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1. 发明授权

US4534758A Controlled release infusion system 失效
标题翻译：控制释放输液系统
公开(公告)号：US4534758A
公开(公告)日：1985-08-13
申请号：US514268
申请日：1983-07-15
申请人： Michael J. Akers , William W. Hargrove , Dale C. Harris , Charles R. Sperry
发明人： Michael J. Akers , William W. Hargrove , Dale C. Harris , Charles R. Sperry
IPC分类号： A61M5/14 , A61M5/175 , A61M39/22
CPC分类号： A61M39/223 , A61M5/1409 , A61M5/162
摘要： Valved adaptors are disclosed permitting the introduction of a drug-containing vial in the delivery tube of an I.V. administration set. The adaptors have a three position operation characterized by a bypass mode, a dilution mode, and a delivery mode, the adaptors being manually changed from mode to mode. The disclosed adaptors include gravity operated valves, reciprocating spool valves, and rotating spool valves, each including a spike to penetrate the stopper of a vial and a vent to permit air to escape the vial as liquid is introduced to dilute the vial contents.
摘要翻译：公开的阀门适配器允许在I.V.的输送管中引入含药物的小瓶。管理集适配器具有以旁路模式，稀释模式和传送模式为特征的三位置操作，适配器被手动地从模式改变为模式。所公开的适配器包括重力操作阀，往复式滑阀和旋转滑阀，每个阀都包括一个尖头，以穿透小瓶的塞子和通气孔，以允许空气在引入液体以稀释小瓶内容物时逃离小瓶。

2. 发明授权

US4573967A Vacuum vial infusion system 失效
标题翻译：真空小瓶输液系统
公开(公告)号：US4573967A
公开(公告)日：1986-03-04
申请号：US558060
申请日：1983-12-06
申请人： William W. Hargrove , Dale C. Harris , Michael J. Akers , Charles R. Sperry
发明人： William W. Hargrove , Dale C. Harris , Michael J. Akers , Charles R. Sperry
IPC分类号： A61M5/14
CPC分类号： A61M5/1409
摘要： An apparatus for connecting a vial into the delivery tube of an intravenous administration set, the set including a container of fluid connected to one end of a delivery tube with the other end of the delivery tube adapted for insertion into the patient. The apparatus includes a penetrating spike penetrating an end of the vial which provides two pathways into the interior of the vial with two sections of the delivery tube connected to the two pathways of the penetrating spike. The apparatus also includes a frame for maintaining the two sections of the delivery tube adjacent to each other and clamp for releasably closing the adjacent sections of the delivery tube to temporarily prevent flow of fluid through the penetrating spike.
摘要翻译：一种用于将小瓶连接到静脉内给药组的输送管中的装置，所述装置包括连接到输送管的一端的流体容器，其中输送管的另一端适于插入患者体内。该装置包括穿透小瓶的一端的穿透尖钉，其向入口的内部提供两条通道，其中两段输送管连接到穿透尖峰的两个通道。该装置还包括一个框架，用于将输送管的两个部分保持在彼此相邻并且夹紧以可释放地封闭输送管的相邻部分，以暂时防止流体流过穿透尖。

3. 发明授权

US4465471A Intravenous administration system for dry medicine 失效
标题翻译：干性静脉给药系统
公开(公告)号：US4465471A
公开(公告)日：1984-08-14
申请号：US401874
申请日：1982-07-26
申请人： Dale C. Harris , William W. Hargrove
发明人： Dale C. Harris , William W. Hargrove
IPC分类号： A61M5/14
CPC分类号： A61M5/1409
摘要： The system of this invention provides a method and apparatus for the sterile intravenous administration of dry medicine. Such a system can include standard IV set components such as a source of liquid, means to inject liquid into a human vein, means forming a passageway between the source of liquid and said injection means, a valve to control the flow of liquid through the passageway, and a cartridge-like dry medicine package adapted for use with the system. Such a package can include conduit means adapted to perforate and communicate with the passageway, means forming a cell for dry, particulate medicine with portions forming a liquid-pervious barrier to the dry medicine and an air vent with an air-pervious, liquid barrier. The perforating conduit means is in communication with the liquid-pervious barrier portion of the cell so that, upon perforation of the passageway means by the perforating conduit means below the source of liquid, the cell fills with liquid, the medicine is placed in solution in the liquid, and the medicine solution flows into the vein. Dry medicine can, for example, be administered intravenously in liquid solution in a variety of dosages and at a variety of rates without resort to a pharmacy by enclosing it in such a sterile package adapted for addition to an IV system at a patient's bedside.
摘要翻译：本发明的系统提供了用于无菌静脉内施用干燥药物的方法和装置。这样的系统可以包括标准IV组件，例如液体源，将液体注入人静脉的装置，在液体源和所述注射装置之间形成通道的装置，用于控制液体通过通道的流动的阀以及适于与该系统一起使用的盒式干药剂包装。这种包装可以包括适于穿透和与通道连通的装置，用于形成用于干燥颗粒药物的细胞的装置，其中形成对干药物的液体可透过屏障的部分和具有透气性液体屏障的通气口。穿孔导管装置与细胞的透液性阻挡部分连通，使得当通道装置穿过液体源下方的穿孔导管装置时，细胞充满液体，将药物置于溶液中液体，药液流入静脉。例如，干药可以以各种剂量和各种速率以液体溶液静脉内施用，而不需要通过将其封装在适合于在患者床边添加到IV系统的无菌包装中而不需要药房。

4. 发明授权

US5228883A Portable drug delivery system 失效
标题翻译：便携式药物输送系统
公开(公告)号：US5228883A
公开(公告)日：1993-07-20
申请号：US695495
申请日：1991-05-02
申请人： David C. Blakely , Dale C. Harris
发明人： David C. Blakely , Dale C. Harris
IPC分类号： A61D7/00 , A01K29/00 , A61G12/00 , A61M20060101 , A61M5/00 , A61M5/178 , A61M5/24 , A61M5/28 , A61M5/32 , F41C33/02
CPC分类号： F41C33/0236 , A61M5/24 , A61M5/3205 , A61M2005/2414 , A61M2005/2481 , Y10S128/919
摘要： An improved drug delivery system comprising a gun style injection device used for holding and administering a disposable pre-filled drug cartridge, a holster device used for receiving an end of the gun style injection device and thereafter severing cannula from cartridge and disposing of spent cannulas and cartridges, and an improvement to the drug cartridge is disclosed. The gun style injection device comprises a barrel, a handle, a hinged and spring loaded squeeze lever, and a safety trigger. The holster device comprises a leg protection panel to which a housing is coupled for disposing of spent cartridges. The holster housing is adapted for receiving the barrel of the gun style injection device. The holster housing provides a means for severing the cannula from a used cartridge and disposing of both the cannula and cartridge in separate containers. The cartridge design itself is improved in order to increase the performance of the gun style injection device and the holster cannula severing mechanism.

5. 发明授权

US5454786A Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same 失效
标题翻译：用于形成喷射器笔的一次性部分的冻干化合物的墨盒组件及其方法
公开(公告)号：US5454786A
公开(公告)日：1995-10-03
申请号：US218653
申请日：1994-03-28
申请人： Dale C. Harris
发明人： Dale C. Harris
IPC分类号： A61J1/05 , A61J1/00 , A61J1/06 , A61J1/20 , A61M5/24 , A61M37/00 , A61B19/00 , A61M5/32
CPC分类号： A61J1/2096 , A61J1/062 , A61M5/24 , A61J1/201 , A61J1/2013 , A61J1/2065 , A61M2005/2411 , A61M2005/2488 , A61M5/31553 , A61M5/3158 , A61M5/5086
摘要： A cartridge assembly for holding a lyophilized product, forming a disposable portion of a pen injector includes a cylindrical glass cartridge adapted to receive the product, a closure cap, a cartridge case, and a plunger mechanism. The closure cap is adapted to retain an elastomeric disc seal during lyophilization and includes diametrically opposed ledges. The closure cap and seal are adapted to cover a neck portion of the ampule, the neck portion having on its end a radially extending circumferential flange. The ledges of the closure cap and the flange of the neck portion allow the closure cap to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap aids in snapping the closure cap about the flange without crimping to retain the closure cap underneath the flange. Reconstitution of the lyophilized drug is accomplished without foaming by use of an obliquely angled connector which causes the diluent to indirectly impinge on the drug. The injection pen and cartridge assembly cooperate such that the length of travel of the plunger rod during retraction is less than the axial length of a recess in the rod tip.
摘要翻译：用于保持冷冻干燥产品的盒组件，形成笔式注射器的一次性部分包括适于容纳产品的圆柱形玻璃盒，封闭盖，盒壳和柱塞机构。闭合盖适于在冻干期间保持弹性体盘密封并且包括直径相对的凸缘。闭合盖和密封件适于覆盖安瓿的颈部，颈部在其端部上具有径向延伸的圆周凸缘。闭合盖的凸缘和颈部的凸缘允许封闭帽在冻干，氧气吹扫和氮气覆盖期间保持打开。形成在封闭盖的内侧上的椭圆形凹口有助于围绕凸缘卡扣闭合盖，而不会卷曲以将封闭盖保持在凸缘下方。冻干药物的重建是通过使用倾斜成角度的连接器而实现的而不发泡，这导致稀释剂间接地侵入药物。注射笔和墨盒组件配合使得柱塞杆在缩回期间的行程长度小于杆尖中的凹部的轴向长度。

6. 发明授权

US4415085A Dry pharmaceutical system 失效
标题翻译：干制药系统
公开(公告)号：US4415085A
公开(公告)日：1983-11-15
申请号：US332495
申请日：1981-12-21
申请人： John W. Clarke , Dale C. Harris
发明人： John W. Clarke , Dale C. Harris
IPC分类号： A61J1/10 , A61J1/00 , A61J1/05 , A61J1/16 , A61M1/02 , B65D33/38 , B65D85/62 , B65B57/02 , B65B67/12 , B65D1/02
CPC分类号： A61J1/05 , A61J1/10 , A61M1/0277 , B29C65/02 , B29C66/53263
摘要： A system for the packaging, shipment, storage, and reconstitution of dry pharmaceuticals includes a flexible bag manufactured from two layers of plastic laminated film and a rigid port-forming member. In the system, the package is used for shipment and storage of dry pharmaceuticals and for their reconstitution in a liquid solution and their intravenous administration. A plurality of such packages may be handled as an assembly by flexible plastic strips both during processing and packaging and during the reconstitution of the dry medicine as a liquid solution. The flexible plastic strips are formed with a plurality of cavities. Each cavity of the strip has a plurality of sites located in its central portion and adapted to engage and retain the port-forming member and to protect its opening from contamination. A plurality of such package assemblies can be enclosed within an outer protective bag to provide protection against moisture and the effects of the environment during shipment and storage. The assemblies may be removed from the outer protective bag by the batching strips and placed in a special rack for support. With a plurality of packages supported by the rack, a hospital pharmacist, using a power-operated pump, may fill each container with a controlled quantity of a liquid solute for the dry pharmaceutical. When the dry medicine is in solution, it may be intravenously administered directly from the package.
摘要翻译：用于干燥药物的包装，运输，储存和重建的系统包括由两层塑料层压膜和刚性端口形成构件制成的柔性袋。在该系统中，该包装用于运送和储存干性药物，并用于其在液体溶液中的重建及其静脉内给药。多个这样的包装可以在处理和包装过程中以及作为液体溶液重建干燥药物期间通过柔性塑料条作为组合来处理。柔性塑料条形成有多个空腔。条带的每个空腔具有位于其中心部分中的多个位置，并且适于接合并保持端口形成构件并保护其开口免受污染。多个这样的包装组件可以封闭在外部保护袋内以提供防止湿气和在运输和储存期间环境的影响的保护。可以通过配料条将组件从外保护袋中取出并放置在用于支撑的专用机架中。使用由机架支撑的多个包装，使用动力操作的泵的医院药剂师可以向每个容器填充受控量的用于干燥药物的液体溶质。当干药在溶液中时，可以直接从包装中进行静脉内给药。

7. 外观设计

USD262746S Animal feeder 失效
公开(公告)号：USD262746S
公开(公告)日：1982-01-19
申请号：US88893
申请日：1979-10-29
申请人： Dale C. Harris
设计人： Dale C. Harris

8. 发明授权

US5545147A Anti-backup improvement for hypodermic syringes 失效
标题翻译：皮下注射器的反备份改善
公开(公告)号：US5545147A
公开(公告)日：1996-08-13
申请号：US963815
申请日：1992-10-20
申请人： Dale C. Harris
发明人： Dale C. Harris
IPC分类号： A61M5/24 , A61M5/315 , A61M5/50 , A61M5/00
CPC分类号： A61M5/31551 , A61M5/50 , A61M2005/3151 , A61M5/24 , A61M5/31563 , A61M5/3158 , A61M5/31593
摘要： The present invention provides an improved device for preventing the backing up of a nut on a threaded piston rod in the barrel of a hypodermic syringe at the end of dose administration from such syringe. The preferred device is a pawl mounted on the end of a flexible arm of a nut which cooperates with slots on the inside of a syringe barrel. The nut also has an incline surface at the end which mates with an incline surface in the barrel end. The mating of these surfaces at the end of dose administration forces the pawl into a slot, thereby preventing rotation of the nut in the wrong direction and the concurrent movement of the nut up the piston rod associated therewith.
摘要翻译：本发明提供了一种改进的装置，用于在从这种注射器的剂量给药结束时防止在皮下注射器的筒体中的螺纹活塞杆上的螺母的背衬。优选的装置是安装在螺母的柔性臂的端部上的棘爪，其与注射器筒内侧的狭槽配合。螺母在端部处具有倾斜表面，其与端部的倾斜表面相配合。在剂量施用结束时，这些表面的配合迫使棘爪进入狭槽，从而防止螺母沿错误的方向旋转，并且螺母与其相关联的活塞杆同时移动。

9. 发明授权

US5308340A Multiple dose injection pen 失效
标题翻译：多剂量注射笔
公开(公告)号：US5308340A
公开(公告)日：1994-05-03
申请号：US79307
申请日：1993-06-17
申请人： Dale C. Harris
发明人： Dale C. Harris
IPC分类号： A61J1/00 , A61J1/14 , A61M5/315 , A61M5/50 , A61M5/00
CPC分类号： A61M5/315 , A61J1/1406 , A61M5/31525 , A61M5/31535 , A61M5/31548 , A61M5/31551 , A61M5/31563 , A61M5/3158 , A61M5/31591 , A61M2005/3154 , A61M2205/581 , A61M2205/582 , A61M5/31505 , A61M5/31561 , A61M5/50
摘要： The present invention relates to a hypodermic syringe having the same general appearance as a pen which is specifically adapted to provide for multiple measure injections of materials such as insulin or human growth hormone.
摘要翻译：本发明涉及具有与笔相同的外观的皮下注射器，其特别适用于提供诸如胰岛素或人生长激素的材料的多次测量注射。

10. 发明授权

US4649042A Rumen delivery device 失效
标题翻译：瘤胃输送装置
公开(公告)号：US4649042A
公开(公告)日：1987-03-10
申请号：US719195
申请日：1985-04-03
申请人： Robert C. Davis , John W. Gibson , Daniel S. Skinner, Jr. , Timothy E. Dearth , Dale C. Harris
发明人： Robert C. Davis , John W. Gibson , Daniel S. Skinner, Jr. , Timothy E. Dearth , Dale C. Harris
IPC分类号： A61D7/00 , A61K9/00 , A61K9/22 , A61M31/00 , A61K9/30 , A61K37/24
CPC分类号： A61K9/0068 , A61M31/002
摘要： An improved device for delivery of a medicament to the digestive tract of a ruminant animal comprises a polymeric medicated core retained in a dense tube by a relatively thick layer of an elastic sealant.
摘要翻译：用于将药物递送到反刍动物的消化道的改进装置包括通过相对厚的弹性密封剂层保留在致密管中的聚合物药芯。

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