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1. 外观设计

USD780682S1 Tire 有权
公开(公告)号：USD780682S1
公开(公告)日：2017-03-07
申请号：US29525913
申请日：2015-05-04
申请人： Mingming Zhao , Wen Sun , Yixin Zhang , Junjie Liu , Junrui Wan , Xiaoyun Li , Na Bai
设计人： Mingming Zhao , Wen Sun , Yixin Zhang , Junjie Liu , Junrui Wan , Xiaoyun Li , Na Bai

2. 发明申请

US20210309981A1 VARIANT TYPE V CRISPR/CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20210309981A1
公开(公告)日：2021-10-07
申请号：US17266270
申请日：2019-08-21
申请人： Junjie LIU , The Regents of the University of California
发明人： Jennifer A. Doudna , Benjamin L. Oakes , Natalia Orlova , Junjie Liu
IPC分类号： C12N9/22 , C12N15/11 , A61K9/127 , C12N15/90 , C12N15/88 , A61K38/46 , A61K31/7088 , C12Q1/70 , C12Q1/6841
摘要： The present disclosure provides variant type V CRISPR/Cas effector polypeptides, fusion polypeptides comprising the variant type V CRISPR/Cas effector polypeptides, and nucleic acids comprising nucleotide sequences encoding the variant polypeptides and fusion polypeptides. The present disclosure provides methods of binding, or binding and nicking, a target nucleic acid, using a variant type V CRISPR/Cas effector polypeptide of the present disclosure. The present disclosure provides methods of detecting a single-stranded DNA, using a variant type V CRISPR/Cas effector polypeptide of the present disclosure.

3. 发明申请

US20110288279A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 有权
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的用途
公开(公告)号：US20110288279A1
公开(公告)日：2011-11-24
申请号：US13178189
申请日：2011-07-07
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K16/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed Herein are Non-Natural Amino Acids and Polypeptides that Include at Least One non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及用于制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

4. 发明授权

US07928163B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US07928163B2
公开(公告)日：2011-04-19
申请号：US11873347
申请日：2007-10-16
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C08G65/02 , C08F26/06 , C08F16/00 , C08F16/06
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

5. 发明申请

US20100135959A1 Human Interferon Molecules and Their Uses 审中-公开
标题翻译：人类干扰素分子及其用途
公开(公告)号：US20100135959A1
公开(公告)日：2010-06-03
申请号：US11916026
申请日：2006-06-02
申请人： Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
发明人： Anna-Maria A. Hays Putnam , Bruce E. Kimmel , Ho Sung Cho , Bee-Cheng Sim , David C. Litzinger , Roberto Mariani , Vadim Kraynov , Nick Knudsen , Thomas O. Daniel , Alan Koder , Stuart Bussell , Junjie Liu , Zhenwei Miao , Theresa Morrow
IPC分类号： A61K38/21 , C07K14/52 , C07H21/00 , C12N5/10 , C12P21/00 , A61P37/04
CPC分类号： C07K14/555 , A61K38/00 , C07K14/56
摘要： Modified human interferon polypeptides and uses thereof are provided.
摘要翻译：提供了修饰的人干扰素多肽及其用途。

6. 发明申请

US20090111147A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 审中-公开
标题翻译：含有非离子氨基酸和多肽的组合物，涉及的方法和用途
公开(公告)号：US20090111147A1
公开(公告)日：2009-04-30
申请号：US11925743
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C12P21/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

7. 发明申请

US20080213840A1 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides 审中-公开
公开(公告)号：US20080213840A1
公开(公告)日：2008-09-04
申请号：US11874486
申请日：2007-10-18
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C12P21/00 , C07K2/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

8. 发明授权

US07135578B2 Iminocyclitol inhibitors of hexoaminidase and glycosidase 失效
标题翻译：己酰胺酶和糖苷酶的咪嗪环醇抑制剂
公开(公告)号：US07135578B2
公开(公告)日：2006-11-14
申请号：US10798617
申请日：2004-03-10
申请人： Chi-Huey Wong , Junjie Liu
发明人： Chi-Huey Wong , Junjie Liu
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , A61K31/40 , A61K31/4025 , A61K31/445
摘要： Designed imminocyclitols have potent inhibition activity with respect to hexoaminidases and glycosidases.
摘要翻译：设计的咪喹四环醇对于己糖苷酶和糖苷酶具有有效的抑制活性。

9. 发明申请

US20150031852A1 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE 有权
标题翻译：选择性递送分子和使用方法
公开(公告)号：US20150031852A1
公开(公告)日：2015-01-29
申请号：US14235522
申请日：2012-07-27
申请人： Junjie Liu , Jesus Gonzalez
发明人： Junjie Liu , Jesus Gonzalez
IPC分类号： A61K49/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
摘要翻译：本文公开了一种选择性递送分子，其包含：（a）有效抑制或阻止摄入细胞或组织滞留的酸性序列（部分A），（b）分子转运或保留序列（部分B）和（ c）部分A和部分B之间的接头，和（d）至少一个货物部分。

10. 发明授权

US08865658B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08865658B2
公开(公告)日：2014-10-21
申请号：US13467870
申请日：2012-05-09
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： C07K2/00 , C07K7/00 , A61K38/04 , A61K38/18 , C07K1/00 , C07C229/42
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

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