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1. 发明申请

US20170361042A1 APPARATUS TO ATTAIN AND MAINTAIN TARGET END TIDAL PARTIAL PRESSURE OF A GAS 审中-公开
公开(公告)号：US20170361042A1
公开(公告)日：2017-12-21
申请号：US15585999
申请日：2017-05-03
申请人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito
IPC分类号： A61M16/00 , A61B5/00 , A61M16/10 , A61B5/083 , A61M16/12 , A61M16/08
CPC分类号： A61M16/0051 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/4836 , A61M16/0003 , A61M16/0069 , A61M16/026 , A61M16/085 , A61M16/0883 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0021 , A61M2016/0027 , A61M2016/102 , A61M2016/1025 , A61M2016/103 , A61M2205/502 , A61M2230/43 , A61M2230/432 , A61M2230/435
摘要： A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i]T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i]T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.

2. 发明申请

US20160158481A1 CONTROLLING ARTERIAL BLOOD GAS CONCENTRATION 审中-公开
标题翻译：控制气体血气浓度
公开(公告)号：US20160158481A1
公开(公告)日：2016-06-09
申请号：US14959810
申请日：2015-12-04
申请人： Michael Klein , Joseph Fisher
发明人： Michael Klein , Joseph Fisher
IPC分类号： A61M16/12 , A61M16/00
摘要： A system for controlling an amount of at least one gas X in a subject's lung to target at least one end tidal partial pressure of at least one gas X (PetXT) uses a control system for controlling the gas delivery device, wherein the control system implements a sequential gas delivery system and a feedback algorithm which compares a PetXT for a respective breath of variable size and preferably a respective current PetX value measured by a measurement system, to obtain an error signal, the feedback algorithm adapted for generating a control signal based on the error signal, the control signal determining the amount of gas X to be inspired by the subject in at least a first portion of a respective ensuing respective inspiratory cycle to target PetXT for the respective interval.
摘要翻译：用于控制受试者肺中的至少一种气体X的量以至少达到至少一种气体X（PetXT）的至少一个端部潮气分压的系统用于控制气体输送装置的控制系统，其中控制系统实现顺序气体输送系统和反馈算法，其比较PetXT用于可变尺寸的相应呼吸，并且优选地由测量系统测量的相应的当前PetX值，以获得误差信号，所述反馈算法适于基于所述误差信号，所述控制信号确定在相应的相应吸气循环的至少第一部分中由对象启发的气体X的量，以针对相应间隔的目标PetXT。

3. 发明申请

US20150034085A1 VIRTUAL RESPIRATORY GAS DELIVERY SYSTEMS AND CIRCUITS 审中-公开
标题翻译：虚拟呼吸气体输送系统和电路
公开(公告)号：US20150034085A1
公开(公告)日：2015-02-05
申请号：US14386752
申请日：2013-03-19
申请人： Michael KLEIN , Joseph FISHER
发明人： Michael Klein , Joseph Fisher
IPC分类号： A61M16/00 , A61M16/12
CPC分类号： A61M16/0069 , A61B5/091 , A61M16/0003 , A61M16/01 , A61M16/026 , A61M16/0891 , A61M16/12 , A61M16/122 , A61M16/204 , A61M2016/0027 , A61M2016/0039 , A61M2202/02 , A61M2202/0225 , A61M2202/0283 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , A61M2230/432 , A61M2202/0007
摘要： A respiratory gas delivery system monitors gas flow over the course of a breath in real time and uses this parameter to simulate, in whole or part, the function of a reference respiratory gas delivery system, in particular structural features, particularly structural components of parts of the reference system, to overcome a structural limitation of the reference system.
摘要翻译：呼吸气体输送系统实时监测呼吸过程中的气体流量，并且使用该参数全部或部分地模拟参考呼吸气体输送系统的功能，特别是结构特征，特别是结构部件的结构部件参考系，克服了参考系的结构限制。

4. 发明申请

US20180311454A1 METHOD AND APPARATUS TO ATTAIN AND MAINTAIN TARGET ARTERIAL BLOOD GAS CONCENTRATIONS USING RAMP SEQUENCES 审中-公开
公开(公告)号：US20180311454A1
公开(公告)日：2018-11-01
申请号：US15904235
申请日：2018-02-23
申请人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
IPC分类号： A61M16/00 , A61M16/12 , A61M16/10 , A61B5/091 , A61B5/08
CPC分类号： A61M16/0066 , A61B5/082 , A61B5/091 , A61M16/0045 , A61M16/026 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

5. 发明申请

US20170224230A1 NON-INVASIVE CARDIAC OUTPUT DETERMINATION 审中-公开
公开(公告)号：US20170224230A1
公开(公告)日：2017-08-10
申请号：US15438503
申请日：2017-02-21
申请人： Joseph Fisher , Michael Klein , James Duffin
发明人： Joseph Fisher , Michael Klein , James Duffin
IPC分类号： A61B5/0205 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0813 , A61B5/082 , A61B5/0836 , A61B5/7225 , A61B5/7278 , A61M16/0057 , A61M16/12
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

6. 发明申请

US20140311491A1 APPARATUS TO ATTAIN AND MAINTAIN TARGET END TIDAL PARTIAL PRESSURE OF A GAS 审中-公开
标题翻译：装备和维护目标终端气体局部压力
公开(公告)号：US20140311491A1
公开(公告)日：2014-10-23
申请号：US14363259
申请日：2012-12-05
申请人： Michael KLEIN , Joseph FISHER , James DUFFIN , Marat SLESSAREV , Cathie KESSLER , Shoji ITO
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito
IPC分类号： A61M16/00 , A61M16/12 , A61B5/00 , A61M16/10 , A61M16/08 , A61B5/083
CPC分类号： A61M16/0051 , A61B5/083 , A61B5/0833 , A61B5/0836 , A61B5/4836 , A61M16/0003 , A61M16/0069 , A61M16/026 , A61M16/085 , A61M16/0883 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0021 , A61M2016/0027 , A61M2016/102 , A61M2016/1025 , A61M2016/103 , A61M2205/502 , A61M2230/43 , A61M2230/432 , A61M2230/435
摘要： A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i]T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i]T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.
摘要翻译：处理器获得用于一个或多个相应呼吸[i]的气体X（PetX [i] T）的逻辑可达到的末端潮气分压的输入，并且输入需要被受试者启发的气体X的量的预期计算在一个启发的气体中，使用所需的输入来使用质量平衡关系的输入，使PetX [i] T针对相应的呼吸[i]，其中一个或多个值需要控制输送到主体是从质量平衡关系的表达式输出的。质量平衡关系以考虑（前瞻性）的形式表示，对于相应的呼吸[i]，肺泡周围的毛细血管中的气体量X和肺泡中的气体X的量，可选地基于肺的模型，其占肺中气体的子体积，其基本上影响影响传质的肺泡气体X浓度。

7. 发明申请

US20150114394A1 METHOD AND APPARATUS TO ATTAIN AND MAINTAIN TARGET ARTERIAL BLOOD GAS CONCENTRATIONS USING RAMP SEQUENCES 审中-公开
标题翻译：使用RAMP序列的方法和装置来获取和维持目标病原体血气浓度
公开(公告)号：US20150114394A1
公开(公告)日：2015-04-30
申请号：US14398034
申请日：2013-04-30
申请人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
发明人： Michael Klein , Joseph Fisher , James Duffin , Marat Slessarev , Cathie Kessler , Shoji Ito , Olivia Sobczyk , Anne Battisti-Charbonney , Daniel Michael Mandell
IPC分类号： A61M16/00 , A61M16/10 , A61M16/12
CPC分类号： A61M16/0066 , A61B5/082 , A61B5/091 , A61M16/0045 , A61M16/026 , A61M16/1005 , A61M16/12 , A61M16/122 , A61M2016/0027 , A61M2016/0036 , A61M2016/1025 , A61M2016/103 , A61M2202/0208 , A61M2202/0225 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/202 , A61M2230/205 , A61M2230/208 , A61M2230/432 , A61M2230/435
摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: obtaining input of a series of logistically attainable PetX values for a series of respective breaths: determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.
摘要翻译：用于控制受试者肺中气体X的末端潮气分压的装置和方法，以及用于研究，诊断和治疗目的的这种装置和方法的使用，其中该方法包括：获得一系列用于一系列相应呼吸的逻辑上可获得的PetX值：确定在受启发气体中受试者启发的气体X的量，用于针对所述相应呼吸中的每一个的PetX;以及控制气体输送装置输送量在每个所述各个呼吸中输送到被检者的气体体积中的气体，以对应该呼吸的各自的PetX。

8. 发明申请

US20180353083A1 NON-INVASIVE CARDIAC OUTPUT DETERMINATION 审中-公开
公开(公告)号：US20180353083A1
公开(公告)日：2018-12-13
申请号：US15945436
申请日：2018-04-04
申请人： Joseph Fisher , Michael Klein , James Duffin
发明人： Joseph Fisher , Michael Klein , James Duffin
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/08 , A61B5/026
CPC分类号： A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0813 , A61B5/082 , A61B5/0836 , A61B5/7225 , A61B5/7278 , A61M16/0057 , A61M16/12
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

9. 发明申请

US20180043117A1 VIRTUAL RESPIRATORY GAS DELIVERY SYSTEMS AND CIRCUITS 审中-公开
公开(公告)号：US20180043117A1
公开(公告)日：2018-02-15
申请号：US15789605
申请日：2017-10-20
申请人： Michael Klein , Joseph Fisher
发明人： Michael Klein , Joseph Fisher
IPC分类号： A61M16/00 , A61M16/08 , A61M16/12 , A61M16/20 , A61M16/01 , A61B5/091
CPC分类号： A61M16/0069 , A61B5/091 , A61M16/0003 , A61M16/01 , A61M16/026 , A61M16/0891 , A61M16/12 , A61M16/122 , A61M16/204 , A61M2016/0027 , A61M2016/0039 , A61M2202/02 , A61M2202/0225 , A61M2202/0283 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , A61M2230/432 , A61M2202/0007
摘要： A respiratory gas delivery system monitors gas flow over the course of a breath in real time and uses this parameter to simulate, in whole or part, the function of a reference respiratory gas delivery system, in particular structural features, particularly structural components of parts of the reference system, to overcome a structural limitation of the reference system.

10. 发明申请

US20130109978A1 NON-INVASIVE CARDIAC OUTPUT DETERMINATION 审中-公开
标题翻译：非入侵性心脏输出量测定
公开(公告)号：US20130109978A1
公开(公告)日：2013-05-02
申请号：US13697768
申请日：2011-05-18
申请人： Joseph Fisher , Michael Klein , James Duffin
发明人： Joseph Fisher , Michael Klein , James Duffin
IPC分类号： A61B5/0205 , A61M16/12 , A61M16/00 , A61B5/026 , A61B5/00
CPC分类号： A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0813 , A61B5/082 , A61B5/0836 , A61B5/7225 , A61B5/7278 , A61M16/0057 , A61M16/12
摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.
摘要翻译：一种使用迭代算法控制气体输送装置的方法，所述装置可控变量使用迭代算法递送用于非侵入性地确定受试者的肺血流的测试气体（TG），包括迭代生成并评估迭代变量的测试值算法，以输出满足测试标准的迭代变量的测试值，其中迭代算法的特征在于它定义了至少一个设备可控变量，迭代变量和获得的测试气体的终止潮汐浓度之间的测试数学关系通过设置设备可控变量，使得迭代算法确定测试值上的迭代是否满足测试标准或迭代地生成逐渐改进的测试值。

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