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1. 发明授权

US07147660B2 Advanced endovascular graft 有权
公开(公告)号：US07147660B2
公开(公告)日：2006-12-12
申请号：US10327711
申请日：2002-12-20
申请人： Michael V. Chobotov , Brian A. Glynn , Stuart E. Kari , John M. Marthaler , Robert G. Whirley , Isaac J. Zacharias , W. Patrick Stephens
发明人： Michael V. Chobotov , Brian A. Glynn , Stuart E. Kari , John M. Marthaler , Robert G. Whirley , Isaac J. Zacharias , W. Patrick Stephens
IPC分类号： A61F2/06 , A61F2/86
CPC分类号： A61F2/07 , A61F2/89 , A61F2/915 , A61F2/954 , A61F2/962 , A61F2002/065 , A61F2002/075 , A61F2002/8486 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2250/0003 , A61F2250/0036 , A61M2025/0177
摘要： This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.

2. 发明授权

US08900288B2 Advanced endovascular graft delivery system and method of treatment 有权
标题翻译：先进的血管内移植物输送系统及治疗方法
公开(公告)号：US08900288B2
公开(公告)日：2014-12-02
申请号：US12566104
申请日：2009-09-24
申请人： Michael V. Chobotov , Robert G. Whirley
发明人： Michael V. Chobotov , Robert G. Whirley
IPC分类号： A61F2/06 , A61F2/07 , A61F2/962 , A61F2/954 , A61F2/848 , A61F2/95 , A61M25/01 , A61F2/89
CPC分类号： A61F2/07 , A61F2/82 , A61F2/844 , A61F2/89 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91558 , A61F2002/91583 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/005 , A61F2220/0058 , A61F2250/0003 , A61F2250/0036 , A61M2025/0177
摘要： This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.
摘要翻译：本发明是一种用于治疗身体通道的系统; 特别是具有血管疾病的血管。该系统包括具有低轮廓输送配置的血管内移植物和展开构造，其中它符合要治疗的血管或身体通道以及各种连接器构件和支架的形态。移植物由可膨胀的移植物体部分制成并且可以分叉。一个或多个可充气袖口可以设置在移植物主体部分的任一端。至少一个充气通道设置在可膨胀的袖口之间并且与可膨胀的袖口流体连通。

3. 发明授权

US07766954B2 Advanced endovascular graft 有权
标题翻译：先进的血管内移植物
公开(公告)号：US07766954B2
公开(公告)日：2010-08-03
申请号：US11333595
申请日：2006-01-17
申请人： Michael V. Chobotov , Robert G. Whirley
发明人： Michael V. Chobotov , Robert G. Whirley
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/844 , A61F2/89 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91558 , A61F2002/91583 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/005 , A61F2220/0058 , A61F2250/0003 , A61F2250/0036 , A61M2025/0177
摘要： This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.
摘要翻译：本发明是一种用于治疗身体通道的系统; 特别是具有血管疾病的血管。该系统包括具有低轮廓输送配置的血管内移植物和展开构造，其中它符合要治疗的血管或身体通道以及各种连接器构件和支架的形态。移植物由可膨胀的移植物体部分制成并且可以分叉。一个或多个可充气袖口可以设置在移植物主体部分的任一端。至少一个充气通道设置在可膨胀的袖口之间并且与可膨胀的袖口流体连通。

4. 发明申请

US20120316854A1 VIRTUAL PROTOTYPING AND TESTING FOR MEDICAL DEVICE DEVELOPMENT 有权
标题翻译：虚拟实验和测试用于医疗设备开发
公开(公告)号：US20120316854A1
公开(公告)日：2012-12-13
申请号：US13523765
申请日：2012-06-14
申请人： Robert G. Whirley , Michael V. Chobotov
发明人： Robert G. Whirley , Michael V. Chobotov
IPC分类号： G06F17/50
CPC分类号： G06F17/50 , A61F2/82 , G06G7/48 , G09B23/28
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译：开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。可以使用可视化工具任意地模拟这种应力，应变和变形。

5. 发明申请

US20110218609A1 FILL TUBE MANIFOLD AND DELIVERY METHODS FOR ENDOVASCULAR GRAFT 审中-公开
公开(公告)号：US20110218609A1
公开(公告)日：2011-09-08
申请号：US13024255
申请日：2011-02-09
申请人： Michael V. Chobotov , Mary Jane Marston , Mark E, Purter , Patrick Stephens , James R. Watson , Robert G. Whirley
发明人： Michael V. Chobotov , Mary Jane Marston , Mark E, Purter , Patrick Stephens , James R. Watson , Robert G. Whirley
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/06 , A61B6/4441 , A61B6/487 , A61F2/966 , A61F2002/065 , A61F2250/0003 , A61F2250/0098 , A61L31/022 , A61L31/048 , A61L31/18 , A61L2400/16 , A61M2025/0681 , C08L27/18
摘要： Some embodiments relate in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to inflatable stent grafts and methods of positioning and deploying such devices within the body of a patient. Some embodiments include inflation devices and methods that allow an inflatable portion of an inflatable stent graft to be inflated from a desired location within the inflatable portion.
摘要翻译：一些实施例部分地涉及血管内假体及其部署方法。实施例可以更具体地涉及可充气支架移植物以及将这样的装置定位和部署在患者体内的方法。一些实施例包括充气装置和方法，其允许可充气支架移植物的可膨胀部分从可充气部分内的期望位置膨胀。

6. 发明申请

US20110029297A1 VIRTUAL PROTOTYPING AND TESTING FOR MEDICAL DEVICE DEVELOPMENT 有权
标题翻译：虚拟实验和测试用于医疗设备开发
公开(公告)号：US20110029297A1
公开(公告)日：2011-02-03
申请号：US12904994
申请日：2010-10-14
申请人： Robert G. Whirley , Michael V. Chobotov
发明人： Robert G. Whirley , Michael V. Chobotov
IPC分类号： G06G7/60 , G06T17/20
CPC分类号： G06F17/50 , A61F2/82 , G06G7/48 , G09B23/28
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译：开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。在一个实施例中，几何生成器接收解剖特征的三维体积数据并生成几何模型。然后，网格生成器接收解剖特征或候选医疗装置的体外模型和几何模型的几何模型。在另一个实施例中，网格生成器仅接收候选医疗设备的几何模型。使用接收的几何模型，网格生成器创建或生成网格或有限元模型。应力/应变/变形分析仪接收网格，以及该网格的材料模型和载荷。使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。可以使用可视化工具任意地模拟这种应力，应变和变形。

7. 发明授权

US07840393B1 Virtual prototyping and testing for medical device development 有权
标题翻译：医疗器械开发的虚拟样机和测试
公开(公告)号：US07840393B1
公开(公告)日：2010-11-23
申请号：US09679725
申请日：2000-10-04
申请人： Robert G. Whirley , Michael V. Chobotov
发明人： Robert G. Whirley , Michael V. Chobotov
IPC分类号： G06G7/48
CPC分类号： G06F17/50 , A61F2/82 , G06G7/48 , G09B23/28
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译：开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。在一个实施例中，几何生成器接收解剖特征的三维体积数据并生成几何模型。然后，网格生成器接收解剖特征或候选医疗装置的体外模型和几何模型的几何模型。在另一个实施例中，网格生成器仅接收候选医疗设备的几何模型。使用接收的几何模型，网格生成器创建或生成网格或有限元模型。应力/应变/变形分析仪接收网格，以及该网格的材料模型和载荷。使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。可以使用可视化工具任意地模拟这种应力，应变和变形。

8. 发明授权

US08666714B2 Virtual prototyping and testing for medical device development 有权
标题翻译：医疗器械开发的虚拟样机和测试
公开(公告)号：US08666714B2
公开(公告)日：2014-03-04
申请号：US13523765
申请日：2012-06-14
申请人： Robert G. Whirley , Michael V. Chobotov
发明人： Robert G. Whirley , Michael V. Chobotov
IPC分类号： G06G7/48 , A61F2/06
CPC分类号： G06F17/50 , A61F2/82 , G06G7/48 , G09B23/28
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译：开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。可以使用可视化工具任意地模拟这种应力，应变和变形。

9. 发明申请

US20090099649A1 MODULAR VASCULAR GRAFT FOR LOW PROFILE PERCUTANEOUS DELIVERY 审中-公开
标题翻译：用于低剖面PERCUTANEOUS递送的模块化血管片
公开(公告)号：US20090099649A1
公开(公告)日：2009-04-16
申请号：US12245620
申请日：2008-10-03
申请人： Michael V. Chobotov , Robert G. Whirley , Joseph W. Humphrey
发明人： Michael V. Chobotov , Robert G. Whirley , Joseph W. Humphrey
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2/954 , A61F2/966 , A61F2002/067 , A61F2002/075 , A61F2002/8486 , A61F2002/9511 , A61F2220/005 , A61F2220/0058 , A61F2250/0003 , A61F2250/0069
摘要： A hybrid modular endovascular graft wherein a main graft is sized to span at least a portion of a target vessel lesion in a large percentage of patients. Graft extensions may be secured to the main graft to extend the main graft and provide a sealing function for some applications.
摘要翻译：一种混合模块化血管内移植物，其中主移植物的大小可以在大部分患者中跨越靶血管病变的至少一部分。接枝延伸部可以固定到主移植物以延伸主移植物并为一些应用提供密封功能。

10. 发明授权

US10159557B2 Modular vascular graft for low profile percutaneous delivery 有权
公开(公告)号：US10159557B2
公开(公告)日：2018-12-25
申请号：US12245620
申请日：2008-10-03
申请人： Michael V. Chobotov , Robert G. Whirley , Joseph W. Humphrey
发明人： Michael V. Chobotov , Robert G. Whirley , Joseph W. Humphrey
IPC分类号： A61F2/07 , A61F2/954 , A61F2/966 , A61F2/06 , A61F2/848 , A61F2/95 , A61F2/89
摘要： A hybrid modular endovascular graft wherein a main graft is sized to span at least a portion of a target vessel lesion in a large percentage of patients. Graft extensions may be secured to the main graft to extend the main graft and provide a sealing function for some applications.

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