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1. 发明授权

US07001906B2 Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译：吡啶并吡咯并吡咯并吡咯并吲哚和吡啶并吡咯并吡咯衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US07001906B2
公开(公告)日：2006-02-21
申请号：US10481991
申请日：2002-06-28
申请人： Michelle Prudhomme , Christelle Marminon , Sylvain Routier , Gérard Coudert , Jean-Yves Merour , John Hickman , Alain Pierre , Pierre Renard , Bruno Pfeiffer
发明人： Michelle Prudhomme , Christelle Marminon , Sylvain Routier , Gérard Coudert , Jean-Yves Merour , John Hickman , Alain Pierre , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61K31/4985 , A61K31/437 , C07D491/22 , C07D405/14
CPC分类号： C07H15/252
摘要： Compounds of formula (I): wherein: W1 and W2, together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least one of the groups W1 or W2 represents a pyridyl group, R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom or a hydroxy, alkoxy, mercapto or alkylthio group, Y and Y1 each represent a hydrogen atom, or X and Y, X1 and Y1, together with the carbon atom carrying them, represent a carbonyl or thiocarbonyl group, R4 and R5 are as defined in the description, Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms carrying them, form an aromatic bond. Medicaments.
摘要翻译：式（I）化合物：化学式id =“CHEM-US-00001”num =“000

2. 发明授权

US06569858B2 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo[3,4-c]carbazole and 12,13-(pyranosyl)-furo[3,4-c]indolo[2,3-a]carbazoles 失效
标题翻译： 12,13-（吡喃糖基） - 吲哚并[2,3-a]吡咯并[3,4-c]咔唑和12,13-（吡喃糖基） - 呋喃并[3,4-c]吲哚并[2,3-a] 咔唑
公开(公告)号：US06569858B2
公开(公告)日：2003-05-27
申请号：US10010379
申请日：2001-11-05
申请人： Michelle Prudhomme , Pascale Moreau , Fabrice Anizon , Christelle Marminon , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Michelle Prudhomme , Pascale Moreau , Fabrice Anizon , Christelle Marminon , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： C07D49044
CPC分类号： C07H19/23
摘要： A compound selected from those of formula (I): wherein: R1 and R2, which may be identical or different, represent a group of formula U-V wherein U represents single bond, or alkylene which is optionally substituted and/or unsaturated, and V is as defined in the description, G represents oxygen, or NR3 wherein R3 is as defined in the description, X represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y represents hydrogen, or X+Y represents carbonyl, X1 represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1 represents hydrogen, or X1+Y1 represents carbonyl, R4, R5, and R6 are as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：R 1和R 2可以相同或不同，表示其中U表示单键的式UV基团，或任选被取代和/或不饱和的亚烷基，V是 G表示氧或NR 3，其中R3如说明书中所定义，X表示氢，羟基，烷氧基，巯基或烷硫基，Y表示氢，或X + Y表示羰基，X1表示氢，羟基，烷氧基，巯基或烷硫基，Y1表示氢，或X1 + Y1表示羰基，R4，R5和R6如说明书中所定义，其异构体及其药学上可接受的酸或碱加成盐，以及含有它们的药物可用于治疗癌症。

3. 发明授权

US07151108B2 [3,4-a:3,4-c]carbazole compounds 失效
标题翻译： [3,4-a：3,4-c]咔唑化合物
公开(公告)号：US07151108B2
公开(公告)日：2006-12-19
申请号：US10672418
申请日：2003-09-26
申请人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
发明人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61K31/437 , A61K31/403 , C07D471/22 , C07D487/14 , C07D491/14
CPC分类号： C07D487/14 , A61K9/0019 , C07D491/14 , C07H19/23
摘要： A compound selected from those of formula (I): wherein: W1 represents, together with carbon to which it is bonded, phenyl, pyridyl, Z represents a group of formula U—V as defined in the description, Q1 represents oxygen, NR2 as defined in the description, Q2 represents oxygen, NR′2 as defined in the description, X1, X2, X′1 and X′2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2, Y′1 and Y′2 each represents hydrogen, or X1 and Y1, X2 and Y2, X′1 and Y′1, X′2 and Y′2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：W 1代表与其键合的碳一起，苯基，吡啶基，Z代表如说明书中所定义的式UV基团， Q 1表示氧，NR 2，如说明书中所定义，Q 2表示氧，NR'2，定义在说明书中，X 1，X 2，X'1和X'2各自表示氢，羟基，烷氧基，巯基或烷硫基，Y 1，Y 2，Y'1和Y'2各自表示氢，或X 1和Y 1，X 2和Y 2，X'1 和/或Y'1，X'2，Y'2，和携带它们的碳一起形成羰基或硫代羰基，如本说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，其可用于tr 吃癌。

4. 发明申请

US20060004428A1 Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same 审中-公开
标题翻译：吡咯并（3,4-c）咔唑和吡啶并（2,3-b）吡咯并（3,4-e）吲哚衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US20060004428A1
公开(公告)日：2006-01-05
申请号：US10531620
申请日：2003-10-14
申请人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
发明人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61N1/00
CPC分类号： C07D487/14
摘要： A compound selected from those of formula (I): wherein: Z represents a group of the formula U-V as defined in the description, W1 represents together with carbon to which it is bonded, phenyl, pyridyl, W2 is as defined in the description, X1, X2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2 each represents hydrogen, or X1 and Y1, X2 and Y2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, Q represents oxygen, a group NR2 as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：Z表示如说明书中所定义的式UV基团，W 1代表与其键合的碳，苯基，吡啶基， W 2 2如说明书中所定义，X 1，X 2各自表示氢，羟基，烷氧基，巯基或烷硫基，Y _{1，Y 2各自表示氢，或X 1和Y 1，X 2，和Y 2带有带有它们的碳，一起形成羰基或硫代羰基，R 1如说明书中所定义，Q表示氧，NR 2基团， SUB>，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

5. 发明授权

US07312213B2 Substituted benzo[e][1,4]oxazino[3,2-g]isoindole compounds 失效
标题翻译：取代的苯并[e] [1,4]恶嗪并[3,2-g]异吲哚化合物
公开(公告)号：US07312213B2
公开(公告)日：2007-12-25
申请号：US10531648
申请日：2003-10-17
申请人： Gérard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
发明人： Gérard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
IPC分类号： C07D498/04 , A61K31/5383
CPC分类号： C07D497/04 , C07D497/14
摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

6. 发明申请

US20060040930A1 Novel substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same 失效
标题翻译：新型取代的[1,4]苯并二氧杂环己二烯并[2,3-e]异吲哚衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US20060040930A1
公开(公告)日：2006-02-23
申请号：US10531393
申请日：2003-10-17
申请人： Gerard Coudert , Nathalie Ayerbe , Franck Lepiere , Sylvain Routier , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Stephane Leonce
发明人： Gerard Coudert , Nathalie Ayerbe , Franck Lepiere , Sylvain Routier , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Stephane Leonce
IPC分类号： A61K31/5383 , A61K31/4745 , C07D491/14 , C07D471/14
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14
摘要： Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1-C6)alkyl, aryl and aryl-(C1-C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1-C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.
摘要翻译：式（I）的化合物：其中：A如说明书中所定义，Y表示选自氧原子和亚甲基的基团，R 2表示氢原子，在这种情况下：R 3 表示选自氢原子和直链或支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （ C 1 -C 6 -C 6烷基（其中烷基部分是直链或支链的）和SO 2 -C 3 C 3 >或R 2和R 3'形成键，R 1表示选自氢原子和直链或支链基团的基团（ C 1 -C 6 -C 6烷基，芳基和芳基 - （C 1 -C 6 -C 6）烷基（在其中烷基部分是直链或支链的）或直链或支链（C 1 -C 6 -C 6）亚烷基链，Z 1和Z 2，各自表示氢原子或Z 1和Z 2，以及带有它们的碳原子形成苯基。药剂

7. 发明授权

US07202255B2 Substituted [1,4] benzodioxino[2,3-e] isoindole derivatives, method for preparing and pharmaceutical compositions containing same 失效
标题翻译：取代的[1,4]苯并二氧杂环己二烯并[2,3-e]异吲哚衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US07202255B2
公开(公告)日：2007-04-10
申请号：US10531393
申请日：2003-10-17
申请人： Gerard Coudert , Nathalie Ayerbe , Franck Lepifre , Sylvain Routier , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Stephane Leonce
发明人： Gerard Coudert , Nathalie Ayerbe , Franck Lepifre , Sylvain Routier , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Stephane Leonce
IPC分类号： A61K31/437 , C07D491/22
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14
摘要： Compounds of formula (I): wherein: A is as defined in the description, Y represents a group selected from an oxygen atom and a methylene group, R2 represents a hydrogen atom and in that case: R3 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl, aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) and SO2CF3, or R2 and R3 form a bond, R1 represents a group selected from a hydrogen atom and the groups linear or branched (C1–C6)alkyl, aryl and aryl-(C1–C6)alkyl (in which the alkyl moiety is linear or branched) or a linear or branched (C1–C6)alkylene chain, Z1 and Z2 each represent a hydrogen atom or Z1 and Z2, together with the carbon atoms carrying them, form a phenyl group. Medicaments.
摘要翻译：式（I）的化合物：

8. 发明授权

US6057317A Heterocyclic compounds 失效
标题翻译：杂环化合物
公开(公告)号：US6057317A
公开(公告)日：2000-05-02
申请号：US119423
申请日：1998-07-20
申请人： Gerald Guillaumet , Jean-Yves Merour , Frederique Touzeau , Bruno Pfeiffer , Pierre Renard , Elisabeth Scalbert
发明人： Gerald Guillaumet , Jean-Yves Merour , Frederique Touzeau , Bruno Pfeiffer , Pierre Renard , Elisabeth Scalbert
IPC分类号： A61K31/47 , A61K31/535 , A61K31/54 , A61K31/55 , A61P3/04 , A61P3/08 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D401/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D498/06 , C07D265/34
CPC分类号： C07D413/04 , C07D413/06
摘要： Compound of formula (I): ##STR1## wherein: Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and n are as defined in the description, and medicinal products containing the same which are useful as imidazoline receptor ligands.
摘要翻译：式（I）化合物：其中：Y，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和n如说明书中所定义，和含有它们的药物，可用作咪唑啉受体配体。

9. 发明申请

US20050171114A1 Benzo[b]chromeno-naphthyridin-7-one and pyrano[2',3':7,8]quino[2,3-b]quinoxalin-7-one compounds 失效
公开(公告)号：US20050171114A1
公开(公告)日：2005-08-04
申请号：US11047259
申请日：2005-01-31
申请人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Pierre Renard
IPC分类号： C07D491/147 , A61K31/4375 , A61K31/4985 , A61P35/00 , C07B61/00 , C07D491/14 , C07D491/22 , A61K31/498 , A61K31/4745
CPC分类号： C07D491/14
摘要： A compound selected from those of formula (I): wherein: B1, B2 represent carbon or nitrogen, X, Y, X1 and Y1 represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NRaRb wherein Ra and Rb are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NRa′Rb′, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b wherein R′a, R′b, R″a and Ta are as defined in the description, R3, R4 represent hydrogen or alkyl, A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8)— or —CH(R8)—C(O)— wherein R5, R6, R7 and R8 are as defined in the description, its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

10. 发明授权

US06642248B2 Benzo[b]pyrano[3,2-h]acridin-7-one compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮化合物
公开(公告)号：US06642248B2
公开(公告)日：2003-11-04
申请号：US10205566
申请日：2002-07-25
申请人： Michel Koch , François Tillequin , Sylvie Michel , Elisabeth Seguin , Abdelhakim El Omri , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , François Tillequin , Sylvie Michel , Elisabeth Seguin , Abdelhakim El Omri , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K314741
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)—T1, —O—C(O)—T1, —O—T2-NRaRb, —O—T2-ORa, —NRa—T2-NRaRb, —NRa—T2-ORa and —NRa—T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，巯基，氰基，硝基，烷基，三卤代烷基，三卤代烷基羰基氨基，-OR a，-NR a R b，-NR a -C（O） - T1，-OC（O）-T1，-O-T2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1 ，T 2如说明书中所定义，R 1表示氢或烷基，R 2表示选自氢，-OR a，-NR a R b，-NR a -C（O）-T1，-OC（O）-T1，-O- R2-NRaRb，-O-T2-ORa，-NRa-T2-NRaRb，-NRa-T2-ORa和-NRa-T2-CO2Ra，其中Ra，Rb，T1和T2如上所定义，R3和R4代表氢或烷基，W表示式-CH（R 5）-CH（R 6） - ， - CH = C（R 7） - ， - C（R 7）= CH-或-C（O）-CH（R 8） R5，R6，R7和R8如说明书中所定义，它们的异构体和N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物，可用于治疗癌症。

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