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1. 发明申请

US20110236697A1 ALUMINUM FOR ULTRASONIC BONDING 审中-公开
标题翻译：用于超声波接合的铝
公开(公告)号：US20110236697A1
公开(公告)日：2011-09-29
申请号：US12998861
申请日：2010-11-05
申请人： Michitaka Mikami , Teruo Kikuchi , Shinichiro Nakashima , Yuichi Hirata , Masaharu Nakamura , Keisuke Kimura
发明人： Michitaka Mikami , Teruo Kikuchi , Shinichiro Nakashima , Yuichi Hirata , Masaharu Nakamura , Keisuke Kimura
IPC分类号： B32B15/04
CPC分类号： H01L24/43 , C22C21/00 , H01L24/45 , H01L2224/43 , H01L2224/43848 , H01L2224/45014 , H01L2224/45015 , H01L2224/45124 , H01L2224/45144 , H01L2224/85205 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01009 , H01L2924/01012 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01019 , H01L2924/0102 , H01L2924/01027 , H01L2924/01028 , H01L2924/01029 , H01L2924/01033 , H01L2924/01038 , H01L2924/01049 , H01L2924/01057 , H01L2924/01058 , H01L2924/0106 , H01L2924/01079 , H01L2924/01082 , H01L2924/01083 , H01L2924/01204 , Y10T428/31678 , H01L2924/01205 , H01L2924/00012 , H01L2924/00 , H01L2924/013 , H01L2924/00013 , H01L2924/01003 , H01L2924/01004 , H01L2924/01039 , H01L2224/48 , H01L2924/00015 , H01L2924/206
摘要： [Issues to be Solved] To provide an aluminum ribbon for ultrasonic bonding, is able to realize the high bonding strength and is able to maintain defined level of bonding strength, during several ten thousand bonding cycles.[Means to be Solved] An aluminum ribbon for ultrasonic bonding is consisted aluminum metal or aluminum based alloy, the purity of aluminum is more than 99.99 wt %, and total amount of organic carbon non-ionic surfactant less than 500 molecular weight vaporized and adhered is 100-1,000 μg/m2 on the mirror finished bright surface of aluminum ribbon.
摘要翻译： [待解决的问题]为了提供用于超声波接合的铝带，能够实现高粘结强度并且能够在数万次粘合循环期间保持限定的粘结强度水平。 [待解决的方法]超声波接合用铝带由铝金属或铝基合金构成，铝的纯度大于99.99重量％，小于500分子量的有机碳非离子表面活性剂的总量蒸发并粘附在铝带的镜面光亮表面上为100-1,000μg/ m2。

2. 发明申请

US20130164559A1 ALUMINUM RIBBON FOR ULTRASONIC BONDING 审中-公开
标题翻译：用于超声波接合的铝合金
公开(公告)号：US20130164559A1
公开(公告)日：2013-06-27
申请号：US13392754
申请日：2010-09-09
申请人： Michitaka Mikami , Teruo Kikuchi , Shinichiro Nakashima , Yuichi Hirata , Masaharu Nakamura , Keisuke Kimura
发明人： Michitaka Mikami , Teruo Kikuchi , Shinichiro Nakashima , Yuichi Hirata , Masaharu Nakamura , Keisuke Kimura
IPC分类号： C22C21/00
CPC分类号： H01L24/45 , H01L24/43 , H01L2224/43847 , H01L2224/43848 , H01L2224/45014 , H01L2224/45015 , H01L2224/45124 , H01L2224/85205 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01012 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01029 , H01L2924/01033 , H01L2924/01038 , H01L2924/01049 , H01L2924/01057 , H01L2924/01058 , H01L2924/0106 , H01L2924/01079 , H01L2924/01082 , Y10T428/12993 , H01L2924/01202 , H01L2924/01028 , H01L2924/01014 , H01L2924/01003 , H01L2924/01004 , H01L2924/01039 , H01L2924/01083 , H01L2924/013 , H01L2924/00 , H01L2224/48 , H01L2924/12 , H01L2924/14 , H01L2924/00013 , H01L2924/206
摘要： [Problem to be Solved]The invention providesa bonding ribbon which can guarantee a uniform fusing over the entire joint area throughout hundreds of thousands of continuous ultrasonic bonding cycles and which can realize an improved bonding strength and which also can avoid being broken while it is looped.[Solution]The aluminum ribbon for ultrasonic bonding is formed of an aluminum alloy with aluminum content of 99 mass % or higher, and this ribbon is characterized in that it is in a shape of an extremely thin tape which is obtained by rolling a wire taken from a multi-stage wire drawing, that an average grain size within the cross section of this ribbon is 5-200 micrometers (μm), that the surface(s) of this extremely thin tape is mirror-finished to an extent that the surface roughness Rz is 2 micrometers (μm) or smaller, and that the ribbon has been subjected to an immersion treatment or a gas-exposure treatment wherein the liquid or gas comprises a substance having a vapor pressure higher than water such as a water-soluble hydrocarbons solvent, an alcoholic solvent, a ketone solvent, or an ether type solvent.
摘要翻译： [待解决的问题]本发明提供了一种粘结带，其能够在数十万次连续超声波接合循环中保证在整个接合区域上的均匀熔合，并且可以实现改进的接合强度，并且还可以避免在环路时破坏。 [解决方案]超声波接合用铝带由铝含量为99质量％以上的铝合金形成，该带的特征在于，其是通过卷绕所获得的线而获得的极薄的带状从多级拉丝中，该带的横截面内的平均晶粒尺寸为5-200微米（mum），这种非常薄的带的表面被镜面加工到表面粗糙度Rz为2微米（小时）以下，并且已对带进行了浸渍处理或气体暴露处理，其中液体或气体包括蒸汽压高于水的物质，例如水溶性烃溶剂，醇溶剂，酮溶剂或醚类溶剂。

3. 发明授权

US08530779B2 Disc spring and process of manufacturing the same 有权
标题翻译：盘簧和制造过程相同
公开(公告)号：US08530779B2
公开(公告)日：2013-09-10
申请号：US12833603
申请日：2010-07-09
申请人： Eiji Mizuno , Yuichi Hirata
发明人： Eiji Mizuno , Yuichi Hirata
IPC分类号： B23K15/00 , F16F1/34
CPC分类号： F16F1/32 , B23K15/0006 , B23K15/0033
摘要： A metal strip 10 is bent to form a ring and end parts 12 and 14 are connected to each other. An electron beam 26 may be defocused and emitted to a welded section 20 along a crosswise direction of the metal strip 10. Next, a focal point 28 of the electron beam 26 may be focused onto a weld-melted portion 25 to execute electron beam welding. Subsequently, the electron beam 26 may be defocused emitted to the welded section 20 along the crosswise direction of the metal strip 10, and the welded section 20 may be further cooled. The average of the dendrite secondary arm spacing of the weld-melted portion may fall within a range of 7 to 30 μm.
摘要翻译：金属带10被弯曲以形成环，端部12和14彼此连接。电子束26可以沿着金属条10的横向方向散焦并发射到焊接部分20.接下来，电子束26的焦点28可以聚焦到焊接熔化部分25上以执行电子束焊接。随后，电子束26可以沿着金属带10的横向发射到焊接部分20，并且可以进一步冷却焊接部分20。熔融熔融部分的枝晶次臂间距的平均值可以在7〜30μm的范围内。

4. 发明授权

US07993642B2 Anti-MPL antibodies 失效
标题翻译：抗MPL抗体
公开(公告)号：US07993642B2
公开(公告)日：2011-08-09
申请号：US10551504
申请日：2004-12-10
申请人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
发明人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： A61K39/395 , C12P21/08 , C07K16/00
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
摘要翻译：分离纯化抗人Mpl抗体。使用遗传工程技术制备抗人Mpl双抗体和抗人Mpl sc（Fv）2，抗人Mpl sc（Fv）2也被人源化。测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。

5. 发明申请

US20070202501A1 Proteins Expressed In Ink Cells 有权
标题翻译：在墨水细胞中表达的蛋白质
公开(公告)号：US20070202501A1
公开(公告)日：2007-08-30
申请号：US10574045
申请日：2004-09-29
申请人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
发明人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
IPC分类号： C12Q1/68 , G01N33/53 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
摘要： Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
摘要翻译：分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。

6. 发明授权

US06432674B1 Steroid hormone binding protein 失效
标题翻译：类固醇激素结合蛋白
公开(公告)号：US06432674B1
公开(公告)日：2002-08-13
申请号：US09565808
申请日：2000-05-05
申请人： Yuichi Hirata
发明人： Yuichi Hirata
IPC分类号： C12P2106
CPC分类号： G01N33/743 , C07K14/721
摘要： Several ESTs deduced as a part of a cDNA encoding a protein that is homologous with a membrane-bound steroid binding protein PMBP were found. Based on the sequence data of these ESTs, a consensus sequence was extracted, and primers were designed based on this consensus sequence. Using the thus designed primers, a polymerase chain reaction of human genes was effected. As a result, a gene encoding a novel steroid hormone binding protein that is homologous with PMBP was successfully isolated from a human for the first time.
摘要翻译：发现几种EST被推定为编码与膜结合的类固醇结合蛋白PMBP同源的蛋白质的cDNA的一部分。基于这些EST的序列数据，提取了共有序列，并基于该共有序列设计引物。使用如此设计的引物，进行人基因的聚合酶链反应。结果，与人类第一次成功分离了编码与PMBP同源的新型类固醇激素结合蛋白的基因。

7. 发明授权

US5856135A Reshaped human antibody to human interleukin-6 失效
标题翻译：人类白细胞介素-6重组人抗体
公开(公告)号：US5856135A
公开(公告)日：1999-01-05
申请号：US553501
申请日：1996-02-20
申请人： Masayuki Tsuchiya , Koh Sato , Yuichi Hirata
发明人： Masayuki Tsuchiya , Koh Sato , Yuichi Hirata
IPC分类号： C07K16/00 , C07K16/24 , C12P21/08 , C12P21/04 , C07H21/04 , C12N15/00
CPC分类号： C07K16/00 , C07K16/248 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2319/00
摘要： A reshaped antibody comprising:(A) L chains comprising:(1) a human C region, and(2) an L chain V region comprising human L chain FRs and L chain CDRs of a mouse monoclonal antibody; and(B) H chains comprising:(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and H chain cDRs of a mouse monoclonal antibody to human IL-6. Since the major portions of the reshaped human antibody are derived from human, and the mouse CDRs are less immunogenic, then the present reshaped human antibody is less immunogenic, and therefore inhibits information transfer by IL-6, and is promising as a therapeutic agent for diseases caused by IL-6.
摘要翻译： PCT No.PCT / JP94 / 00859 Sec。 371日期1996年2月20日 102（e）日期1996年2月20日PCT 1994年5月30日PCT PCT。公开号WO94 / 28159 日期：1994年12月8日一种重整抗体，其包含：（A）L链，其包含：（1）人C区，和（2）包含小鼠单克隆抗体的人L链FR和L链CDR的L链V区; 和（B）H链，其包含：（1）人H链C区，和（2）包含人H链FR的H链V区和对人IL-6的小鼠单克隆抗体的H链cR。由于重构人抗体的主要部分来自人，小鼠CDR的免疫原性较小，因此本发明的重组人抗体免疫原性较小，因此抑制IL-6的信息传递，并且作为治疗剂是有希望的 IL-6引起的疾病。

8. 发明授权

US08187506B2 Barium titanate-based semiconductor ceramic composition and barium titanate-based semiconductor ceramic device 有权
标题翻译：钛酸钡系半导体陶瓷组合物和钛酸钡系半导体陶瓷元件
公开(公告)号：US08187506B2
公开(公告)日：2012-05-29
申请号：US13303436
申请日：2011-11-23
申请人： Yoichi Kawase , Syunsuke Okuda , Yuichi Hirata , Yasuhiro Nabika
发明人： Yoichi Kawase , Syunsuke Okuda , Yuichi Hirata , Yasuhiro Nabika
IPC分类号： H01B1/08 , H01B3/12 , C04B35/46 , H01C7/02
CPC分类号： H01C7/025 , C04B35/4682 , C04B2235/3208 , C04B2235/3213 , C04B2235/3224 , C04B2235/3227 , C04B2235/3229 , C04B2235/3262 , C04B2235/3296 , C04B2235/3418 , C04B2235/6565
摘要： A barium titanate-based semiconductor ceramic composition which can be used for PTC thermistors for temperature sensors and which has characteristics, including a linear characteristic, advantageous for such PTC thermistors and a barium titanate-based semiconductor ceramic device. The barium titanate-based semiconductor ceramic composition is represented by the formula (Ba(1-v-w)MevSrw)TixO3+ySiO2, wherein Me is at least one of Er, Sm, Ce, and La, 0.001≦v≦0.005, 0.42≦w≦0.49, 0.99≦x≦1.03, and 0.002≦y≦0.030.
摘要翻译：一种可用于温度传感器的PTC热敏电阻的钛酸钡基半导体陶瓷组合物，其具有包括线性特征的特性，对于这种PTC热敏电阻和钛酸钡基半导体陶瓷器件是有利的。钛酸钡系半导体陶瓷组合物由式（Ba（1-vw）MevSrw）TixO 3 + ySiO 2表示，其中Me为Er，Sm，Ce和La中的至少一种，0.001＆nlE; v＆nlE; 0.005,0.42 ＆nlE; w＆nlE; 0.49,0.99＆amp; nlE; x＆nlE; 1.03和0.002＆amp; nlE; y＆nlE; 0.030。

9. 发明申请

US20110059488A1 Anti-MPL Antibodies 失效
标题翻译：抗MPL抗体
公开(公告)号：US20110059488A1
公开(公告)日：2011-03-10
申请号：US12874872
申请日：2010-09-02
申请人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
发明人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： C12P21/06 , C07H21/00 , C12N15/63 , C12N5/00
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2.The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
摘要翻译：分离和纯化抗人Mpl抗体，然后使用遗传工程技术纯化抗人Mpl双抗体和抗人Mpl sc（Fv）2。此外，本发明人成功地将抗人Mpl sc（Fv）2人源化。测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。

10. 发明授权

US07691588B2 Ligand having agonistic activity to mutated receptor 失效
标题翻译：配体对突变受体具有激动作用
公开(公告)号：US07691588B2
公开(公告)日：2010-04-06
申请号：US10548727
申请日：2004-03-12
申请人： Masayuki Tsuchiya , Yuichi Hirata
发明人： Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： G01N33/53 , G01N33/574 , G01N33/576 , C12P21/08 , C07K16/00
CPC分类号： C09K11/7733 , G21K4/00
摘要： The present inventors used antibody engineering techniques to prepare functional antibodies that correspond to individual mutations in causative genes of diseases, and discovered that such antibodies enable the treatment of the diseases. Specifically, the inventors succeeded in preparing ligands, particularly minibodies, which have agonistic activity to receptors that have almost completely lost responsiveness to their natural ligands because of gene mutations (for example, a thrombopoietin (TPO) receptor whose reactivity to TPO has been markedly impaired), and which can transduce signals by interacting with these mutant receptors at levels comparable to normal.
摘要翻译：本发明人使用抗体工程技术来制备与疾病的致病基因中的个体突变相对应的功能性抗体，并发现这种抗体能够治疗疾病。具体地，本发明人成功地制备了由于基因突变（例如，其对TPO的反应性已被显着损伤的血小板生成素（TPO）受体）而对几乎完全丧失对其天然配体的反应性的受体具有激动作用的配体，特别是微型抗体），并且其可以通过与这些突变体受体的相互作用来转导信号，其水平与正常水平相当。

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