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1. 发明授权

US5869611A Markers for detection of chromosome 16 rearrangements 失效
标题翻译：用于检测16号染色体重排的标记
公开(公告)号：US5869611A
公开(公告)日：1999-02-09
申请号：US742923
申请日：1996-11-01
申请人： Pu Liu , Francis S. Collins , Michael J. Siciliano , David Claxton
发明人： Pu Liu , Francis S. Collins , Michael J. Siciliano , David Claxton
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/574 , C07K14/46 , C07K21/04
CPC分类号： G01N33/57426 , C07K14/4705 , C07K14/4716 , C12Q1/6886 , C07K2319/00 , C12Q2600/158 , G01N2800/382 , Y10S530/828 , Y10S530/841
摘要： The breakpoints of the pericentric inversion of chromosome 16 have been cloned. Two genes, one at each breakpoint, have also been identified, as well as several forms of the inversion 16 fusion gene. Diagnostic applications for chromosome 16 abnormalities and, particularly acute myeloid leukemia are also within the scope of the present invention.
摘要翻译： 16号染色体的中心倒置的断点已被克隆。两个基因，每个断点一个，也已被鉴定，以及几种形式的倒置16融合基因。染色体16异常特别是急性骨髓性白血病的诊断应用也在本发明的范围内。

2. 发明授权

US5837457A Markers for detection of chromosome 16 rearrangements 失效
公开(公告)号：US5837457A
公开(公告)日：1998-11-17
申请号：US533306
申请日：1995-09-25
申请人： Pu Liu , Francis S. Collins , Michael J. Siciliano , David Claxton
发明人： Pu Liu , Francis S. Collins , Michael J. Siciliano , David Claxton
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/574 , H04N1/32
CPC分类号： G01N33/57426 , C07K14/4705 , C07K14/4716 , C12Q1/6886 , C07K2319/00 , C12Q2600/158 , G01N2800/382 , Y10S530/828 , Y10S530/841
摘要： The breakpoints of the pericentric inversion of chromosome 16 have been cloned. Two genes, one at each breakpoint, have also been identified, as well as several forms of the inversion 16 fusion gene. Diagnostic applications for chromosome 16 abnormalities and, particularly acute myeloid leukemia are also within the scope of the present invention.

3. 发明授权

US5538869A In-situ hybridization probes for identification and banding of specific human chromosomes and regions 失效
标题翻译：用于鉴定和条带化特定人染色体和区域的原位杂交探针
公开(公告)号：US5538869A
公开(公告)日：1996-07-23
申请号：US70517
申请日：1993-06-01
申请人： Michael J. Siciliano , Pu Liu
发明人： Michael J. Siciliano , Pu Liu
IPC分类号： C12N15/10 , C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6827 , C12N15/1093 , C12Q1/6841 , C12Q1/6858 , C12Q1/686 , C12Q1/6876 , C12Q2600/156
摘要： The invention relates to novel primer sets useful in preparing DNA probes specific for any chromosome or part of a chromosome, particularly human chromosomes. The DNA probes so produced may be used to paint individual chromosomes or portions of chromosomes in metephase cell spreads and in interphase nuclei. When used to paint chromosomes in metephase spreads, R-bands are readily detectable. The method is sensitive and has been shown to paint R-bands on chromosomes pieces having as few as several hundred kilobases.
摘要翻译：本发明涉及可用于制备对任何染色体或部分染色体特别是人染色体特异的DNA探针的新型引物组。如此生产的DNA探针可用于在细胞间隙和间期细胞核中染色单个染色体或部分染色体。当用于在metephase扩散中染色体时，可以容易地检测到R带。该方法是敏感的并且已经显示出在具有几百千碱基的染色体片上涂上R带。

4. 发明申请

US20070003075A1 Level dependent bass management 有权
标题翻译：水平依赖低音管理
公开(公告)号：US20070003075A1
公开(公告)日：2007-01-04
申请号：US11238338
申请日：2005-09-29
申请人： Joel Cooper , John Melanson , Pu Liu
发明人： Joel Cooper , John Melanson , Pu Liu
IPC分类号： H03G5/00
CPC分类号： H04S3/00
摘要： A signal processing system includes a level dependent bass management system. The level dependent bass management system utilizes audio input signal level information to apply at least one of multiple, available bass management solutions to generate one or more output signals from the audio input signal. In at least one embodiment, initially the level dependent bass management system boosts components of the audio input signal in the low frequency range by an amount sufficient to at least partially compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system. If boosting alone cannot completely compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system, the level dependent bass management system processes the audio input signal using an alternate low frequency management solution.
摘要翻译：信号处理系统包括一个依赖于电平的低音管理系统。电平依赖低音管理系统利用音频输入信号电平信息来应用多个可用低音管理解决方案中的至少一个以从音频输入信号产生一个或多个输出信号。在至少一个实施例中，电平依赖低音管理系统最初将低频范围内的音频输入信号的分量提升足以至少部分地补偿第一扬声器的低频衰减的量，而不超过一个或多个可接受的限制信号处理系统。如果单独升压不能完全补偿第一扬声器的低频衰减，而不超过信号处理系统的一个或多个可接受的限制，则依赖于电平的低音管理系统使用替代的低频管理解决方案处理音频输入信号。

5. 发明申请

US20110072398A1 Methods and Systems Involving Browser Nodes 有权
标题翻译：涉及浏览器节点的方法和系统
公开(公告)号：US20110072398A1
公开(公告)日：2011-03-24
申请号：US12563322
申请日：2009-09-21
申请人： Anthony M. Cocuzza , Shayne Grant , Pu Liu
发明人： Anthony M. Cocuzza , Shayne Grant , Pu Liu
IPC分类号： G06F3/048
CPC分类号： G06F17/30861 , G06F17/30958
摘要： A method comprises creating a first node, determining whether an indicator associated with a head node is present, and designating the first node as a head node, defining and associating a head node identifier with the first node, define a link from the first node to the first node, and create and save an indicator associated with the head node responsive to determining that the indicator associated with a head node is not present.
摘要翻译：一种方法包括创建第一节点，确定与头节点相关联的指示符是否存在，以及将所述第一节点指定为头节点，定义并将头节点标识符与所述第一节点相关联，定义从所述第一节点到第一节点，并且响应于确定与头节点相关联的指示符不存在，创建并保存与头节点相关联的指示符。

6. 发明申请

US20140004082A1 METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFBETA AND RUNX1 PROTEINS 有权
标题翻译：治疗由CBFBETA和RUNX1蛋白介导的白血病和疾病的方法
公开(公告)号：US20140004082A1
公开(公告)日：2014-01-02
申请号：US14005534
申请日：2012-03-15
申请人： Pu Liu , Wei Zheng , Juan Marugan , Noel T. Southall , Lea Cunningham
发明人： Pu Liu , Wei Zheng , Juan Marugan , Noel T. Southall , Lea Cunningham
IPC分类号： A61K31/5513 , A61K45/06 , A61K31/40
CPC分类号： A61K31/5513 , A61K31/203 , A61K31/40 , A61K31/417 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/2013 , A61K45/06 , Y10S514/908 , A61K2300/00
摘要： A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBFβ and RUNX1 binding in the subject, thereby treating the CBF leukemia.
摘要翻译：一种用于治疗受试者中的核心结合因子（CBF）白血病的方法，包括向具有CBF白血病的受试者施用治疗有效量的抑制受试者中CBFbeta和RUNX1结合的化合物或其药学上可接受的盐或酯，从而治疗CBF白血病。

7. 发明申请

US20130224772A1 METHOD FOR DETECTING ANTI-HE4 ANTIBODIES AND METHODS OF DIAGNOSIS AND/OR PROGNOSIS OF CONDITIONS ASSOCIATED WITH HE4-EXPRESSING CELLS 审中-公开
标题翻译：用于检测抗HE4抗体的方法和与HE4表达细胞相关的病症的诊断和/或预处理方法
公开(公告)号：US20130224772A1
公开(公告)日：2013-08-29
申请号：US13818466
申请日：2011-08-26
申请人： Karl Erik Hellstrom , Ingegerd Hellstrom , Pu Liu , Jade Jaffar , Elizabeth Swisher
发明人： Karl Erik Hellstrom , Ingegerd Hellstrom , Pu Liu , Jade Jaffar , Elizabeth Swisher
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N33/57449 , G01N2800/52
摘要： The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer.
摘要翻译：本发明尤其涉及与受试者中表达HE4的肿瘤细胞的检测相关的组合物和方法。所述方法包括从受试者获得的生物样品中检测抗HE4抗体。该方法可用于诊断和监测治疗对HE4表达的癌症的疗效，例如卵巢癌。

8. 发明申请

US20110300186A1 Functionalized Nano- and Micro-materials for Medical Therapies 审中-公开
标题翻译：功能化纳米和微观材料的医疗疗法
公开(公告)号：US20110300186A1
公开(公告)日：2011-12-08
申请号：US13087164
申请日：2011-04-14
申请人： Karl Erik Hellstrom , Ingegerd Hellstrom , Pu Liu , Huafeng Wei , Jun Liu , Chenghong Lei , Baowei Chen , Xiaolin Li
发明人： Karl Erik Hellstrom , Ingegerd Hellstrom , Pu Liu , Huafeng Wei , Jun Liu , Chenghong Lei , Baowei Chen , Xiaolin Li
IPC分类号： A61K9/00 , A61K31/7088 , A61P35/00 , A61K39/00 , A61P37/04 , A61K38/02 , A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K9/1611 , A61K9/167 , A61K47/6921 , A61K2039/505 , C07K16/2809
摘要： Compositions containing an optionally surface-functionalized mesoporous support and a biologically active agent, and pharmaceutical compositions of the same, are provided herein. Such compositions can be useful in the treatment of tumors, for example, by injection of the composition at a location near the site of the tumor.
摘要翻译：本文提供了含有任选的表面官能化介孔载体和生物活性剂的组合物及其药物组合物。这样的组合物可用于治疗肿瘤，例如通过在肿瘤部位附近注射组合物。

9. 发明授权

US08238576B2 Level dependent bass management 有权
标题翻译：水平依赖低音管理
公开(公告)号：US08238576B2
公开(公告)日：2012-08-07
申请号：US11238338
申请日：2005-09-29
申请人： Joel McKee Cooper , John L. Melanson , Pu Liu
发明人： Joel McKee Cooper , John L. Melanson , Pu Liu
IPC分类号： H03G5/00
CPC分类号： H04S3/00
摘要： A signal processing system includes a level dependent bass management system. The level dependent bass management system utilizes audio input signal level information to apply at least one of multiple, available bass management solutions to generate one or more output signals from the audio input signal. In at least one embodiment, initially the level dependent bass management system boosts components of the audio input signal in the low frequency range by an amount sufficient to at least partially compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system. If boosting alone cannot completely compensate for low frequency attenuation of the first speaker without exceeding one or more acceptable limitations of the signal processing system, the level dependent bass management system processes the audio input signal using an alternate low frequency management solution.
摘要翻译：信号处理系统包括一个依赖于电平的低音管理系统。电平依赖低音管理系统利用音频输入信号电平信息来应用多个可用低音管理解决方案中的至少一个以从音频输入信号产生一个或多个输出信号。在至少一个实施例中，电平依赖低音管理系统最初将低频范围内的音频输入信号的分量提升足以至少部分地补偿第一扬声器的低频衰减的量，而不超过一个或多个可接受的限制信号处理系统。如果单独升压不能完全补偿第一扬声器的低频衰减，而不超过信号处理系统的一个或多个可接受的限制，则依赖于电平的低音管理系统使用替代的低频管理解决方案处理音频输入信号。

10. 发明授权

US06349285B1 Audio bass management methods and circuits and systems using the same 有权
标题翻译：音频低音管理方法和使用电路和系统的系统
公开(公告)号：US06349285B1
公开(公告)日：2002-02-19
申请号：US09340619
申请日：1999-06-28
申请人： Pu Liu , Raghunath Rao , Miroslav Dokic
发明人： Pu Liu , Raghunath Rao , Miroslav Dokic
IPC分类号： G10L2100
CPC分类号： H04S3/00 , H04S7/307 , H04S2400/07
摘要： A method of managing multiple channels of audio data in an audio system having multiple speakers. A first channel signal is selectively passed through a software high-pass filter to selectively drive a first one of the speakers. A plurality of channel signals are selectively summed in software to generate a composite signal and the composite signal passed through a software low-pass filter to selectively drive a second one of the speakers.
摘要翻译：一种在具有多个扬声器的音频系统中管理音频数据的多个声道的方法。第一通道信号被选择性地通过软件高通滤波器以选择性地驱动扬声器中的第一个。多个信道信号被选择性地相加在软件中以产生复合信号，并且复合信号通过软件低通滤波器来选择性地驱动第二个扬声器。

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