专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07442718B2 Inhibitors of aspartyl protease 失效
标题翻译：天冬氨酰蛋白酶抑制剂
公开(公告)号：US07442718B2
公开(公告)日：2008-10-28
申请号：US10613650
申请日：2003-07-02
申请人： Michael R Hale , Christopher T Baker , Timothy A Stammers , Ronald G Sherrill , Andrew Spaltenstein , Eric S Furfine , Francois Maltais , Clarence W Andrews, III , John F Miller , Vicente Samano
发明人： Michael R Hale , Christopher T Baker , Timothy A Stammers , Ronald G Sherrill , Andrew Spaltenstein , Eric S Furfine , Francois Maltais , Clarence W Andrews, III , John F Miller , Vicente Samano
IPC分类号： A61K31/357 , C07D317/46
CPC分类号： C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C317/18 , C07D307/20 , C07D319/06 , C07D493/04 , C07F9/6561
摘要： The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
摘要翻译：本发明涉及一类新型的磺酰胺，它们是天冬氨酰蛋白酶抑制剂。在一个实施方案中，本发明涉及以特定结构和物理化学特征为特征的新型HIV天冬氨酰蛋白酶抑制剂。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制HIV-1和HIV-2蛋白酶活性，因此可有利地用作针对HIV-1和HIV-2病毒的抗病毒剂。本发明还涉及使用本发明化合物抑制HIV天冬氨酰蛋白酶活性的方法和用于筛选抗HIV活性化合物的方法。

2. 发明授权

US06438923B2 Method of assembling lightweight sandwich wall panel 失效
标题翻译：轻质三明治墙板组装方法
公开(公告)号：US06438923B2
公开(公告)日：2002-08-27
申请号：US09316202
申请日：1999-05-21
申请人： John F Miller
发明人： John F Miller
IPC分类号： E04C2288
CPC分类号： E04C2/288
摘要： The present invention relates to an improved casting process of mass producing complete lightweight cementitious house walls. More specifically, the invention relates to the manner in which thin cementitious skins are separately cast on either face of the wall against a sub-assembly of thick panels of insulation material shaped and located in a manner to control the movement of displaced cementitious fluid so that the exposed top and bottom chords of small vertical structural trusses, sandwiched between these the panels of insulation and other perimeter reinforcing members are encased with the least amount of cementitious material. The size and strength of each wall component can be varied to achieve the specific characteristics of the wall. Smooth or textured faces in the casting beds reproduce whatever profiles are of required on the finished walls. Accurate window and door openings are cast in such a manner as to eliminate the need for trim. These completed wall panels enable the rapid assembly of many houses, with factory controlled quality and cost controls.
摘要翻译：本发明涉及一种批量生产完整的轻质水泥房屋墙的改进的铸造方法。更具体地说，本发明涉及薄壁水泥表层分别浇铸在壁的两个表面上的方式，该方法相对于绝热材料厚板的子组件成形和定位，以控制置换的水泥质流体的运动，使得夹在这些绝缘板和其他周边加强构件之间的小垂直结构桁架的暴露的顶部和底部和弦被最少量的水泥材料包住。可以改变每个壁部件的尺寸和强度以实现壁的特定特性。浇铸床上光滑或纹理化的面孔可以再现完成的墙壁上所需的轮廓。准确的窗口和门开口以不需要修剪的方式铸造。这些完成的墙板可以快速组装许多房屋，具有工厂控制的质量和成本控制。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式