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1. 发明授权

US08425587B2 Method of treatment with a bioabsorbable stent with time dependent structure and properties and regio-selective degradation 有权
标题翻译：用具有时间依赖性结构和性质和区域选择性降解的生物可吸收支架进行治疗的方法
公开(公告)号：US08425587B2
公开(公告)日：2013-04-23
申请号：US12561971
申请日：2009-09-17
申请人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F. A. Hossainy , David C. Gale
发明人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F. A. Hossainy , David C. Gale
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2210/0004 , A61F2230/0054 , A61F2250/0036 , A61L31/06 , A61L31/10 , A61L31/148 , C08L67/04
摘要： A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements.
摘要翻译：公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态。由于选择的结构元件的修饰，生物可吸收的支架以受控的方式失去机械完整性。

2. 发明申请

US20110066225A1 Bioabsorbable Stent With Time Dependent Structure And Properties And Regio-Selective Degradation 有权
标题翻译：生物可吸收支架与时间依赖的结构和性质和选择性降解
公开(公告)号：US20110066225A1
公开(公告)日：2011-03-17
申请号：US12561971
申请日：2009-09-17
申请人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F.A. Hossainy , David C. Gale
发明人： Mikael Trollsas , Dariush Davalian , Michael Huy Ngo , Hao-Ming Hsiao , Boris Anukhin , Syed F.A. Hossainy , David C. Gale
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2210/0004 , A61F2230/0054 , A61F2250/0036 , A61L31/06 , A61L31/10 , A61L31/148 , C08L67/04
摘要： A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements.
摘要翻译：公开了具有时间依赖性结构的生物可吸收聚合物支架，以及用生物可吸收聚合物支架治疗患病血管的特性和方法。支架的结构和性质随时间而变化，并允许血管恢复到自然不稳定状态。由于选择的结构元件的修饰，生物可吸收的支架以受控的方式失去机械完整性。

3. 发明授权

US08500791B2 Stent designs for use in peripheral vessels 有权
标题翻译：支架设计用于外周血管
公开(公告)号：US08500791B2
公开(公告)日：2013-08-06
申请号：US13557303
申请日：2012-07-25
申请人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
发明人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： System including a delivery catheter and a stent disposed at a distal end of the delivery catheter. The stent includes a plurality of radially expandable rings disposed adjacent to one another to define a tubular member having a proximal end portion, and a distal end portion, and a middle portion, each of the radially expandable rings including a plurality of strut members. The middle portion of the tubular member include a plurality of interconnection members extending between longitudinally adjacent expandable rings, the number of the plurality of the interconnection members being greater than that of the end portion of the tubular member. The stent also includes a transition section between the end portion and the middle portion, the transition section including at least one open cell and at least one closed cell. The stent can be self-expandable or balloon expandable.
摘要翻译：包括输送导管和设置在输送导管远端的支架的系统。所述支架包括彼此相邻设置的多个可径向扩张的环，以限定具有近端部分的管状构件，以及远端部分和中间部分，每个所述径向可扩张环包括多个支柱构件。管状构件的中间部分包括在纵向相邻的可膨胀环之间延伸的多个互连构件，多个互连构件的数量大于管状构件的端部的数量。支架还包括在端部和中间部分之间的过渡部分，过渡部分包括至少一个开放电池和至少一个闭合电池。支架可以是自扩张的或气囊扩张的。

4. 发明授权

US08568471B2 Crush recoverable polymer scaffolds 有权
标题翻译：粉碎可回收的聚合物支架
公开(公告)号：US08568471B2
公开(公告)日：2013-10-29
申请号：US13015488
申请日：2011-01-27
申请人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
发明人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
摘要翻译：医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。

5. 发明申请

US20110190872A1 Crush Recoverable Polymer Scaffolds Having a Low Crossing Profile 有权
标题翻译：具有低交叉轮廓的粉碎可回收聚合物支架
公开(公告)号：US20110190872A1
公开(公告)日：2011-08-04
申请号：US13015474
申请日：2011-01-27
申请人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
发明人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
IPC分类号： A61F2/82 , B29C55/24 , B29C69/00
CPC分类号： A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
摘要翻译：医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架还具有减小的卷边轮廓和在冠部处的支架环形结构的改进，其有助于减小卷曲轮廓。

6. 发明授权

US08808353B2 Crush recoverable polymer scaffolds having a low crossing profile 有权
标题翻译：粉碎具有低交叉分布的可回收聚合物支架
公开(公告)号：US08808353B2
公开(公告)日：2014-08-19
申请号：US13015474
申请日：2011-01-27
申请人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
发明人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
摘要翻译：医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架还具有减小的卷曲轮廓和在冠部处的支架环结构的改进，其有助于减小卷曲轮廓。

7. 发明授权

US08974514B2 Intravascular stent with integrated link and ring strut 有权
标题翻译：具有集成连杆和环支柱的血管内支架
公开(公告)号：US08974514B2
公开(公告)日：2015-03-10
申请号：US11724089
申请日：2007-03-13
申请人： Boris Anukhin , Hao-Ming Hsiao , Keif Fitzgerald
发明人： Boris Anukhin , Hao-Ming Hsiao , Keif Fitzgerald
IPC分类号： A61F2/06 , A61F2/915
CPC分类号： A61F2/915 , A61F2002/91541 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036
摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The stent includes a plurality of rings connected by links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. The stent can be compressed or crimped onto a catheter to a very low profile since links are integrally formed from a portion of the struts forming the rings. The stent is constructed so that the cylindrical rings are very close together in order to provide maximum scaffolding, and if the stent has a drug coating, to provide a uniform drug delivery over the length of the stent. The connecting links are integrally formed from a portion of the struts forming the rings so that the links can have a maximum length thereby providing increased longitudinal flexibility of the stent.
摘要翻译：可扩张支架植入体腔，例如冠状动脉，外周动脉或其他体腔。支架包括通过连杆连接的多个环。支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。支架可以被压缩或卷曲到导管上以非常低的轮廓，因为连杆由形成环的支柱的一部分整体形成。支架被构造成使得圆柱形环非常靠近在一起以便提供最大的脚手架，并且如果支架具有药物涂层，以在支架的长度上提供均匀的药物递送。连接连杆由形成环的支柱的一部分整体形成，使得连杆可以具有最大长度，从而提供支架的增加的纵向柔性。

8. 发明申请

US20080228261A1 Intravascular stent with integrated link and ring strut 有权
标题翻译：具有集成连杆和环支柱的血管内支架
公开(公告)号：US20080228261A1
公开(公告)日：2008-09-18
申请号：US11724089
申请日：2007-03-13
申请人： Boris Anukhin , Hao-Ming Hsiao , Keif Fitzgerald
发明人： Boris Anukhin , Hao-Ming Hsiao , Keif Fitzgerald
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91541 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036
摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. The stent includes a plurality of rings connected by links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. The stent can be compressed or crimped onto a catheter to a very low profile since links are integrally formed from a portion of the struts forming the rings. The stent is constructed so that the cylindrical rings are very close together in order to provide maximum scaffolding, and if the stent has a drug coating, to provide a uniform drug delivery over the length of the stent. The connecting links are integrally formed from a portion of the struts forming the rings so that the links can have a maximum length thereby providing increased longitudinal flexibility of the stent.
摘要翻译：可扩张支架植入体腔，例如冠状动脉，外周动脉或其他体腔。支架包括通过连杆连接的多个环。支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。支架可以被压缩或卷曲到导管上以非常低的轮廓，因为连杆由形成环的支柱的一部分整体形成。支架被构造成使得圆柱形环非常靠近在一起以便提供最大的脚手架，并且如果支架具有药物涂层，以在支架的长度上提供均匀的药物递送。连接连杆由形成环的支柱的一部分整体形成，使得连杆可以具有最大长度，从而提供支架的增加的纵向柔性。

9. 发明授权

US08252041B2 Stent designs for use in peripheral vessels 有权
标题翻译：支架设计用于外周血管
公开(公告)号：US08252041B2
公开(公告)日：2012-08-28
申请号：US11844235
申请日：2007-08-23
申请人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
发明人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： Stent designs for use in peripheral vessels, such as the carotid arteries, are disclosed. The stents consist of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in a longitudinal direction. The cylindrical elements are generally serpentine wave pattern transverse to the longitudinal axis between alternating valley portion and peak portions, the valley portion including alternating double-curved portions and U-shaped portions. The interconnecting members are attached to the double-curved portions to connect a cylindrical element to an adjacent cylindrical element and interconnecting members are attached to the U-shaped portions to connect the cylindrical element to the other adjacent cylindrical element. The designs include an eight crown and six crown stent which exhibit flexibility and sufficient radial strength to support the vessel.
摘要翻译：公开了用于外周血管例如颈动脉的支架设计。支架由多个可径向扩张的圆柱形元件组成，其大体上在公共的纵向支架轴线上对准，并且通过一个或多个相互连接的构件相互连接，以使支架在纵向方向上是柔性的。圆柱形元件通常是在交替的谷部分和峰部分之间横向于纵向轴线的蛇形波形图案，谷部分包括交替的双曲面部分和U形部分。互连构件附接到双曲面部分以将圆柱形元件连接到相邻的圆柱形元件，并且互连构件附接到U形部分以将圆柱形元件连接到另一相邻圆柱形元件。这些设计包括八冠和六冠支架，其具有弹性和足够的径向强度以支撑血管。

10. 发明申请

US20080051877A1 STENT DESIGNS FOR USE IN PERIPHERAL VESSELS 有权
标题翻译：外围设备用于外围船舶
公开(公告)号：US20080051877A1
公开(公告)日：2008-02-28
申请号：US11844235
申请日：2007-08-23
申请人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
发明人： Hao-Ming Hsiao , Keif Fitzgerald , Boris Anukhin
IPC分类号： A61F2/82
CPC分类号： A61F2/06 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： Stent designs for use in peripheral vessels, such as the carotid arteries, are disclosed. The stents consist of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in a longitudinal direction. The cylindrical elements are generally serpentine wave pattern transverse to the longitudinal axis between alternating valley portion and peak portions, the valley portion including alternating double-curved portions and U-shaped portions. The interconnecting members are attached to the double-curved portions to connect a cylindrical element to an adjacent cylindrical element and interconnecting members are attached to the U-shaped portions to connect the cylindrical element to the other adjacent cylindrical element. The designs include an eight crown and six crown stent which exhibit flexibility and sufficient radial strength to support the vessel.
摘要翻译：公开了用于外周血管例如颈动脉的支架设计。支架由多个可径向扩张的圆柱形元件组成，其大体上在公共的纵向支架轴线上对准，并且通过一个或多个相互连接的构件相互连接，以使支架在纵向方向上是柔性的。圆柱形元件通常是在交替的谷部分和峰部分之间横向于纵向轴线的蛇形波形图案，谷部分包括交替的双曲面部分和U形部分。互连构件附接到双曲面部分以将圆柱形元件连接到相邻的圆柱形元件，并且互连构件附接到U形部分以将圆柱形元件连接到另一相邻圆柱形元件。这些设计包括八冠和六冠支架，其具有弹性和足够的径向强度以支撑血管。

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