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1. 发明授权

US07534837B2 Random copolymers of ethylene and 4-vinylphenyl esters and method for preparing the same 失效
标题翻译：乙烯和4-乙烯基苯基酯的无规共聚物及其制备方法
公开(公告)号：US07534837B2
公开(公告)日：2009-05-19
申请号：US11235300
申请日：2005-09-26
申请人： Michael Thomas Sheehan , Mark E. Wagman
发明人： Michael Thomas Sheehan , Mark E. Wagman
IPC分类号： C08F226/06 , C08F16/18
CPC分类号： C08F6/001 , C08F210/02 , C08L23/08 , C08F4/32 , C08F2/00 , C08F218/12 , C08F2500/01 , C08F2500/12 , C08F2500/20 , C08F220/06
摘要： The invention discloses a composition consisting essentially of an E/X/M random copolymer wherein X is from 0.1 to 20 mol % of the E/X/M copolymer and is a 4-vinylphenyl ester, preferably 4-acetoxystyrene; M is from 0 to 40 mol % of the E/X/M copolymer and is one or more ethylenically unsaturated monomers; and E is ethylene. The invention further encompasses a high pressure radical polymerization process for providing the novel polymers; and a base catalyzed transesterification process for conversion of the E/X/M copolymer to an E/Y/M copolymer wherein Y is derived from 4-hydroxystyrene. Another embodiment of the invention is a composition consisting essentially of an E/Y/M random copolymer wherein Y is greater than 1.0 to about 20 mol % of the E/Y/M copolymer and is 4-hydroxystyrene; M is from 0 to 40 mol % of the E/Y/M copolymer and is one or more ethylenically unsaturated monomers; and E is ethylene.
摘要翻译：本发明公开了一种基本上由E / X / M无规共聚物组成的组合物，其中X为E / X / M共聚物的0.1-20摩尔％，是4-乙烯基苯基酯，优选4-乙酰氧基苯乙烯; M为E / X / M共聚物的0〜40摩尔％，为一种或多种烯属不饱和单体; E是乙烯。本发明还包括用于提供新型聚合物的高压自由基聚合方法; 以及用于将E / X / M共聚物转化成其中Y衍生自4-羟基苯乙烯的E / Y / M共聚物的碱催化酯交换方法。本发明的另一个实施方案是基本上由E / Y / M无规共聚物组成的组合物，其中Y大于E / Y / M共聚物的1.0至约20mol％且为4-羟基苯乙烯; M为0〜40摩尔％的E / Y / M共聚物，为一种或多种烯属不饱和单体; E是乙烯。

2. 发明授权

US5397829A Low-melting tetrafluoroethylene copolymer and its uses 失效
标题翻译：低熔点四氟乙烯共聚物及其用途
公开(公告)号：US5397829A
公开(公告)日：1995-03-14
申请号：US156621
申请日：1993-11-23
申请人： Richard A. Morgan , William H. Tuminello , Mark E. Wagman
发明人： Richard A. Morgan , William H. Tuminello , Mark E. Wagman
IPC分类号： C08J3/11 , B29C47/00 , B29C65/48 , B29K23/00 , B32B27/30 , C08F214/26 , C08J5/12 , C08L23/00 , C08L23/02 , C08L27/00 , C08L27/12 , C08L27/18 , C09D127/12 , C09D127/18 , C09J127/12 , C09J127/18 , C08K5/02 , C08K5/03
CPC分类号： C09D127/18 , C08F214/26 , C08L23/02 , C08L23/16 , C08L27/18 , C08L27/20
摘要： Copolymers of tetrafluoroethylene (TFE) and hexafluoropropylene (HFP) having high HFP content and end-of-melting temperature, T.sub.m (end), as low as 200.degree. C. are disclosed. Exceptional performance as a processing aid in polyolefins results from having T.sub.m (end) of the TFE/HFP copolymer close to the processing temperature of the polyolefin. These TFE/HFP copolymers are soluble in fluorinated cyclic solvents. Copolymer/solvent systems copolymer at significant concentrations in selected solvents are fluid and stable at room temperature.
摘要翻译：公开了具有高HFP含量和末端熔融温度Tm（末端）低至200℃的四氟乙烯（TFE）和六氟丙烯（HFP）的共聚物。由于TFE / HFP共聚物的Tm（末端）接近聚烯烃的加工温度，所以作为聚烯烃的加工助剂具有卓越的性能。这些TFE / HFP共聚物可溶于氟化环状溶剂。在选择的溶剂中显着浓度的共聚物/溶剂体系共聚物在室温下是流动性和稳定性的。

3. 发明授权

US5266639A Low-melting tetrafluorethylene copolymer and its uses 失效
标题翻译：低熔点四氟乙烯共聚物及其用途
公开(公告)号：US5266639A
公开(公告)日：1993-11-30
申请号：US935353
申请日：1992-08-28
申请人： George R. Chapman, Jr. , Lewis E. Crenshaw , Rita S. McMinn , Richard A. Morgan , Donnan E. Priester , Charles W. Stewart , William H. Tuminello , Robert E. Tarney , John G. Van Alsten , Mark E. Wagman
发明人： George R. Chapman, Jr. , Lewis E. Crenshaw , Rita S. McMinn , Richard A. Morgan , Donnan E. Priester , Charles W. Stewart , William H. Tuminello , Robert E. Tarney , John G. Van Alsten , Mark E. Wagman
IPC分类号： C08F214/26 , C08F214/28
CPC分类号： C08F214/26
摘要： Copolymers of tetrafluoroethylene (TFE) and hexafluoropropylene (HFP) having high HFP content and end-of-melting temperature, T.sub.m (end), as low as 200.degree. C. are disclosed. Exceptional performance as a processing aid in polyolefins results from having T.sub.m (end) of the TFE/HFP copolymer close to the processing temperature of the polyolefin. These TFE/HFP copolymers are soluble in fluorinated cyclic solvents. Copolymer/solvent systems copolymer at significant concentrations in selected solvents are fluid and stable at room temperature.
摘要翻译：公开了具有高HFP含量和末端熔融温度Tm（末端）低至200℃的四氟乙烯（TFE）和六氟丙烯（HFP）的共聚物。由于TFE / HFP共聚物的Tm（末端）接近聚烯烃的加工温度，所以作为聚烯烃的加工助剂具有卓越的性能。这些TFE / HFP共聚物可溶于氟化环状溶剂。在选择的溶剂中显着浓度的共聚物/溶剂体系共聚物在室温下是流动性和稳定性的。

4. 发明申请

US20100160960A1 HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME 审中-公开
标题翻译： HYDROGEL TISSUE粘合剂具有降低的降解时间
公开(公告)号：US20100160960A1
公开(公告)日：2010-06-24
申请号：US12614659
申请日：2009-11-09
申请人： Mark E. Wagman , Kai Qi , Keith Kunitsky , Hing Wan Yim
发明人： Mark E. Wagman , Kai Qi , Keith Kunitsky , Hing Wan Yim
IPC分类号： A61B17/03 , C08K5/05 , C08L5/00
CPC分类号： A61L24/0031 , A61B17/00491 , A61L24/08 , C08B37/0021 , C08G2650/50 , C08J3/075 , C08L71/02 , C08L2205/05 , C08L5/00
摘要： A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.
摘要翻译：描述了具有增加的降解时间的水凝胶组织粘合剂。通过在多元醇添加剂的存在下使氧化多糖与水分散性多臂胺反应形成水凝胶组织粘合剂，其延缓了水凝胶的降解。水凝胶可用作用于医疗应用的组织粘合剂或密封剂，包括但不限于眼科应用，例如由诸如角膜撕裂等创伤引起的伤口，或外科手术如玻璃体切除术，白内障手术，LASIK手术，青光眼手术和角膜移植; 神经外科应用如密封硬脑膜; 作为密封瘘管或泪点的塞子; 防止粘附以防止由创伤或手术导致的不想要的组织到组织粘连; 并作为止血剂密封胶。

5. 发明授权

US5547761A Low melting tetrafluoroethylene copolymer and its uses 失效
标题翻译：低熔点四氟乙烯共聚物及其用途
公开(公告)号：US5547761A
公开(公告)日：1996-08-20
申请号：US457080
申请日：1995-06-01
申请人： George R. Chapman, Jr. , Richard A. Morgan , Charles W. Stewart , William H. Tuminello , John G. Van Alsten , Randall A. Vogel , Mark E. Wagman
发明人： George R. Chapman, Jr. , Richard A. Morgan , Charles W. Stewart , William H. Tuminello , John G. Van Alsten , Randall A. Vogel , Mark E. Wagman
IPC分类号： C08F214/26 , C08L23/02 , C09D127/18 , B32B27/00
CPC分类号： C09D127/18 , C08F214/26 , C08L23/02 , Y10T428/31544 , Y10T428/31855
摘要： Copolymers of tetrafluoroethylene (TFE) and hexafluoropropylene (HFP) having high HFP content and end-of-melting temperature, T.sub.m (end), as low as 200.degree. C. are disclosed. Exceptional performance as a processing aid in polyolefins results from having T.sub.m (end) of the TFE/HFP copolymer close to the processing temperature of the polyolefin. These TFE/HFP copolymers are soluble in fluorinated cyclic solvents. Copolymer/solvent systems copolymer at significant concentrations in selected solvents are fluid and stable at room temperature.
摘要翻译：公开了具有高HFP含量和末端熔融温度Tm（末端）低至200℃的四氟乙烯（TFE）和六氟丙烯（HFP）的共聚物。由于TFE / HFP共聚物的Tm（末端）接近聚烯烃的加工温度，所以作为聚烯烃的加工助剂具有卓越的性能。这些TFE / HFP共聚物可溶于氟化环状溶剂。在选择的溶剂中显着浓度的共聚物/溶剂体系共聚物在室温下是流动性和稳定性的。

6. 发明授权

US5063263A Polyacetal compositions containing a non-meltable polymer stabilizer improved with a minor amount of at least one meltable co-stabilizer and at least one primary antioxidant 失效
标题翻译：含有不可熔融聚合物稳定剂的聚缩醛组合物用少量的至少一种可熔融共稳定剂和至少一种主抗氧化剂
公开(公告)号：US5063263A
公开(公告)日：1991-11-05
申请号：US536343
申请日：1990-06-11
申请人： Richard A. Hayes , Leonard E. R. Kosinski , Mark E. Wagman
发明人： Richard A. Hayes , Leonard E. R. Kosinski , Mark E. Wagman
IPC分类号： C08L1/00 , C08L13/00 , C08L23/08 , C08L33/00 , C08L59/00 , C08L77/00 , C08L83/04 , G07C9/00 , G07F7/10
CPC分类号： G07F7/1008 , C08L59/00 , C08L1/00 , C08L13/00 , C08L23/08 , C08L33/00 , C08L77/00 , C08L83/04
摘要： Incorporation into polyacetal molding compositions stabilized for processing with a non-meltable polymer stabilizer of 0.01-1.00 weight percent of at least one meltable co-stabilizer, said co-stabilizer being a thermal stabilizer for polyacetal, and 0.02-1.0 weight percent of at least one primary antioxidant results in significantly improved long term stability, as evidenced by greater retention of physical properties over time, of such compositions.
摘要翻译：掺入聚缩醛成型组合物中，稳定用于使用0.01-1.00重量％的至少一种可熔融共稳定剂的非可熔融聚合物稳定剂进行处理，所述共稳定剂是聚缩醛的热稳定剂，和至少0.02-1.0重量％这种组合物的一个主要抗氧化剂导致长期稳定性的显着改善，这通过随时间推移的物理性质的更大保留证明。

7. 发明授权

US08951989B2 Hydrogel tissue adhesive having reduced degradation time 有权
标题翻译：水凝胶组织粘合剂具有降低的降解时间
公开(公告)号：US08951989B2
公开(公告)日：2015-02-10
申请号：US13263364
申请日：2010-04-09
申请人： Mark E. Wagman
发明人： Mark E. Wagman
IPC分类号： A61K31/70 , A61K31/715 , C08L5/08 , C08L5/12 , C08L71/02 , A61K31/717 , A61K31/718 , A61K31/719 , A61K31/721 , A61L24/00 , A61L24/04 , A61L31/04 , A61L31/14 , C08L1/04 , C08L3/10 , C08L5/02
CPC分类号： A61L24/0031 , A61L24/0042 , A61L24/043 , A61L31/041 , A61L31/145 , A61L31/148 , C08L1/04 , C08L3/10 , C08L5/02 , C08L5/08 , C08L5/12 , C08L71/02
摘要： A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm polyether amine in the presence of an oligomer additive, which promotes the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.
摘要翻译：描述了具有降低的降解时间的水凝胶组织粘合剂。水凝胶组织粘合剂通过使氧化多糖与水分散性多臂聚醚胺在低聚物添加剂的存在下反应形成，其促进水凝胶的降解。水凝胶可用作用于医疗应用的组织粘合剂或密封剂，例如止血剂密封剂或用于防止由创伤或手术引起的不希望的组织与组织粘连。

8. 发明申请

US20080167433A1 METHOD FOR PREPARING GLYCIDYLOXYSTYRENE MONOMERS AND POLYMERS THEREOF 失效
标题翻译：制备甘氨酰基苯乙烯单体及其聚合物的方法
公开(公告)号：US20080167433A1
公开(公告)日：2008-07-10
申请号：US11961093
申请日：2007-12-20
申请人： KEITH KUNITSKY , Mukesh C. Shah , Steven W. Shuey , Mark E. Wagman
发明人： KEITH KUNITSKY , Mukesh C. Shah , Steven W. Shuey , Mark E. Wagman
IPC分类号： C08F2/00 , C07D301/02 , C07D407/02
CPC分类号： C08F12/22 , C07D303/23
摘要： It was found that glycidyloxystyrenes, including glycidyloxystyrene and substituted glycidyloxystyrene, can be synthesized from hydroxycinnamic acid or substituted hydroxycinnamic acids in a one-pot, two-step process. The substrate can be thermally decarboxylated and then without purification, reacted in the presence of a halomethyl-oxirane and a base. The resulting product can be polymerized or coppolymerized to a fully substituted product.
摘要翻译：发现缩水甘油氧基苯乙烯，包括缩水甘油氧基苯乙烯和取代的缩水甘油氧基苯乙烯，可以一锅二步法从羟基肉桂酸或取代的羟基肉桂酸合成。底物可以热脱羧，然后不经纯化，在卤代甲基 - 环氧乙烷和碱的存在下反应。所得产物可以被聚合或共聚合成完全取代的产物。

9. 发明授权

US4972014A Polyacetal compositions containing a non-meltable polymer stabilizer improved with at least one amide-containing phenolic antioxidant 失效
标题翻译：含有不可熔融聚合物稳定剂的聚缩醛组合物用至少一种含酰胺的酚类抗氧化剂改进
公开(公告)号：US4972014A
公开(公告)日：1990-11-20
申请号：US366850
申请日：1989-06-15
申请人： Richard A. Hayes , Leonard E. R. Kosinski , Mark E. Wagman
发明人： Richard A. Hayes , Leonard E. R. Kosinski , Mark E. Wagman
IPC分类号： C08L1/00 , C08L13/00 , C08L23/08 , C08L33/00 , C08L59/00 , C08L77/00 , C08L83/04 , G07C9/00 , G07F7/10
CPC分类号： G07F7/1008 , C08L59/00 , G07C9/00015 , C08L1/00 , C08L13/00 , C08L23/08 , C08L33/00 , C08L77/00 , C08L83/04
摘要： Incorporation into polyacetal molding compositions stabilized with a non-meltable polymer stabilizer of 0.02-1.0 weight percent of at least one amide-containing phenolic antioxidant results in significantly improved long term stability, as evidenced by greater retention of physical properties over time, of such compositions.
摘要翻译：通过0.02-1.0重量％的至少一种含酰胺的酚类抗氧化剂稳定的聚缩醛成型组合物的结合显示出显着改善的长期稳定性，如通过随时间推移的物理性质的更大保留所证明的，这些组合物。

10. 发明申请

US20120094955A1 METHOD OF DISSOLVING AN OXIDIZED POLYSACCHARIDE IN AN AQUEOUS SOLUTION 审中-公开
标题翻译：在水溶液中溶解氧化多糖的方法
公开(公告)号：US20120094955A1
公开(公告)日：2012-04-19
申请号：US13263379
申请日：2010-04-09
申请人： Mark E. Wagman
发明人： Mark E. Wagman
IPC分类号： A61K31/721 , A61K47/26 , A61P43/00 , C09J105/02
CPC分类号： A61K31/721 , C08B37/0021 , C08J3/05 , C08J2301/04 , C08J2301/28 , C08J2303/02 , C08J2303/10 , C08J2305/00 , C08J2305/02 , C08J2305/08 , C08J2305/12 , C08L3/02 , C08L5/00 , C08L5/02 , C09D105/02 , C08L71/02
摘要： A method of dissolving an oxidized polysaccharide in an aqueous solution using an oligomer additive is described. The resulting aqueous solution of the oxidized polysaccharide may be used in combination with an aqueous solution comprising an amine-containing component to prepare hydrogel tissue adhesives and sealants for medical and veterinary applications, such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.
摘要翻译：描述了使用低聚物添加剂将氧化多糖溶解在水溶液中的方法。所得到的氧化多糖水溶液可与包含含胺组分的水溶液组合使用以制备用于医疗和兽医应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或更换内部手术中的缝线或缝钉手术如肠吻合和血管吻合术，组织修复，眼科手术，药物递送，并防止手术后粘连。

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