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1. 发明申请

US20050261268A1 Aminotriazole compounds useful as inhibitors of protein kinases 有权
标题翻译：可用作蛋白激酶抑制剂的氨基三唑化合物
公开(公告)号：US20050261268A1
公开(公告)日：2005-11-24
申请号：US10914051
申请日：2004-08-06
申请人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
发明人： Michael J. Arnost , Guy W. Bemis , Robert J. Davies , Cornelia J. Forster , Ronald Grey , Mark W. Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert C. Pierce , Francesco Salituro , Jian Wang
IPC分类号： A61P35/00 , C07D249/14 , C07D401/04 , C07D401/14 , C07D403/04 , A61K31/545 , A61K31/4196 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D501/14 , C07D43/02
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及蛋白激酶抑制剂。本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。

2. 发明申请

US20080096901A1 Aminotriazole compounds useful as inhibitors of protein kinases 有权
标题翻译：可用作蛋白激酶抑制剂的氨基三唑化合物
公开(公告)号：US20080096901A1
公开(公告)日：2008-04-24
申请号：US11787165
申请日：2007-04-13
申请人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
发明人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
IPC分类号： A61K31/4196 , C07D401/04 , A61K31/4439 , A61K31/496 , C07D403/04 , C07D249/08 , A61P11/06 , A61P27/14 , A61P29/00 , A61P37/08 , A61P37/00 , A61P35/00 , A61P25/16 , A61P25/28
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及蛋白激酶抑制剂。本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。

3. 发明授权

US07601718B2 Compositions useful as inhibitors of protein kinases 有权
标题翻译：可用作蛋白激酶抑制剂的组合物
公开(公告)号：US07601718B2
公开(公告)日：2009-10-13
申请号：US10772219
申请日：2004-02-04
申请人： Jeremy Green , Ronald Grey , Albert C. Pierce
发明人： Jeremy Green , Ronald Grey , Albert C. Pierce
IPC分类号： C07D487/00 , A61K31/50
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula I: or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐或其混合物。这些化合物是蛋白激酶的抑制剂，特别是GSK哺乳动物蛋白激酶的抑制剂，特别是GSK-3哺乳动物蛋白激酶的抑制剂。本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

4. 发明申请

US20070254868A1 C-MET protein kinase inhibitors 有权
标题翻译： C-MET蛋白激酶抑制剂
公开(公告)号：US20070254868A1
公开(公告)日：2007-11-01
申请号：US11726170
申请日：2007-03-21
申请人： David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
发明人： David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号： A61K31/4439 , A61K31/437 , A61K31/454 , A61K31/55 , C07D213/82 , C07D401/04 , C07D471/04 , C12N9/99 , C07D403/14 , C07D223/00 , A61P35/00 , A61K31/497 , A61K31/44
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用于蛋白激酶抑制剂的化合物。本发明还提供了制备本发明化合物的方法，包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗各种疾病的方法。

5. 发明授权

US08317502B1 Texture pattern imprinting apparatus 失效
标题翻译：纹理图案压印设备
公开(公告)号：US08317502B1
公开(公告)日：2012-11-27
申请号：US12590395
申请日：2009-11-06
申请人： Ronald Grey
发明人： Ronald Grey
IPC分类号： B28B7/02 , B28B1/26
CPC分类号： B28B11/10 , E01C19/43 , E01F15/083 , E04F21/04
摘要： The present invention may be attached to a vehicle for movement adjacent to a generally vertical wall structure for imprinting a pattern in a surface of the wall structure. An imprint form frame may be attached to an imprint form. The imprint form frame may be attached to a support frame that may be of generally rectangular form with horizontal and vertical members. The support frame may be attached to one or more position support members so as to be movable in a horizontal and perpendicular direction relative to the plane of the support frame. The perpendicular movement may be controlled by a power actuator. The position support member may be attached to a frame support beam for attachment to a vehicle and may be movable vertically.
摘要翻译：本发明可以附接到用于移动的车辆，其邻近大致垂直的壁结构，用于将图案压印在壁结构的表面中。压印格式框架可以附加到印记格式。压印框架可以附接到可以具有水平和垂直构件的大致矩形形式的支撑框架。支撑框架可以附接到一个或多个位置支撑构件，以便能够相对于支撑框架的平面在水平和垂直的方向上移动。垂直运动可以由动力致动器来控制。位置支撑构件可以附接到框架支撑梁，用于附接到车辆并且可以垂直移动。

6. 发明申请

US20050247115A1 Rheometer 有权
标题翻译：流变仪
公开(公告)号：US20050247115A1
公开(公告)日：2005-11-10
申请号：US10523917
申请日：2003-08-08
申请人： Ronald Grey , Geoffrey Condick , Dean Svendsen
发明人： Ronald Grey , Geoffrey Condick , Dean Svendsen
IPC分类号： G01N3/32 , G01N11/00 , G01N11/16 , G01N33/44 , G01N11/10
CPC分类号： G01N11/16 , G01N33/442 , G01N2011/0013
摘要： A rheometer and method of making rheological measurements is disclosed, in which a sample is supported between plates and an alternating movement is applied by a driver, support rod and plate. Force and displacement measurements are taken and the property determined from those measurements. The vibrating signal which is applied is in the form of a frequency sweep signal having a monotonic group delay function. The top plate is provided with a surface which causes a meniscus to form up a side edge of the plate to reduce the spring nature of the sample when the movement is supplied to the sample, and a supporting rod which supports the top plate is preferably formed from a material having a low coefficient of thermal expansion so that the gap between the plates is maintained substantially constant if the sample is heated to take measurements at different temperatures.
摘要翻译：公开了流变仪和制造流变学测量的方法，其中样品被支撑在板之间，并且由驱动器，支撑杆和板施加交替的运动。采取力和位移测量，并从这些测量中确定属性。所施加的振动信号是具有单调组延迟功能的频率扫描信号的形式。顶板设置有表面，当表面向样品供给运动时，弯液面形成板的侧边缘以减小样品的弹性，并且优选地形成支撑顶板的支撑杆从具有低热膨胀系数的材料，使得如果样品被加热以在不同温度下进行测量，则板之间的间隙保持基本上恒定。

7. 发明申请

US20070224311A1 PROCESS FOR THE PREPARATION OF COMPRESSED GUM 审中-公开
标题翻译：压缩胶的制备方法
公开(公告)号：US20070224311A1
公开(公告)日：2007-09-27
申请号：US11689143
申请日：2007-03-21
申请人： Ronald Grey , Bruno Padovani , Douglas Fritz
发明人： Ronald Grey , Bruno Padovani , Douglas Fritz
IPC分类号： A23G4/18
CPC分类号： A23G4/18 , A23G4/08 , A23G4/10 , A23L29/35 , A23P10/20
摘要： The present invention generally relates to a granulated chewing gum composition which may be compressed, and to a process for the preparation thereof. In particular, the present invention relates to such a granulated chewing gum composition which comprises a solid hydrogenated starch hydrolysate, as well as to a process for the preparation thereof. Additionally, or alternatively, the present invention relates to a process for preparing a granulated chewing gum composition, wherein a chewing gum base is used therein which may be comminuted at an elevated temperature, as well as a composition comprising such a base. The granular chewing gum composition may be compressed into a tablet, and optionally coated.
摘要翻译：本发明一般涉及可压缩的造粒口香糖组合物及其制备方法。特别地，本发明涉及这样的颗粒状口香糖组合物，其包含固体氢化淀粉水解物，以及其制备方法。另外或备选地，本发明涉及一种制备颗粒状口香糖组合物的方法，其中使用其中可以在升高的温度下粉碎的口香糖胶基，以及包含这种碱的组合物。颗粒状口香糖组合物可以压制成片剂，并且任选包衣。

8. 发明申请

US20070008527A1 Atomic absorption spectrometer 失效
标题翻译：原子吸收光谱仪
公开(公告)号：US20070008527A1
公开(公告)日：2007-01-11
申请号：US11522573
申请日：2006-09-18
申请人： Ronald Grey , Peter Saunders
发明人： Ronald Grey , Peter Saunders
IPC分类号： G01J3/28
CPC分类号： G01J3/04 , G01J3/42 , G01N21/3103 , G01N21/74
摘要： An atomic absorption spectrometer is disclosed which includes a monochromater and an optical path defined by a toric mirror, a flat mirror, a flat mirror, a flat mirror, a toric mirror, and a further toric mirror. The toric mirror directs light through entrance slit of the monochromater so that radiation is reflected from diffraction grating and out exit slit to a detector. A sample stage in the form of a furnace is located between the mirrors. The monochromater is oriented so that the entrance slit is arranged transverse to the vertical. In one arrangement, a magnifying means is also provided which magnifies an image of the aperture at the sample station to increase the amount of radiation which is focused at the sample stage, and which is passed through the aperture to the detector or a focusing element provided by one of the mirrors may be provided for focusing radiation at a location other than sample station so an enlarged out of focus image of the entrance slit is produced at the sample station to increase the amount of radiation which passes through the slit and is received by the detector.
摘要翻译：公开了一种原子吸收光谱仪，其包括由复曲面镜，平面镜，平面镜，平面镜，复曲面镜和其他复曲面镜定义的单色仪和光路。复曲面镜通过单色仪的入口狭缝引导光线，使得辐射从衍射光栅反射并出射出口到检测器。炉子形式的样品台位于反射镜之间。单色仪被定向成使得入口狭缝横向于垂直布置。在一种布置中，还提供了一种放大装置，其放大在采样台处的孔径的图像，以增加聚焦在样品台处的辐射量，并且其被穿过孔径到达检测器或提供的聚焦元件可以通过一个反射镜提供用于在除了采样站之外的位置聚焦辐射，使得在采样站处产生入射狭缝的放大焦点图像，以增加通过狭缝的辐射量并且被检测器。

9. 发明申请

US20070224310A1 COMPRESSED GUM 审中-公开
标题翻译：压缩胶
公开(公告)号：US20070224310A1
公开(公告)日：2007-09-27
申请号：US11689111
申请日：2007-03-21
申请人： Ronald Grey , Bruno Padovani , Douglas Fritz
发明人： Ronald Grey , Bruno Padovani , Douglas Fritz
IPC分类号： A23G4/18
CPC分类号： A23G4/18 , A23G4/08 , A23G4/10 , A23L29/35 , A23P10/20
摘要： The present invention generally relates to a granulated chewing gum composition which may be compressed, and to a process for the preparation thereof. In particular, the present invention relates to such a granulated chewing gum composition which comprises a solid hydrogenated starch hydrolysate, as well as to a process for the preparation thereof. Additionally, or alternatively, the present invention relates to a process for preparing a granulated chewing gum composition, wherein a chewing gum base is used therein which may be comminuted at an elevated temperature, as well as a composition comprising such a base. The granular chewing gum composition may be compressed into a tablet, and optionally coated.
摘要翻译：本发明一般涉及可压缩的造粒口香糖组合物及其制备方法。特别地，本发明涉及这样的颗粒状口香糖组合物，其包含固体氢化淀粉水解物，以及其制备方法。另外或备选地，本发明涉及一种制备颗粒状口香糖组合物的方法，其中使用其中可以在升高的温度下粉碎的口香糖胶基，以及包含这种碱的组合物。颗粒状口香糖组合物可以压制成片剂，并且任选包衣。

10. 发明授权

US5690021A Strainer insert for blender 失效
标题翻译：用于搅拌机的过滤器插件
公开(公告)号：US5690021A
公开(公告)日：1997-11-25
申请号：US613616
申请日：1996-03-11
申请人： Ronald Grey
发明人： Ronald Grey
IPC分类号： A23N1/00 , A47J19/02 , A47J43/07 , B02C15/00 , B04B5/10
CPC分类号： A47J19/027 , A23N1/00 , A47J43/0716
摘要： The strainer insert is a cylindrical chamber having strainer openings about a portion of its circumference. The strainer chamber is open at both ends. The bottom end is attached to a mounting base which is attached to a blender base. When the strainer chamber is attached in a blender it is completely contained in the blender mixing chamber and it encloses the blender blades. Items such as fruits or vegetables may then be placed in the strainer chamber and the open end closed with a lid. When the blender is activated the blender chops or cuts up the items into solid pieces and produces a liquid. The liquid passes through the strainer openings to be poured out of the blender mixing chamber.
摘要翻译：过滤器插件是具有围绕其圆周的一部分的过滤器开口的圆柱形腔室。过滤室在两端打开。底端连接到安装在底座上的安装座上。当过滤器室连接在搅拌器中时，其完全容纳在搅拌器混合室中，并且其包围搅拌器叶片。然后将诸如水果或蔬菜的物品放置在过滤器室中，并且开口端用盖子封闭。当搅拌机启动时，搅拌机将物料切碎或切成固体块并产生液体。液体通过过滤器开口以从混合器混合室中倒出。

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