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1. 发明授权

US5236803A Color light-sensitive material with hydroquinone reducing agent 失效
标题翻译：具有降氢剂的色光敏感材料
公开(公告)号：US5236803A
公开(公告)日：1993-08-17
申请号：US918612
申请日：1992-07-27
申请人： Michio Ono , Takeshi Nakamine , Hiroyuki Hirai
发明人： Michio Ono , Takeshi Nakamine , Hiroyuki Hirai
IPC分类号： G03C8/08 , G03C8/22 , G03C8/36 , G03C8/40
CPC分类号： G03C8/08
摘要： A color light-sensitive material comprising a support having thereon at least one light-sensitive layer containing light-sensitive silver halide, and further comprising in the at least one light-sensitive layer or any other layer, independently, a binder, a reducible dye-providing compound, and a reducing agent represented by formula (I): ##STR1## wherein X represents --CO-- or --SO.sub.2 --; R.sup.1 and R.sup.2, which may be the same or different, each represents an alkyl group, an aryl group or a heterocyclic group, any of which groups may be substituted; R.sup.3 represents a hydrogen atom, a halogen atom, an aryl group, an acylamino group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an acyl group, a sulfonyl group, a carbamoyl group or a sulfamoyl group, any of which groups may be substituted; R.sup.2 and R.sup.3 may be combined together to form a carbocyclic ring or a heterocyclic ring; and the reducing agent may be in the form of a dimer or a trimer through R.sup.1 or R.sup.2.

2. 发明授权

US5202225A Silver halide photographic materials with redox releasers containing nucleophilic groups 失效
标题翻译：具有含有亲核基团的氧化还原释放剂的卤化银照相材料
公开(公告)号：US5202225A
公开(公告)日：1993-04-13
申请号：US744741
申请日：1991-08-14
申请人： Takeshi Nakamine , Takayuki Ito , Naoto Matsuda , Koki Nakamura , Hiroyuki Hirai
发明人： Takeshi Nakamine , Takayuki Ito , Naoto Matsuda , Koki Nakamura , Hiroyuki Hirai
IPC分类号： G03C7/305
CPC分类号： G03C7/30511 , Y10S430/156 , Y10S430/158 , Y10S430/16
摘要： Disclosed is a silver halide photographic material comprising a support, having thereon at least one silver halide emulsion layer, wherein there is contained in the silver halide emulsion layer or other hydrophilic colloid layer a compound of which an oxidized form is produced in accordance with development of the silver halide and is capable of releasing a photographically useful group by means of a conjugated addition-elimination mechanism due to an intramolecular nucleophilic group attack.
摘要翻译：公开了一种卤化银照相材料，其包含载体，其上具有至少一个卤化银乳剂层，其中包含在卤化银乳剂层或其它亲水胶体层中，根据其发展形成氧化形式的化合物卤化银，并且由于分子内的亲核基团攻击，能够通过共轭加成 - 消除机理释放照相用的基团。

3. 发明授权

US5139919A Heat-developable color photographic materials with combination of electron transfer agent and precursor 失效
标题翻译：具有电子转移剂和前体组合的可热显色彩色照相材料
公开(公告)号：US5139919A
公开(公告)日：1992-08-18
申请号：US657937
申请日：1991-02-21
申请人： Toshiki Taguchi , Takeshi Nakamine , Ken Kawata , Hiroyuki Hirai
发明人： Toshiki Taguchi , Takeshi Nakamine , Ken Kawata , Hiroyuki Hirai
IPC分类号： G03C8/08 , G03C8/40
CPC分类号： G03C8/408 , G03C8/08 , G03C8/4033 , Y10S430/16
摘要： A heat-developable color photographic material comprising a support having thereon at least a light-sensitive silver halide, a binder, at least one of an electron-donating agent and a precursor thereof, a reducible dye-forming compound which releases a diffusible dye by reduction and an electron-transferring agent, wherein an electron-transferring agent precursor co-exists together with the electron-transferring agent.
摘要翻译：一种可热显影的彩色照相材料，包括其上至少含有感光卤化银，粘合剂，给电子剂及其前体中的至少一种的载体，可释放的染料形成化合物，其通过还原和电子转移剂，其中电子转移剂前体与电子转移剂一起共存。

4. 发明授权

US5206131A Diffusion transfer type silver halide color photosensitive materials 失效
标题翻译：扩散转印型银色颜料色素光敏材料
公开(公告)号：US5206131A
公开(公告)日：1993-04-27
申请号：US683913
申请日：1991-04-11
申请人： Naoto Matsuda , Takeshi Nakamine , Koki Nakamura , Hiroyuki Hirai
发明人： Naoto Matsuda , Takeshi Nakamine , Koki Nakamura , Hiroyuki Hirai
IPC分类号： G03C8/08 , G03C7/305 , G03C7/392 , G03C8/40
CPC分类号： G03C7/30511 , G03C7/39208 , Y10S430/158
摘要： A diffusion transfer-type silver halide color photographic photosensitive material comprising a support, having thereon at least a photosensitive thermally developable silver halide, a binder, a dye donating compound which is fast to diffusion and which forms or releases a diffusible dye, a development inhibitor releasing compound which releases a development inhibitor and a compound represented by formula (I)R.sup.1 --Y--O--H [I]wherein R.sup.1 represents an alkyl group, an aryl group, an alkylamino group, an arylamino group, an alkoxy group, an aryloxy group, a heterocyclic residual group or a polymer residual group of said groups, Y represents ##STR1## or --SO.sub.2 --NR.sup.2 -- and R.sup.2 represents a hydrogen atom, an alkyl group, an aryl group or an acyl group, and R.sup.1 and R.sup.2 may be joined together to form a five or eight membered ring is disclosed.

5. 发明授权

US5736293A Image forming method 失效
标题翻译：图像形成方法
公开(公告)号：US5736293A
公开(公告)日：1998-04-07
申请号：US736205
申请日：1996-10-25
申请人： Hiroyuki Hirai , Michio Ono , Takashi Nakamura
发明人： Hiroyuki Hirai , Michio Ono , Takashi Nakamura
IPC分类号： G03C8/28 , G03C1/42 , G03C1/498 , G03C5/29 , G03C8/36 , G03C8/40 , G03C8/56 , G03C5/30 , G03C8/06
CPC分类号： G03C8/408 , G03C1/49827
摘要： An image forming method comprising the steps of: (a) superposing a heat development photosensitive material on a sheet after or simultaneously with imagewise exposing the heat development photosensitive material, wherein the photosensitive material comprises a support having thereon at least a photosensitive silver halide, a hydrophilic binder and a slightly water-soluble basic metal compound, and the sheet comprises a support having thereon at least a compound which forms a complex with the metal ion constituting the basic metal compound, a solvent for a silver halide and a physical development nucleus; and (b) heat developing the laminate in the presence of a reducing agent and water to form an image on either or both of the photosensitive material and the sheet, wherein the reducing agent comprises a 1-phenyl-3-pyrazolidone compound and a dihydroxybenzene compound having an inorganic value of not less than 215 and an organic value of from 120 to 400.
摘要翻译：一种图像形成方法，包括以下步骤：（a）将成像感光材料叠加在成像曝光所述显影感光材料之后或同时曝光所述热显影感光材料，其中所述感光材料包括至少具有感光卤化银的支撑体，亲水性粘合剂和轻微水溶性碱性金属化合物，并且该片材包含其上至少具有与构成碱性金属化合物的金属离子形成络合物的化合物，卤化银溶剂和物理显影核的载体; 和（b）在还原剂和水的存在下对层压体进行热显影，以在感光材料和片材之一或两者上形成图像，其中还原剂包括1-苯基-3-吡唑烷酮化合物和二羟基苯化合物，其无机值不小于215，有机值为120-400。

6. 发明授权

US5032487A Color light-sensitive material 失效
公开(公告)号：US5032487A
公开(公告)日：1991-07-16
申请号：US489637
申请日：1990-03-07
申请人： Michio Ono , Masuzi Motoki , Hiroyuki Hirai
发明人： Michio Ono , Masuzi Motoki , Hiroyuki Hirai
IPC分类号： G03C7/392 , G03C8/08 , G03C8/40
CPC分类号： G03C8/08 , G03C7/39216 , G03C8/408
摘要： A color light-sensitive material comprising at least light-sensitive silver halide, a binder, a reducible dye providing compound and a reducing agent represented by the following formula (I). ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an acylamino group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an acyl group, a sulfonyl group, a carbamoyl group or a sulfamoyl group, or R.sup.1 and R.sup.2 may be combined together to form a carbon ring or a heterocyclic ring; R.sup.3 represents an alkylene group; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a nitro group, an alkyl group, an acylamino group, a sulfonamido group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an amino group, an acyl group, an acyloxy group, a carbamoyl group, a carbamoylamino group, a sulfamoyl group, a sulfamoylamino group, an alkoxycarbonyl group, an aryloxycarbonyl group, a heterocyclic group, an aryloxycarbonyloxy group, an alkoxysulfonyl group or an aryloxysulfonyl group (with the proviso that R.sup.5 is not a hydroxyl group), or two adjoining groups may be combined together to form a carbon ring or a heterocyclic ring; X represents --NHCO--, --NHCONH--, --CONH--, --NHSO.sub.2 --, --NHSO.sub.2 NH-- --SO.sub.2 NH-- or ##STR2## m and n each represents 0 or 1; and the sum total of carbon atoms of R.sup.1 to R.sup.7 is not less than 8.

7. 发明授权

US5026634A Color light-sensitive material 失效
公开(公告)号：US5026634A
公开(公告)日：1991-06-25
申请号：US382447
申请日：1989-07-20
申请人： Michio Ono , Hiroyuki Hirai , Nobutaka Ohki , Kouichi Hanaki , Koki Nakamura
发明人： Michio Ono , Hiroyuki Hirai , Nobutaka Ohki , Kouichi Hanaki , Koki Nakamura
IPC分类号： C07C39/15 , C07C39/17 , C07C233/18 , C07C233/25 , C07C233/65 , C07C233/73 , C07C275/26 , C07C311/08 , C07C311/17 , C07C311/19 , C07C311/29 , C07C317/22 , C07C317/40 , C07C323/20 , C07C323/40 , G03C8/08
CPC分类号： C07C311/29 , C07C233/18 , C07C233/25 , C07C233/65 , C07C233/73 , C07C275/26 , C07C311/08 , C07C311/17 , C07C311/19 , C07C317/22 , C07C317/40 , C07C323/20 , C07C323/40 , C07C39/15 , C07C39/17 , G03C8/08 , C07C2101/14 , C07C2103/66
摘要： A color light sensitive material which provides a positive dye image having high density, good color reproducibility and which exhibits excellent preservability before use. The material comprises a support having provided thereon a light-sensitive silver halide, a binder, a reducible dye donating compound, and at least one reducing agent selected from the group consisting of a compound represented by formula (IA) and a compound represented by formula (IB): ##STR1## wherein the substituents have the meanings indicated in the specification.

8. 发明授权

US09580689B2 Induced pluripotent stem cells 有权
标题翻译：诱导多能干细胞
公开(公告)号：US09580689B2
公开(公告)日：2017-02-28
申请号：US13811572
申请日：2011-07-22
申请人： Nobuaki Kikyo , Hiroyuki Hirai
发明人： Nobuaki Kikyo , Hiroyuki Hirai
IPC分类号： C12N5/00 , C12N5/074 , C07K14/47 , C12N15/85
CPC分类号： C12N5/0696 , A01K2207/12 , A01K2227/105 , C07K14/4702 , C07K2319/71 , C12N15/8509 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2510/00 , C12N2740/15041
摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
摘要翻译：这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

9. 发明申请

US20130195812A1 INDUCED PLURIPOTENT STEM CELLS 有权
标题翻译：诱导的大脑干细胞
公开(公告)号：US20130195812A1
公开(公告)日：2013-08-01
申请号：US13811572
申请日：2011-07-22
申请人： Nobuaki Kikyo , Hiroyuki Hirai
发明人： Nobuaki Kikyo , Hiroyuki Hirai
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , A01K2207/12 , A01K2227/105 , C07K14/4702 , C07K2319/71 , C12N15/8509 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1307 , C12N2510/00 , C12N2740/15041
摘要： Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs.
摘要翻译：这里描述的是核重新编程和诱导多能干细胞（iPSC）技术的重大突破。将MyoD强大的转录激活结构域（TAD）融合到Oct4蛋白质中，使得iPSC生成更快，更有效，更纯净，更安全，更无饲料。此外，本文公开的是使用与转录因子融合的TAD作为制备iPSC的方法的第一个报告。通过组合转录因子和TAD，这种核重新编程方法可以具有诱导多能性诱导转分化而不通过iPSC过渡的应用范围。

10. 发明申请

US20090130022A1 MRI CONTRAST MEDIUM CONTAINING LIPOSOMES 审中-公开
标题翻译： MRI对比中药含有脂质体
公开(公告)号：US20090130022A1
公开(公告)日：2009-05-21
申请号：US11916391
申请日：2006-06-06
申请人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
发明人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
IPC分类号： A61B5/055 , A61K9/127
CPC分类号： A61K49/1812
摘要： A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.
摘要翻译：含有磷脂酰胆碱和磷脂酰丝氨酸的磷脂酰丝氨酸组合为磷脂酰胆碱的膜组分：磷脂酰丝氨酸摩尔比为3:1至1:2，所述脂质体含有平均粒度不小于1nm且不大于50的超顺磁性颗粒 nm。用于选择性地累积由血管平滑肌细胞的异常增殖引起的血管疾病的病变中的MRI造影剂的手段，所述血管病变由PTCA提供之后的动脉硬化和再狭窄引起。

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