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1. 发明申请

US20090275743A1 METHOD OF PREPARING CARRIER TO SEPARATE NUCLEIC ACIDS, CARRIER AND MICRO CHANNEL TO SEPARATE NUCLEIC ACIDS, AND METHOD AND APPARATUS FOR SEPARATING NUCLEIC ACIDS 有权
标题翻译：制备分离核酸的载体的方法，分离核酸的载体和微通道的方法以及分离核酸的方法和装置
公开(公告)号：US20090275743A1
公开(公告)日：2009-11-05
申请号：US12432078
申请日：2009-04-29
申请人： Michihiro Ohnishi , Noriyuki Kishii , Takuya Kishimoto , Naoyuki Sasaki , Hidetoshi Watanabe
发明人： Michihiro Ohnishi , Noriyuki Kishii , Takuya Kishimoto , Naoyuki Sasaki , Hidetoshi Watanabe
IPC分类号： C07H1/00 , B01J19/00 , B05D3/00
CPC分类号： C12N15/1006
摘要： The present invention provides a method for producing a carrier for nucleic acid separation, the method including a step of: immobilizing capturing chains onto a porous carrier having cation-exchangeable groups thereon by ion exchange bonding, the capturing chains having a base sequence complementary to target nucleic acid chains and being modified with functional groups having positive charges.
摘要翻译：本发明提供了一种核酸分离用载体的制造方法，该方法包括以下步骤：通过离子交换键将捕获链固定在其上具有阳离子交换基团的多孔载体上，捕获链具有与靶相互补充的碱基序列核酸链，并用具有正电荷的官能团修饰。

2. 发明授权

US08785348B2 Method of preparing carrier to separate nucleic acids, carrier and micro channel to separate nucleic acids, and method and apparatus for separating nucleic acids 有权
标题翻译：制备分离核酸，载体和微通道以分离核酸的载体的方法，以及用于分离核酸的方法和装置
公开(公告)号：US08785348B2
公开(公告)日：2014-07-22
申请号：US12432078
申请日：2009-04-29
申请人： Michihiro Ohnishi , Noriyuki Kishii , Takuya Kishimoto , Naoyuki Sasaki , Hidetoshi Watanabe
发明人： Michihiro Ohnishi , Noriyuki Kishii , Takuya Kishimoto , Naoyuki Sasaki , Hidetoshi Watanabe
IPC分类号： B01J20/00 , B01J23/02 , C07H21/00
CPC分类号： C12N15/1006
摘要： The present disclosure relates to a method and apparatus for separating nucleic acids. A carrier may include a porous microbead having cation-exchangeable groups attached to the surface of the porous microbead. Capturing chains modified with positively charged functional groups and having a base sequence complementary to a target nucleic acid chain sequence are immobilized on to the surface of the porous microbead. In various embodiments, capturing chains are immobilized on to the surface of the porous microbead through an ion exchange bond or a covalent bond with the cation-exchangeable groups of the porous microbead. In some cases, the porous microbead has a number of through pores adapted to permit a solution to pass rapidly through the through pores and a number of diffusive pores adapted to permit a solute of the solution to diffuse into the diffusive pores. A solution having a target nucleic acid chain corresponding to the target nucleic acid chain sequence of the capturing chains may be passed through a channel that is packed with porous microbeads so as to result in hybridization of the capturing chain and the target nucleic acid chain. The porous microbeads may be structured such that the pressure in the channel upon passing of the solution through the channel does not build significantly.
摘要翻译：本公开涉及用于分离核酸的方法和装置。载体可以包括具有连接到多孔微珠表面的可阳离子交换基团的多孔微珠。用正电荷的官能团修饰并具有与靶核酸链序列互补的碱基序列的捕获链被固定在多孔微珠的表面上。在各种实施方案中，捕获链通过与多孔微珠的可阳离子交换基团的离子交换键或共价键固定在多孔微珠的表面上。在一些情况下，多孔微珠具有适于使溶液快速通过通孔的多个通孔，并且适于允许溶液的溶质扩散到扩散孔中的许多扩散孔。具有对应于捕获链的靶核酸链序列的靶核酸链的溶液可以通过填充有多孔微珠的通道，从而导致捕获链和靶核酸链的杂交。多孔微珠可以被构造成使得溶液通过通道时通道中的压力不会显着增加。

3. 发明申请

US20120010097A1 MICROCHANNEL, AND NUCLEIC ACID HYBRIDIZATION MICROCHIP, COLUMN, SYSTEM AND METHOD 审中-公开
标题翻译：微通道和核酸混合微孔，柱，系统和方法
公开(公告)号：US20120010097A1
公开(公告)日：2012-01-12
申请号：US13171851
申请日：2011-06-29
申请人： Michihiro Ohnishi , Naoyuki Sasaki , Takuya Kishimoto , Hidetoshi Watanabe
发明人： Michihiro Ohnishi , Naoyuki Sasaki , Takuya Kishimoto , Hidetoshi Watanabe
IPC分类号： C40B30/04 , C40B40/06 , B01D35/00
CPC分类号： C12Q1/6813 , C12Q2527/101 , C12Q2565/629
摘要： A microchannel capable of passing therethrough a solution with target nucleic acid strands contained therein includes: an agarose gel carrier having light transmission properties, supporting capture strands having a base sequence complementary to that of the target nucleic acid strands and immobilized on the agarose gel carrier, and packed in the microchannel; and a filter arranged in the microchannel on a downstream side as viewed in a passing direction of the solution and retaining the agarose gel carrier.
摘要翻译：能够通过其中含有目标核酸链的溶液的微通道包括：具有透光性的琼脂糖凝胶载体，支持具有与靶核酸链互补的碱基序列并固定在琼脂糖凝胶载体上的捕获链，并包装在微通道中; 以及在溶液的通过方向上观察的下游侧的微通道中布置的过滤器，并保持琼脂糖凝胶载体。

4. 发明申请

US20080299541A1 METHOD AND APPARATUS FOR MEASURING ENZYMATIC ACTIVITY BY USE OF LASER 失效
标题翻译：通过使用激光测量酶活性的方法和装置
公开(公告)号：US20080299541A1
公开(公告)日：2008-12-04
申请号：US12110969
申请日：2008-04-28
申请人： Takuya Kishimoto , Hidetoshi Watanabe , Michihiro Ohnishi
发明人： Takuya Kishimoto , Hidetoshi Watanabe , Michihiro Ohnishi
IPC分类号： C12Q1/00 , C12M1/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/441
摘要： A method of measuring an enzymatic activity, includes measuring the quantity of a substrate metabolite produced upon metabolism of a substrate by an enzyme, through detecting a radiant wave generated from a multiple photon excitation process of the substrate or the substrate metabolite.
摘要翻译：测量酶活性的方法包括通过检测由底物或底物代谢物的多光子激发过程产生的辐射波来测量由酶代谢基质时产生的底物代谢物的量。

5. 发明申请

US20090324498A1 METHOD OF MEASURING QUANTITY OF IN-VIVO SUBSTANCE BY USE OF COHERENT ANTI-STOKES RAMAN SCATTERED LIGHT 审中-公开
标题翻译：通过使用相同的反坦克拉曼散射光来测量体内物质的数量的方法
公开(公告)号：US20090324498A1
公开(公告)日：2009-12-31
申请号：US12486290
申请日：2009-06-17
申请人： Takuya Kishimoto , Michihiro Ohnishi , Hidetoshi Watanabe
发明人： Takuya Kishimoto , Michihiro Ohnishi , Hidetoshi Watanabe
IPC分类号： A61K49/00 , C12Q1/02
CPC分类号： G01N21/65 , A61B5/14546 , A61B5/1455 , G01N2021/653 , G01N2021/656
摘要： A method of measuring the quantity of an in-vivo substance includes the steps of: irradiating an in-vivo substance with two near infrared femtosecond laser beams of different frequencies; detecting coherent anti-Stokes Raman scattered light emitted from the in-vivo substance due to coincidence of the frequency difference between the two near infrared femtosecond laser beams with a natural frequency of the in-vivo substance; and determining the quantity of the in-vivo substance, based on a peak intensity of a Raman scattering spectrum obtained.
摘要翻译：测定体内物质量的方法包括以下步骤：用两个不同频率的近红外飞秒激光照射体内物质; 由体内物质的固有频率引起的两个近红外飞秒激光束之间的频率差的一致性检测从体内物质发射的相干反斯托克斯拉曼散射光; 并且基于所获得的拉曼散射光谱的峰值强度来确定体内物质的量。

6. 发明授权

US08753898B2 Microbead analysis method and microbead analyzer 失效
标题翻译：微珠分析法和微珠分析仪
公开(公告)号：US08753898B2
公开(公告)日：2014-06-17
申请号：US12877237
申请日：2010-09-08
申请人： Kenzo Machida , Noriyuki Kishii , Mari Ichimura , Kazumine Ito , Takuya Kishimoto , Naohisa Sakamoto
发明人： Kenzo Machida , Noriyuki Kishii , Mari Ichimura , Kazumine Ito , Takuya Kishimoto , Naohisa Sakamoto
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N21/6452
摘要： Provided is a microbead analysis method for a microbead. The microbead is formed in a columnar shape having a top surface and a bottom surface facing each other, as placed almost in parallel, and a side surface extending therefrom, and carries an identification pattern formed on at least one of the top surface and the bottom surface and a substance immobilized on a surface thereof having affinity to an analyte substance. The method includes detecting fluorescence emitted from the microbead surface due to interaction of the analyte substance with the substance having affinity to the analyte substance from a region including a region of the top surface and the bottom surface where there is no identification pattern formed and the side surface.
摘要翻译：微珠的微珠分析方法。微珠形成为具有彼此面对的顶表面和底表面的几乎平行的柱状和从其延伸的侧表面，并且携带形成在顶表面和底部中的至少一个上的识别图案表面和固定在其对分析物质具有亲和性的表面上的物质。该方法包括检测由于分析物质与对分析物质具有亲和性的物质的相互作用而从微珠表面发射的荧光，该区域包括不形成识别图案的顶表面和底表面的区域，侧面表面。

7. 发明申请

US20110136263A1 MICROBEAD ANALYSIS METHOD AND MICROBEAD ANALYZER 失效
标题翻译： MICROBEAD分析方法和MICROBEAD分析仪
公开(公告)号：US20110136263A1
公开(公告)日：2011-06-09
申请号：US12877237
申请日：2010-09-08
申请人： Kenzo Machida , Noriyuki Kishii , Mari Ichimura , Kazumine Ito , Takuya Kishimoto , Naohisa Sakamoto
发明人： Kenzo Machida , Noriyuki Kishii , Mari Ichimura , Kazumine Ito , Takuya Kishimoto , Naohisa Sakamoto
IPC分类号： G01N33/543 , G01N21/64
CPC分类号： G01N33/54366 , G01N21/6452
摘要： Provided is a microbead analysis method for a microbead. The microbead is formed in a columnar shape having a top surface and a bottom surface facing each other, as placed almost in parallel, and a side surface extending therefrom, and carries an identification pattern formed on at least one of the top surface and the bottom surface and a substance immobilized on a surface thereof having affinity to an analyte substance. The method includes detecting fluorescence emitted from the microbead surface due to interaction of the analyte substance with the substance having affinity to the analyte substance from a region including a region of the top surface and the bottom surface where there is no identification pattern formed and the side surface.
摘要翻译：微珠的微珠分析方法。微珠形成为具有彼此面对的顶表面和底表面的几乎平行的柱状和从其延伸的侧表面，并且携带形成在顶表面和底部中的至少一个上的识别图案表面和固定在其对分析物质具有亲和性的表面上的物质。该方法包括检测由于分析物质与对分析物质具有亲和性的物质的相互作用而从微珠表面发射的荧光，该区域包括不形成识别图案的顶表面和底表面的区域，侧面表面。

8. 发明授权

US09361667B2 Image processing apparatus and method 有权
标题翻译：图像处理装置及方法
公开(公告)号：US09361667B2
公开(公告)日：2016-06-07
申请号：US13818027
申请日：2011-08-26
申请人： Kazuki Aisaka , Seiji Kobayashi , Takuya Kishimoto , Tomoyuki Ootsuki
发明人： Kazuki Aisaka , Seiji Kobayashi , Takuya Kishimoto , Tomoyuki Ootsuki
IPC分类号： G06T5/00 , A61B3/12 , G06T3/40 , A61B3/15 , G06T5/50 , G06T7/00
CPC分类号： A61B3/0025 , A61B3/12 , A61B3/152 , G06T3/4053 , G06T5/001 , G06T5/002 , G06T5/50 , G06T2207/20208 , H04N1/387 , H04N2201/0414
摘要： The present technology relates to an image processing apparatus and an image processing method, and particularly to an image processing apparatus and an image processing method capable of suppressing an increase in a load on a subject and obtaining a captured image of the subject with higher image quality.An imaging unit reduces a light amount and performs a plurality of imagings of the fundus of the eye so as to generate a plurality of fundus images. A biological information alignment processing unit aligns the fundus images by using biological information of a subject. A super-resolution processing unit superimposes an aligned input image on a previous super-resolution result image so as to generate a new super-resolution result image. The super-resolution processing unit stores or outputs the super-resolution result image in a storage unit or from an output unit, and supplies the super-resolution result image to a super-resolution result image buffer so as to be stored. The present technology may be applied to, for example, an image processing apparatus.
摘要翻译：本技术涉及一种图像处理装置和图像处理方法，特别涉及一种能够抑制对对象的负担增加并获得具有较高图像质量的被摄体的拍摄图像的图像处理装置和图像处理方法。成像单元减少光量并执行眼睛的眼底的多个图像，以产生多个眼底图像。生物信息对齐处理单元通过使用对象的生物信息对准眼底图像。超分辨率处理单元将对准的输入图像叠加在先前的超分辨率结果图像上，以生成新的超分辨率结果图像。超分辨率处理单元将超分辨率结果图像存储或输出到存储单元或输出单元中，并将超分辨率结果图像提供给超分辨率结果图像缓冲器以便被存储。本技术可以应用于例如图像处理装置。

9. 发明授权

US08734593B2 Substrate treatment apparatus and substrate treatment method 有权
标题翻译：基板处理装置及基板处理方法
公开(公告)号：US08734593B2
公开(公告)日：2014-05-27
申请号：US13044925
申请日：2011-03-10
申请人： Takuya Kishimoto , Koji Ando
发明人： Takuya Kishimoto , Koji Ando
IPC分类号： B08B3/02 , B08B3/04 , B08B11/02
CPC分类号： H01L21/02052 , H01L21/02087 , H01L21/465 , H01L21/67051 , H01L21/6708 , H01L21/6875
摘要： A substrate treatment apparatus includes: substrate holding unit which horizontally holds a substrate; a rotating unit which rotates the substrate held by the substrate holding unit about a vertical axis; and a first nozzle having a first opposing face to be opposed to a region of a lower surface of the substrate inward of a peripheral portion of the substrate in spaced relation to the lower surface of the substrate during rotation of the substrate by the rotating unit and a treatment liquid spout provided in the first opposing face for filling a space defined between the lower surface of the substrate and the first opposing face with a treatment liquid spouted from the treatment liquid spout to keep the space in a liquid filled state.
摘要翻译：基板处理装置包括：水平保持基板的基板保持单元; 旋转单元，其使由所述基板保持单元保持的所述基板绕垂直轴旋转; 以及第一喷嘴，所述第一喷嘴具有第一相对面，所述第一相对面在所述基板由所述旋转单元旋转期间与所述基板的与所述基板的下表面间隔开的向内的与所述基板的下表面的区域相对的区域相对; 设置在所述第一相对面中的处理液体喷口，用于将从所述处理液喷口喷出的处理液体填充在所述基板的下表面和所述第一相对面之间的空间，以保持所述空间处于液体填充状态。

10. 发明申请

US20120004856A1 SPECTRAL DATA ANALYZER, BIOLOGICAL SUBSTANCE DETECTION SYSTEM, AND BIOLOGICAL SUBSTANCE DETECTION METHOD 审中-公开
标题翻译：光谱数据分析仪，生物物质检测系统和生物物质检测方法
公开(公告)号：US20120004856A1
公开(公告)日：2012-01-05
申请号：US13170429
申请日：2011-06-28
申请人： Eriko Matsui , Sakuya Tamada , Takuya Kishimoto , Akio Yasuda
发明人： Eriko Matsui , Sakuya Tamada , Takuya Kishimoto , Akio Yasuda
IPC分类号： G06F19/00
CPC分类号： A61B3/1173 , A61B5/0059 , A61B5/14546 , A61B5/4088 , G01N21/65 , G01N33/54373 , G01N33/6896 , G01N2800/2821
摘要： A spectral data analyzer is disclosed. The spectral data analyzer calculates the spectral intensity ratio of a C—H band and an amide I band in a Raman spectrum that corresponds to a substance present in a body tissue; and automatically determines the presence or absence of amyloid beta in the substance based on the calculated ratio.
摘要翻译：公开了一种光谱数据分析仪。光谱数据分析器计算对应于存在于身体组织中的物质的拉曼光谱中的C-H波段和酰胺I波段的光谱强度比; 并基于计算的比例自动确定物质中淀粉样蛋白β的存在或不存在。

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