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1. 发明授权

US5023085A Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals 失效
标题翻译：透皮通量增强剂与局部给药药物中的离子电渗疗法相结合
公开(公告)号：US5023085A
公开(公告)日：1991-06-11
申请号：US443699
申请日：1989-11-29
申请人： Michael L. Francoeur , Russell O. Potts
发明人： Michael L. Francoeur , Russell O. Potts
IPC分类号： A61K31/16 , A61K9/00 , A61K31/19 , A61K31/40 , A61K31/425 , A61K31/43 , A61K31/445 , A61K31/455 , A61K31/495 , A61K31/54 , A61K31/60 , A61K31/65 , A61K31/70 , A61K38/00 , A61K38/28 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61M31/00 , A61N1/30 , A61P17/00
CPC分类号： A61K47/12 , A61K47/22 , A61K9/0014 , A61M31/002 , A61K9/0009 , A61M2037/0007 , Y10S514/946 , Y10S514/947
摘要： Transdermal flux enhancers such as oleic acid and 1-dodecylazacycloheptan-2-one are used in combination with iontophoresis in the topical administration of pharmaceutical agents.

2. 发明授权

US5391548A Transdermal flux enhancing compositions to treat hypertension, diabetes and angina pectoris 失效
标题翻译：用于治疗高血压，糖尿病和心绞痛的透皮通量增强组合物
公开(公告)号：US5391548A
公开(公告)日：1995-02-21
申请号：US977369
申请日：1992-11-17
申请人： Michael L. Francoeur , Russell O. Potts
发明人： Michael L. Francoeur , Russell O. Potts
IPC分类号： A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , A61K31/55 , A61K9/70 , A61K31/22 , A61K31/44
CPC分类号： A61K47/22 , A61K47/10 , A61K47/12 , A61K47/18 , A61K9/0014 , Y10S514/866 , Y10S514/946 , Y10S514/947
摘要： A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of a pharmacologically active compound or a prodrug thereof, an aqueous solvent system comprising from about 15 to 75% by volume of one or more water miscible solvents, and a penetration enhancer selected from certain 1-alkylazacycloheptan-2-ones and cis-olefin compounds of the formulaCH.sub.3 (CH.sub.2).sub.x CH.dbd.CH(CH.sub.2).sub.y R.sup.3where R.sup.3 is CH.sub.2 OH, CH.sub.2 NH.sub.2 or COR.sup.4 and R.sup.4 is OH or (C.sub.1 -C.sub.4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; methods for their use in treating various illnesses in a human or lower animal by transdermal administration of said composition.
摘要翻译：一种透皮通量增强药物组合物，其用于向人或更低级动物受试者透皮给药，其包含安全有效量的药理活性化合物或其前药，含水溶剂体系包含约15至75体积％的一种或多种水可溶性溶剂，以及选自式CH3（CH2）xCH = CH（CH2）yR3的某些1-烷基氮杂环庚烷-2-酮和顺式烯烃化合物的渗透促进剂，其中R 3为CH 2 OH，CH 2 NH 2或COR 4，R 4为OH或（ C1-C4）烷氧基，x和y各自为3至13的整数，x和y的和为10至16; 其用于通过经皮给药所述组合物治疗人或低等动物中的各种疾病的方法。

3. 发明授权

US5196410A Transdermal flux enhancing compositions 失效
标题翻译：透皮通量增强组合物
公开(公告)号：US5196410A
公开(公告)日：1993-03-23
申请号：US759705
申请日：1991-09-11
申请人： Michael L. Francoeur , Russell O. Potts
发明人： Michael L. Francoeur , Russell O. Potts
IPC分类号： A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22
CPC分类号： A61K47/22 , A61K47/10 , A61K47/12 , A61K47/18 , A61K9/0014 , Y10S514/866 , Y10S514/946 , Y10S514/947
摘要： A transdermal flux enhancing pharmaceutical composition for transdermal administration to a human or lower animal subject comprising a safe and effective amount of pharmacologically active compound or a prodrug thereof, an aqueous solvent system comprising from about 15 to 75% by volume of one or more water miscible solvents, and a penetration enhancer selected from certain 1-alkylazacycloheptan-2-ones and cis-olefin compounds of the formulaCH.sub.3 (CH.sub.2).sub.x CH.dbd.CH(CH.sub.2).sub.y R.sup.3where R.sup.3 is CH.sub.2 OH, CH.sub.2 NH.sub.2 or COR.sup.4 and R.sup.4 is OH or (C.sub.1 -C.sub.4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; methods for their use in treating various illnesses in a human or lower animal by transdermal administration of said composition.
摘要翻译：一种经皮通透增强药物组合物，其用于经皮给药至人类或低级动物受试者，其包含安全有效量的药理学活性化合物或其前药，含水溶剂体系包含约15至75体积％的一种或多种水混溶溶剂和渗透促进剂，其选自式CH3（CH2）xCH = CH（CH2）yR3的某些1-烷基氮杂环庚烷-2-酮和顺式烯烃化合物，其中R 3是CH 2 OH，CH 2 NH 2或COR 4，R 4是OH或（C 1 -C 4）烷氧基，x和y各自为3〜13的整数，x和y的和为10〜16; 其用于通过经皮给药所述组合物治疗人或低等动物中的各种疾病的方法。

4. 发明授权

US4959365A Topical compositions of lipophilic pharmaceuticals agents 失效
标题翻译：亲脂性药物的局部组合物
公开(公告)号：US4959365A
公开(公告)日：1990-09-25
申请号：US340112
申请日：1989-04-18
申请人： Michael L. Francoeur , Russell O. Potts
发明人： Michael L. Francoeur , Russell O. Potts
IPC分类号： A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22
CPC分类号： A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , A61K9/0014 , Y10S514/863 , Y10S514/947
摘要： Improved pharmaceutical compositions for the topical administration of a lipophilic, pharmaceutical agent to a human or lower animal subject comprising a safe and effective amount of a pharmaceutical agent, an aqueous solvent system comprising from about 15 to 75% by volume of one or more water miscible solvents, and a compound selected from certain 1-alkylazacycloheptan-2-ones and cis-olefin compounds of the formulaCH.sub.3 (CH.sub.2).sub.x CH.dbd.CH(CH.sub.2).sub.y R.sup.3where R.sup.3 is CH.sub.2 OH, CH.sub.2 NH.sub.2 or COR.sup.4 and R.sup.4 is OH or (C.sub.1 -C.sub.4)alkoxy, x and y are each an integer from 3 to 13 and the sum of x and y is from 10 to 16; and methods for treating disease in a human or lower animal by topical administration of such compositions.
摘要翻译：用于将亲脂性药物局部施用给人或低级动物受试者的改进的药物组合物，其包含安全有效量的药剂，水溶剂体系，其包含约15至75体积％的一种或多种水混溶溶剂和选自式CH3（CH2）xCH = CH（CH2）yR3的某些1-烷基氮杂环庚烷-2-酮和顺式烯烃化合物，其中R3是CH2OH，CH2NH2或COR4，R4是OH或（C1- C4）烷氧基，x和y各自为3至13的整数，x和y的和为10至16; 以及通过局部施用这种组合物来治疗人或低等动物疾病的方法。

5. 发明授权

US5658587A Transdermal delivery of alpha adrenoceptor blocking agents 失效
标题翻译：透皮递送α肾上腺素能受体阻断剂
公开(公告)号：US5658587A
公开(公告)日：1997-08-19
申请号：US546106
申请日：1995-10-20
申请人： Giancarlo Santus , Aeri Kim , Michael L. Francoeur , Ulrike Bremer
发明人： Giancarlo Santus , Aeri Kim , Michael L. Francoeur , Ulrike Bremer
IPC分类号： A61K9/70 , A61K31/495 , A61K31/496 , A61K47/14 , A61P13/02 , A61P15/00 , A61F13/00
CPC分类号： A61K31/496 , A61K31/495 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： The present invention relates to the transdermal administration of alpha-adrenoceptor blocking compounds. The invention provides methods of administering these compounds to a patient in therapeutically effective amounts.
摘要翻译：本发明涉及α-肾上腺素能受体阻断化合物的透皮给药。本发明提供了以治疗有效量向患者施用这些化合物的方法。

6. 发明授权

US5503843A Transdermal delivery of alpha adrenoceptor blocking agents 失效
标题翻译：透皮递送α肾上腺素能受体阻断剂
公开(公告)号：US5503843A
公开(公告)日：1996-04-02
申请号：US231413
申请日：1994-04-22
申请人： Giancarlo Santus , Aeri Kim , Michael L. Francoeur , Ulrike Bremer
发明人： Giancarlo Santus , Aeri Kim , Michael L. Francoeur , Ulrike Bremer
IPC分类号： A61K9/70 , A61K31/495 , A61K31/496 , A61K47/14 , A61P13/02 , A61P15/00 , A61F13/00
CPC分类号： A61K31/496 , A61K31/495 , A61K9/7061 , A61K9/7069 , A61K9/7084
摘要： The subject invention provides a transdermal patch for the delivery of Compound IV having the formula: ##STR1## to the skin of a patient. The patch comprises a backing layer, a drug depot comprising Compound IV and a permeation enhancer composition.
摘要翻译：本发明提供了用于将具有下式的化合物IV递送至患者皮肤的透皮贴剂。贴片包括背衬层，包含化合物IV的药物贮库和渗透促进剂组合物。

7. 发明授权

US5490415A Diffusion test apparatus and method 失效
标题翻译：扩散试验装置及方法
公开(公告)号：US5490415A
公开(公告)日：1996-02-13
申请号：US227964
申请日：1994-04-15
申请人： Vivien H. W. Mak , Michael L. Francoeur
发明人： Vivien H. W. Mak , Michael L. Francoeur
IPC分类号： G01N13/00 , G01N13/04 , G01N33/15 , G01N35/00
CPC分类号： G01N13/00 , G01N13/04 , G01N2035/00198 , G01N33/15
摘要： A diffusion test apparatus (2), used to test diffusion of a drug within a vehicle through a test membrane (8), includes a receiver assembly (6) and a donor assembly (4) secured to one another. The receiver assembly includes a number of open-top receiver receptacles (26) arranged in a chosen pattern along its face (12). Similarly, the donor assembly includes a number of open-top donor receptacles (38) arranged along its face (10) in a mirror image of the chosen pattern. The test membrane is captured between the receiver and donor faces. The drug diffuses through the test membrane and into the receiver liquid (53) during an incubation period (62). Samples (66) of the receiver liquid are preferably automatically transferred to a conventional microtiter plate (70) using a programmed liquid transfer system for assay by a scintillation counter (76).
摘要翻译：用于通过测试膜（8）测试车辆内的药物扩散的扩散测试装置（2）包括彼此固定的接收器组件（6）和供体组件（4）。接收器组件包括沿着其表面（12）以选定的图案布置的多个敞开式接收器插座（26）。类似地，施主组件包括沿所选择的图案的镜像沿着其面（10）布置的多个开顶施主插座（38）。测试膜被捕获在接收器和供体面之间。在潜伏期（62）期间，药物通过测试膜扩散入接收液体（53）。接收液体的样品（66）优选使用编程的液体转移系统自动转移到常规微量滴定板（70），以便通过闪烁计数器（76）进行测定。

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