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1. 发明申请

US20110034434A1 PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂的制备
公开(公告)号：US20110034434A1
公开(公告)日：2011-02-10
申请号：US12852215
申请日：2010-08-06
申请人： Michele L. R. Heffernan , Richard Dennis , James M. Dorsey , Robert J. Foglesong , Michael L. Jones , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear , Michael A. Orsini
发明人： Michele L. R. Heffernan , Richard Dennis , James M. Dorsey , Robert J. Foglesong , Michael L. Jones , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear , Michael A. Orsini
IPC分类号： A61K31/397 , C07D491/04 , A61K31/407 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/454 , C07D403/14 , A61K31/496 , A61K31/4178 , A61P29/00 , A61P25/28
CPC分类号： C07D491/04 , C07D491/14
摘要： The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
摘要翻译：本发明涉及D-氨基氧化酶（DAAO）的稠合杂环抑制剂的前药和治疗疾病和病症的方法，其中D-氨基酸氧化酶活性，D-丝氨酸水平，D-丝氨酸氧化产物和NMDA受体活性的调节哺乳动物受试者的神经系统是有效的。

2. 发明申请

US20100120740A1 PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂的制备
公开(公告)号：US20100120740A1
公开(公告)日：2010-05-13
申请号：US12537104
申请日：2009-08-06
申请人： Michele L. R. Heffernan , Richard Dennis , James M. Dorsey , Robert J. Foglesong , Michael L. Jones , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear , H. Scott Wilkinson , Michael Anthony Orsini
发明人： Michele L. R. Heffernan , Richard Dennis , James M. Dorsey , Robert J. Foglesong , Michael L. Jones , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear , H. Scott Wilkinson , Michael Anthony Orsini
IPC分类号： A61K31/407 , C07D491/048 , A61K31/497 , A61K31/5377
CPC分类号： C07D491/04
摘要： The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D-amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
摘要翻译：本发明涉及D-氨基氧化酶（DAAO）的稠合杂环抑制剂的前药和治疗疾病和病症的方法，其中D-氨基酸氧化酶活性，D-丝氨酸水平，D-丝氨酸氧化产物和NMDA受体活性的调节哺乳动物受试者的神经系统是有效的。

3. 发明申请

US20100029741A1 FUSED HETEROCYCLES 审中-公开
标题翻译：熔融杂环
公开(公告)号：US20100029741A1
公开(公告)日：2010-02-04
申请号：US12537896
申请日：2009-08-07
申请人： James M. Dorsey , Michele L. R. Heffernan , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
发明人： James M. Dorsey , Michele L. R. Heffernan , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
IPC分类号： A61K31/407 , A61P25/00
CPC分类号： A61K31/407 , C07D491/04 , C07D495/04
摘要： This invention provides methods of improving cognitive function by administering to a subject a therapeutically effective amount of a fused heterocycle having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3 is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
摘要翻译：本发明提供了通过向受试者施用治疗有效量的具有下式的稠合杂环来提高认知功能的方法：其中R1是选自H，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R2是选自H取代或未取代的烯基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R3是选自H，C1-C6取代或未取代的烷基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R4是选自OH和O-X +的成员，其中X +是选自有机正离子和无机阳离子的正离子。取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式：其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。索引n是从1到4的整数。

4. 发明申请

US20100022612A1 FUSED HETEROCYCLES 审中-公开
标题翻译：熔融杂环
公开(公告)号：US20100022612A1
公开(公告)日：2010-01-28
申请号：US12537925
申请日：2009-08-07
申请人： James M. Dorsey , Michele L. R. Heffernan , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
发明人： James M. Dorsey , Michele L. R. Heffernan , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
IPC分类号： A61K31/407 , A61P29/00
CPC分类号： A61K31/407 , C07D491/04 , C07D495/04
摘要： This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3 is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
摘要翻译：本发明提供具有下式的稠合杂环：其中R1是选自H，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R2是选自H取代或未取代的烯基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R3是选自H，C1-C6取代或未取代的烷基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R4是选自OH和O-X +的成员，其中X +是选自有机正离子和无机阳离子的正离子。取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式：其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。索引n是从1到4的整数。

5. 发明授权

US07579370B2 Fused heterocycles 失效
标题翻译：融合杂环
公开(公告)号：US07579370B2
公开(公告)日：2009-08-25
申请号：US11833903
申请日：2007-08-03
申请人： Michele L. R. Heffernan , James M. Dorsey , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
发明人： Michele L. R. Heffernan , James M. Dorsey , Qun Kevin Fang , Robert J. Foglesong , Seth C. Hopkins , Cyprian O. Ogbu , Mustapha Soukri , Kerry L. Spear
IPC分类号： A61K31/40 , A61K31/34 , A61K31/19 , A01N43/38 , A01N43/08 , A01N37/00
CPC分类号： A61K31/407 , C07D491/04 , C07D495/04
摘要： This invention provides fused heterocycles having the formula: in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula: in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.
摘要翻译：本发明提供具有下式的稠合杂环：其中R1是选自H，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R2是选自H取代或未取代的烯基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R3是选自H，C1-C6取代或未取代的烷基，取代或未取代的芳基烷基和取代或未取代的杂芳基烷基的成员。 R4是选自OH和O-X +的成员，其中X +是选自有机正离子和无机阳离子的正离子。取代或未取代的芳基烷基和取代或未取代的杂芳基烷基部分具有下式：其中Ar是选自取代或未取代的芳基和取代或未取代的杂芳基的成员。索引n是从1到4的整数。

6. 发明授权

US5467390A Data transmission via a public switched telephone network 失效
标题翻译：通过公共交换电话网络进行数据传输
公开(公告)号：US5467390A
公开(公告)日：1995-11-14
申请号：US232841
申请日：1994-04-22
申请人： Russell J. Brankley , James M. Dorsey
发明人： Russell J. Brankley , James M. Dorsey
IPC分类号： H04L12/58 , H04M3/42 , H04M3/53 , H04M11/00 , H04N1/32 , H04Q3/00
CPC分类号： H04N1/32411 , H04L51/28 , H04M11/00 , H04M3/4228 , H04M3/5307 , H04N1/324 , H04N1/32438 , H04Q3/0029 , H04Q2213/13541 , H04Q2213/13542
摘要： A Public Switched Telephone Network (PSTN) linking an originating facility and a terminating facility through an originating switch connected to the originating facility and a terminating switch connected to the terminating facility where the terminating facility includes multi-format data terminal devices including a telephone terminal and an additional non-telephone data terminal where the telephone terminal and the non-telephone terminal each have an NPA-NXX-XXXX address, a method including the steps of (a) creating a message at the originating facility, (b) creating an address for the message comprising the NPA-NXX-XXXX address of the telephone station plus an added data characteristic indicative of the non-telephone terminal to which the message is directed, (c) transmitting the address through the originating switch to the terminating switch, (d) analyzing the address at the terminating switch and (e) connecting the message to the data terminal characterized by the added data set.
摘要翻译：公共交换电话网（PSTN），其通过连接到始发设备的始发交换机连接发端设备和终端设备，以及连接到终端设备的终端交换机，其中终端设备包括多格式数据终端设备，包括电话终端和电话终端和非电话终端各自具有NPA-NXX-XXXX地址的附加非电话数据终端，包括以下步骤的方法：（a）在始发设备处创建消息，（b）创建地址对于包括电话站的NPA-NXX-XXXX地址的消息加上指示消息所针对的非电话终端的附加数据特征，（c）通过始发交换机将该地址发送到终接交换机（ d）分析终端交换机的地址，（e）将该消息连接到由附加数据集表征的数据终端的。

7. 发明授权

US5692039A Improved data transmission via a public switched telephone network 失效
标题翻译：通过公共交换电话网络改进数据传输
公开(公告)号：US5692039A
公开(公告)日：1997-11-25
申请号：US460680
申请日：1995-06-02
申请人： Russell J. Brankley , James M. Dorsey
发明人： Russell J. Brankley , James M. Dorsey
IPC分类号： H04L12/58 , H04M3/42 , H04M3/53 , H04M11/00 , H04N1/32 , H04Q3/00
CPC分类号： H04N1/32411 , H04L51/28 , H04M11/00 , H04M3/4228 , H04M3/5307 , H04N1/324 , H04N1/32438 , H04Q3/0029 , H04Q2213/13541 , H04Q2213/13542
摘要： A Public Switched Telephone Network (PSTN) linking an originating facility and a terminating facility through an originating switch connected to the originating facility and a terminating switch connected to the terminating facility where the terminating facility includes multi-format data terminal devices including a telephone terminal and an additional non-telephone data terminal where the telephone terminal and the non-telephone terminal each have an NPA-NXX-XXXX address, a method including the steps of (a) creating a message at the originating facility, (b) creating an address for the message comprising the NPA-NXX-XXXX address of the telephone station plus an added data characteristic indicative of the non-telephone terminal to which the message is directed, (c) transmitting the address through the originating switch to the terminating switch, (d) analyzing the address at the terminating switch and (e) connecting the message to the data terminal characterized by the added data set.
摘要翻译：公共交换电话网（PSTN），其通过连接到始发设备的始发交换机连接发端设备和终端设备，以及连接到终端设备的终端交换机，其中终端设备包括多格式数据终端设备，包括电话终端和电话终端和非电话终端各自具有NPA-NXX-XXXX地址的附加非电话数据终端，包括以下步骤的方法：（a）在始发设备处创建消息，（b）创建地址对于包括电话站的NPA-NXX-XXXX地址的消息加上指示消息所针对的非电话终端的附加数据特征，（c）通过始发交换机将地址发送到终接交换机（ d）分析终端交换机的地址，（e）将该消息连接到由附加数据集表征的数据终端。

8. 发明授权

US4614089A Controlled refrigeration system 失效
标题翻译：控制制冷系统
公开(公告)号：US4614089A
公开(公告)日：1986-09-30
申请号：US713617
申请日：1985-03-19
申请人： James M. Dorsey
发明人： James M. Dorsey
IPC分类号： F25B49/02 , F25B1/00
CPC分类号： F25B49/022 , F25B2400/075 , F25B2400/22 , F25B2500/06 , F25B2500/26 , F25B2600/0251
摘要： A controlled refrigeration system includes a plurality of refrigerant compressors fed from a common suction manifold (line). Each compressor is associated with a respective controller. The individual controllers are set to effect the cutting in of its associated compressor at different levels of input voltage from a pressure transducer using digital techniques. The individual controllers each produce respective digital cut-in, cut-out, down-time delay and power-up delay signals. Respective logic circuitry is provided within each controller for producing control outputs which effect the energization and deenergization of the individual controllers. The compressors are turned on and off in sequence as the demand for compression respectively increases and decreases. The power-up delay period differs for each controller so that no more than one is energized at a given time when the system comes on line after a power failure or extended period of shut down.
摘要翻译：受控的制冷系统包括从公共吸入歧管（管线）供给的多个制冷剂压缩机。每个压缩机与相应的控制器相关联。各个控制器被设置为利用数字技术在压力传感器的不同输入电压水平下对相关联的压缩机进行切割。单个控制器各自产生相应的数字切入，切断，停机延迟和上电延迟信号。在每个控制器内提供相应的逻辑电路，用于产生控制输出，其实现各个控制器的通电和断电。随着压缩的需求分别增加和减少，压缩机依次打开和关闭。每个控制器的上电延迟时间不同，因此在电源故障或延长的停机时间后系统上线时，给定时间内不超过一个通电。

9. 发明授权

US06593374B2 Tubulin binding ligands and corresponding prodrug constructs 有权
公开(公告)号：US06593374B2
公开(公告)日：2003-07-15
申请号：US09804280
申请日：2001-03-12
申请人： Kevin G. Pinney , Vani P. Mocharla , Zhi Chen , Charles M. Garner , Anjan Ghatak , James M. Dorsey
发明人： Kevin G. Pinney , Vani P. Mocharla , Zhi Chen , Charles M. Garner , Anjan Ghatak , James M. Dorsey
IPC分类号： A61K31075
CPC分类号： C07F9/655354 , C07C43/215 , C07C43/23 , C07C45/512 , C07C45/64 , C07C49/84 , C07C205/45 , C07C217/84 , C07C217/94 , C07C225/22 , C07C2602/08 , C07C2602/10 , C07D307/80 , C07D307/81 , C07D333/56 , C07D333/64 , C07F9/12 , C07F9/18 , C07F9/247 , C07F9/65517 , C07C49/755
摘要： A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl—aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, and phosphoramidates capable of demonstrating selective targeting and destruction of tumor cell vasculature.

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