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1. 发明授权

US08361082B2 Marker delivery device with releasable plug 有权
标题翻译：带可释放插头的标记输送装置
公开(公告)号：US08361082B2
公开(公告)日：2013-01-29
申请号：US13037971
申请日：2011-03-01
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B17/00
CPC分类号： A61B5/064 , A61B5/055 , A61B5/062 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61K49/12 , A61K49/18 , A61K2123/00 , A61M5/007 , A61M37/0069
摘要： A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.
摘要翻译：标记输送装置包括细长的输送套管，其具有与内腔连通的远端部分中的远端部分，内腔和排出口。至少一个细长的纤维标记物体可滑动地设置在细长的输送套管的内腔内。所述至少一个细长的纤维标记物主体包括多个生物可吸收的聚合物链。股线被压缩成压缩构型并且在插入细长的输送套管之前用压缩构型与聚合物粘合剂结合在一起。可释放插塞设置在内腔的远侧部分内并且远离至少一个细长纤维标记体，以至少部分地封闭远端部分中的排出口。

2. 发明授权

US08498693B2 Intracorporeal marker and marker delivery device 有权
标题翻译：体内标记和标记物递送装置
公开(公告)号：US08498693B2
公开(公告)日：2013-07-30
申请号：US13082463
申请日：2011-04-08
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B5/00
CPC分类号： A61B19/54 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： An elongated intracorporeal remotely detectable marker includes a core of bioabsorbable fibers. An outer jacket of bioabsorbable fibers is disposed around at least part of the core. In one embodiment, for example, the core has a longitudinal extent and a pair of opposed ends, and the outer jacket is disposed around the longitudinal extent of the core, with the pair of opposed ends being exposed.
摘要翻译：细长的体内可远程检测标记包括生物可吸收纤维的核心。生物可吸收纤维的外护套设置在芯的至少一部分周围。在一个实施例中，例如，芯具有纵向范围和一对相对的端部，并且外护套围绕芯的纵向延伸部设置，其一对相对的端部露出。

3. 发明申请

US20110166448A1 MARKER DELIVERY DEVICE WITH RELEASABLE PLUG 有权
标题翻译：具有可释放插头的标记传送设备
公开(公告)号：US20110166448A1
公开(公告)日：2011-07-07
申请号：US13037971
申请日：2011-03-01
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61M25/00
CPC分类号： A61B5/064 , A61B5/055 , A61B5/062 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61K49/12 , A61K49/18 , A61K2123/00 , A61M5/007 , A61M37/0069
摘要： A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.
摘要翻译：标记输送装置包括细长的输送套管，其具有与内腔连通的远端部分中的远端部分，内腔和排出口。至少一个细长的纤维标记物体可滑动地设置在细长的输送套管的内腔内。所述至少一个细长的纤维标记物主体包括多个生物可吸收的聚合物链。股线被压缩成压缩构型并且在插入细长的输送套管之前用压缩构型与聚合物粘合剂结合在一起。可释放插塞设置在内腔的远侧部分内并且远离至少一个细长纤维标记体，以至少部分地封闭远端部分中的排出口。

4. 发明申请

US20110184280A1 INTRACORPOREAL MARKER AND MARKER DELIVERY DEVICE 有权
标题翻译：内部标记和标记交付设备
公开(公告)号：US20110184280A1
公开(公告)日：2011-07-28
申请号：US13082463
申请日：2011-04-08
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B6/00
CPC分类号： A61B19/54 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： An elongated intracorporeal remotely detectable marker includes a core of bioabsorbable fibers. An outer jacket of bioabsorbable fibers is disposed around at least part of the core. In one embodiment, for example, the core has a longitudinal extent and a pair of opposed ends, and the outer jacket is disposed around the longitudinal extent of the core, with the pair of opposed ends being exposed.
摘要翻译：细长的体内可远程检测标记包括生物可吸收纤维的核心。生物可吸收纤维的外护套设置在芯的至少一部分周围。在一个实施例中，例如，芯具有纵向范围和一对相对的端部，并且外护套围绕芯的纵向延伸部设置，其一对相对的端部露出。

5. 发明授权

US07970454B2 Marker delivery device with releasable plug 有权
标题翻译：带可释放插头的标记输送装置
公开(公告)号：US07970454B2
公开(公告)日：2011-06-28
申请号：US12214398
申请日：2008-06-18
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B6/00
CPC分类号： A61B90/39 , A61B17/0057 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/3954 , A61B2090/3987
摘要： The invention is directed to marker delivery devices and methods of using such devices. The delivery devices embodying features of the invention include a delivery cannula with a discharge opening and a releasable plug disposed in the inner lumen of the delivery cannula so as to at least partially occlude the discharge opening. The releasable plug prevents ingress of tissue, body fluids and the like into the bore of the tube, and prevents the premature discharge of any markers proximal to the releasable plug from passing through the discharge opening before the distal end of the cannula is properly positioned at a desired location within a patient's body. The releasable plug preferably has an MRI detectable element. Preferably, at least one remotely detectable marker mass is provided in the inner lumen of the cannula proximal to the releasable plug.
摘要翻译：本发明涉及标记物递送装置和使用这种装置的方法。体现本发明特征的递送装置包括具有放电开口的输送套管和设置在输送插管的内腔中的可释放插塞，以至少部分地封闭排出口。可释放的塞子防止组织，体液等进入管的孔中，并且防止任何靠近可释放塞的标记的过早排放通过排出口，在套管的远端被适当地定位在患者体内所需的位置。可释放插塞优选具有MRI可检测元件。优选地，至少一个可远程检测的标记物质在靠近可释放塞的插管的内腔中提供。

6. 发明申请

US20090171198A1 Powdered marker 审中-公开
标题翻译：粉状标记
公开(公告)号：US20090171198A1
公开(公告)日：2009-07-02
申请号：US12317339
申请日：2008-12-19
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B6/00 , A61K49/00
CPC分类号： A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/0807 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The marker delivery system described has a delivery tube or cannula which has a bioabsorbable powdered mass and a radiographically detectable element within an inner lumen thereof. The powdered material is a starch such as USP (corn) starch or other suitable polysaccharide. The radiographically detectable element may be disposed within or coupled to a bioabsorbable pellet.
摘要翻译：所述的标记递送系统具有输送管或插管，其在其内腔内具有生物可吸收的粉末质量和可放射线检测的元件。粉末材料是淀粉如USP（玉米）淀粉或其它合适的多糖。可放射线检测的元件可以设置在生物可吸收的颗粒中或与生物可吸收的颗粒结合。

7. 发明申请

US20090018439A1 Marker delivery divice with releasable plug 有权
标题翻译：带可拆卸插头的标记送货
公开(公告)号：US20090018439A1
公开(公告)日：2009-01-15
申请号：US12214398
申请日：2008-06-18
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61M31/00 , A61B6/00
CPC分类号： A61B90/39 , A61B17/0057 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/392 , A61B2090/3925 , A61B2090/3954 , A61B2090/3987
摘要： The invention is directed to marker delivery devices and methods of using such devices. The delivery devices embodying features of the invention include a delivery cannula with a discharge opening and a releasable plug disposed in the inner lumen of the delivery cannula so as to at least partially occlude the discharge opening. The releasable plug prevents ingress of tissue, body fluids and the like into the bore of the tube, and prevents the premature discharge of any markers proximal to the releasable plug from passing through the discharge opening before the distal end of the cannula is properly positioned at a desired location within a patient's body. The releasable plug preferably has an MRI detectable element. Preferably, at least one remotely detectable marker mass is provided in the inner lumen of the cannula proximal to the releasable plug.
摘要翻译：本发明涉及标记物递送装置和使用这种装置的方法。体现本发明特征的递送装置包括具有放电开口的输送套管和设置在输送插管的内腔中的可释放插塞，以至少部分地封闭排出口。可释放的塞子防止组织，体液等进入管的孔中，并且防止任何靠近可释放塞的标记的过早排放通过排出口，在套管的远端被适当地定位在患者体内所需的位置。可释放插塞优选具有MRI可检测元件。优选地，至少一个可远程检测的标记物质在靠近可释放塞的插管的内腔中提供。

8. 发明申请

US20120215230A1 PLUGGED TIP DELIVERY TUBE FOR MARKER PLACEMENT 有权
标题翻译：用于标记放置的插入式输送管
公开(公告)号：US20120215230A1
公开(公告)日：2012-08-23
申请号：US13458206
申请日：2012-04-27
申请人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
发明人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
IPC分类号： A61B17/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： An intracorporeal marker delivery device includes a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice. A plug is releasably secured within the inner bore. The plug may itself serve as a marker, and may be the sole marker. Markers may be positioned proximal to the plug, and may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements.
摘要翻译：体内标记递送装置包括具有远端，输出孔和延伸到排出口的内孔的输送管。塞子可释放地固定在内孔内。插头本身可以用作标记，并且可以是唯一的标记。标记物可以位于插塞附近，并且可以通过超声，X射线，磁共振成像和其它成像装置检测，并且可以包括生物活性元件。

9. 发明授权

US07651505B2 Plugged tip delivery for marker placement 有权
标题翻译：用于标记放置的插头提示
公开(公告)号：US07651505B2
公开(公告)日：2010-01-26
申请号：US10174401
申请日：2002-06-17
申请人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
发明人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
IPC分类号： A61B17/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： The invention provides marker delivery devices, assemblies, and methods. Assemblies embodying features of the invention include marker delivery devices having a delivery tube with an orifice, markers, and a plug releasably disposed in the tube occluding the orifice. The plug prevents markers from passing through the orifice before the marker is to be placed at a desired location within a patient's body, prevents ingress of tissue into the bore of the tube, and allows markers to pass out of the orifice when marker delivery is desired. Guidance of a delivery tube to a desired location within a patient's body may include the use of an imaging device, with or without the use of a guide cannula. The plug may itself serve as a marker, and may be the sole marker. Markers may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements.
摘要翻译：本发明提供标记递送装置，组件和方法。体现本发明特征的组件包括具有输送管的标记输送装置，该输送管具有孔口，标记物和可释放地设置在阻塞孔口的管中的塞子。在将标记物放置在患者体内的期望位置之前，塞子防止标记物通过孔口，防止组织进入管孔中，并且当需要标记物递送时允许标记物从孔中流出孔口。将输送管引导到患者体内的期望位置可以包括在使用或不使用引导套管的情况下使用成像装置。插头本身可以用作标记，并且可以是唯一的标记。标记可以通过超声，X射线，磁共振成像和其他成像装置检测，并且可以包括生物活性元件。

10. 发明授权

US08784433B2 Plugged tip delivery tube for marker placement 有权
标题翻译：用于标记放置的堵塞尖端输送管
公开(公告)号：US08784433B2
公开(公告)日：2014-07-22
申请号：US13458206
申请日：2012-04-27
申请人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
发明人： Paul Lubock , Jason H. Safabash , Martin Shabaz , John Merritt
IPC分类号： A61B17/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： An intracorporeal marker delivery device includes a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice. A plug is releasably secured within the inner bore. The plug may itself serve as a marker, and may be the sole marker. Markers may be positioned proximal to the plug, and may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements.
摘要翻译：体内标记递送装置包括具有远端，输出孔和延伸到排出口的内孔的输送管。塞子可释放地固定在内孔内。插头本身可以用作标记，并且可以是唯一的标记。标记物可以位于插塞附近，并且可以通过超声，X射线，磁共振成像和其它成像装置检测，并且可以包括生物活性元件。

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