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1. 发明授权

US09012204B2 Activation and monitoring of cellular transmembrane potentials 有权
标题翻译：激活和监测细胞跨膜电位
公开(公告)号：US09012204B2
公开(公告)日：2015-04-21
申请号：US13187297
申请日：2011-07-20
申请人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
发明人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
IPC分类号： C12M1/34 , G01N33/68 , B82Y5/00 , B82Y15/00 , G01N33/58
CPC分类号： G01N33/6872 , B82Y5/00 , B82Y15/00 , G01N33/588 , G01N2500/10
摘要： The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.
摘要翻译：公开了使用纳米结构来监测或调节细胞膜电位的变化。

2. 发明申请

US20120034622A1 ACTIVATION AND MONITORING OF CELLULAR TRANSMEMBRANE POTENTIALS 有权
标题翻译：激活和监测细胞转移能力
公开(公告)号：US20120034622A1
公开(公告)日：2012-02-09
申请号：US13187297
申请日：2011-07-20
申请人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
发明人： Michael J. Ignatius , Elena Molokanova , Alexei Savtchenko , Joseph A. Bartel , Weiwen Zhao , Joseph A. Treadway
IPC分类号： G01N33/566 , B05D5/00 , B05D1/36
CPC分类号： G01N33/6872 , B82Y5/00 , B82Y15/00 , G01N33/588 , G01N2500/10
摘要： The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.
摘要翻译：公开了使用纳米结构来监测或调节细胞膜电位的变化。

3. 发明授权

US08290714B2 Monitoring and manipulating cellular transmembrane potentials using nanostructures 有权
标题翻译：使用纳米结构监测和操纵细胞跨膜电位
公开(公告)号：US08290714B2
公开(公告)日：2012-10-16
申请号：US12651221
申请日：2009-12-31
申请人： Michael Ignatius , Elena Molokanova , Alexei Savtchenko
发明人： Michael Ignatius , Elena Molokanova , Alexei Savtchenko
IPC分类号： G01N33/48 , H01L51/42
CPC分类号： G01N33/6872 , B82Y5/00 , B82Y15/00 , G01N33/588
摘要： The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed. Nanoparticles having phospholipid coatings were found to display improved responses relative to nanoparticles having other coatings that do not promote localization or attraction to membranes.
摘要翻译：公开了使用纳米结构来监测或调节细胞膜电位的变化。发现具有磷脂涂层的纳米颗粒相对于不促进对膜的定位或吸引的其它涂层的纳米颗粒显示改善的反应。

4. 发明授权

US06899800B2 Polymeric electrode for electrophysiological testing 失效
标题翻译：用于电生理测试的聚合物电极
公开(公告)号：US06899800B2
公开(公告)日：2005-05-31
申请号：US10176183
申请日：2002-06-20
申请人： Yuri Osipchuk , Alexei Savtchenko , Alexander A. Dromaretsky
发明人： Yuri Osipchuk , Alexei Savtchenko , Alexander A. Dromaretsky
IPC分类号： B01L3/00 , G01N33/487 , G01N27/327 , C12M1/34 , C12N13/00
CPC分类号： G01N33/48728 , B01L3/5085
摘要： A polymeric material such as PDMS is molded into an electrode structure containing a micron-size aperture for receiving and forming a giga-ohm seal with a biological membrane. One end of a tube is filled with uncured polymeric material and pressed against a support surface to prevent drainage. A conventional micropipette having a size suitable for sliding through the tube is introduced, tip first, into the tube and is allowed to fall through the polymeric material and rest against the support surface. The assembly is heated to cure the polymer and the micropipette is removed from the tube, thereby leaving a polymeric plug at the end of the tube with an aperture suitable in shape and size for patch-clamp giga-ohm seal electrode applications. A multi-well tray with a polymeric electrode plug in each well is constructed using the same approach.
摘要翻译：诸如PDMS的聚合物材料被模制成包含微米级孔径的电极结构，用于接收并用生物膜形成千兆欧密封。管的一端填充有未固化的聚合物材料并压靠支撑表面以防止排水。将具有适合于穿过管滑动的尺寸的常规微量移液管首先引入管中并且允许其通过聚合物材料落下并靠在支撑表面上。将组件加热以固化聚合物，并从管中移除微量移液管，从而在管的端部留下聚合物塞，其孔适于用于膜片钳千兆欧密封电极应用的形状和尺寸。使用相同的方法构建在每个孔中具有聚合物电极塞的多孔盘。

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