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1. 发明授权

US08512395B2 Stent with horseshoe shaped bridges 有权
标题翻译：支架与马蹄形桥梁
公开(公告)号：US08512395B2
公开(公告)日：2013-08-20
申请号：US13239098
申请日：2011-09-21
申请人： Michael P. Meyer , Timothy J. Mickley
发明人： Michael P. Meyer , Timothy J. Mickley
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2230/0054 , A61F2250/0036
摘要： In at least one embodiment, a stent includes an unexpanded configuration, a nominally expanded configuration, and a fully expanded configuration. The stent further includes a plurality of circumferential bands and a plurality of connectors connecting adjacent circumferential bands to one another. Each circumferential band has a plurality of struts interconnected by bridges. Adjacent struts form strut pairs and are connected to one another at a first end or a second end but not both. Each strut pair defines an opening between the struts of the strut pair; the bridges extend into the openings. In the unexpanded configuration, the struts are straight along their length. Also in the unexpanded configuration, the bridges include two adjacent straight segments that are connected by a u-shaped segment, and the straight segments are parallel to one another and to the longitudinal axis of the stent.
摘要翻译：在至少一个实施例中，支架包括未膨胀构型，标称扩张构型和完全扩张构型。所述支架还包括多个周向带和将相邻周向带彼此连接的多个连接器。每个周向带具有通过桥互连的多个支柱。相邻的支柱形成支柱对，并且在第一端或第二端彼此连接，但不是两者连接。每个支柱对限定支柱对的支柱之间的开口; 桥梁延伸到开口中。在未膨胀的配置中，支柱沿其长度是直的。同样在未膨胀的构造中，桥包括两个相邻的直线段，其通过U形段连接，并且直段彼此平行并且与支架的纵向轴线平行。

2. 发明申请

US20120172972A1 Multi Stage Opening Stent Designs 有权
标题翻译：多阶段开放支架设计
公开(公告)号：US20120172972A1
公开(公告)日：2012-07-05
申请号：US13239098
申请日：2011-09-21
申请人： Michael P. Meyer , Timothy J. Mickley
发明人： Michael P. Meyer , Timothy J. Mickley
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2230/0054 , A61F2250/0036
摘要： In at least one embodiment, a stent comprises an unexpanded configuration, a nominally expanded configuration, and a fully expanded configuration. The stent further comprises a plurality of circumferential bands and a plurality of connectors connecting adjacent circumferential bands to one another. Each circumferential band has a plurality of struts interconnected by bridges. Adjacent struts form strut pairs and are connected to one another at a first end or a second end but not both. Each strut pair defines an opening between the struts of the strut pair; the bridges extend into the openings. In the unexpanded configuration, the struts are straight along their length. Also in the unexpanded configuration, the bridges comprise two adjacent straight segments that are connected by a u-shaped segment, and the straight segments are parallel to one another and to the longitudinal axis of the stent.
摘要翻译：在至少一个实施例中，支架包括未膨胀构型，标称扩张构型和完全扩张构型。支架还包括多个周向带和将相邻周向带彼此连接的多个连接器。每个周向带具有通过桥互连的多个支柱。相邻的支柱形成支柱对，并且在第一端或第二端彼此连接，但不是两者连接。每个支柱对限定支柱对的支柱之间的开口; 桥梁延伸到开口中。在未膨胀的配置中，支柱沿其长度是直的。同样在未膨胀的构造中，桥包括两个相邻的直段，其通过U形段连接，并且直段彼此平行并且与支架的纵向轴线平行。

3. 发明申请

US20120239128A1 STENT AND DELIVERY SYSTEM 审中-公开
标题翻译： STENT和交付系统
公开(公告)号：US20120239128A1
公开(公告)日：2012-09-20
申请号：US13240678
申请日：2011-09-22
申请人： Brian Tischler , James F. Hemerick , Daniel Gregorich , Michael P. Meyer , Timothy J. Mickley , Jan Weber , Dennis A. Boismier
发明人： Brian Tischler , James F. Hemerick , Daniel Gregorich , Michael P. Meyer , Timothy J. Mickley , Jan Weber , Dennis A. Boismier
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/91 , A61F2/844 , A61F2/958 , A61F2002/9583 , A61F2220/0075 , A61F2220/0091 , A61F2230/006
摘要： Techniques are disclosed that allow a stent to be folded within a balloon of a stent delivery system. In one example, a stent has first and second columns that extend from a proximal end to a distal end along a longitudinal axis. Each of the first columns extend substantially parallel to the longitudinal axis and comprise a plurality of elements that each have a substantially polygonal shape. Each of the second columns extend substantially parallel to the longitudinal axis and are between adjacent first columns. Each of the respective second columns include a plurality of first connectors that have a curvilinear shape and that extend in a substantially circumferential direction to connect adjacent first columns. The stent also has a plurality of second connectors, wherein at least one of the second connectors extends between a first element and a second element.
摘要翻译：公开了允许支架在支架输送系统的球囊内折叠的技术。在一个示例中，支架具有沿着纵向轴线从近端延伸到远端的第一和第二柱。每个第一列基本上平行于纵向轴线延伸并且包括多个元件，每个元件具有基本上多边形的形状。每个第二列基本上平行于纵向轴线延伸并且在相邻的第一列之间。每个相应的第二列包括多个第一连接器，其具有曲线形状并且沿大致圆周方向延伸以连接相邻的第一列。支架还具有多个第二连接器，其中至少一个第二连接器在第一元件和第二元件之间延伸。

4. 发明申请

US20110160840A1 Repetitive Cell Bifurcation / Side Branch Ostia Support Stent 审中-公开
标题翻译：重复细胞分叉/侧支支气管支架
公开(公告)号：US20110160840A1
公开(公告)日：2011-06-30
申请号：US12964175
申请日：2010-12-09
申请人： Michael P. Meyer , Alison Julson , Timothy J. Mickley
发明人： Michael P. Meyer , Alison Julson , Timothy J. Mickley
IPC分类号： A61F2/82
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915
摘要： A stent comprises at least one closed pathway that defines a single cell. In some embodiments, the closed pathway includes a plurality of petals constructed and arranged to extend away from the tubular wall of the stent. In one embodiment, some of the petals of the closed pathway overlap other of the petals of the closed pathway when the stent is in a reduced state. In at least one embodiment, the stent comprises a plurality of closed pathways. In one embodiment, the closed pathways are arranged in bands that extend either along the length of the stent or about the circumference of the stent.
摘要翻译：支架包括限定单个电池的至少一个闭合通路。在一些实施例中，封闭通路包括构造和布置为远离支架的管状壁延伸的多个花瓣。在一个实施例中，当支架处于减小状态时，闭合通道的一些花瓣与闭合通路的其他花瓣重叠。在至少一个实施例中，支架包括多个闭合通路。在一个实施例中，闭合通道被布置成沿着支架的长度或者围绕支架的圆周延伸的带。

5. 发明申请

US20100145306A1 Various Catheter Devices for Myocardial Injections or Other Uses 审中-公开
标题翻译：用于心肌注射或其他用途的各种导管装置
公开(公告)号：US20100145306A1
公开(公告)日：2010-06-10
申请号：US12509105
申请日：2009-07-24
申请人： Timothy J. Mickley , Grace Kim , Samuel J. Epstein , Mark Griffin , John Edrington , Greg Furnish
发明人： Timothy J. Mickley , Grace Kim , Samuel J. Epstein , Mark Griffin , John Edrington , Greg Furnish
IPC分类号： A61M25/06 , A61M25/00
CPC分类号： A61M25/0068 , A61B17/3478 , A61B2017/00243 , A61B2017/00247 , A61B2018/00392 , A61B2090/036 , A61B2090/08021 , A61M25/0069 , A61M25/0074 , A61M25/0082 , A61M25/0084 , A61M2025/0089 , A61M2025/0096 , A61M2025/0681 , A61M2025/1093 , A61M2210/125 , A61M2230/04
摘要： A catheter device comprising a proboscis shaft and a proboscis disposed within the proboscis shaft. In certain embodiments, the catheter device further comprises an elongate tubular member, wherein the proboscis shaft is disposed within the elongate tubular member. In certain embodiments, the catheter device comprises a tissue surface engagement structure, which has a first configuration and a second configuration. In the second configuration, the tissue surface engagement structure presents a larger transverse profile in comparison to the first configuration. The tissue surface engagement structure may have any of various designs, including an expandable assembly and a hinged assembly. In certain embodiments, a deformable cushion is positioned at the distal end of the proboscis shaft. The deformable cushion comprises a pocket that is filled with a reshapeable material. In certain embodiments, the proboscis shaft comprises a longitudinally compressible portion.
摘要翻译：导管装置，其包括设置在所述长鼻轴内的长鼻轴和长鼻。在某些实施例中，导管装置还包括细长管状构件，其中，长鼻管轴设置在细长管状构件内。在某些实施例中，导管装置包括具有第一构造和第二构造的组织表面接合结构。在第二构造中，与第一构造相比，组织表面接合结构呈现较大的横向轮廓。组织表面接合结构可以具有各种设计中的任何一种，包括可扩张组件和铰接组件。在某些实施例中，可变形缓冲垫位于长鼻杆的远端。可变形的衬垫包括一个填充有可再形成材料的口袋。在某些实施例中，长鼻杆包括纵向可压缩部分。

6. 发明授权

US07544183B2 Elongated medical device with functional distal end 有权
标题翻译：具有功能性远端的细长的医疗装置
公开(公告)号：US07544183B2
公开(公告)日：2009-06-09
申请号：US11360764
申请日：2006-02-24
申请人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
发明人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
IPC分类号： A61M5/178
CPC分类号： A61M25/0069 , A61B17/3478 , A61B2017/00247 , A61B2017/22069 , A61B2017/22077 , A61B2017/348 , A61B2017/3488 , A61B2018/00392 , A61B2018/00738 , A61B2090/036 , A61B2218/002 , A61M25/10 , A61M2025/1093
摘要： An elongate medical device that may be used for performing medical procedures on a patient is provided. This elongate medical device may include a first member having a distal end, an outer surface, and a first lumen, where the first member may have an elongated configuration such that the length of the first member is at least ten times greater than the width of the first member. The elongate medical device may also have a second member positioned within the first member and a hood stop. The hood stop in this device may be positioned within the first member and may have a distal region and a shoulder region where the shoulder region may be configured to limit the travel of the first member or the second member past the hood stop.
摘要翻译：提供了可用于对患者执行医疗程序的细长医疗装置。该细长的医疗装置可以包括具有远端，外表面和第一内腔的第一构件，其中第一构件可以具有细长构造，使得第一构件的长度比第一构件的宽度大至少十倍第一个成员。细长医疗装置还可以具有定位在第一构件内的第二构件和罩止动件。该装置中的罩止挡件可以定位在第一构件内并且可以具有远侧区域和肩部区域，其中肩部区域可以被配置为限制第一构件或第二构件经过罩止挡件的移动。

7. 发明授权

US06595958B1 Tortuous path injection device and method 失效
公开(公告)号：US06595958B1
公开(公告)日：2003-07-22
申请号：US09634117
申请日：2000-08-08
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61M5178
CPC分类号： A61M25/0136 , A61M25/0041 , A61M25/0084 , A61M25/0133 , A61M25/0662 , A61M2025/0089 , A61M2025/0681
摘要： Devices and methods for delivering therapeutic or diagnostic agents to a target tissue of a human body are disclosed. A catheter in accordance with the present invention includes an elongate shaft having a distal end, a proximal end, and a lumen therethrough. The elongate shaft includes a first curved portion proximate the distal end of the elongate shaft. The first curved portion of the elongate shaft defines a first plane. The elongate shaft also includes a second curved portion disposed between the distal end of the elongate shaft and the first curved portion of the elongate shaft. The second curved portion of the elongate shaft defines a second plane. The second plane intersects the first plane at an angle.

8. 发明授权

US06582400B1 Variable tip catheter 失效
标题翻译：可变尖端导管
公开(公告)号：US06582400B1
公开(公告)日：2003-06-24
申请号：US09695527
申请日：2000-10-24
申请人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
发明人： Matthew Hawk , Scott Larson , Timothy J. Mickley , Chad Harris
IPC分类号： A61M5178
CPC分类号： A61M25/0069 , A61B17/3478 , A61B2017/00247 , A61B2017/22069 , A61B2017/22077 , A61B2017/348 , A61B2017/3488 , A61B2018/00392 , A61B2018/00738 , A61B2090/036 , A61B2218/002 , A61M25/10 , A61M2025/1093
摘要： Therapeutic catheters for increasing myocardial blood perfusion in procedures including percutaneous myocardial revascularization (PMR), which can include tips for cutting into the myocardium to stimulate a healing response and/or for injecting angiogenic substances. PMR catheters can include an outer shaft slidably housing an inner shaft having a distal therapeutic tip. The outer shaft can be slidably disposed in a guide catheter and have an expandable atraumatic distal tip for presenting an enlarged distal profile against the heart chamber wall. The enlarged atraumatic profile can reduce the likelihood of the outer shaft penetrating undesirably into the myocardium. One expandable distal tip expands radially when forced against the endocardium. Another expandable tip expands when unconstrained by the guide catheter. Yet another expandable tip expands when manipulated by an elongate manipulation member.
摘要翻译：用于在包括经皮心肌血运重建（PMR）的手术中增加心肌血液灌注的治疗导管，其可以包括切入心肌以刺激愈合反应和/或注射血管生成物质的尖端。 PMR导管可以包括可滑动地容纳具有远侧治疗末端的内轴的外轴。外轴可以可滑动地设置在引导导管中并且具有可膨胀的无创伤的远侧末端，用于呈现抵靠心室壁的扩大的远端轮廓。扩大的无创伤轮廓可以减少外轴不期望地进入心肌的可能性。一个可扩展的远侧末端在被迫靠在心内膜上时径向扩张。当引导导管不受约束时，另一个可扩展的尖端膨胀。当由细长的操纵构件操纵时，另一个可膨胀尖端膨胀。

9. 发明授权

US06530914B1 Deflectable tip guide in guide system 有权
公开(公告)号：US06530914B1
公开(公告)日：2003-03-11
申请号：US09695525
申请日：2000-10-24
申请人： Timothy J. Mickley
发明人： Timothy J. Mickley
IPC分类号： A61M2501
CPC分类号： A61M25/0147 , A61M25/0662 , A61M2025/0063 , A61M2025/0161
摘要： Guide catheters which can be used in percutaneous myocardial revascularization (PMR) to deliver therapeutic catheters to difficult to reach heart chamber wall regions. Some guide catheters include distal regions which can be bent under control from the proximal region of the catheter. One steerable guide catheter has a flexible distal region, a more proximal, less flexible intermediate region, a first lumen for receiving a therapeutic catheter, and an elongate manipulation member slidably disposed in a second, blind lumen. The elongate manipulation member can be secured off-center near the distal end of the flexible distal region. The distal region can be bent by retracting the manipulation member and straightened by pushing the manipulation member. Controllably bendable guide catheters according to the present invention can be nested inside other, similar guide catheters. The invention also includes means for resisting free rotation of guide catheters relative to other adjacent catheters or tubes.

10. 发明授权

US08740844B2 Medical device with drug delivery member 失效
标题翻译：医疗器械配药
公开(公告)号：US08740844B2
公开(公告)日：2014-06-03
申请号：US10645653
申请日：2003-08-20
申请人： Toby Freyman , Timothy J. Mickley , Maria J. Palasis , Wendy Naimark
发明人： Toby Freyman , Timothy J. Mickley , Maria J. Palasis , Wendy Naimark
IPC分类号： A61M31/00 , A61M29/02
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/0057 , A61M2025/105
摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。还可以设置保持构件以选择性地折叠输送构件。

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