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1. 发明授权

US09250211B2 Magnetic separation of lipoproteins using dextran sulfate 有权
标题翻译：使用硫酸葡聚糖磁性分离脂蛋白
公开(公告)号：US09250211B2
公开(公告)日：2016-02-02
申请号：US13340547
申请日：2011-12-29
申请人： Michael P. Caulfield , Jackie Liu , Dawn Shalhout , Zhihong Chen
发明人： Michael P. Caulfield , Jackie Liu , Dawn Shalhout , Zhihong Chen
IPC分类号： G01N27/62 , C07K1/22 , C07K1/30 , C07K1/36
CPC分类号： C07K1/30 , C07K1/22 , C07K1/36 , G01N27/447 , G01N27/622
摘要： The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译：本发明提供了用于利用差示带电粒子迁移率分析方法的诊断目的从生物样品（包括HDL，LDL，Lp（a），IDL和VLDL）制备脂蛋白的装置和方法。还提供了通过差异带电粒子迁移率分析脂蛋白的尺寸分布的方法，该脂蛋白通过本发明的方法制备。还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。

2. 发明申请

US20120285831A1 MAGNETIC SEPARATION OF LIPOPROTEINS USING DEXTRAN SULFATE 有权
标题翻译：使用德州硫酸盐的脂蛋白的磁分离
公开(公告)号：US20120285831A1
公开(公告)日：2012-11-15
申请号：US13340547
申请日：2011-12-29
申请人： Michael P. Caulfield , Jackie Liu , Dawn Shalhout , Zhihong Chen
发明人： Michael P. Caulfield , Jackie Liu , Dawn Shalhout , Zhihong Chen
IPC分类号： C07K1/30 , G01N27/447
CPC分类号： C07K1/30 , C07K1/22 , C07K1/36 , G01N27/447 , G01N27/622
摘要： The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged-particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged-particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
摘要翻译：本发明提供了用于利用差示带电粒子迁移率分析方法的诊断目的从生物样品（包括HDL，LDL，Lp（a），IDL和VLDL）制备脂蛋白的装置和方法。还提供了通过差异带电粒子迁移率分析脂蛋白的尺寸分布的方法，该脂蛋白通过本发明的方法制备。还提供了评估脂质相关健康风险，心血管疾病，心血管疾病风险以及对治疗性干预的反应性的方法，该方法利用通过本发明方法测定的脂蛋白大小分布。

3. 发明授权

US09082856B2 Graphene devices with local dual gates 有权
标题翻译：石墨烯装置与本地双门
公开(公告)号：US09082856B2
公开(公告)日：2015-07-14
申请号：US13613198
申请日：2012-09-13
申请人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han
发明人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han
IPC分类号： H01L29/66 , H01L29/786 , H01L29/16 , H01L29/49
CPC分类号： H01L29/66045 , H01L21/02178 , H01L21/02181 , H01L21/02527 , H01L21/044 , H01L29/1606 , H01L29/42376 , H01L29/42384 , H01L29/4908 , H01L29/4916 , H01L29/517 , H01L29/66015 , H01L29/66742 , H01L29/78645 , H01L29/78648 , H01L29/78684
摘要： An electronic device comprises an insulator, a local first gate embedded in the insulator with a top surface of the first gate being substantially coplanar with a surface of the insulator, a first dielectric layer formed over the first gate and insulator, and a channel. The channel comprises a bilayer graphene layer formed on the first dielectric layer. The first dielectric layer provides a substantially flat surface on which the channel is formed. A second dielectric layer formed over the bilayer graphene layer and a local second gate formed over the second dielectric layer. Each of the local first and second gates is capacitively coupled to the channel of the bilayer graphene layer. The local first and second gates form a first pair of gates to locally control a first portion of the bilayer graphene layer.
摘要翻译：电子设备包括绝缘体，嵌入在绝缘体中的局部第一栅极，第一栅极的顶表面与绝缘体的表面基本共面;形成在第一栅极和绝缘体上的第一介电层，以及沟道。通道包括形成在第一介电层上的双层石墨烯层。第一电介质层提供基本上平坦的表面，在其上形成沟道。形成在双层石墨烯层上的第二介电层和在第二介电层上形成的局部第二栅极。局部第一和第二栅极中的每一个电容耦合到双层石墨烯层的沟道。局部第一和第二栅极形成第一对栅极以局部控制双层石墨烯层的第一部分。

4. 发明申请

US20120326126A1 Graphene or Carbon Nanotube Devices with Localized Bottom Gates and Gate Dielectric 有权
标题翻译：石墨烯或碳纳米管器件，具有局部底栅和栅介质
公开(公告)号：US20120326126A1
公开(公告)日：2012-12-27
申请号：US13167570
申请日：2011-06-23
申请人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han , James Bowler Hannon , Katherine L. Saenger , George Stojan Tulevski
发明人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han , James Bowler Hannon , Katherine L. Saenger , George Stojan Tulevski
IPC分类号： H01L21/336 , H01L29/786 , H01L29/06 , H01L29/16 , B82Y40/00 , B82Y99/00
CPC分类号： H01L29/7781 , B82Y10/00 , B82Y30/00 , H01L29/1075 , H01L29/1606 , H01L29/42384 , H01L29/4908 , H01L29/66742 , H01L29/78684 , H01L51/0023 , H01L51/0048 , H01L51/0545 , H01L51/055
摘要： Transistor devices having nanoscale material-based channels (e.g., carbon nanotube or graphene channels) and techniques for the fabrication thereof are provided. In one aspect, a transistor device is provided. The transistor device includes a substrate; an insulator on the substrate; a local bottom gate embedded in the insulator, wherein a top surface of the gate is substantially coplanar with a surface of the insulator; a local gate dielectric on the bottom gate; a carbon-based nanostructure material over at least a portion of the local gate dielectric, wherein a portion of the carbon-based nanostructure material serves as a channel of the device; and conductive source and drain contacts to one or more portions of the carbon-based nanostructure material on opposing sides of the channel that serve as source and drain regions of the device.
摘要翻译：提供具有基于纳米材料的通道（例如，碳纳米管或石墨烯通道）的晶体管器件及其制造技术。一方面，提供一种晶体管器件。晶体管器件包括衬底; 衬底上的绝缘体; 嵌入绝缘体中的局部底栅，其中栅极的顶表面与绝缘体的表面基本共面; 底栅上的局部栅极电介质; 在所述局部栅极电介质的至少一部分上的碳基纳米结构材料，其中所述碳基纳米结构材料的一部分用作所述器件的通道; 并且导电源极和漏极接触到用作器件的源极和漏极区域的沟道的相对侧上的碳基纳米结构材料的一个或多个部分。

5. 发明申请

US20070141345A1 Transparent and electrically conductive single wall carbon nanotube films 有权
标题翻译：透明导电单壁碳纳米管薄膜
公开(公告)号：US20070141345A1
公开(公告)日：2007-06-21
申请号：US11583545
申请日：2006-10-19
申请人： Andrew Rinzler , Zhihong Chen
发明人： Andrew Rinzler , Zhihong Chen
IPC分类号： B32B9/00
CPC分类号： H01B1/04 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B2202/02 , D01F9/12 , H01L51/0048 , H01L51/0052 , H01L51/444 , Y10S977/742 , Y10T428/30
摘要： An optically transparent and electrically conductive single walled carbon nanotube (SWNT) film comprises a plurality of interpenetrated single walled carbon nanotubes, wherein for a 100 nm film the film has sufficient interpenetration to provide a 25° C. sheet resistance of less than 200 ohm/sq. The film also provides at least 20% optical transmission throughout a wavelength range from 0.4 μm to 5 μm.
摘要翻译：光学透明且导电的单壁碳纳米管（SWNT）膜包括多个互穿的单壁碳纳米管，其中对于100nm膜，膜具有足够的相互渗透，以提供小于200欧姆/ 平方该薄膜还在0.4μm至5μm的波长范围内提供至少20％的光学透射。

6. 发明申请

US20230109688A1 SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS THEREOF 有权
公开(公告)号：US20230109688A1
公开(公告)日：2023-04-13
申请号：US17856761
申请日：2022-07-01
申请人： Zhihong Chen
发明人： Zhihong Chen
IPC分类号： C07D405/14 , C07D405/12 , C07D473/16 , C07D487/04 , C07D495/04
摘要： The invention provide novel pyrimidine derivatives and analogs having inhibitory activities towards certain tyrosine kinases, e.g., Bruton's tyrosine kinase (Btk) and/or Focal adhesion kinase (FAK), extracellular signal-regulated kinase (ERK), pharmaceutical compositions thereof, and methods of treatment, reduction or prevention of certain diseases or conditions mediated by such by tyrosine kinases, e.g., cancers, tumors, fibrosis, inflammatory diseases, autoimmune diseases, diabetes, or immunologically mediated diseases.

7. 发明申请

US20130001519A1 GRAPHENE DEVICES WITH LOCAL DUAL GATES 审中-公开
公开(公告)号：US20130001519A1
公开(公告)日：2013-01-03
申请号：US13613198
申请日：2012-09-13
申请人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han
发明人： Zhihong Chen , Aaron Daniel Franklin , Shu-Jen Han
IPC分类号： H01L29/66
CPC分类号： H01L29/66045 , H01L21/02178 , H01L21/02181 , H01L21/02527 , H01L21/044 , H01L29/1606 , H01L29/42376 , H01L29/42384 , H01L29/4908 , H01L29/4916 , H01L29/517 , H01L29/66015 , H01L29/66742 , H01L29/78645 , H01L29/78648 , H01L29/78684
摘要： An electronic device comprises an insulator, a local first gate embedded in the insulator with a top surface of the first gate being substantially coplanar with a surface of the insulator, a first dielectric layer formed over the first gate and insulator, and a channel. The channel comprises a bilayer graphene layer formed on the first dielectric layer. The first dielectric layer provides a substantially flat surface on which the channel is formed. A second dielectric layer formed over the bilayer graphene layer and a local second gate formed over the second dielectric layer. Each of the local first and second gates is capacitively coupled to the channel of the bilayer graphene layer. The local first and second gates form a first pair of gates to locally control a first portion of the bilayer graphene layer.

8. 发明授权

US08311224B2 Method and system utilizing quantum authentication 有权
标题翻译：使用量子认证的方法和系统
公开(公告)号：US08311224B2
公开(公告)日：2012-11-13
申请号：US12253256
申请日：2008-10-17
申请人： Zhihong Chen , Jingyi Wang
发明人： Zhihong Chen , Jingyi Wang
IPC分类号： H04L29/06
CPC分类号： A63B23/04 , A63B7/00 , A63B21/0055 , A63B21/0455 , A63B21/055 , A63B21/169 , A63B22/0002 , A63B22/0005 , A63B22/0605 , A63B22/14 , A63B22/16 , A63B22/18 , A63B23/03508 , A63B23/03541 , A63B23/0488 , A63B23/08 , A63B26/003 , A63B69/0057 , A63B71/0009 , A63B2022/0038 , A63B2023/003 , A63B2023/0452 , A63B2071/0018 , A63B2208/0204 , A63B2208/0209 , A63B2220/10 , A63B2220/13 , A63B2220/30 , A63B2220/40 , A63B2225/09 , A63B2230/06 , A63B2230/75
摘要： A system and a method with quantum cryptography authentication. The system includes an optical link connecting a sender and a receiver. The sender transmitting a first optical pulse and a second optical pulse having a defined time delay therebetween. The first pulse is modulated with a first authentication phase shift; and the second pulse is modulated with phases selected from one basis of two non-orthogonal bases, and encoded with one of two orthogonal states within the one basis based on an information of the sender, and with a second authentication phase shift. The receiver includes a splitter receiving and splitting the first and the second pulse into pulses of interest. The split pulses of interest are modulated with the first authentication phase shift; and the second authentication phase shift, respectively. The receiver includes a second coupler whereby the split pulses of interest arrive at the second coupler simultaneously. The receiver includes a first set of detectors receiving the combined pulses, which determine the one basis of the two non-orthogonal bases; and a second set of detectors receiving the combined pulses, and determine the one of the two orthogonal states within the basis and thereby decoding the information of the sender.
摘要翻译：一种具有量子加密认证的系统和方法。该系统包括连接发送器和接收器的光学链路。发送方发送第一光脉冲和第二光脉冲，其间具有限定的时间延迟。用第一认证相移调制第一个脉冲; 并且第二脉冲以从两个非正交基底的一个基础中选择的相位进行调制，并且基于发送器的信息在一个基础中的两个正交状态之一进行编码，并且具有第二认证相移。接收机包括一个接收和分离第一和第二脉冲到脉冲的分路器。利用第一认证相位调制感兴趣的分离脉冲; 和第二认证相移。接收机包括第二耦合器，由此感兴趣的分离脉冲同时到达第二耦合器。接收机包括接收组合脉冲的第一组检测器，其确定两个非正交基底的一个基础; 以及接收组合脉冲的第二组检测器，并确定基准内的两个正交状态中的一个，从而解码发送器的信息。

9. 发明授权

US08274072B2 Ultrathin spacer formation for carbon-based FET 有权
标题翻译：碳基FET的超薄间隔物形成
公开(公告)号：US08274072B2
公开(公告)日：2012-09-25
申请号：US13401967
申请日：2012-02-22
申请人： Zhihong Chen , Dechao Guo , Shu-jen Han , Kai Zhao
发明人： Zhihong Chen , Dechao Guo , Shu-jen Han , Kai Zhao
IPC分类号： H01L29/76
CPC分类号： H01L29/1606 , H01L29/4908 , H01L29/66742 , H01L29/7781 , H01L29/78684
摘要： A carbon-based field effect transistor (FET) includes a substrate; a carbon layer located on the substrate, the carbon layer comprising a channel region, and source and drain regions located on either side of the channel region; a gate electrode located on the channel region in the carbon layer, the gate electrode comprising a first dielectric layer, a gate metal layer located on the first dielectric layer, and a nitride layer located on the gate metal layer; and a spacer comprising a second dielectric layer located adjacent to the gate electrode, wherein the spacer is not located on the carbon layer.
摘要翻译：碳基场效应晶体管（FET）包括基板; 位于所述基板上的碳层，所述碳层包括沟道区，以及位于所述沟道区两侧的源区和漏区; 位于所述碳层中的沟道区上的栅电极，所述栅电极包括第一电介质层，位于所述第一电介质层上的栅极金属层和位于所述栅极金属层上的氮化物层; 以及间隔件，其包括邻近所述栅电极的第二电介质层，其中所述间隔物不位于所述碳层上。

10. 发明授权

US07776444B2 Transparent and electrically conductive single wall carbon nanotube films 有权
标题翻译：透明导电单壁碳纳米管薄膜
公开(公告)号：US07776444B2
公开(公告)日：2010-08-17
申请号：US11583545
申请日：2006-10-19
申请人： Andrew G. Rinzler , Zhihong Chen
发明人： Andrew G. Rinzler , Zhihong Chen
IPC分类号： B32B9/00
CPC分类号： H01B1/04 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B2202/02 , D01F9/12 , H01L51/0048 , H01L51/0052 , H01L51/444 , Y10S977/742 , Y10T428/30
摘要： An optically transparent and electrically conductive single walled carbon nanotube (SWNT) film comprises a plurality of interpenetrated single walled carbon nanotubes, wherein for a 100 nm film the film has sufficient interpenetration to provide a 25° C. sheet resistance of less than 200 ohm/sq. The film also provides at least 20% optical transmission throughout a wavelength range from 0.4 μm to 5 μm.
摘要翻译：光学透明且导电的单壁碳纳米管（SWNT）膜包括多个互穿的单壁碳纳米管，其中对于100nm膜，膜具有足够的相互渗透，以提供小于200欧姆/ 平方该膜还在0.4μm至5μm的波长范围内提供至少20％的光学透射。

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