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1. 发明授权

US08501161B2 Oral care regimen 有权
标题翻译：口腔护理方案
公开(公告)号：US08501161B2
公开(公告)日：2013-08-06
申请号：US11745158
申请日：2007-05-07
申请人： Michael Prencipe , Isabelle Van Rycke , Richard Lovell
发明人： Michael Prencipe , Isabelle Van Rycke , Richard Lovell
IPC分类号： A61K8/00
CPC分类号： A61K8/25 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61K2800/884 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100 g and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次接触，并在约42天的时间内将口腔表面与周期性口腔护理组合物接触至少一次。适用于该方法的定期口腔护理组合物包括具有大于约5毫克损失/ 100,000次旋转的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些大于约90cm 3 / 100g和/或Einlehner硬度，每100,000次旋转损失小于约5mg。第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和低于约100的放射性牙本质磨损约200。

2. 发明申请

US20080274065A1 Oral Care Regimen 审中-公开
标题翻译：口腔护理方案
公开(公告)号：US20080274065A1
公开(公告)日：2008-11-06
申请号：US12028782
申请日：2008-02-08
申请人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
发明人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
IPC分类号： A61K8/21 , A61P1/02
CPC分类号： A61K8/25 , A61K8/44 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form and optionally contacting the oral surface with a periodic oral care cleaning composition at least once monthly. The periodic oral care cleaning compositions suitable for use in the method comprise an abrasive system.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括每天至少一次使口腔表面与主要口腔护理组合物接触，使口腔表面与定期的口腔护理维持组合物每月至少一次接触，其中定期口腔护理维持组合物包含游离或任选地使口腔表面与定期的口腔护理清洁组合物每月至少一次接触。适用于该方法的定期口腔护理清洁组合物包括研磨系统。

3. 发明申请

US20090202452A1 ORAL CARE REGIMEN 审中-公开
标题翻译：口腔护理
公开(公告)号：US20090202452A1
公开(公告)日：2009-08-13
申请号：US12272257
申请日：2008-11-17
申请人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia, III , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
发明人： Richard Scott Robinson , Richard J. Sullivan , Michael Prencipe , Rajnish Kohli , Isabelle Van Rycke , Richard Lovell , Sergio Leite , Eric A. Simon , Ralph Peter Santarpia, III , Diane Cummins , Sarita V. Mello , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Qin Wang , Gary Edward Tambs , Virginia Monsul Barnes
IPC分类号： A61K8/66 , A61K8/44 , A61K8/97 , A61Q11/00 , A61P31/04 , A61K8/21
CPC分类号： A61K8/25 , A61K8/44 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, contacting the oral surface with a periodic oral care maintenance composition at least once monthly, wherein the periodic oral care maintenance composition comprises a basic amino acid, in free or salt form and optionally contacting the oral surface with a periodic oral care cleaning composition at least once monthly. The periodic oral care cleaning compositions suitable for use in the method comprise an abrasive system.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括每天至少一次使口腔表面与主要口腔护理组合物接触，使口腔表面与定期的口腔护理维持组合物每月至少一次接触，其中定期口腔护理维持组合物包含游离或任选地使口腔表面与定期的口腔护理清洁组合物每月至少一次接触。适用于该方法的定期口腔护理清洁组合物包括研磨系统。

4. 发明申请

US20070286820A1 Oral Care Regimen 有权
标题翻译：口腔护理方案
公开(公告)号：US20070286820A1
公开(公告)日：2007-12-13
申请号：US11745158
申请日：2007-05-07
申请人： Michael Prencipe , Isabelle Rycke , Richard Lovell
发明人： Michael Prencipe , Isabelle Rycke , Richard Lovell
IPC分类号： A61K8/18 , A61Q11/00
CPC分类号： A61K8/25 , A61K2800/28 , A61K2800/412 , A61K2800/88 , A61K2800/884 , A61Q11/00
摘要： The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100 g and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.
摘要翻译：本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次接触，并在约42天的时间内将口腔表面与周期性口腔护理组合物接触至少一次。适用于该方法的定期口腔护理组合物包括具有大于约5毫克损失/ 100,000次旋转的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些大于约90cm 3 / 100g和/或Einlehner硬度小于每10万次旋转约5mg的损失。第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和低于约100的放射性牙本质磨损约200。

5. 发明授权

US10959967B2 Effervescent compositions 有权
公开(公告)号：US10959967B2
公开(公告)日：2021-03-30
申请号：US12866609
申请日：2009-02-06
申请人： Rajnish Kohli , Richard Scott Robinson , Ralph Peter Santarpia, III , James R. Brown , Richard J. Sullivan , Michael Prencipe
发明人： Rajnish Kohli , Richard Scott Robinson , Ralph Peter Santarpia, III , James R. Brown , Richard J. Sullivan , Michael Prencipe
IPC分类号： A61K31/19 , A61Q11/00 , A61K8/44 , A61K9/46 , A61K9/20
摘要： The present invention is directed to effervescent compositions comprising a basic amino acid.

6. 发明授权

US09855200B2 Oral care formulations that enhance amount of soluble zinc 有权
公开(公告)号：US09855200B2
公开(公告)日：2018-01-02
申请号：US13266938
申请日：2010-05-26
申请人： Thomas S. Campbell , Thomas J. Boyd , Steven W. Fisher , Michael Prencipe
发明人： Thomas S. Campbell , Thomas J. Boyd , Steven W. Fisher , Michael Prencipe
IPC分类号： A61K8/27 , A61K8/34 , A61K8/73 , A61K8/81 , A61K8/86
CPC分类号： A61K8/27 , A61K8/345 , A61K8/73 , A61K8/731 , A61K8/8164 , A61K8/86 , A61K2800/56 , A61K2800/592
摘要： An oral care composition and method are described in which the composition includes a film or a plurality of film fragments entrained in a carrier. The film or plurality of film fragments comprises a zinc compound and the carrier comprises a polysaccharide and a maleic anhydride copolymer. The composition and methods provide benefits including one or more of increased consumer acceptability, improved solubility of zinc thus permitting the use of lower amounts of zinc compounds and reducing the adverse astringency associated with zinc, decreased adverse reactions brought about by the presence of zinc ions, enhanced aesthetics, improved stability for active or other functional materials, and controlled delivery of active materials such as zinc.

7. 发明授权

US09682027B2 Oral care product and methods of use and manufacture thereof 有权
公开(公告)号：US09682027B2
公开(公告)日：2017-06-20
申请号：US12058424
申请日：2008-03-28
申请人： Michael Prencipe , Diane Cummins , Richard Scott Robinson , Sarita V. Mello , Richard J. Sullivan , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Ralph Peter Santarpia, III , Qin Wang , Gary Edward Tambs , Rajnish Kohli , Virginia Monsul Barnes , Sergio Leite , Eric A. Simon
发明人： Michael Prencipe , Diane Cummins , Richard Scott Robinson , Sarita V. Mello , Richard J. Sullivan , Suman Chopra , Karen J. DePierro , Lynette Zaidel , Constantina Christopoulou , Ravi Subramanyam , Donghui Wu , Andre M. Morgan , Ralph Peter Santarpia, III , Qin Wang , Gary Edward Tambs , Rajnish Kohli , Virginia Monsul Barnes , Sergio Leite , Eric A. Simon
IPC分类号： A61K8/00 , A61Q11/00 , A61K8/21 , A61K8/25 , A61K8/19 , A61K8/40 , A61K8/44 , A61K31/198
CPC分类号： A61K8/44 , A61K8/25 , A61K31/198 , A61Q11/00
摘要： This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and a small particle fraction: and to methods of using and of making these compositions.

8. 发明授权

US09072672B2 Compositions and methods for altering the color of teeth 有权
标题翻译：用于改变牙齿颜色的组合物和方法
公开(公告)号：US09072672B2
公开(公告)日：2015-07-07
申请号：US11168681
申请日：2005-06-28
申请人： Prithwiraj Maitra , Suman K. Chopra , Sayed Ibrahim , Eugene Pashkovski , Michael Prencipe
发明人： Prithwiraj Maitra , Suman K. Chopra , Sayed Ibrahim , Eugene Pashkovski , Michael Prencipe
IPC分类号： A61K9/00 , A61K8/19 , A61K8/24 , A61K8/26 , A61K8/29 , A61K8/81 , A61Q11/00
CPC分类号： A61K8/19 , A61K8/24 , A61K8/26 , A61K8/29 , A61K8/8111 , A61K8/8123 , A61K8/8152 , A61Q11/00
摘要： Compositions for altering the color of teeth, including tooth-coating compositions comprising a colorant and an acrylate polymer. Colorants among those useful herein include whiteness-imparting particulate materials, such as hydroxyapatite.
摘要翻译：用于改变牙齿颜色的组合物，包括包含着色剂和丙烯酸酯聚合物的牙齿涂层组合物。可用于本文的着色剂包括赋予白度的颗粒材料，例如羟基磷灰石。

9. 发明申请

US20140314690A1 ORAL CARE COMPOSITIONS 审中-公开
标题翻译：口腔护理组合物
公开(公告)号：US20140314690A1
公开(公告)日：2014-10-23
申请号：US14365187
申请日：2011-12-20
申请人： Steven Fisher , Mary Colligan , Michael Prencipe , Gary Tambs
发明人： Steven Fisher , Mary Colligan , Michael Prencipe , Gary Tambs
IPC分类号： A61K8/34 , A61Q11/00 , A61K8/73 , A61K8/25
CPC分类号： A61K8/34 , A61K8/25 , A61K8/731 , A61K8/732 , A61Q11/00
摘要： Described herein are preservative systems which prevent the growth of microorganisms in silica based dentifrices, compositions comprising the same; and methods of making and using the same.
摘要翻译：本文描述了防止微生物在二氧化硅基洁牙剂中生长的防腐剂体系，包含它们的组合物; 以及制作和使用它们的方法。

10. 发明授权

US08815215B2 Hydrophobic tooth whitening system and methods of use 有权
标题翻译：疏水牙齿美白系统及使用方法
公开(公告)号：US08815215B2
公开(公告)日：2014-08-26
申请号：US10915125
申请日：2004-08-10
申请人： Michael Prencipe , Suman K Chopra , Michael Collins
发明人： Michael Prencipe , Suman K Chopra , Michael Collins
IPC分类号： A61Q11/00 , A61K6/00 , A61K8/25 , A61K8/22 , A61C19/06 , A61K8/81 , A61K8/891
CPC分类号： A61K8/89 , A61C19/066 , A61K8/22 , A61K8/8176 , A61K8/891 , A61K8/895 , A61Q11/00
摘要： A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier.
摘要翻译：一种牙齿美白系统，其包括具有可操作以面对牙齿表面的表面的牙托盘，和包含增白剂和疏水性聚合物载体的牙齿增白组合物。牙齿美白组合物优选基本上是非水溶性的。还使用牙科托盘和含有美白组合物和疏水性聚合物载体的牙齿增白组合物来提供牙齿美白试剂盒。

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