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1. 发明授权

US06407872B1 Optical path length scanner using moving prisms 失效
标题翻译：使用移动棱镜的光程长扫描仪
公开(公告)号：US06407872B1
公开(公告)日：2002-06-18
申请号：US09784834
申请日：2001-02-16
申请人： Ming Lai , Jay Wei , Manish D. Kulkarni , Kabir M. Arianta
发明人： Ming Lai , Jay Wei , Manish D. Kulkarni , Kabir M. Arianta
IPC分类号： G02B504
CPC分类号： G02B26/108
摘要： One embodiment of the present invention is an optical path length scanner which includes: (a) a set of prisms mounted evenly along a movable carrier; and (b) a mechanism that drives the movable carrier to move.
摘要翻译：本发明的一个实施例是光路长度扫描仪，其包括：（a）沿着可移动的载体均匀安装的一组棱镜; 和（b）驱动可动载体移动的机构。

2. 再颁专利

USRE42641E1 Depth-resolved spectroscopic optical coherence tomography 有权
标题翻译：深度分辨光谱相干断层扫描
公开(公告)号：USRE42641E1
公开(公告)日：2011-08-23
申请号：US10020041
申请日：2001-12-14
申请人： Joseph A. Izatt , Manish D. Kulkarni , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Michael V. Sivak
IPC分类号： G01B9/02
CPC分类号： G01J3/4412 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35
摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
摘要翻译：描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中，样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。

3. 发明申请

US20100208270A1 Low-cost, portable, rugged optical coherence tomography system 审中-公开
标题翻译：低成本，便携式，坚固的光学相干断层扫描系统
公开(公告)号：US20100208270A1
公开(公告)日：2010-08-19
申请号：US12706717
申请日：2010-02-17
申请人： Manish D. Kulkarni , Balasigamani Devaraj , Shuqing Ma
发明人： Manish D. Kulkarni , Balasigamani Devaraj , Shuqing Ma
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , A61B5/0066 , A61B5/6852 , G01B9/02044 , G01B2290/35 , G01B2290/70 , G01N2021/1787
摘要： An interferometric system for metrology as well as imaging (e.g., optical coherence tomography or OCT) is described here. The system leverages advancements in telecommunication and device technologies. For example, the reference arm in the interferometric system can be a fiber-optically integrated Faraday rotating mirror. By way of example, but not limitation, typically, the light in the detection arm of the Michelson interferometer can be measured using a Volume phase holographic dispersion grating. By way of example, but not limitation, the dispersed light can be focused on a line-scan camera or multi-line 2-D camera.
摘要翻译：这里描述了用于计量学以及成像（例如，光学相干断层摄影或OCT）的干涉测量系统。该系统利用电信和设备技术的进步。例如，干涉式系统中的参考臂可以是光纤一体化的法拉第旋转镜。作为示例而非限制，通常可以使用体积相位全息色散光栅测量迈克尔逊干涉仪的检测臂中的光。作为示例而非限制，分散的光可以聚焦在线扫描照相机或多行2-D相机上。

4. 发明授权

US6002480A Depth-resolved spectroscopic optical coherence tomography 失效
标题翻译：深度分辨光谱相干断层扫描
公开(公告)号：US6002480A
公开(公告)日：1999-12-14
申请号：US88519
申请日：1998-06-02
申请人： Joseph A. Izatt , Manish D. Kulkarni , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Michael V. Sivak
IPC分类号： G01B9/02 , G01J3/28
CPC分类号： G01J3/4412 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35
摘要： A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation interferogram data using an interferometer having a sample arm with the sample in the sample arm, wherein the sample includes a distribution of scatterers therein, and wherein the acquiring step includes the step of altering the distribution of scatterers within the sample with respect to the sample arm for substantially each acquisition; and averaging, in the Fourier domain, the cross-correlation interferogram data, thereby revealing backscattering characteristics of the scatterers within the sample.
摘要翻译：描述了一种用于确定样本内的散射体的深度分辨后向散射特性的方法，包括以下步骤：使用具有样本臂的样本臂与样本臂中的样本的干涉仪获取多组互相干涉图数据，其中，样本包括其中散射体的分布，并且其中所述获取步骤包括基本上每次获取相对于所述样本臂改变所述样本内的散射体的分布的步骤; 并且在傅里叶域中平均互相关干涉图数据，从而揭示样品内的散射体的后向散射特性。

5. 发明申请

US20110273721A1 Novel compact, affordable optical test, measurement or imaging device 有权
标题翻译：新颖紧凑，经济实惠的光学测试，测量或成像设备
公开(公告)号：US20110273721A1
公开(公告)日：2011-11-10
申请号：US12941991
申请日：2010-11-08
申请人： Manish D. Kulkarni , Balasigamani Devaraj , Shuqing Ma
发明人： Manish D. Kulkarni , Balasigamani Devaraj , Shuqing Ma
IPC分类号： G01B9/02
CPC分类号： A61B3/102 , A61B3/107 , A61B3/12 , G01N21/4795
摘要： The system disclosed is for optical coherence tomography (OCT). The system includes an improved interferometric system for metrology, detection, ranging as well as imaging system based on optical coherence tomography (OCT). Further, the method provides advancements in detection, imaging of samples in biological, medical, ophthalmic, corneal and retinal diagnosis.
摘要翻译：所公开的系统用于光学相干断层扫描（OCT）。该系统包括用于计量，检测，测距以及基于光学相干断层扫描（OCT）的成像系统的改进的干涉测量系统。此外，该方法提供了在生物，医学，眼科，角膜和视网膜诊断中检测，成像的进展。

6. 发明申请

US20100245836A1 Low-cost, compact, & automated diabetic retinopathy diagnostics & management device 审中-公开
标题翻译：低成本，紧凑，自动化的糖尿病视网膜病变诊断和管理装置
公开(公告)号：US20100245836A1
公开(公告)日：2010-09-30
申请号：US12732484
申请日：2010-03-26
申请人： Manish D. Kulkarni , Balasigamani Devaraj
发明人： Manish D. Kulkarni , Balasigamani Devaraj
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/02045 , G01B2290/70
摘要： A Diabetic Retinopathy Diagnostic system based on OCT which will map 3-D blood circulation including velocity information with micron-scale resolution in the retina is disclosed here. The system leverages the advancements in telecommunication and device technologies and employs novel Doppler algorithms. For example, the reference arm in the interferometric system can be a fiber-optically integrated Faraday rotating mirror. By way of example, but not limitation, typically, the light in the detection arm of the Michelson interferometer can be measured using a Volume phase holographic dispersion grating. By way of example, but not limitation, the dispersed light can be focused on a line-scan camera or multi-line 2-D camera.
摘要翻译：本文介绍了基于OCT的糖尿病性视网膜病变诊断系统，其将在视网膜中将含有微尺度分辨率的速度信息的3D血液循环映射到视网膜。该系统利用电信和设备技术的进步，并采用新颖的多普勒算法。例如，干涉式系统中的参考臂可以是光纤一体化的法拉第旋转镜。作为示例而非限制，通常可以使用体积相位全息色散光栅测量迈克尔逊干涉仪的检测臂中的光。作为示例而非限制，分散的光可以聚焦在线扫描照相机或多行2-D相机上。

7. 发明授权

US06735463B2 Doppler flow imaging using optical coherence tomography 有权
标题翻译：多普勒血流成像使用光学相干断层扫描
公开(公告)号：US06735463B2
公开(公告)日：2004-05-11
申请号：US09468674
申请日：1999-12-21
申请人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
IPC分类号： A61B502
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/7257 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译：一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

8. 发明授权

US6006128A Doppler flow imaging using optical coherence tomography 失效
标题翻译：多普勒血流成像使用光学相干断层扫描
公开(公告)号：US6006128A
公开(公告)日：1999-12-21
申请号：US88562
申请日：1998-06-02
申请人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
IPC分类号： A61B5/00 , A61B5/026 , A61B5/0285 , A61B10/00 , G01B9/02 , G01N21/17 , A61B5/02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , A61B5/7257 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译：一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体的位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

9. 发明授权

US5994690A Image enhancement in optical coherence tomography using deconvolution 失效
标题翻译：使用去卷积的光学相干断层扫描中的图像增强
公开(公告)号：US5994690A
公开(公告)日：1999-11-30
申请号：US40128
申请日：1998-03-17
申请人： Manish D. Kulkarni , Joseph A. Izatt , Michael V. Sivak
发明人： Manish D. Kulkarni , Joseph A. Izatt , Michael V. Sivak
IPC分类号： A61B5/053 , G01B9/02 , G01N21/47 , H01J3/14
CPC分类号： A61B5/7257 , G01B9/02002 , G01B9/02007 , G01B9/02069 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01N21/4795 , A61B5/0536 , G01B2290/35
摘要： The present invention provides an improved optical coherence tomography system and involves estimating the impulse response (which is indicative of the actual reflecting and scattering sites within a tissue sample) from the output interferometric signal of an interferometer according to the following steps: (a) acquiring auto-correlation data from the interferometer system; (b) acquiring cross-correlation data from the interferometer system having the biological tissue sample in the sample arm; and (c) processing the auto-correlation data and the cross correlation data to produce an optical impulse response of the tissue. The impulse response may be obtained from the cross-correlation and auto-correlation data by: (d) obtaining an auto-power spectrum from the auto-correlation data by performing a Fourier transform on the auto-correlation data; (e) obtaining a cross-power spectrum from the cross-correlation data by performing a Fourier transform on the cross-correlation data; (f) obtaining a transfer function of the LSI system by taking a ratio of the cross-power spectrum to the auto-power spectrum; and (g) obtaining the optical impulse response of the LSI system by performing an inverse-Fourier transform on the transfer function. Preferably, coherent demodulation is used in combination with the above deconvolution technique to resolve closely-spaced reflecting sites in the sample. By utilizing both the magnitude and phase data of the demodulated interferometric signals, the OCT system of the present invention is able to distinguish between closely spaced reflecting sites within the sample.
摘要翻译：本发明提供了一种改进的光学相干断层摄影系统，并且包括根据以下步骤从干涉仪的输出干涉测量信号估计脉冲响应（其指示组织样本内的实际反射和散射位置）：（a）获取来自干涉仪系统的自相关数据; （b）从具有样品臂中的生物组织样品的干涉仪系统获取互相关数据; 和（c）处理自相关数据和互相关数据以产生组织的光脉冲响应。脉冲响应可以通过以下方式从互相关和自相关数据获得：（d）通过对自相关数据执行傅里叶变换，从自相关数据获得自动功率谱; （e）通过对互相关数据执行傅立叶变换从互相关数据获得交叉功率谱; （f）通过将交叉功率谱与自动功率谱的比率取得来获得LSI系统的传递函数; 和（g）通过对传递函数执行傅立叶逆变换获得LSI系统的光脉冲响应。优选地，相干解调与上述反褶积技术组合使用以解决样品中紧密间隔的反射部位。通过利用解调的干涉信号的幅度和相位数据，本发明的OCT系统能够区分样本内的紧密间隔的反射部位。

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