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1. 发明授权

US09282958B2 Devices and method for treating pelvic dysfunctions 有权
标题翻译：用于治疗盆腔功能障碍的装置和方法
公开(公告)号：US09282958B2
公开(公告)日：2016-03-15
申请号：US12341701
申请日：2008-12-22
申请人： Michael S. H. Chu , Hamid Davoudi , Ty Fairneny , James Goddard , Roger P. Goldberg , Jianmin Li , Steven A. Olivieri , John Petricca , Jozef Slanda , Ken Toso , Michael Weiser
发明人： Michael S. H. Chu , Hamid Davoudi , Ty Fairneny , James Goddard , Roger P. Goldberg , Jianmin Li , Steven A. Olivieri , John Petricca , Jozef Slanda , Ken Toso , Michael Weiser
IPC分类号： A61F2/00 , A61F2/02 , A61B17/04 , A61B17/06 , A61B19/02 , A61B17/00
CPC分类号： A61B17/0401 , A61B17/0482 , A61B17/06109 , A61B50/20 , A61B2017/00805 , A61B2017/0475 , A61B2017/0496 , A61B2017/06042 , A61B2017/06176 , A61F2/0045
摘要： In one embodiment, a method includes securing an implant that includes a pre-formed loop to a vaginal apex. An end of the suture is inserted through a selected portion of a pelvic tissue to dispose at least a portion of the implant within a pelvic region of the patient. The end of the suture is drawn through the loop while simultaneously advancing a uterus to approximate the vaginal apex to the selected portion of pelvic tissue. An apparatus includes an implant and a suture coupled to the implant having a pre-formed loop. configured to receive a portion of a delivery device therethrough. A trocar is coupled to an end of the suture that can be releasably coupled to an end of the delivery device. The trocar can be inserted through a pelvic tissue and drawn through the loop forming a knot to secure the implant to the pelvic tissue.
摘要翻译：在一个实施例中，一种方法包括将包括预形成环的植入物固定到阴道顶点。缝合线的一端插入通过骨盆组织的选定部分，以将至少一部分植入物置于患者的骨盆区域内。缝合线的末端穿过环，同时推进子宫以将阴道顶点近似到盆腔组织的选定部分。一种装置包括植入物和连接到具有预成形环的植入物的缝合线。被配置为接收通过其中的输送装置的一部分。套针针连接到缝合线的端部，其可以可释放地联接到输送装置的端部。套管针可以插入通过盆腔组织并通过环形成一个结，以将植入物固定在骨盆组织上。

2. 发明申请

US20090171143A1 DEVICES AND METHOD FOR TREATING PELVIC DYSFUNCTIONS 有权
标题翻译：用于治疗药物功能的装置和方法
公开(公告)号：US20090171143A1
公开(公告)日：2009-07-02
申请号：US12341701
申请日：2008-12-22
申请人： Michael S. H. Chu , Hamid Davoudi , Ty Fairneny , James Goddard , Roger P. Goldberg , Jianmin Li , Steven A. Olivieri , John Petricca , Jozef Slanda , Ken Toso , Michael Weiser
发明人： Michael S. H. Chu , Hamid Davoudi , Ty Fairneny , James Goddard , Roger P. Goldberg , Jianmin Li , Steven A. Olivieri , John Petricca , Jozef Slanda , Ken Toso , Michael Weiser
IPC分类号： A61F2/02
CPC分类号： A61B17/0401 , A61B17/0482 , A61B17/06109 , A61B50/20 , A61B2017/00805 , A61B2017/0475 , A61B2017/0496 , A61B2017/06042 , A61B2017/06176 , A61F2/0045
摘要： In one embodiment, a method includes securing an implant that includes a pre-formed loop to a vaginal apex. An end of the suture is inserted through a selected portion of a pelvic tissue to dispose at least a portion of the implant within a pelvic region of the patient. The end of the suture is drawn through the loop while simultaneously advancing a uterus to approximate the vaginal apex to the selected portion of pelvic tissue. An apparatus includes an implant and a suture coupled to the implant having a pre-formed loop. configured to receive a portion of a delivery device therethrough. A trocar is coupled to an end of the suture that can be releasably coupled to an end of the delivery device. The trocar can be inserted through a pelvic tissue and drawn through the loop forming a knot to secure the implant to the pelvic tissue.
摘要翻译：在一个实施例中，一种方法包括将包括预形成环的植入物固定到阴道顶点。缝合线的一端插入通过骨盆组织的选定部分，以将至少一部分植入物置于患者的骨盆区域内。缝合线的末端穿过环，同时推进子宫以将阴道顶点近似到盆腔组织的选定部分。一种装置包括植入物和连接到具有预成形环的植入物的缝合线。被配置为接收通过其中的输送装置的一部分。套针针连接到缝合线的端部，其可以可释放地联接到输送装置的端部。套管针可以插入通过盆腔组织并通过环形成一个结，以将植入物固定在骨盆组织上。

3. 发明授权

US08414501B2 Thermal monitoring 有权
标题翻译：热监测
公开(公告)号：US08414501B2
公开(公告)日：2013-04-09
申请号：US12342959
申请日：2008-12-23
申请人： Brian M. Hanley , Michael S. H. Chu , Kenneth J. Daignault , Aidan Petrie , Justin Sirotin , David Robson , Andrew W. Marsella , Dan Nelsen , Michael Weiser , Ramin N. Tehrani
发明人： Brian M. Hanley , Michael S. H. Chu , Kenneth J. Daignault , Aidan Petrie , Justin Sirotin , David Robson , Andrew W. Marsella , Dan Nelsen , Michael Weiser , Ramin N. Tehrani
IPC分类号： A61B5/00 , G01K1/08 , G01K1/00 , A61M29/00
CPC分类号： A61B5/4381 , A61B5/01
摘要： A rectal thermal monitor for transrectal prostate temperature measurement includes a handle arranged in a proximal end portion of the monitor for gripping by a user, an elongate shaft extending from the handle, and an expandable distal probe portion arranged on a distal end of the shaft. The distal probe portion is arranged at a position opposite the handle portion, and is shaped to facilitate insertion through an anal sphincter and into a rectum of a patient. A cover element, is provided for covering at least a portion of the distal probe portion, and is made from a resilient material. A temperature sensing element is arranged within the distal probe portion, beneath the cover element, and is adapted and configured to sense a temperature of the prostate of the patient through the rectum wall of the patient. Further, and actuator can be provided to actuate the expandable distal probe portion, to increase a diameter thereof.
摘要翻译：用于经直肠前列腺温度测量的直肠热监测器包括布置在监护仪的近端部分中的用于由使用者握持的手柄，从手柄延伸的细长轴和布置在轴的远端上的可扩展远端探针部分。远端探针部分布置在与把手部分相对的位置处，并且被成形为便于通过肛门括约肌插入并进入患者的直肠。提供覆盖元件，用于覆盖远端探针部分的至少一部分，并且由弹性材料制成。温度感测元件布置在远端探针部分内，覆盖元件下方，并且适于和构造成通过患者的直肠壁感测患者的前列腺的温度。此外，可以提供致动器来致动可扩展远端探针部分，以增加其直径。

4. 发明申请

US20130177522A1 NON-IRRITATING OPTHALMIC POVIDONE-IODINE COMPOSITIONS 审中-公开
标题翻译：无意义的POVIDONE-IODINE组合物
公开(公告)号：US20130177522A1
公开(公告)日：2013-07-11
申请号：US13515987
申请日：2010-12-15
申请人： Bo Liang , Joseph A. Capriotti , C. Michael Samson , Jason Stein , Michael Weiser
发明人： Bo Liang , Joseph A. Capriotti , C. Michael Samson , Jason Stein , Michael Weiser
IPC分类号： A61K47/10 , A61K47/08 , A61K9/00 , A61K31/79 , A61K45/06
CPC分类号： A61K47/10 , A61K9/0048 , A61K31/74 , A61K31/79 , A61K33/18 , A61K45/06 , A61K47/08 , A61K47/32 , A61K2300/00
摘要： Disclosed are compositions and methods comprising povidone-iodine and a cooling-effective amount of a chemical agent. The compositions are useful to relieve mild ocular irritation, enhance ocular comfort, and to provide a refreshing effect and improved sensation, when the povidone-iodine solution is applied to the eye.
摘要翻译：公开了包含聚维酮碘和冷却有效量的化学试剂的组合物和方法。当将聚维酮碘溶液施用于眼睛时，该组合物可用于缓解轻度眼睛刺激，增强眼睛舒适度，并提供清爽效果和改善的感觉。

5. 发明申请

US20060009789A1 Tissue capturing devices 审中-公开
标题翻译：组织捕获装置
公开(公告)号：US20060009789A1
公开(公告)日：2006-01-12
申请号：US11199955
申请日：2005-08-09
申请人： Richard Gambale , Michael Weiser
发明人： Richard Gambale , Michael Weiser
IPC分类号： A61B17/10
CPC分类号： A61B17/0469 , A61B17/0487 , A61B17/1114 , A61B2017/00349 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0443 , A61B2017/0458 , A61B2017/0464 , A61B2017/06171 , A61B2017/0649 , A61B2017/1103 , A61B2017/1142 , A61B2017/308
摘要： The present invention provides tissue capture devices configured to hold tissue in a distorted configuration. The devices may hold precaptured tissue in a distorted configuration or it may change their shape to cause the tissue to become deformed. Some embodiments of the device alter the configuration in areas that remain external to the tissue, while other embodiments change their configuration in areas that are implanted in the tissue. Other embodiments may be mechanically altered to hold the tissue in a distorted shape.
摘要翻译：本发明提供了构造成将组织保持在变形构型中的组织捕获装置。这些装置可以将预先组织的组织保持在变形构型中，或者它们可以改变它们的形状以导致组织变形。该装置的一些实施例在保留在组织外部的区域中改变构造，而其他实施例在植入组织的区域中改变其构型。可以机械地改变其它实施例以将组织保持在变形形状。

6. 发明申请

US20050060019A1 Implant and agent delivery device 审中-公开
标题翻译：植入物和药剂输送装置
公开(公告)号：US20050060019A1
公开(公告)日：2005-03-17
申请号：US10951735
申请日：2004-09-28
申请人： Richard Gambale , Stephen Forcucci , Michael Weiser , Sean Forde
发明人： Richard Gambale , Stephen Forcucci , Michael Weiser , Sean Forde
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/88
CPC分类号： A61F2/88 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2250/0067
摘要： The present invention provides a system (178) for delivering a therapeutic agent in combination with an implantable device (2) to maximize a therapeutic benefit offered by each. Preferably, the therapeutic agent is contained within a solid matrix form such as a pellet or gel to facilitate its handling and to regulate its rate of dissipation into the tissue after delivery. The implant device (2) is specially configured to receive and retain the matrix but permit blood to interact with the matrix so that the agent can be released to the blood in and around the device and the surrounding tissue. A delivery system (178) comprises an implant delivery device having an obturator (180) capable of piercing the tissue and an agent matrix delivery device (210) to place a matrix form, such as a pellet, into the interior of the implant (2) after it has been implanted. Preferably, the implant delivery device (180) and the matrix delivery device (210) are contained in one apparatus to facilitate delivery of the pellet into the embedded implant. The present invention is useful for treating tissue in any area of the body, especially ischemic tissue experiencing reduced blood flow. The present devices and methods are especially useful for treatment of ischemia of the myocardium. In treatment of the myocardium, the present implant device and matrix combination may be delivered surgically through the epicardium of the heart.
摘要翻译：本发明提供了一种用于将治疗剂与可植入装置（2）组合递送以最大化由每个提供的治疗益处的系统（178）。优选地，治疗剂包含在固体基质形式例如丸粒或凝胶中，以促进其处理并调节其在分娩后向组织中的耗散速率。植入装置（2）被特别地构造成接收和保持基质，但允许血液与基质相互作用，使得试剂可以释放到装置周围的组织和周围的组织中和周围。递送系统（178）包括植入物递送装置，其具有能够刺穿组织的闭孔器（180）和药剂矩阵输送装置（210），以将诸如颗粒的矩阵形式放置在植入物（2）的内部）植入后。优选地，植入物递送装置（180）和基质递送装置（210）被包含在一个装置中以便于将颗粒递送到嵌入的植入物中。本发明可用于治疗身体的任何区域中的组织，特别是经历血流减少的缺血组织。本发明的装置和方法对于治疗心肌缺血特别有用。在心肌的治疗中，本发明的植入装置和基质组合可以通过心脏的心外膜手术递送。

7. 发明授权

US5733325A Non-migrating vascular prosthesis and minimally invasive placement system 失效
标题翻译：非迁移性血管假体和微创置入系统
公开(公告)号：US5733325A
公开(公告)日：1998-03-31
申请号：US643527
申请日：1996-05-06
申请人： Timothy Robinson , Michael Weiser , John Carey , Dennis Kujawski
发明人： Timothy Robinson , Michael Weiser , John Carey , Dennis Kujawski
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61F2/82 , A61F2/06
CPC分类号： A61F2/07 , A61F2/95 , A61F2/966 , A61F2/848 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2002/825 , A61F2002/8486 , A61F2002/9522 , A61F2002/9665 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , Y10S623/921
摘要： A graft assembly for securely positioning a graft at a predetermined location across an abdominal aortic aneurysm. The assembly includes a resilient self-expanding anchor that is secured to the graft. The anchor is characterized as being at least as long as the graft, and further as being adapted to be removed or repositioned at any time prior to complete deployment in the patient.
摘要翻译：一种用于将移植物牢固地定位在穿过腹主动脉瘤的预定位置的移植物组件。该组件包括固定到移植物上的弹性自膨胀锚。锚固体的特征在于至少与移植物一样长，并且进一步适于在完全展开患者之前的任何时间被移除或重新定位。

8. 发明申请

US20090263345A1 Otic compositions for the treatment of infections of the internal and external ear in mammals 审中-公开
标题翻译：用于治疗哺乳动物内耳和外耳感染的耳用组合物
公开(公告)号：US20090263345A1
公开(公告)日：2009-10-22
申请号：US12380463
申请日：2009-02-27
申请人： Joseph A. Capriotti , Bo Liang , C. Michael Samson , Jason Stein , Michael Weiser
发明人： Joseph A. Capriotti , Bo Liang , C. Michael Samson , Jason Stein , Michael Weiser
IPC分类号： A61K31/79 , A61P27/16
CPC分类号： A61K31/79 , A61K9/0031 , A61K9/0046 , A61K9/06 , A61K31/573 , A61K2300/00
摘要： Disclosed herein compositions including povidone-iodine (PVP-I) useful in the treatment of acute and chronic bacterial, viral and fungal infections of the internal, middle and external ear of mammals, including humans.
摘要翻译：本文公开了包含聚维酮碘（PVP-1）的组合物，其可用于治疗哺乳动物（包括人）的内部，中部和外部的耳朵的急性和慢性细菌，病毒和真菌感染。

9. 发明申请

US20050131391A1 Systems, methods and devices relating to delivery of medical implants 有权
公开(公告)号：US20050131391A1
公开(公告)日：2005-06-16
申请号：US10642365
申请日：2003-08-14
申请人： Michael Chu , Alfred Intoccia , Barry Gellman , Joseph Raneri , Michael Weiser , Kenneth Daignault
发明人： Michael Chu , Alfred Intoccia , Barry Gellman , Joseph Raneri , Michael Weiser , Kenneth Daignault
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/34 , A61F2/00
CPC分类号： A61F2/0045 , A61B17/00234 , A61B17/06109 , A61B17/3468 , A61B2017/00805 , A61B2017/06019 , A61B2017/06042 , A61B2017/06052 , A61B2017/06076 , A61B2017/06171 , A61F2002/0072 , A61F2220/0083
摘要： Implant delivery systems are disclosed. In general overview, an exemplary system includes any number of the following: a delivery device, a sling assembly, guide members, and connectors that interconnect the above. Embodiments of all the above components and their combinations are disclosed. Methods of using the above system in suprapubic, prepubic, transvaginal, trans-obturator and other approaches are also disclosed.

10. 发明申请

US20050049608A1 Stent delivery catheter 审中-公开
标题翻译：支架输送导管
公开(公告)号：US20050049608A1
公开(公告)日：2005-03-03
申请号：US10867428
申请日：2004-06-14
申请人： Harold Aznoian , Michael Weiser
发明人： Harold Aznoian , Michael Weiser
IPC分类号： A61F2/04 , A61F2/94 , A61F11/00 , A61M20060101
CPC分类号： A61F2/95 , A61F2/07 , A61F2/94 , A61F2002/041 , A61F2002/9505
摘要： A delivery device for a biliary stent constructed of thermoplastic material with ridges and valleys formed along the outer surface of the stent that provide a helical, thread-like configuration. The delivery device comprises an external surface that is selectively expandable to engage an interior surface of the tubular stent. Additionally the exterior surface may include ridges and valleys that coincide with ridges and valleys defined by the helical thread extending through the stent in order to provide a more secure engagement with the stent during delivery.
摘要翻译：用于由热塑性材料构成的胆管支架的输送装置，所述热塑性材料具有沿支架的外表面形成的具有螺旋状的线状构造的脊和谷。输送装置包括外表面，其被选择性地可膨胀以接合管状支架的内表面。此外，外表面可以包括与由延伸穿过支架的螺旋螺纹限定的脊和谷重合的脊和谷，以便在递送期间提供与支架更牢固的接合。

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