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1. 发明授权

US08637559B2 Oxazole compound and pharmaceutical composition 有权
标题翻译：恶唑化合物和药物组合物
公开(公告)号：US08637559B2
公开(公告)日：2014-01-28
申请号：US12090951
申请日：2006-11-14
申请人： Minoru Okada , Masaya Kato , Norifumi Sato , Tetsuyuki Uno , Hideki Kitagaki , Junpei Haruta , Hidetaka Hiyama , Tomonori Shibata
发明人： Minoru Okada , Masaya Kato , Norifumi Sato , Tetsuyuki Uno , Hideki Kitagaki , Junpei Haruta , Hidetaka Hiyama , Tomonori Shibata
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4709 , A61K31/4439 , A61K31/422 , A61K31/421 , C07D413/12 , C07D413/06 , C07D263/32
CPC分类号： A61K31/421 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , C07D263/32 , C07D263/34 , C07D413/06 , C07D413/12 , C12N9/16 , C12Y301/04012
摘要： The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y1-A1- or —Y2—C(═O)— wherein Y1 is a group such as —C(═O)—, A1 is a group such as a lower alkylene group, and Y2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.
摘要翻译：本发明提供由式（1）表示的恶唑化合物或其盐：其中R 1为可具有一个或多个取代基的芳基; R2是含有一个或多个取代基的芳基或含氮原子的杂环基; W为由-Y1-A1-或-Y2-C（= O）表示的二价基团，其中Y1为-C（= O） - ，A1为低级亚烷基等基团， Y2是哌嗪二基等基团。恶唑化合物对磷酸二酯酶4具有特异性的抑制作用。

2. 发明申请

US20090221586A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION 有权
标题翻译：奥沙唑化合物和药物组合物
公开(公告)号：US20090221586A1
公开(公告)日：2009-09-03
申请号：US12090951
申请日：2006-11-14
申请人： Minoru Okada , Masaya Kato , Norifumi Sato , Tetsuyuki Uno , Hideki Kitagaki , Junpei Haruta , Hidetaka Hiyama , Tomonori Shibata
发明人： Minoru Okada , Masaya Kato , Norifumi Sato , Tetsuyuki Uno , Hideki Kitagaki , Junpei Haruta , Hidetaka Hiyama , Tomonori Shibata
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/421 , C07D413/12 , C07D263/34
CPC分类号： A61K31/421 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , C07D263/32 , C07D263/34 , C07D413/06 , C07D413/12 , C12N9/16 , C12Y301/04012
摘要： The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R1 is an aryl group which may have one or more substituents; R2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y1-A1- or —Y2—C(═O)— wherein Y1 is a group such as —C(═O)—, A1 is a group such as a lower alkylene group, and Y2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.
摘要翻译：本发明提供由式（1）表示的恶唑化合物或其盐：其中R 1为可具有一个或多个取代基的芳基; R2是含有一个或多个取代基的芳基或含氮原子的杂环基; W是由-Y1-A1-或-Y2-C（-O） - 表示的二价基团，其中Y1是-C（-O） - ，A1是低级亚烷基等基团， Y2是哌嗪二基等基团。恶唑化合物对磷酸二酯酶4具有特异性的抑制作用。

3. 发明授权

US09052257B2 Method of testing rubber wear, and method, device and program of calculating rubber index of tire using method of testing rubber wear 有权
标题翻译：橡胶磨损试验方法，轮胎橡胶指数的计算方法，装置及程序使用橡胶磨损试验方法
公开(公告)号：US09052257B2
公开(公告)日：2015-06-09
申请号：US13580923
申请日：2011-02-24
申请人： Tomonori Shibata
发明人： Tomonori Shibata
IPC分类号： G01N19/02 , G01N3/56 , G01M17/02
CPC分类号： G01N3/56 , G01M17/022 , G01N2203/0218
摘要： Provided is a method of testing rubber wear in which a wear phenomenon occurred in a tire can be precisely reproduced in a sample, and a method of calculating the rubber index of a tire using the method of testing rubber wear.Also provided is a test method for predicting the anti-wear properties of a tire by using a test piece of the same rubber as that of a tire tread, which is a method of testing rubber wear in which, while a disk-shaped sample 3 and a disk-shaped grinding wheel 1 are rotated at individually predetermined numbers of rotations, the sample 3 is pressed on the outer periphery of the grinding wheel 1. A pressing load is applied to the sample 3 such that a contact pressure when the sample is pressed on the outer periphery of the grinding wheel 1 and a contact pressure at a site related to the evaluation of rubber wear of tread are the same.
摘要翻译：提供一种测试橡胶磨损的方法，其中可以在样品中精确地再现轮胎中发生的磨损现象，并且使用橡胶磨损测试方法计算轮胎的橡胶指数的方法。还提供了一种用于通过使用与轮胎胎面相同的橡胶的试验片来预测轮胎的耐磨性的测试方法，该轮胎胎面是测试橡胶磨损的方法，其中，当盘形样品3 并且盘状砂轮1以各自预定的转数旋转，样品3被压在砂轮1的外周上。对样品3施加按压负荷，使得样品为1时的接触压力压在砂轮1的外周上，并且与评价胎面橡胶磨损有关的部位的接触压力相同。

4. 发明申请

US20130036791A1 METHOD OF TESTING RUBBER WEAR, AND METHOD, DEVICE AND PROGRAM OF CALCULATING RUBBER INDEX OF TIRE USING METHOD OF TESTING RUBBER WEAR 有权
标题翻译：测试橡胶磨损的方法，以及使用橡胶磨损测试方法计算轮胎橡胶指数的方法，装置和程序
公开(公告)号：US20130036791A1
公开(公告)日：2013-02-14
申请号：US13580923
申请日：2011-02-24
申请人： Tomonori Shibata
发明人： Tomonori Shibata
IPC分类号： G01N19/02
CPC分类号： G01N3/56 , G01M17/022 , G01N2203/0218
摘要： Provided is a method of testing rubber wear in which a wear phenomenon occurred in a tire can be precisely reproduced in a sample, and a method of calculating the rubber index of a tire using the method of testing rubber wear.Also provided is a test method for predicting the anti-wear properties of a tire by using a test piece of the same rubber as that of a tire tread, which is a method of testing rubber wear in which, while a disk-shaped sample 3 and a disk-shaped grinding wheel 1 are rotated at individually predetermined numbers of rotations, the sample 3 is pressed on the outer periphery of the grinding wheel 1. A pressing load is applied to the sample 3 such that a contact pressure when the sample is pressed on the outer periphery of the grinding wheel 1 and a contact pressure at a site related to the evaluation of rubber wear of tread are the same.
摘要翻译：提供一种测试橡胶磨损的方法，其中可以在样品中精确地再现轮胎中发生的磨损现象，并且使用橡胶磨损测试方法计算轮胎的橡胶指数的方法。还提供了一种用于通过使用与轮胎胎面相同的橡胶的试验片来预测轮胎的耐磨性的测试方法，该轮胎胎面是测试橡胶磨损的方法，其中，当盘形样品3 并且盘状砂轮1以各自预定的转数旋转，样品3被压在砂轮1的外周上。对样品3施加按压负荷，使得样品为1时的接触压力压在砂轮1的外周上，并且与评价胎面橡胶磨损有关的部位的接触压力相同。

5. 发明授权

US09423320B2 Tire rubber index calculating method, device, and computer-readable storage medium 有权
标题翻译：轮胎橡胶指数计算方法，装置和计算机可读存储介质
公开(公告)号：US09423320B2
公开(公告)日：2016-08-23
申请号：US13391999
申请日：2010-08-25
申请人： Yusuke Kuramoto , Tomonori Shibata
发明人： Yusuke Kuramoto , Tomonori Shibata
IPC分类号： G01B3/44 , G01M17/02 , B60C11/24 , G01N19/02 , B60C99/00
CPC分类号： G01M17/02 , B60C11/24 , B60C11/246 , B60C99/006 , B60T2210/12 , G01N19/02
摘要： In order to precisely calculate the rubber index of a tire, a rubber index calculating device: measures, by a frictional energy measuring device, frictional energies of a tire in plural tire input conditions applied to the tire on the basis of the shear force and the slippage of a tire contact patch; measures, by the frictional energy measuring device, frictional energies of a sample of the same material as the tire in sample input conditions that have been set on the basis of the frictional energies of the tire in the tire input conditions that were measured, and sets measurement conditions for measuring amounts of wear of the sample on the basis of the frictional energies of the tire in the tire input conditions that were measured and the frictional energies of the sample in the tire input conditions that were measured; measures, by an amount of wear measuring device, the amounts of wear of the sample in the measurement conditions that were set, and calculates the rubber index of the tire on the basis of the frictional energies and the amounts of wear of the sample that were measured.
摘要翻译：为了精确地计算轮胎的橡胶指数，橡胶指数计算装置：通过摩擦能量测量装置，基于剪切力来测量轮胎在施加到轮胎的多个轮胎输入条件下的摩擦能，轮胎接触片的滑动; 通过摩擦能量测量装置测量在根据轮胎输入条件下的轮胎的摩擦能量设定的样品输入条件下与轮胎相同的材料的样品的摩擦能量，并且设定根据测量的轮胎输入条件和所测量的轮胎输入条件下的样品的摩擦能，基于轮胎的摩擦能量测量样品的磨损量的测量条件; 通过一定量的磨损测量装置测量在设定的测量条件下的样品的磨损量，并且基于摩擦力和样品的磨损量来计算轮胎的橡胶指数测量。

6. 发明申请

US20120197548A1 TIRE RUBBER INDEX CALCULATING METHOD, DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM 有权
标题翻译：轮胎橡胶指数计算方法，装置和计算机可读存储介质
公开(公告)号：US20120197548A1
公开(公告)日：2012-08-02
申请号：US13391999
申请日：2010-08-25
申请人： Yusuke Kuramoto , Tomonori Shibata
发明人： Yusuke Kuramoto , Tomonori Shibata
IPC分类号： G01M17/02 , G06F19/00
CPC分类号： G01M17/02 , B60C11/24 , B60C11/246 , B60C99/006 , B60T2210/12 , G01N19/02
摘要： To precisely calculate the rubber index of a tire.A rubber index calculating device measures, by a frictional energy measuring device, frictional energies of a tire in plural tire input conditions applied to the tire on the basis of the shear force and the slippage of a tire contact patch, measures, by the frictional energy measuring device, frictional energies of a sample of the same material as the tire in sample input conditions that have been set on the basis of the frictional energies of the tire in the tire input conditions that were measured, and sets a measurement conditions for measuring amounts of wear of the sample on the basis of the frictional energies of the tire in the tire input conditions that were measured and the frictional energies of the sample in the tire input conditions that were measured, measures, by an amount of wear measuring device, the amounts of wear of the sample in the measurement conditions that were set, and calculates the rubber index of the tire on the basis of the frictional energies and the amounts of wear of the sample that were measured.
摘要翻译：精确计算轮胎的橡胶指数。橡胶指数计算装置通过摩擦能量测量装置，根据剪切力和轮胎接触片的滑动度，在施加到轮胎的多个轮胎输入条件下测量轮胎的摩擦能量，通过摩擦能量测量装置，在根据所测量的轮胎输入条件中轮胎的摩擦能量设定的样本输入条件下与轮胎相同材料的样品的摩擦力，并设定测量量的测量条件在所测量的轮胎输入条件下的轮胎的摩擦能量和所测量的轮胎输入条件下的样品的摩擦能量的基础上的样品的磨损量通过磨损测量装置的量测量在设定的测量条件下样品的磨损量，并且基于摩擦能和运动计算轮胎的橡胶指数测量样品的磨损量。

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