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    • 10. 发明申请
    • Direct synthesis of di-heteroatom containing cyclic organic compounds
    • 直接合成含二杂原子的环状有机化合物
    • US20050043532A1
    • 2005-02-24
    • US10894804
    • 2004-07-20
    • Michael SiskinEdmund Mozeleski
    • Michael SiskinEdmund Mozeleski
    • C07D295/02C07D295/027C07D319/12C07D279/12C07D265/30C07D339/02
    • C07D295/027C07D319/12
    • The present invention provides for the simplified, direct synthesis of di-heteroatom containing cyclic organic compounds by forming an aqueous mixture of material of the formula 1 wherein X and Y are heteroatoms which may be the same or different and X is selected from the group consisting of O, S and N, and both Y's are the same and are selected from the group consisting of O, S and N, and R1 through R8 are the same or different and are selected from the group consisting of H, C1 to C10 alkyl radicals, C1 to C10 aryl radicals, C1 to C10 alkyl aryl radicals, and z is zero when X and Y are O or S, and z is 1 when X and Y are N, and water at a mole ratio of water to material of formula I in the range of about 10:1 to about 0.001:1 and heating the mixture to a temperature in the range of about 250° C. to about 350° C. under autogeneous pressure for a time of from about 0.5 to 10 hours. Trace amounts of liquid, solid or gaseous acid can be present to further accelerate dehydration, dehydrosulfurization or deamination and cyclization.
    • 本发明通过形成式1的材料的水性混合物来简化,直接合成含二杂原子的环状有机化合物,其中X和Y是可以相同或不同的杂原子,X选自 的O,S和N,并且两个Y都相同并且选自O,S和N,并且R 1至R 8相同或不同,并且选自由以下组成的组: H,C1至C10烷基,C1至C10芳基,C1至C10烷基芳基,当X和Y为O或S时z为零,当X和Y为N时z为1, 水与式I物质的比例在约10:1至约0.001:1的范围内,并将混合物在自压下加热至约250℃至约350℃的温度,持续一段时间 约0.5至10小时。 可以存在微量的液体,固态或气态酸,以进一步加速脱水,脱硫脱硫或脱氨和环化。