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1. 发明授权

US5914327A Biaryl-pyridoquinazolinone derivatives as anti-cancer agents 失效
标题翻译：二芳基吡啶并喹唑啉酮衍生物作为抗癌剂
公开(公告)号：US5914327A
公开(公告)日：1999-06-22
申请号：US965552
申请日：1997-11-06
申请人： Michael P. Trova , Nan Zhang , Douglas B. Kitchen
发明人： Michael P. Trova , Nan Zhang , Douglas B. Kitchen
IPC分类号： C07D471/04 , A61K31/505 , A61K31/55
CPC分类号： C07D471/04
摘要： This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3)alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which may taken together to form a 4- to 7-membered ring;(C) R.sub.3 is selected from H, --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) X is located at the 2-, or 3-position and is selected from the group consisting of 2-naphthyl, 1-naphthyl, 1-phenanthrenyl, 2-phenanthrenyl, 3-phenanthrenyl, 4-phenanthrenyl, 9-phenanthrenyl, phenyl, and mono- or polysubstituted phenyl wherein the substituents are selected from the group consisting of --OR.sub.4, --NR.sub.5 R.sub.6, (C.sub.1 -C.sub.3) alkyl, --CF.sub.3, F, Cl, Br, I, --NO.sub.2, --CN, --SO.sub.3 H, --SO.sub.2 NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, and phenyl;R.sub.4 is H or (C.sub.1 -C.sub.4)alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from H, or (C.sub.1 -C.sub.4)alkyl, or R.sub.5 and R.sub.6 are alkyl groups which may be taken together to form a 4-7 membered ring;(E) W is selected from H, --OR.sub.4, --NR.sub.5 R.sub.6, (C.sub.1 -C.sub.3)alkyl, --CF.sub.3, F, Cl, Br, I, --NO.sub.2, --CN, --SO.sub.2 NR.sub.5 R.sub.6, --CO.sub.2 R.sub.4 ; or a pharmacologically acceptable salt thereof which is useful as an antineoplastic agent.
摘要翻译：本发明提供具有下式的化合物：其中：（A）n = 2-4; （B）R 1和R 2相同或不同，选自H，（C 1 -C 3）烷基，-CH 2 CH 2 OH，-CH 2 CH 2 NH 2和-CH 2 CH 2 N（CH 3）2或R 1和R 2是可以被取代的烷基部分一起形成4-至7-元环; （C）R 3选自H，-CH 3，-CH 2 CH 3，-CH 2 CH 2 NH 2; （D）X位于2-或3-位，并且选自2-萘基，1-萘基，1-菲基，2-菲基，3-菲基，4-菲基，9-菲基，苯基和单取代或多取代的苯基，其中取代基选自-OR4，-NR5R6，（C1-C3）烷基，-CF3，F，Cl，Br，I，-NO2，-CN， SO 3 H，-SO 2 NR 5 R 6，-CO 2 H，-CO 2 R 4和苯基; R4是H或（C1-C4）烷基; R5和R6相同或不同并且选自H或（C1-C4）烷基，或R5和R6是可以一起形成4-7元环的烷基; （E）W选自H，-OR4，-NR5R6，（C1-C3）烷基，-CF3，F，Cl，Br，I，-NO2，-CN，-SO2NR5R6，-CO2R4; 或其药理学上可接受的盐，其可用作抗肿瘤剂。

2. 发明申请

US20110065679A1 Substituted Porphyrins 有权
标题翻译：取代卟啉
公开(公告)号：US20110065679A1
公开(公告)日：2011-03-17
申请号：US12885198
申请日：2010-09-17
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/555 , A61P11/00 , A61P29/00
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

3. 发明授权

US08546562B2 Substituted porphyrins 有权
公开(公告)号：US08546562B2
公开(公告)日：2013-10-01
申请号：US13457232
申请日：2012-04-26
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： C07D487/22 , A01N55/02
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

4. 发明申请

US20120214780A1 SUBSTITUTED PORPHYRINS 有权
标题翻译：取代的PORPHYRINS
公开(公告)号：US20120214780A1
公开(公告)日：2012-08-23
申请号：US13457232
申请日：2012-04-26
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/555 , A61P9/10
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

5. 发明授权

US06544975B1 Substituted porphyrins 有权
公开(公告)号：US06544975B1
公开(公告)日：2003-04-08
申请号：US09490537
申请日：2000-01-25
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31409
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

6. 发明授权

US08217026B2 Substituted porphyrins 有权
标题翻译：取代卟啉
公开(公告)号：US08217026B2
公开(公告)日：2012-07-10
申请号：US12885198
申请日：2010-09-17
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polvina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

7. 发明授权

US07820644B2 Substituted porphyrins 有权
标题翻译：取代卟啉
公开(公告)号：US07820644B2
公开(公告)日：2010-10-26
申请号：US11424662
申请日：2006-06-16
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A01N55/02 , A01N43/36 , A61K31/40 , C07B47/00 , C07B487/22
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

8. 发明授权

US07189707B2 Substituted porphyrins 有权
标题翻译：取代卟啉
公开(公告)号：US07189707B2
公开(公告)日：2007-03-13
申请号：US10349171
申请日：2003-01-23
申请人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
发明人： James D. Crapo , Brian J. Day , Michael P. Trova , Polivina Jolicia F. Gauuan , Douglas B. Kitchen , Irwin Fridovich , Ines Batinic-Haberle
IPC分类号： A61K31/409
CPC分类号： A61K31/555 , A61K31/409 , C07D487/22 , C09B47/00
摘要： The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
摘要翻译：本发明一般涉及一种调节生理和病理过程的方法，特别涉及一种调节氧化剂细胞水平的方法，从而涉及这种氧化剂是参与者的过程。本发明还涉及适用于这些方法的化合物和组合物。

9. 发明授权

US5908840A Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents 失效
标题翻译：杂环芳基吡啶并喹唑啉酮衍生物作为抗癌剂
公开(公告)号：US5908840A
公开(公告)日：1999-06-01
申请号：US965217
申请日：1997-11-06
申请人： Michael P. Trova , Nan Zhang
发明人： Michael P. Trova , Nan Zhang
IPC分类号： C07D471/04 , A61K31/505 , A61K31/55
CPC分类号： C07D471/04
摘要： This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4;(B) R.sub.1 and R.sub.2 are the same or different and selected from the group consisting of H, (C.sub.1 -C.sub.3) alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.1 and R.sub.2 are alkyl moieties which are taken together to form a 4- to 7- membered ring;(C) R.sub.3 is selected from the group consisting of H, --CH.sub.3, --CH.sub.2 CH.sub.3, and --CH.sub.2 CH.sub.2 NH.sub.2 ;(D) Y is a heterocyclic radical having 5-14 atoms, located at the 2- or 3- position of the pyridoquinazolinone nucleus, in which 1-3 of the heterocyclic ring atoms are independently nitrogen, oxygen, or sulfur; wherein Y may be optionally mono-, di-, or tri- substituted with --OR.sub.4, --NR.sub.5 R.sub.6, --CO.sub.2 H, --CO.sub.2 R.sub.4, or phenyl;R.sub.4 is H or (C.sub.1 -C.sub. 4) straight-chain alkyl;R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of H, (C.sub.1 -C.sub.4) straight-chain alkyl, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 NH.sub.2, and --CH.sub.2 CH.sub.2 N(CH.sub.3).sub.2 or R.sub.5 and R.sub.6 are alkyl moieties which are taken together to form a 4-7 membered ring;or a pharmaceutically acceptable salt thereof which is useful as an antineoplastic agent.
摘要翻译：本发明提供具有下式的化合物：其中：（A）n = 2-4; （B）R 1和R 2相同或不同，选自H，（C 1 -C 3）烷基，-CH 2 CH 2 OH，-CH 2 CH 2 NH 2和-CH 2 CH 2 N（CH 3）2或R 1和R 2为被取代的烷基部分一起形成4-至7-元环; （C）R 3选自H，-CH 3，-CH 2 CH 3和-CH 2 CH 2 NH 2; （D）Y是位于吡啶并喹啉酮核的2-或3-位的具有5-14个原子的杂环基，其中1-3个杂环环原子独立地是氮，氧或硫; 其中Y可任选被-OR 4，-NR 5 R 6，-CO 2 H，-CO 2 R 4或苯基单，二或三取代; R4是H或（C1-C4）直链烷基; R5和R6相同或不同，选自H，（C1-C4）直链烷基，-CH2CH2OH，-CH2CH2NH2和-CH2CH2N（CH3）2或R5和R6是烷基部分，它们是一起形成4-7元环; 或其药学上可接受的盐，其可用作抗肿瘤剂。

10. 发明授权

US5430150A Retroviral protease inhibitors 失效
标题翻译：逆转录病毒蛋白酶抑制剂
公开(公告)号：US5430150A
公开(公告)日：1995-07-04
申请号：US991876
申请日：1992-12-16
申请人： Michael P. Trova , Robert E. Babine , Nan Zhang , Steven R. Schow , Allan Wissner
发明人： Michael P. Trova , Robert E. Babine , Nan Zhang , Steven R. Schow , Allan Wissner
IPC分类号： C12N9/99 , A61K31/395 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K38/00 , A61P31/12 , C07D205/04 , C07D207/16 , C07D209/02 , C07D211/60 , C07D213/40 , C07D213/81 , C07D215/48 , C07D217/26 , C07D223/06 , C07D225/00 , C07D235/14 , C07D263/22 , C07D401/12 , C07D413/06 , C07D413/12 , C07K5/02 , C07K5/078 , C07K5/097 , C07D217/18 , C07D217/12 , C07D217/14
CPC分类号： C07D213/40 , C07D215/48 , C07D217/26 , C07D235/14 , C07D263/22 , C07D401/12 , C07D413/10 , C07K5/022 , C07K5/06139 , C07K5/0821 , A61K38/00
摘要： Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
摘要翻译：提供式I化合物：其中X，Y，Z，a，b，c，R1，R2，R3，R4和R5在说明书中定义。这些化合物可用作逆转录病毒蛋白酶的抑制剂。

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