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1. 发明授权

US09326927B2 Use of cannabinoid compounds for stimulating melanogenesis 有权
标题翻译：使用大麻素化合物刺激黑素生成
公开(公告)号：US09326927B2
公开(公告)日：2016-05-03
申请号：US14237015
申请日：2012-08-03
申请人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
发明人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
IPC分类号： A61K8/42 , A61Q5/10 , A61Q19/04 , A61K31/164 , A61K31/16 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/42 , A61K31/16 , A61K31/164 , A61Q5/00 , A61Q5/10 , A61Q19/00 , A61Q19/04
摘要： The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R3 and R4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.
摘要翻译：本发明涉及至少一种选自对应于通式（I）的化合物的大麻素化合物及其几何异构体和旋光异构体，其美容上可接受的酸或碱盐及其水合物的非治疗性美容用途; 其中式（I）化合物：R 1表示氢原子或C 1 -C 30烷基; 所述烷基可以任选被羟基（OH）基团取代; R2表示卤素原子或选自羟基，硫醇（SH）和任选被一个或两个C 1 -C 6烷基取代的氨基的基团; R3和R4与带有它们的碳原子一起形成氧代基，或者R3和R4表示氢原子; R5表示氢原子或C1-C6烷基; X表示选自氧和硫原子的杂原子和二价基团-N（R 6） - ，其中R 6表示氢原子或C 1 -C 6烷基; 代表单键或双键; n为1,2或3，优选1或2; 应当理解，当R3和R4一起形成具有带有碳原子的氧代基并且X表示氧原子时，则R1不能代表作为角蛋白材料着色剂的羟甲基。它还涉及这些特定的大麻素化合物之一，用于治疗白癜风或疣状糠疹，用于对皮肤着色或用于治疗阴茎的非治疗性美容方法，包括局部应用于皮肤和/或头发，或在生理上可接受的介质中包含这些大麻素化合物之一的组合物的口服给药，以及用于选择促进角蛋白材料着色的活性剂的方法。

2. 发明申请

US20140193349A1 USE OF CANNABINOID COMPOUNDS FOR STIMULATING MELANOGENESIS 有权
标题翻译：使用CANNABINOID化合物刺激造血细胞
公开(公告)号：US20140193349A1
公开(公告)日：2014-07-10
申请号：US14237015
申请日：2012-08-03
申请人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
发明人： Michela Zuccolo , Roland Jourdain , Lionel Breton , Mauro Maccarrone
IPC分类号： A61K8/42 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/42 , A61K31/16 , A61K31/164 , A61Q5/00 , A61Q5/10 , A61Q19/00 , A61Q19/04
摘要： The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R3 and R4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.
摘要翻译：本发明涉及至少一种选自对应于通式（I）的化合物的大麻素化合物及其几何异构体和旋光异构体，其美容上可接受的酸或碱盐及其水合物的非治疗性美容用途; 其中式（I）化合物：R 1表示氢原子或C 1 -C 30烷基; 所述烷基可以任选被羟基（OH）基团取代; R2表示卤素原子或选自羟基，硫醇（SH）和任选被一个或两个C 1 -C 6烷基取代的氨基的基团; R3和R4与带有它们的碳原子一起形成氧代基，或者R3和R4表示氢原子; R5表示氢原子或C1-C6烷基; X表示选自氧和硫原子的杂原子和二价基团-N（R 6） - ，其中R 6表示氢原子或C 1 -C 6烷基; 代表单键或双键; n为1,2或3，优选1或2; 应当理解，当R3和R4一起形成具有带有碳原子的氧代基并且X表示氧原子时，则R1不能代表作为角蛋白材料着色剂的羟甲基。它还涉及这些特定的大麻素化合物之一，用于治疗白癜风或疣状糠疹，用于对皮肤着色或用于治疗阴茎的非治疗性美容方法，包括局部应用于皮肤和/或头发，或在生理上可接受的介质中包含这些大麻素化合物之一的组合物的口服给药，以及用于选择促进角蛋白材料着色的活性剂的方法。

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