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1. 发明授权

US5443846A Granulated preparations and method of producing the same 失效
标题翻译：颗粒制剂及其制备方法
公开(公告)号：US5443846A
公开(公告)日：1995-08-22
申请号：US217770
申请日：1994-03-25
申请人： Minoru Yoshioka , Hidetoshi Horibe , Toshio Kashihara
发明人： Minoru Yoshioka , Hidetoshi Horibe , Toshio Kashihara
IPC分类号： A01N25/12 , A23K1/00 , A23L1/00 , A23P1/02 , A61K9/16 , A61K47/14 , B01J2/16 , B01J2/28 , C11B15/00
CPC分类号： A23K40/10 , A23P10/20 , A61K9/1617 , A61K9/1623 , A61K9/1652
摘要： Granulated preparations are provided by causing a granular, preferably spherical polyglycerol fatty acid ester having a melting poing of 40.degree.-80.degree. C. together with a powder for fluidized bed formation and heating the resulting fluidized mixture at a temperature in the vicinity of the melting point of the polyglycerol fatty acid ester. The powder may be contain as least one pharmacologically active ingredient. The polyglycerol fatty acid ester shows no crystal polymorphism and does not inactivate the pharmacologically active ingredient. Furthermore, the dissolution and release of the pharmacologically active ingredient can be controlled by varying the HLB of the polyglycerol fatty acid ester.
摘要翻译：颗粒状制剂是通过使熔融点为40°-80℃的粒状，优选球形的聚甘油脂肪酸酯与用于流化床形成的粉末一起，并在熔融附近的温度下加热得到的流化混合物聚甘油脂肪酸酯点。粉末可以含有至少一种药理活性成分。聚甘油脂肪酸酯不显示晶体多晶型物并且不使药理活性成分失活。此外，可以通过改变聚甘油脂肪酸酯的HLB来控制药理活性成分的溶解和释放。

2. 发明授权

US5399357A Sustained release preparations 失效
标题翻译：缓释制剂
公开(公告)号：US5399357A
公开(公告)日：1995-03-21
申请号：US807630
申请日：1991-12-13
申请人： Yohko Akiyama , Hidetoshi Horibe , Minoru Yoshioka
发明人： Yohko Akiyama , Hidetoshi Horibe , Minoru Yoshioka
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/54 , A61K47/14 , A61K47/22 , A61K47/34 , A61K9/50
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/2077 , A61K9/2081 , Y10S514/951 , Y10S514/963 , Y10S514/965
摘要： There is provided a matrix preparation produced by dispersing a pharmaceutically active ingredient into a matrix which is solid at ambient temperature and comprised of a fatty acid ester of a polyglycerol. The preparation has stable release controlling ability, can be processed to fine granules, granules, capsules, tablets etc., and contributes to reduction of the administration times of the active ingredient and side effects of the ingredient.
摘要翻译：提供了通过将药物活性成分分散在在环境温度下为固体并由聚甘油的脂肪酸酯组成的基质中制备的基质制剂。该制剂具有稳定的释放控制能力，可加工成细颗粒剂，颗粒剂，胶囊剂，片剂等，有助于减少活性成分的给药时间和成分的副作用。

3. 发明授权

US5593690A Sustained release preparations 失效
标题翻译：缓释制剂
公开(公告)号：US5593690A
公开(公告)日：1997-01-14
申请号：US388520
申请日：1995-02-14
申请人： Yohko Akiyama , Hidetoshi Horibe , Minoru Yoshioka
发明人： Yohko Akiyama , Hidetoshi Horibe , Minoru Yoshioka
IPC分类号： A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/54 , A61K47/14 , A61K47/22 , A61K47/34 , A61K9/50
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/2077 , A61K9/2081 , Y10S514/951 , Y10S514/963 , Y10S514/965
摘要： There is provided a matrix preparation produced by dispersing a pharmaceutically active ingredient into a matrix which is solid at ambient temperature and comprised of a fatty acid ester of a polyglycerol. The preparation has stable release-controlling ability, can be processed to fine granules, granules, capsules, tablets etc., and contributes to reduce the administration times of the active ingredient and side effects of the ingredient.
摘要翻译：提供了通过将药物活性成分分散在在环境温度下为固体并由聚甘油的脂肪酸酯组成的基质中制备的基质制剂。该制剂具有稳定的释放控制能力，可加工成细颗粒剂，颗粒剂，胶囊剂，片剂等，有助于减少活性成分的给药时间和成分的副作用。

4. 发明申请

US20070231112A1 POD CRAMPING UNIT, LOAD PORT EQUIPPED WITH POD CRAMPING UNIT AND MINI-ENVIRONMENT SYSTEM INCLUDING POD AND LOAD PORT 有权
标题翻译： POD冲压单元，装有POD冲压单元的负载端口和包括POD和负载端口的微型环境系统
公开(公告)号：US20070231112A1
公开(公告)日：2007-10-04
申请号：US11691683
申请日：2007-03-27
申请人： Toshihiko Miyajima , Jun Emoto , Hidetoshi Horibe
发明人： Toshihiko Miyajima , Jun Emoto , Hidetoshi Horibe
IPC分类号： B65H1/00
CPC分类号： H01L21/67379 , H01L21/67772 , H01L21/67775 , Y10S414/14
摘要： The invention is directed to a pod cramping unit for fixing a pod to a support table in a load port, the pod including a pod body capable of storing a wafer in the interior thereof and having an opening through which the wafer is to be taken out of/brought into the interior and a lid attached to the pod body to close/open the opening, the load port having a pod opener that opens/closes the lid to allow to bring the wafer out of/into the interior of the pod. The pod cramping unit includes a cramp portion that is provided on the support table and adapted to engage with a first engagement portion provided on a lower surface of the pod body to restrict upward movement of the pod relative to the support table, a restriction pin that is movable upwardly and downwardly relative to the support table and adapted to engage with a second engagement portion provided on the lower surface of the pod body to restrict movement of the pod in a disengaging direction that causes disengagement between the first engagement portion and the cramp portion, and a vertically driving portion that moves the restriction pin up to/down from the second engagement portion.
摘要翻译：本发明涉及一种用于将容器固定到装载端口中的支撑台上的荚式捣实单元，所述荚包括能够在其内部存储晶片并且具有开口的荚体，所述荚体在晶片内部被取出进入内部和附接到荚体主体以关闭/打开开口的盖子，负载端口具有打开/关闭盖子的荚果开启器，以允许将晶片带出/进入荚果的内部。荚式捣实单元包括一个抽吸部分，该部分设置在支撑台上并且适于与设置在荚果体的下表面上的第一接合部分接合，以限制荚果相对于支撑台的向上运动;限制销，可相对于支撑台向上和向下移动并且适于与设置在荚体主体的下表面上的第二接合部分接合，以限制荚在分离方向上的移动，从而导致第一接合部分和痉挛部分之间的脱离以及使所述限制销从所述第二接合部向上/向下移动的垂直驱动部。

5. 发明授权

US07927058B2 Pod clamping unit load port equipped with pod clamping unit and mini environment system including pod and load port 有权
标题翻译：荚式单元装载端口配有荚果装置和迷你环境系统，包括荚和装载端口
公开(公告)号：US07927058B2
公开(公告)日：2011-04-19
申请号：US11691683
申请日：2007-03-27
申请人： Toshihiko Miyajima , Jun Emoto , Hidetoshi Horibe
发明人： Toshihiko Miyajima , Jun Emoto , Hidetoshi Horibe
IPC分类号： B65G49/07
CPC分类号： H01L21/67379 , H01L21/67772 , H01L21/67775 , Y10S414/14
摘要： The invention is directed to a pod clamping unit for fixing a pod to a support table in a load port, the pod including a pod body capable of storing a wafer in the interior thereof and a lid, the load port having a pod opener that opens/closes the lid. The pod clamping unit includes a clamp portion that is provided on the support table and adapted to engage with a first engagement portion provided on a lower surface of the pod body to restrict upward movement of the pod relative to the support table, a restriction pin that is movable upwardly and downwardly relative to the support table and adapted to engage with a second engagement portion provided on the lower surface of the pod body to restrict movement of the pod in a disengaging direction that causes disengagement between the first engagement portion and the clamp portion, and a vertically driving portion that moves the restriction pin up to/down from the second engagement portion.
摘要翻译：本发明涉及一种用于将货舱固定到装载端口中的支撑台的吊舱夹紧单元，所述吊舱包括能够在其内部存储晶片的舱体和盖子，所述装载端口具有打开的开启装置 /关闭盖子。所述荚夹持单元包括夹紧部分，所述夹持部分设置在所述支撑台上并且适于与设置在所述荚果体的下表面上的第一接合部分接合，以限制所述荚相对于所述支撑台的向上移动;限制销，可相对于支撑台向上和向下移动并且适于与设置在荚体主体的下表面上的第二接合部分接合，以限制荚果在分离方向上的移动，从而导致第一接合部分和夹紧部分之间的脱离以及使所述限制销从所述第二接合部向上/向下移动的垂直驱动部。

6. 发明授权

US06583164B1 Antimycotic drug composition 失效
标题翻译：抗真菌药物组合物
公开(公告)号：US06583164B1
公开(公告)日：2003-06-24
申请号：US09787656
申请日：2001-03-19
申请人： Hidetoshi Horibe , Yoko Nishida , Masao Nagao
发明人： Hidetoshi Horibe , Yoko Nishida , Masao Nagao
IPC分类号： A61K3141
CPC分类号： A61K9/19 , A61K9/0019 , A61K9/08 , A61K31/4178 , A61K31/4196 , A61K47/26
摘要： The composition of the present invention comprises a quaternized nitrogen-containing imidazole-1-yl or 1,2,4-triazole-1-yl compound wherein one of the nitrogen atoms constituting the azole ring is quaternized with a group eliminating in vivo and represented by the formula: wherein R1 represents a hydrocarbon or heterocyclic group which may be substituted, R2 represents a hydrogen atom or a lower alkyl group, and n is 0 or 1, and a saccharide, said compound being capable of being converted into an anti-fungal azole compound upon elimination of said group in vivo. The composition of the present invention is stable and usable particularly as a pharmaceutical preparation for an injection composition.
摘要翻译：本发明的组合物包含季铵化的含氮咪唑-1-基或1,2,4-三唑-1-基化合物，其中构成唑环的氮原子之一被一个在体内消除的基团季铵化并代表其中R 1表示可被取代的烃基或杂环基，R 2表示氢原子或低级烷基，n为0或1，并且所述化合物能够转化为抗 - 真菌唑化合物在体内消除所述组。本发明的组合物特别是作为注射用组合物的药物制剂是稳定和可用的。

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