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1. 发明授权

US06475524B1 Composition of matter 失效
标题翻译：物质组成
公开(公告)号：US06475524B1
公开(公告)日：2002-11-05
申请号：US09486675
申请日：2000-03-01
申请人： Mikael Bisrat , Saeed Moshashaee , Håkan Nyqvist , Mustafa Demirbüker
发明人： Mikael Bisrat , Saeed Moshashaee , Håkan Nyqvist , Mustafa Demirbüker
IPC分类号： A61K914
CPC分类号： A61K47/26 , Y10S514/958
摘要： The invention provides a process for crystallization of amorphous and/or meta-stable crystalline regions of preformed particles by treating the particles with a supercritical or subcritical fluid containing an anti-solvent and a solvent. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceutically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.
摘要翻译：本发明提供了通过用含有抗溶剂和溶剂的超临界或亚临界流体处理颗粒来结晶预制颗粒的无定形和/或间稳定结晶区域的方法。本发明进一步提供了包含根据本发明方法制备的颗粒的制剂，其含有一种或多种药理学活性物质和一种或多种药学上可接受的赋形剂，所述制剂在治疗鼻或肺的过敏和/或炎性病症中的用途和方法用于治疗这种情况。

2. 发明授权

US06461642B1 Crystallization using supercritical or subcritical fluids 失效
标题翻译：使用超临界或亚临界流体结晶
公开(公告)号：US06461642B1
公开(公告)日：2002-10-08
申请号：US09486689
申请日：2000-03-01
申请人： Mikael Bisrat , Saeed Moshashaee , Håkan Nyqvist , Mustafa Demirbüker
发明人： Mikael Bisrat , Saeed Moshashaee , Håkan Nyqvist , Mustafa Demirbüker
IPC分类号： A61K914
CPC分类号： B01D11/0411 , A61K9/14 , A61K9/1688 , A61K31/00 , A61K31/137 , A61K31/167 , A61K31/24 , A61K31/44 , A61K31/4458 , A61K31/4704 , A61K31/522 , Y10S514/951
摘要： The invention provides a process for preparing essentially crystalline particles containing a substance in solvated form, by dissolving the substance in a first solvent, introducing the solution and a supercritical or subcritical fluid into an apparatus, wherein the fluid contains an anti-solvent and a second solvent, which is water. Preferably, the anti-solvent is carbon dioxide which is totally saturated with the second solvent, which is water. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceu-tically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.
摘要翻译：本发明提供了一种通过将物质溶解在第一溶剂中，将溶液和超临界或亚临界流体引入设备中来制备基本上含有溶剂化物质的结晶颗粒的方法，其中流体含有抗溶剂和第二溶剂溶剂，它是水。优选地，反溶剂是二氧化碳，其是完全饱和的第二溶剂，其是水。本发明进一步提供包含根据本发明方法制备的颗粒的制剂，其含有一种或多种药理学活性物质和一种或多种药学上可接受的赋形剂，所述制剂在治疗鼻或肺的过敏和/或炎性病症中的用途以及治疗这些病症的方法。

3. 发明授权

US08585943B2 Method and arrangement for the production of particles 有权
标题翻译：生产颗粒的方法和布置
公开(公告)号：US08585943B2
公开(公告)日：2013-11-19
申请号：US12745072
申请日：2008-12-01
申请人： Mustafa Demirbüker
发明人： Mustafa Demirbüker
IPC分类号： B29B9/00
CPC分类号： B01J2/06 , A61K9/1688 , B01J2/04 , B01J4/002 , B01J19/26
摘要： A method for producing particles, from a substance, having predetermined size and/or morphology characteristics. The method consists of mixing within a spray nozzle a solution stream containing the substance in dissolved or dispersed form with a supercritical fluid stream. Spraying the mixture through a nozzle into a particle collecting chamber and there separating the particles. The characteristic feature is an additional step, providing a make-up agent (modifier) to the fluid stream, possibly combined with recycling of the fluid and/or performing the method essentially simultaneously in several spray nozzles. Additional features are also a production system comprising functions for performing the method above and the introduction of the make-up agent, recycling of the fluid and performing several runs essentially simultaneously in the same production system. Also a pharmaceutical formulation in which particles produced according to the method has been used for its manufacture.
摘要翻译：从具有预定尺寸和/或形态特征的物质制备颗粒的方法。该方法包括在喷雾喷嘴内混合含有溶解或分散形式的物质与超临界流体流的溶液流。将混合物通过喷嘴喷射到颗粒收集室中，并分离颗粒。该特征是额外的步骤，为流体流提供补充剂（改性剂），可能与流体的再循环相结合，和/或在几个喷嘴中基本上同时进行该方法。附加特征也是包括用于执行上述方法的功能和补充剂的引入，流体的再循环以及在同一生产系统中基本上同时执行几个运行的功能的生产系统。还有一种药物制剂，其中根据该方法生产的颗粒已被用于其制造。

4. 发明授权

US08585942B2 Process and arrangement for producing particles utilizing subcritical fluids 有权
标题翻译：使用亚临界流体生产颗粒的工艺和布置
公开(公告)号：US08585942B2
公开(公告)日：2013-11-19
申请号：US12745055
申请日：2008-12-05
申请人： Mustafa Demirbüker
发明人： Mustafa Demirbüker
IPC分类号： B29B9/00
CPC分类号： B01J2/06 , A61K9/1688 , B01J2/04 , B01J4/002 , B01J19/26
摘要： A method for producing particles of predetermined sized and/or morphology of a substance in a production arrangement comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a liquid solution in which the substance is dissolved with a stream of a fluid, and ii) passing the mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting container, and iii) separating and collecting within the container the particles. The characteristic feature is that the solvent is a liquid and the fluid is an aqueous liquid in a subcritical state. Preferred nozzles have two coaxial internal transport conduits. One aspect is a production arrangement that can be used in the method. Its characteristic features are functions for a) recycling fluid used in the process, b) for including a make-up agent in the fluid stream, and/or increasing production by paralleling particle formation.
摘要翻译：一种用于生产生产装置中物质的预定尺寸和/或形态的颗粒的方法，包括以下步骤：i）在喷嘴内和流动条件下将物质溶解的液体流与流的流体，以及ii）使喷雾形式的混合物通过喷嘴的喷雾出口进入颗粒收集容器，以及iii）在容器内分离和收集颗粒。特征是溶剂是液体，流体是亚临界状态的水性液体。优选的喷嘴具有两个同轴的内部输送管道。一方面是可用于该方法的生产布置。其特征是用于a）在该方法中使用的再循环流体的功能，b）用于在流体流中包含补充剂，和/或通过平行颗粒形成增加生产。

5. 发明申请

US20100308483A1 Process and Arrangement for Producing Particles Utilizing Subcritical Fluids 有权
标题翻译：生产亚临界流体颗粒的工艺和布置
公开(公告)号：US20100308483A1
公开(公告)日：2010-12-09
申请号：US12745055
申请日：2008-12-05
申请人： Mustafa Demirbüker
发明人： Mustafa Demirbüker
IPC分类号： B29B9/00
CPC分类号： B01J2/06 , A61K9/1688 , B01J2/04 , B01J4/002 , B01J19/26
摘要： A method for producing particles of predetermined sized and/or morphology of a substance in a production arrangement comprising the steps of: i) mixing within a spray nozzle and under flow conditions a stream of a liquid solution in which the substance is dissolved with a stream of a fluid, and ii) passing the mixture in the form of a spray through a spray outlet of the nozzle into a particle collecting container, and iii) separating and collecting within the container the particles. The characteristic feature is that the solvent is a liquid and the fluid is an aqueous liquid in a subcritical state. Preferred nozzles have two coaxial internal transport conduits. One aspect is a production arrangement that can be used in the method. Its characteristic features are functions for a) recycling fluid used in the process, b) for including a make-up agent in the fluid stream, and/or increasing production by paralleling particle formation.
摘要翻译：一种用于生产生产装置中物质的预定尺寸和/或形态的颗粒的方法，包括以下步骤：i）在喷嘴内和流动条件下将物质溶解的液体流与流的流体，以及ii）使喷雾形式的混合物通过喷嘴的喷雾出口进入颗粒收集容器，以及iii）在容器内分离和收集颗粒。特征是溶剂是液体，流体是亚临界状态的水性液体。优选的喷嘴具有两个同轴的内部输送管道。一方面是可用于该方法的生产布置。其特征是用于a）在该方法中使用的再循环流体的功能，b）用于在流体流中包含补充剂，和/或通过平行颗粒形成增加生产。

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