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1. 发明授权

US07947282B2 Methods of treatment using vascular occlusion in combination therapies 有权
标题翻译：联合治疗中使用血管闭塞的治疗方法
公开(公告)号：US07947282B2
公开(公告)日：2011-05-24
申请号：US11464250
申请日：2006-08-14
申请人： Michael W. Stewart , Antoine Noujaim , Bruce D. Hirsche, legal representative , Roland H. Person
发明人： Michael W. Stewart , Antoine Noujaim , Roland H. Person
IPC分类号： A61K39/00
CPC分类号： C07K16/3076 , A61K31/727 , A61K38/00 , A61K47/6898 , A61K2039/505 , B82Y5/00 , C07K16/28 , C07K16/30 , C07K2317/34
摘要： The present invention relates generally to methods and compositions for treating a disease or condition by administering a first therapeutic protocol comprising targeting and delivering solid-phase platelet-dependent vascular occlusion agents, and administering at least one second therapeutic composition or method.
摘要翻译：本发明一般涉及通过施用包含靶向和递送固相血小板依赖性血管阻塞剂的第一治疗方案，以及施用至少一种第二治疗组合物或方法来治疗疾病或病症的方法和组合物。

2. 发明授权

US07387994B2 Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent 失效
标题翻译：使用固相血小板结合剂产生血管闭塞的组合物和方法
公开(公告)号：US07387994B2
公开(公告)日：2008-06-17
申请号：US11205047
申请日：2005-08-17
申请人： Michael W. Stewart , Antoine Noujaim , Roland H. Person
发明人： Michael W. Stewart , Antoine Noujaim , Roland H. Person
IPC分类号： A61K38/00 , A61K9/14 , A61F2/00
CPC分类号： A61L24/108 , A61K9/167 , A61K31/16 , A61K38/36 , A61K38/37 , A61K47/62 , A61K47/6921 , A61K47/6927 , A61L31/047 , A61L31/16 , A61L2300/252 , A61L2300/418
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
摘要翻译：本发明一般涉及靶向和递送固相血小板依赖性血管阻塞剂的方法和组合物。特别地，涂覆有血小板结合剂的颗粒或线圈或支架被引导到目标脉管系统，例如实体肿瘤块的血管系统或AV畸形或动脉瘤或内漏; 然后固相剂结合并激活血小板，血小板又结合并激活其他血小板。该过程导致关于导致血管闭塞的固相剂快速形成血小板介导的血栓。

3. 发明授权

US06960352B2 Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent 有权
公开(公告)号：US06960352B2
公开(公告)日：2005-11-01
申请号：US10241717
申请日：2002-09-12
申请人： Antoine Noujaim , Roland H. Person , Michael W. Stewart
发明人： Antoine Noujaim , Roland H. Person , Michael W. Stewart
IPC分类号： A61K9/00 , A61B17/12 , A61F2/82 , A61K9/16 , A61K31/16 , A61K38/36 , A61K38/37 , A61K38/43 , A61K45/00 , A61K47/48 , A61L24/10 , A61L27/00 , A61L31/00 , A61L31/04 , A61L31/16 , A61P35/00 , A61F2/00
CPC分类号： A61L24/108 , A61K9/167 , A61K31/16 , A61K38/36 , A61K38/37 , A61K47/62 , A61K47/6921 , A61K47/6927 , A61L31/047 , A61L31/16 , A61L2300/252 , A61L2300/418
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.

4. 发明授权

US07390488B2 Compositions and methods for producing vascular occlusion 失效
标题翻译：用于产生血管闭塞的组合物和方法
公开(公告)号：US07390488B2
公开(公告)日：2008-06-24
申请号：US11205045
申请日：2005-08-17
申请人： Michael W. Stewart , Antoine Noujaim , Roland H. Person
发明人： Michael W. Stewart , Antoine Noujaim , Roland H. Person
IPC分类号： A61K39/395 , C07K14/745 , C07K16/28
CPC分类号： C07K16/3076 , A61K31/727 , A61K38/00 , A61K47/6898 , A61K2039/505 , B82Y5/00 , C07K16/28 , C07K16/30 , C07K2317/34
摘要： The present invention relates generally to methods and compositions for targeting, delivering, and activating platelet-dependent vascular occlusion agents. In particular, antibodies carrying platelet binding agents are targeted to hyperplastic cells or tissues, such as the vasculature of solid tumor masses; the platelet binding agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the formation of a platelet-mediated thrombus-causing vessel occlusion.
摘要翻译：本发明一般涉及靶向，递送和激活血小板依赖性血管闭塞剂的方法和组合物。特别地，携带血小板结合剂的抗体靶向增生细胞或组织，例如实体肿瘤块的脉管系统; 血小板结合剂然后结合并激活血小板，血小板又结合并激活其他血小板。该过程导致血小板介导的引起血栓的血管闭塞的形成。

5. 发明申请

US20110135736A1 Compositions and Methods for Producing Vascular Occlusion using a Solid-phase Platelet Binding Agent 审中-公开
标题翻译：使用固相血小板结合剂产生血管闭塞的组合物和方法
公开(公告)号：US20110135736A1
公开(公告)日：2011-06-09
申请号：US12744796
申请日：2008-11-26
申请人： Michael W. Stewart , Roland H. Person , Irwin J. Griffith , Paul B. Tiege , Antoine Noujiam , Bruce Hirsche
发明人： Michael W. Stewart , Roland H. Person , Irwin J. Griffith , Paul B. Tiege , Antoine Noujiam , Bruce Hirsche
IPC分类号： A61K9/14 , C07K14/76 , C08G63/91 , A61K38/38 , A61K47/48 , A61P7/04
CPC分类号： A61K38/36 , A61K31/405 , A61K31/675 , A61K31/713 , A61K33/30 , A61K45/06 , A61L24/046 , A61L31/10 , A61L2430/36 , A61K2300/00 , C08L67/04
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
摘要翻译：本发明一般涉及靶向和递送固相血小板依赖性血管阻塞剂的方法和组合物。特别地，涂覆有血小板结合剂的颗粒或线圈或支架被引导到目标脉管系统，例如实体肿瘤块的血管系统或AV畸形或动脉瘤或内漏; 然后固相剂结合并激活血小板，血小板又结合并激活其他血小板。该过程导致关于导致血管闭塞的固相剂快速形成血小板介导的血栓。

6. 发明申请

US20080160063A1 Compositions and Methods for Producing Vascular Occlusion Using a Solid-Phase Platelet Binding Agent 审中-公开
标题翻译：使用固相血小板结合剂产生血管闭塞的组合物和方法
公开(公告)号：US20080160063A1
公开(公告)日：2008-07-03
申请号：US11928595
申请日：2007-10-30
申请人： Michael W. Stewart , Antoine Noujiam , Roland H. Person
发明人： Michael W. Stewart , Antoine Noujiam , Roland H. Person
IPC分类号： A61K9/00 , A61K47/42 , A61K38/37 , A61K9/14
CPC分类号： A61L24/108 , A61K9/167 , A61K31/16 , A61K38/36 , A61K38/37 , A61K47/62 , A61K47/6921 , A61K47/6927 , A61L31/047 , A61L31/16 , A61L2300/252 , A61L2300/418
摘要： The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
摘要翻译：本发明一般涉及靶向和递送固相血小板依赖性血管阻塞剂的方法和组合物。特别地，涂覆有血小板结合剂的颗粒或线圈或支架被引导到目标脉管系统，例如实体肿瘤块的血管系统或AV畸形或动脉瘤或内漏; 然后固相剂结合并激活血小板，血小板又结合并激活其他血小板。该过程导致关于导致血管闭塞的固相剂快速形成血小板介导的血栓。

7. 发明授权

US07892597B2 In situ processing of high-temperature electrical insulation 有权
标题翻译：高温电气绝缘原位处理
公开(公告)号：US07892597B2
公开(公告)日：2011-02-22
申请号：US11351654
申请日：2006-02-09
申请人： Matthew W. Hooker , Michael W. Stewart , Paul E. Fabian , Michael L. Tupper
发明人： Matthew W. Hooker , Michael W. Stewart , Paul E. Fabian , Michael L. Tupper
IPC分类号： B05D5/12
CPC分类号： E21B36/04 , C23C18/1208 , E21B43/2401
摘要： Methods are provided of producing a heater cable. An electrical conductor is coated with a preceramic resin. At least a portion of the coated electrical conductor is deployed into a operational location. The preceramic resin is pyrolyzed while the portion of the coated electrical conductor is in the operational location to convert the preceramic resin into a ceramic insulator disposed to electrically insulate the electrical conductor from the sheath.
摘要翻译：提供了制造加热器电缆的方法。电导体涂覆有预陶瓷树脂。涂覆的电导体的至少一部分被部署到操作位置。预陶瓷树脂被热解，而涂覆的电导体的部分处于操作位置，以将陶瓷绝缘体转化成陶瓷绝缘体，以将电导体与护套电绝缘。

8. 发明授权

US06581549B2 Sootblower lance port with leak resistant cardon joint 有权
公开(公告)号：US06581549B2
公开(公告)日：2003-06-24
申请号：US09944924
申请日：2001-08-31
申请人： Michael W. Stewart , Jeffrey A. Atchley
发明人： Michael W. Stewart , Jeffrey A. Atchley
IPC分类号： F28G300
CPC分类号： F28G1/16 , F28G15/02
摘要： A cardon joint is provided for mounting in a wall of a boiler to accommodate a sootblower lance and to allow the lance to be manipulated with respect to the boiler wall. The cardon joint includes a wall box having a central opening. An outer ball having a substantially spherical outer surface and a central bore is mounted for axial rotation about a first axis within the central opening of the wall box. An inner ball having a substantially spherical outer surface and a central bore is mounted for axial rotation about a second axis within the central bore of the outer ball. The first and second axes are mutually orthogonal and the central bore of the inner ball is sized to accommodate the lance of a sootblower. As the lance is manipulated to clean an opposite wall of the boiler, the inner and outer balls rotate about their axes to accommodate the manipulation. Substantially constant gaps are maintained between the outer ball and the wall box and between the inner ball and the outer ball to provide a controlled constant flow of seal air through the gaps.

9. 发明授权

US5427913A Methods for determining platelet function 失效
标题翻译：确定血小板功能的方法
公开(公告)号：US5427913A
公开(公告)日：1995-06-27
申请号：US985679
申请日：1992-12-03
申请人： Andrew R. E. Shaw , Michael W. Stewart
发明人： Andrew R. E. Shaw , Michael W. Stewart
IPC分类号： G01N33/86 , G01N33/546 , C12Q1/56 , G01N33/547 , G01N33/567
CPC分类号： G01N33/86 , G01N2333/755
摘要： The invention provides a method for determining platelet function in a mammal comprising providing platelets from the mammal, contacting the platelets in suspension with at least one immobilised ECM protein or an effective fragment or analog thereof while applying to the platelets an effective mechanical stimulus for an effective period of time and determining the platelet activation produced.The invention also provides a method for detecting a bleeding disorder in a human. Further, the invention provides a method for monitoring the efficacy of pharmacological agents affecting platelet function in vivo.
摘要翻译：本发明提供了一种确定哺乳动物血小板功能的方法，包括从哺乳动物提供血小板，使悬浮液中的血小板与至少一种固定的ECM蛋白或其有效片段或类似物接触，同时向血小板施加有效的机械刺激一段时间并确定产生的血小板活化。本发明还提供了一种用于检测人类出血障碍的方法。此外，本发明提供了一种用于监测影响体内血小板功能的药理学效果的方法。

10. 发明授权

US07367079B2 Integral packing housing and packing material unit 有权
标题翻译：一体化包装箱和包装材料单元
公开(公告)号：US07367079B2
公开(公告)日：2008-05-06
申请号：US10612195
申请日：2003-07-02
申请人： Hans Schwade , Bruce Townsend , Michael W. Stewart
发明人： Hans Schwade , Bruce Townsend , Michael W. Stewart
IPC分类号： A47L5/38
CPC分类号： F28G3/166
摘要： An integral packing housing and packing material unit; a method for packing replacement, boiler cleaning; and a method for maintenance of a desired boiler output rating. The integral packing unit includes a housing for removably holding a sacrificial packing material that is configured to form a steam seal between a sootblower steam tube and lance spindle when the packing unit is installed in an operative position in association with the steam tube and the spindle and the packing material is loaded by applying compression to the packing material. A compression unit is typically coupled to the housing unit to apply such compression to load the packing material while the packing unit is installed in the operative position. The packing unit may also includes a detent mechanism, such set screws, for unloading the packing material to facilitate installing the packing unit on, and removing the packing unit from, the operative position.
摘要翻译：整体包装材料和包装材料单元; 包装更换方法，锅炉清洗; 以及用于维持所需锅炉输出额定值的方法。整体包装单元包括用于可移除地保持牺牲包装材料的壳体，该牺牲包装材料被构造成当所述包装单元与所述蒸汽管和所述主轴相关联地安装在操作位置时在吹灰器蒸汽管和喷枪轴之间形成蒸汽密封;以及通过对包装材料施加压缩来填充包装材料。通常，压缩单元联接到壳体单元以施加这种压缩以在包装单元安装在操作位置时装载包装材料。包装单元还可以包括制动机构，这种固定螺钉，用于卸载包装材料，以便于将包装单元安装在操作位置上，以及将包装单元从操作位置移除。

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