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1. 发明申请

US20130222931A1 PRISM SHEET AND DISPLAY DEVICE 有权
标题翻译： PRISM表和显示设备
公开(公告)号：US20130222931A1
公开(公告)日：2013-08-29
申请号：US13701644
申请日：2012-07-20
申请人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
发明人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
IPC分类号： G02B5/04
CPC分类号： G02B5/04 , G02B5/0231 , G02B5/0268 , G02B5/0278
摘要： The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.
摘要翻译：本发明公开了一种棱镜片和显示装置，包括用于提高液晶显示装置中的背光模块的性能的棱镜片。所述棱镜片包括第一基板和第二基板，其中所述第一基板包括与所述第一表面相对的第一表面和第二表面，并且所述第二表面包括沿着第一方向平行布置的多个第一突起; 所述第二基板包括与所述第三表面相对的第三表面和第四表面，所述第三表面包括沿所述第一方向平行布置的多个第二突起，并且所述第四表面包括沿着第二表面平行设置的多个第三突起方向; 并且第二表面和第三表面通过第一突起与第二突起的啮合而接合。

2. 发明授权

US08964318B2 Prism sheet and display device 有权
标题翻译：棱镜片和显示装置
公开(公告)号：US08964318B2
公开(公告)日：2015-02-24
申请号：US13701644
申请日：2012-07-20
申请人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
发明人： Minghui Zhang , Ning Sun , Zhishuai Jia , Jie Liu , Yihong Ma
IPC分类号： G02B5/04 , G02B5/02
CPC分类号： G02B5/04 , G02B5/0231 , G02B5/0268 , G02B5/0278
摘要： The present invention discloses a prism sheet and a display device comprising the prism sheet for improving performances of a backlight module in a liquid crystal display device. The prism sheet comprises a first substrate and a second substrate, wherein the first substrate comprises a first surface and a second surface opposite to the first surface, and the second surface comprises a plurality of first protrusions arranged in parallel along a first direction; the second substrate comprises a third surface and a fourth surface opposite to the third surface, the third surface comprises a plurality of second protrusions arranged in parallel along the first direction, and the fourth surface comprises a plurality of third protrusions arranged in parallel along a second direction; and the second surface and the third surface are joined by meshing of the first protrusions with the second protrusions.
摘要翻译：本发明公开了一种棱镜片和显示装置，包括用于提高液晶显示装置中的背光模块的性能的棱镜片。所述棱镜片包括第一基板和第二基板，其中所述第一基板包括与所述第一表面相对的第一表面和第二表面，并且所述第二表面包括沿着第一方向平行布置的多个第一突起; 所述第二基板包括与所述第三表面相对的第三表面和第四表面，所述第三表面包括沿所述第一方向平行布置的多个第二突起，并且所述第四表面包括沿着第二表面平行设置的多个第三突起方向; 并且第二表面和第三表面通过第一突起与第二突起的啮合而接合。

3. 发明申请

US20110053977A1 SMALL MOLECULE E2F INHIBITOR 有权
标题翻译：小分子E2F抑制剂
公开(公告)号：US20110053977A1
公开(公告)日：2011-03-03
申请号：US12872263
申请日：2010-08-31
申请人： Douglas W. Cress , Yihong Ma
发明人： Douglas W. Cress , Yihong Ma
IPC分类号： A61K31/4709 , C12N5/071 , A61P35/00 , A61P35/02
CPC分类号： C07D215/26
摘要： A small molecular inhibitor of E2F (HLM006474) was identified using a computer-based virtual screen and the known crystal structure of the DNA bound E2F4/DP2 heterodimer. Treatment of multiple cell lines resulted in the loss of intracellular E2F4 DNA-binding activity. Overnight exposure to HLM006474 resulted in down regulation of total E2F4 protein as well as several known E2F targets. The effects of treatment on different cell lines included a reduction in cell proliferation and an increase in apoptosis. Apoptosis was induced in a manner distinct from cisplatin and doxorubicin. E2F4-null MEFs were less sensitive than wildtype counterparts to the apoptosis-inducing activity of the compound revealing its biological specificity. A375 cells were extremely sensitive to the apoptosis-inducing activity of the compound in two-dimensional culture and HLM006474 was a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system.
摘要翻译：使用基于计算机的虚拟屏幕和DNA结合的E2F4 / DP2异源二聚体的已知晶体结构鉴定了E2F的小分子抑制剂（HLM006474）。多种细胞系的治疗导致细胞内E2F4 DNA结合活性的丧失。过夜暴露于HLM006474导致总E2F4蛋白以及几种已知的E2F靶的下调。治疗对不同细胞系的作用包括细胞增殖的减少和凋亡的增加。以不同于顺铂和多柔比星的方式诱导细胞凋亡。 E2F4-null MEFs比野生型对照组对该化合物的细胞凋亡诱导活性敏感，表明其生物学特异性。 A375细胞对二维培养中化合物的细胞凋亡诱导活性非常敏感，HLM006474是三维组织培养模型系统中黑色素细胞增殖和随后侵袭的有效抑制剂。

4. 发明授权

US08202886B2 Small molecule E2F inhibitor 有权
标题翻译：小分子E2F抑制剂
公开(公告)号：US08202886B2
公开(公告)日：2012-06-19
申请号：US12872263
申请日：2010-08-31
申请人： Douglas W. Cress , Yihong Ma
发明人： Douglas W. Cress , Yihong Ma
IPC分类号： A61K31/4709
CPC分类号： C07D215/26
摘要： A small molecular inhibitor of E2F (HLM006474) was identified using a computer-based virtual screen and the known crystal structure of the DNA bound E2F4/DP2 heterodimer. Treatment of multiple cell lines resulted in the loss of intracellular E2F4 DNA-binding activity. Overnight exposure to HLM006474 resulted in down regulation of total E2F4 protein as well as several known E2F targets. The effects of treatment on different cell lines included a reduction in cell proliferation and an increase in apoptosis. Apoptosis was induced in a manner distinct from cisplatin and doxorubicin. E2F4-null MEFs (mouse embryo fibroblasts) were less sensitive than wildtype counterparts to the apoptosis-inducing activity of the compound revealing its biological specificity. A375 cells were extremely sensitive to the apoptosis-inducing activity of the compound in two-dimensional culture and HLM006474 was a potent inhibitor of melanocytes proliferation and subsequent invasion in a three-dimensional tissue culture model system.
摘要翻译：使用基于计算机的虚拟屏幕和DNA结合的E2F4 / DP2异源二聚体的已知晶体结构鉴定了E2F的小分子抑制剂（HLM006474）。多种细胞系的治疗导致细胞内E2F4 DNA结合活性的丧失。过夜暴露于HLM006474导致总E2F4蛋白以及几种已知的E2F靶的下调。治疗对不同细胞系的作用包括细胞增殖的减少和凋亡的增加。以不同于顺铂和多柔比星的方式诱导细胞凋亡。 E2F4-null MEFs（小鼠胚胎成纤维细胞）比野生型对照组对该化合物的细胞凋亡诱导活性敏感，表现出其生物学特异性。 A375细胞对二维培养中化合物的细胞凋亡诱导活性非常敏感，HLM006474是三维组织培养模型系统中黑色素细胞增殖和随后侵袭的有效抑制剂。

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