F9/52 , G06F11/00 , G06F11/10 , G06F11/16 , G06F11/20 , G06F12/08 , G06F12/10 , G06F12/12 , G06F12/14 , G06F13/00 , G06F13/12 , G06F13/20 , G06F13/28 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G06F13/36 , G06F13/42
CPC分类号： G06F7/78 , G06F11/10 , G06F11/1044 , G06F11/2007 , G06F11/2015 , G06F11/2023 , G06F11/2035 , G06F11/2043 , G06F11/2097 , G06F12/08 , G06F12/14 , G06F12/1458 , G06F13/122 , G06F13/20 , G06F13/287 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G06F5/06
摘要： In a multiprocessor system comprising a plurality of individual processor modules interconnected by a bus structure, including a bus controller, for providing communication between the processor modules, a method and apparatus for interprocessor communication includes one of the processor modules sending a request signal to the bus controller to request a transmission; the bus controller polling the processor modules to identify the requesting processor module; the requestor processor module responding to the poll with the identification of the receiver processor module; the bus controller interrogating the receiver processor module to determine its status (i.e., busy or available); and the bus controller then signaling transmission commencement.
摘要翻译：在包括由包括总线控制器在内的总线控制器互连的多个单独处理器模块的多处理器系统中，用于提供处理器模块之间的通信，用于处理器间通信的方法和装置包括处理器模块之一向总线发送请求信号控制器请求传输; 总线控制器轮询处理器模块以识别请求处理器模块; 所述请求者处理器模块用所述接收器处理器模块的标识响应所述轮询; 总线控制器询问接收机处理器模块以确定其状态（即忙或可用）; 并且总线控制器然后信令传输开始。

8. 发明授权

US4378588A Buffer control for a data path system 失效
标题翻译：数据路径系统的缓冲区控制
公开(公告)号：US4378588A
公开(公告)日：1983-03-29
申请号：US147091
申请日：1980-05-06
申请人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
发明人： James A. Katzman , Joel F. Bartlett , Richard M. Bixler , William H. Davidow , John A. Despotakis , Peter J. Graziano , Michael D. Green , David A. Greig , Steven J. Hayashi , David R. Mackie , Dennis L. McEvoy , James G. Treybig , Steven W. Wierenga
IPC分类号： G06F11/18 , G06F1/26 , G06F5/06 , G06F7/78 , G06F9/46 , G06F9/52 , G06F11/00 , G06F11/10 , G06F11/16 , G06F11/20 , G06F12/08 , G06F12/10 , G06F12/12 , G06F12/14 , G06F13/00 , G06F13/12 , G06F13/20 , G06F13/28 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G11C9/00
CPC分类号： G06F7/78 , G06F11/10 , G06F11/1044 , G06F11/2007 , G06F11/2015 , G06F11/2023 , G06F11/2035 , G06F11/2043 , G06F11/2097 , G06F12/08 , G06F12/14 , G06F12/1458 , G06F13/122 , G06F13/20 , G06F13/287 , G06F13/366 , G06F13/38 , G06F15/16 , G06F15/167 , G06F15/173 , G06F5/06
摘要： A datapath system and protocol is disclosed in which data is transferred between a computer memory and one or more peripheral devices through device controllers, each of which includes a buffer, through periodic connection of the device controller to the channel. The system and protocol are structured to permit multiple device controllers to cooperatively interact on a single channel, without direct communication between device controllers. Each device controller monitors the level of stress on its buffer and at appropriate times presents a reconnect request to the channel, together with indica for permitting the channel to determine the priority of a particular request relative to other reconnect requests. The times at which a reconnect signal should be presented are determined by monitoring the level of information storage in the buffer and relating that level to a threshold level; both overfilling and overemptying are prevented. The threshold level can be varied in accordance with a criteria which makes allowance for the number and combination of device controllers attached to the channel; and is set such that the remaining space in the buffer is sufficient to allow the buffer to transfer data to or from the associated peripheral device, at the rate demanded by that peripheral device, long enough to allow the channel to connect to one lower priority device controller, and all higher priority device controllers. The threshold level and buffer size are also set such that, after a reconnect, the buffer is capable of transferring data to or from the associated peripheral device, at the rate demanded by the peripheral, long enough for the channel to reconnect to all lower priority device controllers, to ensure that all device controllers, no matter the priority, are allowed access to the channel. The invention has broad application, but is particularly well-suited to fault tolerant computing systems.
摘要翻译：公开了一种数据路径系统和协议，其中数据通过设备控制器在计算机存储器和一个或多个外围设备之间传送，每个设备控制器通过设备控制器到通道的周期性连接而包括缓冲器。系统和协议被构造成允许多个设备控制器在单个信道上协作地交互，而不需要设备控制器之间的直接通信。每个设备控制器监视其缓冲器上的压力水平，并且在适当的时间向通道呈现重新连接请求，以及用于允许信道确定特定请求相对于其他重新连接请求的优先级的标记。通过监视缓冲器中的信息存储的级别并将该级别与阈值级别相关联来确定应该呈现重新连接信号的时间; 防止过度填充和过度捕捞。可以根据允许附加到信道的设备控制器的数量和组合的标准来改变阈值水平; 并且被设置为使得缓冲器中的剩余空间足以允许缓冲器按照该外围设备所要求的速率将数据传送到相关联的外围设备或从相关联的外围设备传输数据，其长度足以允许信道连接到一个较低优先级的设备控制器和所有较高优先级的设备控制器。阈值电平和缓冲器大小也被设置为使得在重新连接之后，缓冲器能够以相应的外围设备的数据传输数据，以外围设备要求的速率足以使信道重新连接到所有较低优先级设备控制器，以确保所有设备控制器，无论优先级，都允许访问该通道。本发明具有广泛的应用，但是特别适用于容错计算系统。

9. 发明申请

US20100267947A1 EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 有权
标题翻译：苯菌胺类似物的选择性合成
公开(公告)号：US20100267947A1
公开(公告)日：2010-10-21
申请号：US12827000
申请日：2010-06-30
申请人： Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
发明人： Tiruvettipuram K. Thiruvengadam , Anantha R. Sudhakar , Ngiap Kie Lim , Daw-long Kwok , George G. Wu , Tao Wang , Mingsheng Huang , Michael D. Green
IPC分类号： C07D413/12 , C07D317/72 , C07C269/06 , C07D307/92 , C07D405/08
CPC分类号： C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:
摘要翻译：本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。由此制备的化合物可用作凝血酶受体拮抗剂。本文公开的化学例如以下合成顺序：

10. 发明授权

US08435794B2 Colorimetric test for antimalarial artemesin derivatives 有权
标题翻译：抗疟药青蒿素衍生物的比色试验
公开(公告)号：US08435794B2
公开(公告)日：2013-05-07
申请号：US12741434
申请日：2008-11-05
申请人： Michael D. Green
发明人： Michael D. Green
IPC分类号： G01N33/00
CPC分类号： G01N33/94 , G01N21/29 , G01N21/80 , G01N33/9446 , Y10T436/142222 , Y10T436/200833
摘要： A process for testing a composition as containing an artemisinin derivative is provided that includes contacting the composition with a reagent made up of a hydrogen bonding polar organic solvent and an acid having a pK value of less than 3.8 at 25° Celsius and capable of acid catalyzing a decomposition reaction of the artemisinin derivative so as to provide a reaction mixture. The reaction mixture is allowed sufficient time at a reaction temperature for the artemisinin derivative to decompose to yield a colored decomposition product discerned by a normal unaided human eye. A kit for testing a composition for an artemisinin derivative according to the process is provided together with instructions for contacting the solvent and the acid with the composition to decompose the artemisinin derivative to yield the colored decomposition.
摘要翻译：提供了测试含有青蒿素衍生物的组合物的方法，其包括使组合物与氢键极性有机溶剂和pK值小于3.8的酸在25℃下接触并能够酸催化青蒿素衍生物的分解反应以提供反应混合物。反应混合物在反应温度下允许足够的时间使青蒿素衍生物分解，从而产生由正常肉眼辨别出的着色分解产物。提供根据该方法测试青蒿素衍生物的组合物的试剂盒以及用于使溶剂和酸与组合物接触的说明书，以分解青蒿素衍生物以产生着色分解。

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