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1. 发明授权

US08500644B2 Applying renyi entropy to detect changes in scattering architecture 有权
标题翻译：应用renyi熵来检测散射体系结构的变化
公开(公告)号：US08500644B2
公开(公告)日：2013-08-06
申请号：US13126099
申请日：2009-10-28
申请人： Michael S. Hughes , John McCarthy , Gregory Lanza , Mladen Victor Wickerhauser , Samuel Wickline
发明人： Michael S. Hughes , John McCarthy , Gregory Lanza , Mladen Victor Wickerhauser , Samuel Wickline
IPC分类号： A61B8/00 , G06K9/00
CPC分类号： A61B8/08
摘要： A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data.
摘要翻译：用于对身体内的感兴趣区域（ROI）进行成像的方法。该方法包括：将超声能量应用于ROI，响应于所施加的超声波能量接收用于ROI的超声数据，对所接收的超声波数据执行移动窗口分析以产生多个信息窗口，将Renyi熵信号接收机应用于每个生成的窗口生成Renyi熵数据，并且基于Renyi熵数据呈现ROI的图像。

2. 发明申请

US20110208058A1 Applying Renyi Entropy To Detect Changes In Scattering Architecture 有权
标题翻译：应用Renyi熵来检测散射体系结构中的变化
公开(公告)号：US20110208058A1
公开(公告)日：2011-08-25
申请号：US13126099
申请日：2009-10-28
申请人： Michael S. Hughes , John McCarthy , Gregory Lanza , Mladen Victor Wickerhauser , Samuel Wickline
发明人： Michael S. Hughes , John McCarthy , Gregory Lanza , Mladen Victor Wickerhauser , Samuel Wickline
IPC分类号： A61B8/14
CPC分类号： A61B8/08
摘要： A method for imaging a region of interest (ROI) within a body. The method includes applying ultrasound energy to the ROI, receiving ultrasound data for the ROI in response to the applied ultrasound energy, executing a moving window analysis on the received ultrasound data to generate a plurality of windows of information, applying a Renyi entropy signal receiver to each of the generated windows to generate Renyi entropy data, and presenting an image of the ROI based on the Renyi entropy data.
摘要翻译：用于对身体内的感兴趣区域（ROI）进行成像的方法。该方法包括：将超声能量应用于ROI，响应所施加的超声能量接收用于ROI的超声数据，对所接收的超声波数据执行移动窗口分析以产生多个信息窗口，将Renyi熵信号接收机应用于每个生成的窗口生成Renyi熵数据，并且基于Renyi熵数据呈现ROI的图像。

3. 发明申请

US20050175541A1 Enhanced drug delivery 审中-公开
标题翻译：增强药物输送
公开(公告)号：US20050175541A1
公开(公告)日：2005-08-11
申请号：US10993578
申请日：2004-11-19
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K20060101 , A61K9/00 , A61K9/127 , A61K9/51 , A61K41/00 , A61K47/48 , A61K49/00
CPC分类号： A61K9/0009 , A61K9/1075 , A61K41/0047 , A61K47/6909 , A61K51/0408 , A61K51/1227
摘要： The invention is directed to methods for the delivery of a therapeutic agent using lipid-encapsulated particles containing the therapeutic agent and ultrasound energy. For example, it particularly relates to the use of ultrasound with a lipid-encapsulated emulsion comprising an oil where the emulsion is coupled a targeting ligand and comprises a therapeutic agent.
摘要翻译：本发明涉及使用含有治疗剂和超声能量的脂质包封颗粒递送治疗剂的方法。例如，它特别涉及超声与包含油的脂质包封的乳液的使用，其中乳液与靶向配体偶联并且包含治疗剂。

4. 发明申请

US20050079131A1 Emulsion particles for imaging and therapy and methods of use thereof 审中-公开
标题翻译：用于成像和治疗的乳液颗粒及其使用方法
公开(公告)号：US20050079131A1
公开(公告)日：2005-04-14
申请号：US10913846
申请日：2004-08-06
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K49/00 , A61K49/04 , A61K51/00
CPC分类号： B82Y5/00 , A61K49/049
摘要： Emulsions preferably of nanoparticles formed from oil compounds coupled to a high Z number atom, said particles coated with a lipid/surfactant coating. The nanoparticles are made specific to targeted cells or tissues by coupling said nanoparticles to a ligand specific for the target cells or tissues. The nanoparticles may further include biologically active agents, radionuclides and/or other imaging agents.
摘要翻译：优选由与高Z数原子连接的油性化合物形成的纳米颗粒的乳液，所述颗粒涂覆有脂质/表面活性剂涂层。通过将所述纳米颗粒偶联到靶细胞或组织特异的配体，使纳米颗粒对靶细胞或组织是特异性的。纳米颗粒可以进一步包括生物活性剂，放射性核素和/或其他成像剂。

5. 发明申请

US20070010577A1 Targeted atherosclerosis treatment 失效
标题翻译：靶向动脉粥样硬化治疗
公开(公告)号：US20070010577A1
公开(公告)日：2007-01-11
申请号：US10492749
申请日：2004-01-16
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K31/336 , A61K9/14
CPC分类号： A61K49/1806 , A61K9/1075 , A61K31/336 , A61K47/59 , A61K47/64 , A61K47/6907 , B82Y5/00
摘要： This invention relates generally to methods for ameliorating at least one symptom or aspect of atherosclerosis. The methods include administration of targeted carrier compositions comprising a therapeutic agent effective in ameliorating at least one aspect of atherosclerosis coupled to a targeting ligand effective is targeting the therapeutic agent to tissue associated with atherosclerotic plaque.
摘要翻译：本发明一般涉及改善动脉粥样硬化的至少一种症状或方面的方法。所述方法包括施用包含有效改善与靶向配体偶联的动脉粥样硬化的至少一个方面的治疗剂的靶向载体组合物，其有效的是将治疗剂靶向与动脉粥样硬化斑块相关的组织。

6. 发明申请

US20060147380A1 Integrin targeted imaging agents 失效
标题翻译：整合素靶向成像剂
公开(公告)号：US20060147380A1
公开(公告)日：2006-07-06
申请号：US11305416
申请日：2005-12-16
申请人： Gregory Lanza , Samuel Wickline , Tom Harris
发明人： Gregory Lanza , Samuel Wickline , Tom Harris
IPC分类号： A61K38/04 , A61K49/10 , A61K31/4745 , A61K31/4709
CPC分类号： A61K49/223 , A61K47/6907 , A61K49/0002 , A61K49/1833 , B82Y5/00
摘要： Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
摘要翻译：优选由高沸点液体全氟化学物质形成的纳米颗粒，所述涂覆有脂质/表面活性剂涂层的颗粒由活化内皮细胞的区域特异性地形成，所述纳米颗粒通过将所述纳米颗粒与特异于α 除了抗体以外，还有3个整联蛋白。纳米颗粒可以进一步包括生物活性剂，放射性核素或其它成像剂。

7. 发明申请

US20060239919A1 MR coronary angiography with a fluorinated nanoparticle contrast agent at 1.5 T 审中-公开
标题翻译：用1.5 T的氟化纳米颗粒造影剂进行MR冠状动脉造影
公开(公告)号：US20060239919A1
公开(公告)日：2006-10-26
申请号：US11367971
申请日：2006-03-03
申请人： Samuel Wickline , Gregory Lanza
发明人： Samuel Wickline , Gregory Lanza
IPC分类号： A61B5/055
CPC分类号： B82Y5/00 , A61K49/1806
摘要： Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19F signal can be used, or dual tuned coils for 19F and 1H imaging can be used. Clinical field strengths (e.g. 1.5 T) and clinical doses may be used while still providing effective images.
摘要翻译：本文公开了一种医疗成像技术，其使用氟化纳米颗粒造影剂来成像身体的内部部分。氟化纳米颗粒优选包含非靶向的血管内碳氟化合物或全氟化碳纳米颗粒。内部主体部分可以是患者的脉管系统，并且医学成像优选是非侵入性MR血管造影术，其可以包括（用于2D成像或3D成像）MR冠状动脉造影，MR颈动脉血管造影术，MR周围血管造影术，MR脑血管造影术，MR动脉血管造影和MR静脉血管造影。可以使用调谐到与^{19F信号相匹配的线圈，或者可以使用用于<20> F和<1> H / H成像的双调谐线圈。可以在仍然提供有效图像的同时使用临床场强（例如1.5T）和临床剂量。}

8. 发明申请

US20070202040A1 Blood clot-targeted nanoparticles 审中-公开
公开(公告)号：US20070202040A1
公开(公告)日：2007-08-30
申请号：US11796064
申请日：2007-04-25
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K51/12 , A61K103/10
CPC分类号： A61K51/1227 , A61K47/6843 , A61K47/6907 , A61K49/0471 , A61K49/1806 , A61K49/1812 , A61K49/227 , B82Y5/00
摘要： Emulsions comprising nanoparticles formed from high boiling perfluorochemical substances, said particles coated with a lipid/surfactant coating are made target-specific by directly coupling said nanoparticles to a targeting ligand. The nanoparticles may further include biologically active agents, radionuclides, and/or other imaging agents.

9. 发明申请

US20070140965A1 Methods to ameliorate and image angioplasty-induced vascular injury 审中-公开
标题翻译：改善血管成形术诱导的血管损伤的方法
公开(公告)号：US20070140965A1
公开(公告)日：2007-06-21
申请号：US11607683
申请日：2006-12-01
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K51/00 , A61K39/395 , A61K38/17 , A61K31/704 , A61K31/4745 , A61K31/337 , A61K31/336
CPC分类号： A61K49/1866 , A61K9/0024 , A61K9/10 , A61K31/336 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K38/17 , A61K47/62 , A61K47/6907 , A61K47/6911 , A61K49/0002 , A61K49/1809 , A61K49/1812 , A61K51/1217 , B82Y5/00
摘要： Methods for inhibiting restenosis in blood vessels expanded by angioplasty are described. The method comprises administering blood vessel wall-targeted emulsion containing an anti-restenotic agent.
摘要翻译：描述了通过血管成形术扩张的血管中抑制再狭窄的方法。该方法包括施用含有抗再狭窄剂的血管壁靶乳剂。

10. 发明申请

US20070258908A1 Detection and imaging of target tissue 审中-公开
标题翻译：目标组织的检测和成像
公开(公告)号：US20070258908A1
公开(公告)日：2007-11-08
申请号：US11796415
申请日：2007-04-27
申请人： Gregory Lanza , Samuel Wickline
发明人： Gregory Lanza , Samuel Wickline
IPC分类号： A61K49/10
CPC分类号： A61K49/1809 , A61K49/0041 , A61K49/0082 , A61K49/0093 , A61K51/122
摘要： Methods for high resolution imaging of a suspected target tissue are encompassed by the invention. Such methods include administering low resolution and high resolution contrast agents specific to targeted cells or tissues. The contrast agents are allowed to bind to the target cells or accumulate in a target tissue. A low resolution imaging technique is used to localize an accumulation of the low resolution contrast agent in a target tissue. A high resolution image of the target tissue is then obtained to localize an accumulation of the higher resolution contrast agent, allowing the generation of a higher resolution image than that obtained by the use of the low resolution contrast agent alone. These methods may utilize nanoparticles optionally in an emulsion as a contrast agent.
摘要翻译：本发明涉及可疑目标组织的高分辨率成像方法。这样的方法包括施用对靶细胞或组织特异的低分辨率和高分辨率造影剂。使造影剂与靶细胞结合或聚集在靶组织中。低分辨率成像技术用于定位目标组织中低分辨率造影剂的积聚。然后获得目标组织的高分辨率图像以定位较高分辨率造影剂的累积，允许产生比通过仅使用低分辨率造影剂获得的更高分辨率图像。这些方法可以任选地使用乳剂中的纳米颗粒作为造影剂。

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