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1. 发明授权

US09187488B2 Process for preparing chiral dipeptidyl peptidase-IV inhibitors 有权
标题翻译：制备手性二肽基肽酶-IV抑制剂的方法
公开(公告)号：US09187488B2
公开(公告)日：2015-11-17
申请号：US14119063
申请日：2012-06-25
申请人： Michael J. Zacuto , Robert F. Dunn , Aaron J. Moment , Jacob M. Janey , David Lieberman , Faye Sheen , Nadine Bremeyer , Jeremy Scott , Jeffrey T. Kuethe , Lushi Tan , Qinghao Chen
发明人： Michael J. Zacuto , Robert F. Dunn , Aaron J. Moment , Jacob M. Janey , David Lieberman , Faye Sheen , Nadine Bremeyer , Jeremy Scott , Jeffrey T. Kuethe , Lushi Tan , Qinghao Chen
IPC分类号： C07D487/04 , A61K31/4439 , A61K31/4985 , A61K31/513
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4439 , A61K31/4985 , A61K31/513 , C07B2200/13 , Y02P20/55
摘要： A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
摘要翻译：制备结构式I的吡唑并吡咯烷的方法：W是或P，其中在P中是胺保护基团。这些化合物可用于合成用于治疗2型糖尿病的二肽基肽酶-IV抑制剂。还提供了从该方法获得的有用的中间体。

2. 发明申请

US20140107346A1 PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS 有权
标题翻译：制备精氨酸肽酶IV抑制剂的方法
公开(公告)号：US20140107346A1
公开(公告)日：2014-04-17
申请号：US14119063
申请日：2012-06-25
申请人： Michael J. Zacuto , Robert F. Dunn , Aaron J. Moment , Jacob M. Janey , David Lieberman , Faye Sheen , Nadine Bremeyer , Jeremy Scott , Jeffrey T. Kuethe
发明人： Michael J. Zacuto , Robert F. Dunn , Aaron J. Moment , Jacob M. Janey , David Lieberman , Faye Sheen , Nadine Bremeyer , Jeremy Scott , Jeffrey T. Kuethe
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4439 , A61K31/4985 , A61K31/513 , C07B2200/13 , Y02P20/55
摘要： A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
摘要翻译：制备结构式I的吡唑并吡咯烷的方法：W是或P，其中在P中是胺保护基团。这些化合物可用于合成用于治疗2型糖尿病的二肽基肽酶-IV抑制剂。还提供了从该方法获得的有用的中间体。

3. 发明申请

US20070225520A1 Stereoselective Synthesis of a 4,4-Disubstituted Cyclohexanepropanoic Acid 有权
标题翻译：立体选择性合成4,4-二取代的环己丙酸
公开(公告)号：US20070225520A1
公开(公告)日：2007-09-27
申请号：US10589098
申请日：2005-02-16
申请人： Karel Brands , Sarah Brewer , Antony Davies , Ulf Dolling , Deborah Hammond , David Lieberman , Jeremy Scott
发明人： Karel Brands , Sarah Brewer , Antony Davies , Ulf Dolling , Deborah Hammond , David Lieberman , Jeremy Scott
IPC分类号： C07C51/353 , C07C315/02 , C07C317/44 , C07C319/14 , C07C59/56 , C07C53/23 , C07C319/16 , C07C323/61
CPC分类号： C07C57/62 , C07B2200/09 , C07C51/60 , C07C59/56 , C07C315/02 , C07C319/14 , C07C319/16 , C07C2601/14 , C07C2601/16 , C07C63/68 , C07C317/44 , C07C323/61
摘要： There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl.
摘要翻译：提供了式I化合物的立体选择性途径：其中R表示H或碱金属，Ar 1表示4-氯苯基，Ar 2表示2,5-二氟苯基。

4. 发明申请

US20050286796A1 Darkness control using pattern matching 有权
标题翻译：黑暗控制使用模式匹配
公开(公告)号：US20050286796A1
公开(公告)日：2005-12-29
申请号：US10878693
申请日：2004-06-28
申请人： John Handley , Andre Blaakman , Anthony Lanza , Francis Tse , Xing Li , Aron Nacman , David Lieberman
发明人： John Handley , Andre Blaakman , Anthony Lanza , Francis Tse , Xing Li , Aron Nacman , David Lieberman
IPC分类号： G06K9/40
CPC分类号： H04N1/40037 , H04N1/4092
摘要： The present invention is a method and apparatus for processing image data to accomplish tuning or adjustment of images, so as to modify at least the darkness thereof, using compact, efficient methods and designs.
摘要翻译：本发明是用于处理图像数据以完成图像调谐或调整的方法和装置，以便使用紧凑，有效的方法和设计来至少修改其暗度。

5. 发明授权

US08345329B2 Systems and methods for improving image quality in image forming devices 有权
标题翻译：用于提高图像形成装置中图像质量的系统和方法
公开(公告)号：US08345329B2
公开(公告)日：2013-01-01
申请号：US11858996
申请日：2007-09-21
申请人： David Lieberman
发明人： David Lieberman
IPC分类号： H04N1/46
CPC分类号： H04N1/405 , H04N1/40 , H04N1/46
摘要： An image forming device may select from among a plurality of rendering parameters to include selectable halftone frequency candidates automatically based on an internal determination regarding an operating condition of the device to improve image quality for formed images. As a time varying function of the status and/or condition of the components and/or consumables employed in the image forming device, a capability is provided for the device to independently determine an optimal individual or set of rendering parameters to be employed based on a monitored device status. Available monitoring data for a current overall condition of the image forming device, to include monitoring a condition of the components and/or the consumables within the device, is used to allow the device to internally perform automatic adjustment of one or more image rendering parameters, including automatically implementing an optimal halftone frequency election scheme.
摘要翻译：图像形成装置可以从多个渲染参数中选择，以基于关于装置的操作条件的内部确定来自动地包括可选择的半色调频率候选，以提高形成的图像的图像质量。作为在图像形成装置中使用的部件和/或消耗品的状态和/或状态的时变功能，提供了一种能力，用于该装置独立地确定要使用的最佳个体或一组渲染参数，其基于监控设备状态。使用用于图像形成装置的当前总体状况的可用监视数据，以包括监视装置内的部件和/或消耗品的状况，以允许装置在内部执行一个或多个图像渲染参数的自动调整，包括自动实施最佳半色调频率选择方案。

6. 发明申请

US20090080040A1 Systems and Methods for Improving Image Quality in Image Forming Devices 有权
标题翻译：提高图像形成装置图像质量的系统和方法
公开(公告)号：US20090080040A1
公开(公告)日：2009-03-26
申请号：US11858996
申请日：2007-09-21
申请人： David Lieberman
发明人： David Lieberman
IPC分类号： H04N1/46 , H04N1/50
CPC分类号： H04N1/405 , H04N1/40 , H04N1/46
摘要： An image forming device may select from among a plurality of rendering parameters to include selectable halftone frequency candidates automatically based on an internal determination regarding an operating condition of the device to improve image quality for formed images. As a time varying function of the status and/or condition of the components and/or consumables employed in the image forming device, a capability is provided for the device to independently determine an optimal individual or set of rendering parameters to be employed based on a monitored device status. Available monitoring data for a current overall condition of the image forming device, to include monitoring a condition of the components and/or the consumables within the device, is used to allow the device to internally perform automatic adjustment of one or more image rendering parameters, including automatically implementing an optimal halftone frequency election scheme.
摘要翻译：图像形成装置可以从多个渲染参数中选择，以基于关于装置的操作条件的内部确定来自动地包括可选择的半色调频率候选，以提高形成的图像的图像质量。作为在图像形成装置中使用的部件和/或消耗品的状态和/或状态的时变功能，提供了一种能力，用于该装置独立地确定要使用的最佳个体或一组渲染参数，其基于监控设备状态。使用用于图像形成装置的当前总体状况的可用监视数据，以包括监视装置内的部件和/或消耗品的状况，以允许装置在内部执行一个或多个图像渲染参数的自动调整，包括自动实施最佳半色调频率选择方案。

7. 发明申请

US20060132847A1 Systems and methods for rank-order error diffusion image processing 有权
标题翻译：用于秩序误差扩散图像处理的系统和方法
公开(公告)号：US20060132847A1
公开(公告)日：2006-06-22
申请号：US11013787
申请日：2004-12-17
申请人： Beilei Xu , David Lieberman , Robert Loce
发明人： Beilei Xu , David Lieberman , Robert Loce
IPC分类号： H04N1/40
CPC分类号： H04N1/4052
摘要： One aspect of the invention provides a method of halftoning an image which involves determining a quantization error for a selected target pixel of an image, selecting a diffusion mask, the mask relating to the target pixel and pixels neighboring thereto, receiving a first pair of neighboring pixel values for a first pixel pair including a first neighboring pixel and a second neighboring pixel, and receiving a second pair of neighboring pixel values for a second pixel pair including a third neighboring pixel and a fourth neighboring pixel. The method further involves determining a ranking order of the first, second, third and fourth neighboring pixels by comparing pixel values of the first, second, third and fourth neighboring pixels, and diffusing error to at least one of the first, second, third and fourth neighboring pixels based on the determined ranking order of the first, second, third and fourth neighboring pixels.
摘要翻译：本发明的一个方面提供了一种对图像进行半色调的方法，该方法涉及确定图像的所选目标像素的量化误差，选择扩散掩模，与目标像素相关的掩模和与其相邻的像素，接收第一对邻近包括第一相邻像素和第二相邻像素的第一像素对的像素值，以及接收包括第三相邻像素和第四相邻像素的第二像素对的第二对相邻像素值。该方法还包括通过比较第一，第二，第三和第四相邻像素的像素值来确定第一，第二，第三和第四相邻像素的排序顺序，以及将误差扩散到第一，第二，第三相邻像素和第四相邻像素中的至少一个，基于所确定的第一，第二，第三和第四相邻像素的排序顺序的第四相邻像素。

8. 发明授权

US06599285B1 Method for improving vision 失效
标题翻译：改善视力的方法
公开(公告)号：US06599285B1
公开(公告)日：2003-07-29
申请号：US09634336
申请日：2000-08-08
申请人： David Lieberman , Jonathan Grierson
发明人： David Lieberman , Jonathan Grierson
IPC分类号： A61B1732
CPC分类号： A61F9/013 , A61B34/10 , A61F9/00804 , A61F9/00819 , A61F2009/00872 , A61F2009/00882
摘要： Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.
摘要翻译：公开了使眼睛的光学中心对准角膜前表面的“高点”的方法和装置。根据涉及角膜消融过程的本发明的一个方面，眼睛的高点被用作球形表面的极点，该球形表面近似地装配在“有界区域”内的角膜前表面的一部分上。对于角膜消融程序，“有界区域”包括眼睛前表面的大致倒杯状的区域，其边缘在其周边被基本上垂直于局部z轴的平面限定。在操作过程中，突出高于球面的局部高点被消融。根据本发明涉及径向角膜切开手术的另一方面，在角膜中形成“大圆”平面中的一对切口，以削弱和平坦化。如本文所使用的，“大圆”由包含HIGH点并平行于局部z轴的平面形成。用于径向角膜切开术的“有界区域”绝对按照投射到角膜表面上的圆定义，该圆周围绕穿过高分辨率点并平行于z轴的轴线居中。

9. 发明授权

US5807381A Method and apparatus for improving vision 失效
公开(公告)号：US5807381A
公开(公告)日：1998-09-15
申请号：US731344
申请日：1996-10-11
申请人： David Lieberman
发明人： David Lieberman
IPC分类号： A61B19/00 , A61F9/008 , A61F9/01 , A61F9/013 , A61B17/32 , A61N5/06
CPC分类号： A61F9/013 , A61F9/00804 , A61F9/00819 , A61B34/10 , A61F2009/00872 , A61F2009/00882
摘要： Methods and apparatus are disclosed for causing the optical center of the eye to align "HIGH point" of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a "bounded region." For corneal ablation procedures, the "bounded region" comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a "great circle" are formed in the cornea to weaken and flatten it. As used herein, a "great circle" is formed by a plane containing the HIGH point and parallel to the local z-axis. The "bounded region" for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.

10. 发明申请

US20110112805A1 METHOD AND APPARATUS FOR IMPROVING VISION 审中-公开
标题翻译：改善视觉的方法和装置
公开(公告)号：US20110112805A1
公开(公告)日：2011-05-12
申请号：US13004559
申请日：2011-01-11
申请人： David Lieberman , Jonathan Grierson
发明人： David Lieberman , Jonathan Grierson
IPC分类号： G06F17/50 , G02C7/04 , G06F19/00 , A61F9/008
CPC分类号： A61F9/013 , A61B34/10 , A61F9/00804 , A61F9/00819 , A61F2009/00872 , A61F2009/00882
摘要： Methods and apparatus are disclosed for causing the optical center of the eye to align “HIGH point” of the anterior surface of the cornea. In accordance with one aspect of the invention relating to corneal ablation procedures, the HIGH point of the eye is used as the pole of a spherical surface which is fitted approximately to a portion of the anterior surface of the cornea within a “bounded region.” For corneal ablation procedures, the “bounded region” comprises a generally inverted-cup shaped region of the anterior surface of the eye bounded at its periphery by a plane which is substantially perpendicular to a local z-axis. During the operation local high points which project above the spherical surface are ablated. According to another aspect of the invention relating to radial keratotomy procedures, a pair of incisions in the plane of a “great circle” are formed in the cornea to weaken and flatten it. As used herein, a “great circle” is formed by a plane containing the HIGH point and parallel to the local z-axis. The “bounded region” for radial keratotomy procedures is defined absolutely in terms of a circle projected onto the corneal surface which is centered about an axis passing through the HIGH point and parallel to the z-axis.
摘要翻译：公开了使眼睛的光学中心对准角膜前表面的“高点”的方法和装置。根据涉及角膜消融过程的本发明的一个方面，眼睛的高点被用作球形表面的极点，该球形表面近似地装配在“有界区域”内的角膜前表面的一部分上。对于角膜消融程序，“有界区域”包括眼睛前表面的大致倒杯状的区域，其边缘在其周边被基本上垂直于局部z轴的平面限定。在操作过程中，突出高于球面的局部高点被消融。根据本发明涉及径向角膜切开手术的另一方面，在角膜中形成“大圆”平面中的一对切口，以削弱和平坦化。如本文所使用的，“大圆”由包含HIGH点并平行于局部z轴的平面形成。用于径向角膜切开术的“有界区域”绝对按照投射到角膜表面上的圆定义，该圆周围绕穿过高分辨率点并平行于z轴的轴线居中。

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