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1. 发明申请

US20140235537A1 N-GLYCOSYLATED INSULIN ANALOGUES 审中-公开
标题翻译： N-糖苷类胰蛋白酶类似物
公开(公告)号：US20140235537A1
公开(公告)日：2014-08-21
申请号：US14237369
申请日：2012-08-03
申请人： Michael Meehl , Natarajan Sethuraman , Sandra Rios
发明人： Michael Meehl , Natarajan Sethuraman , Sandra Rios
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K38/00 , A61K38/28
摘要： Compositions and formulations comprising N-glycosylated insulin analogues are described. In particular embodiments, the glycosylated insulin analogues are produced in vivo and comprise one or more the N-linked N-glycans selected from high mannose or fucosylated or non-fucosylated hybrid, paucimannose, or complex N-glycans. In other embodiments, the N-glycan comprising the high mannose or fucosylated or non-fucosylated hybrid, paucimannose, or complex N-glycan is attached to the insulin analogue in vitro. Examples of N-glycans include but are not limited to a molecule having a structure selected from N-glycans in the group consisting of Man(1—9)GlcNAc2; or selected from N-glycans in the group consisting of GlcNAc(1—4)Man3GlcNAc2; or selected from N-glycans in the group consisting of Gal(j. 4)GlcNAc(1—4)Man3GlcNAe2; or selected from N-glycans in the group consisting of NANA({umlaut over (ι)}_4)Gal(1—4)GlcN Ac(1—4)Man3 GlcN Ac2—
摘要翻译：描述了包含N-糖基化胰岛素类似物的组合物和制剂。在具体实施方案中，糖基化胰岛素类似物在体内产生，并且包含一种或多种选自高甘露糖或岩藻糖基化或非岩藻糖基化杂合物，低聚西南糖或复合N-聚糖的N-连接的N-聚糖。在其它实施方案中，包含高甘露糖或岩藻糖基化或非岩藻糖基化的杂交体，低聚甘露糖或复合N-聚糖的N-聚糖在体外与胰岛素类似物连接。 N-聚糖的实例包括但不限于具有选自Man（1-9）GlcNAc2组中的N-聚糖的结构的分子; 或选自由GlcNAc（1-4）Man 3 GlcNAc 2组成的组中的N-聚糖; 或选自由Gal（j.4）GlcNAc（1-4）Man3GlcNAe2组成的组中的N-聚糖; 或选自NANA（{umlaut over（ι）} _4）Gal（1-4）GlcN Ac（1-4）Man3 GlcN Ac2-

2. 发明申请

US20120213728A1 GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS 审中-公开
标题翻译：在GLYCOENGINEER PICHIA PASTORIS生产的GRANULOCYTE-COLONY刺激因子
公开(公告)号：US20120213728A1
公开(公告)日：2012-08-23
申请号：US13504528
申请日：2010-10-25
申请人： Michael Meehl , Sandra Rios , Sujatha Gomathinayagam , Huijuan Li , Piotr Bobrowicz
发明人： Michael Meehl , Sandra Rios , Sujatha Gomathinayagam , Huijuan Li , Piotr Bobrowicz
IPC分类号： A61K38/19 , C12P21/02 , C12N15/62 , C12N1/19
CPC分类号： C12N15/81 , C07K14/535 , C12P21/005 , C12P21/06
摘要： Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of Pichia pastoris glycoengineered to produce a GCSF wherein greater than 18% of the molecules comprise an 0-glycan with one mannose per (0-glycan is described. In particular aspects, the GCSF is PEGylated at the JV-terminus.
摘要翻译：在巴斯德毕赤氏酵母菌株中产生的产生GCSF的粒细胞集落刺激因子（GCSF）的组合物，其生产GCSF，其中大于18％的分子包含每个（O-聚糖）含有一个甘露糖的O-聚糖， GCSF在JV端聚乙二醇化。

3. 发明申请

US20050265988A1 Glycosylated glucocerebrosidase expression in fungal hosts 审中-公开
标题翻译：真菌宿主中糖基化葡糖脑苷脂酶的表达
公开(公告)号：US20050265988A1
公开(公告)日：2005-12-01
申请号：US11083446
申请日：2005-03-18
申请人： Byung-Kwon Choi , Sandra Rios , Stefan Wildt , Tillman Gerngross
发明人： Byung-Kwon Choi , Sandra Rios , Stefan Wildt , Tillman Gerngross
IPC分类号： A61K38/47 , C07H21/04 , C12N1/18 , C12N9/24 , C12N15/74 , C12P21/06
CPC分类号： A61K38/47 , C12N9/2402 , C12Y302/01045
摘要： A recombinant fungal host cell producing recombinant glucocerebrosidase is provided. A functional recombinant glucocerebrosidase produced in recombinant fungal host cells is also provided. Methods for producing and isolating functional recombinant glucocerebrosidase from fungal hosts are also provided.
摘要翻译：提供了重组真菌宿主细胞产生重组葡糖脑苷脂酶。还提供了在重组真菌宿主细胞中产生的功能性重组葡糖脑苷脂酶。还提供了从真菌宿主生产和分离功能性重组葡糖脑苷脂酶的方法。

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