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1. 发明授权

US06694057B1 Method and apparatus for processing images with curves 有权
标题翻译：用曲线处理图像的方法和装置
公开(公告)号：US06694057B1
公开(公告)日：2004-02-17
申请号：US09492693
申请日：2000-01-27
申请人： Michael I. Miller , Navin Khaneja , Muge Bakircioglu
发明人： Michael I. Miller , Navin Khaneja , Muge Bakircioglu
IPC分类号： G06K946
CPC分类号： G06K9/6204
摘要： A system according to the invention identifies image data points defining a curve. The method comprises the steps of determining a start point and an end point for the curve, establishing a search space that includes at least the start point, the end point, and other image data elements comprising the curve, and searching the search space using a dynamic programming algorithm to locate image data elements corresponding to the curve. Another embodiment consistent with the present invention identifies image data points defining a curve. The method comprises the steps of determining a start point and an end point for the curve, generating a model of the curve, establishing a search space that includes at least the start point, the end point, and other image data elements comprising the curve, and searching the search space using a dynamic programming algorithm and the model for the curve to locate image data elements corresponding to the curve. Yet another embodiment consistent with the present invention matches a first curve to a second curve. The method comprises the steps of identifying a first curve, identifying a second curve, generating a higher order distance measure for comparing the first curve and the second curve, and matching the first curve to the second curve using the higher order distance measure.
摘要翻译：根据本发明的系统识别定义曲线的图像数据点。该方法包括以下步骤：确定曲线的起点和终点，建立至少包括起点，终点和包括曲线的其他图像数据元素的搜索空间，并使用动态编程算法来定位对应于曲线的图像数据元素。与本发明一致的另一实施例识别定义曲线的图像数据点。该方法包括以下步骤：确定曲线的起始点和终点，生成曲线的模型，建立搜索空间，该搜索空间至少包括起始点，终点和包括该曲线的其他图像数据元素，并使用动态规划算法搜索搜索空间，并且用于曲线的模型来定位与该曲线相对应的图像数据元素。符合本发明的另一个实施例将第一曲线与第二曲线相匹配。该方法包括以下步骤：识别第一曲线，识别第二曲线，产生用于比较第一曲线和第二曲线的较高阶距离度量，以及使用较高阶距离度量将第一曲线与第二曲线匹配。

2. 发明授权

US06226418B1 Rapid convolution based large deformation image matching via landmark and volume imagery 有权
标题翻译：通过地标和体积图像快速卷积的大型变形图像匹配
公开(公告)号：US06226418B1
公开(公告)日：2001-05-01
申请号：US09186359
申请日：1998-11-05
申请人： Michael I. Miller , Sarang C. Joshi , Gary E. Christensen
发明人： Michael I. Miller , Sarang C. Joshi , Gary E. Christensen
IPC分类号： G06K936
CPC分类号： G06T3/0068 , G06K9/6206 , G06T7/33 , G06T7/37 , G06T7/73 , G06T2207/30004
摘要： An apparatus and method for image registration of a template image with a target image with large deformation. The apparatus and method involve computing a large deformation transform based on landmark manifolds, image data or both. The apparatus and method are capable of registering images with a small number of landmark points. Registering the images is accomplished by applying the large deformation transform.
摘要翻译：用于具有大变形的目标图像的模板图像的图像配准的装置和方法。该装置和方法涉及基于地标歧管，图像数据或两者计算大变形变换。该装置和方法能够用少量地标点登记图像。通过应用大变形变换来实现图像的注册。

3. 发明授权

US08600131B2 Advanced cost functions for image registration for automated image analysis: multi-channel, hypertemplate and atlas with built-in variability 有权
标题翻译：用于自动图像分析的图像配准的高级成本函数：具有内置变异性的多通道，超模板和图集
公开(公告)号：US08600131B2
公开(公告)日：2013-12-03
申请号：US12999721
申请日：2009-07-07
申请人： Michael I. Miller , Susumu Mori , Anqi Qiu , Jiangyang Zhang , Can Ceritoglu
发明人： Michael I. Miller , Susumu Mori , Anqi Qiu , Jiangyang Zhang , Can Ceritoglu
IPC分类号： G06K9/00
CPC分类号： A61B6/563 , A61B5/055 , A61B6/032 , A61B6/501 , A61B6/5235 , G06F19/00 , G06K9/6206 , G06K9/6215 , G06K9/6255 , G16H50/70
摘要： A non-invasive imaging system, comprising: an imaging scanner; a signal processing system in communication with the imaging scanner to receive an imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit stores template data corresponding to a tissue region of a subject under observation, wherein the signal processing system is adapted to compute, using the imaging signal and the template data, refined template data corresponding to the tissue region, and wherein the refined template data incorporates subpopulation variability information associated with the tissue region such that the signal processing system provides an image of the tissue region in which a substructure is automatically identified taking into account the subpopulation variability information.
摘要翻译：一种非侵入性成像系统，包括：成像扫描仪; 与成像扫描仪通信的信号处理系统，以从成像扫描器接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元存储对应于被观察对象的组织区域的模板数据，其中所述信号处理系统适于使用所述成像信号和所述模板数据对应于所述组织区域的精细模板数据，并且其中所述精制模板数据包含与所述组织区域相关联的亚群体变异性信息，使得所述信号处理系统提供所述组织区域的图像，其中在考虑到亚群的情况下自动识别子结构变异性信息。

4. 发明授权

US06633686B1 Method and apparatus for image registration using large deformation diffeomorphisms on a sphere 有权
标题翻译：用于在球体上使用大的变形不同形态的图像配准的方法和装置
公开(公告)号：US06633686B1
公开(公告)日：2003-10-14
申请号：US09665688
申请日：2000-09-20
申请人： Muge M. Bakircioglu , Sarang Joshi , Michael I. Miller
发明人： Muge M. Bakircioglu , Sarang Joshi , Michael I. Miller
IPC分类号： G06K932
CPC分类号： G06T3/0081 , G06K9/6206 , G06T7/33 , G06T7/37 , G06T7/70 , G06T2207/30004
摘要： An apparatus and method for image registration of a template image with a target image with large deformation. The apparatus and method involve computing a large deformation transform based on landmark manifolds, image data or both. The apparatus and method are capable of registering images with a small number of landmark points. Registering the images is accomplished by applying the large deformation transform.
摘要翻译：用于具有大变形的目标图像的模板图像的图像配准的装置和方法。该装置和方法涉及基于地标歧管，图像数据或两者计算大变形变换。该装置和方法能够用少量地标点登记图像。通过应用大的变形变换来实现注册图像。

5. 发明授权

US06553152B1 Method and apparatus for image registration 有权
标题翻译：图像配准方法和装置
公开(公告)号：US06553152B1
公开(公告)日：2003-04-22
申请号：US09299567
申请日：1999-04-27
申请人： Michael I. Miller , Gary E. Christensen , Sarang C. Joshi , Ulf Grenander
发明人： Michael I. Miller , Gary E. Christensen , Sarang C. Joshi , Ulf Grenander
IPC分类号： G06K932
CPC分类号： G06K9/6206 , G06K9/32 , G06T3/0081 , G06T7/33
摘要： An apparatus and method for image registration involves computing a first transform based on landmark manifolds, using a distance measure, computing a second transform from the distance measure and the first transform. Registering the images is accomplished by applying the second transform.
摘要翻译：一种用于图像配准的设备和方法包括使用距离测量法，基于地标歧管来计算第一变换，从距离测量和第一变换计算第二变换。通过应用第二个变换来实现注册图像。

6. 发明授权

US06408107B1 Rapid convolution based large deformation image matching via landmark and volume imagery 有权
标题翻译：通过地标和体积图像快速卷积的大型变形图像匹配
公开(公告)号：US06408107B1
公开(公告)日：2002-06-18
申请号：US09710844
申请日：2000-11-14
申请人： Michael I. Miller , Sarang C. Joshi , Gary E. Christensen
发明人： Michael I. Miller , Sarang C. Joshi , Gary E. Christensen
IPC分类号： G06K900
CPC分类号： G06T3/0081 , G06K9/6206 , G06T7/33 , G06T7/37 , G06T7/70 , G06T2207/30004
摘要： An apparatus and method for image registration of a template image with a target image with large deformation. The apparatus and method involve computing a large deformation transform based on landmark manifolds, image data or both. The apparatus and method are capable of registering images with a small number of landmark points. Registering the images is accomplished by applying the large deformation transform.
摘要翻译：一种用于具有大变形的目标图像的模板图像的图像配准的装置和方法。该装置和方法涉及基于地标歧管，图像数据或两者计算大变形变换。该装置和方法能够用少量地标点登记图像。通过应用大变形变换来实现图像的注册。

7. 发明申请

US20150015253A1 AUTOMATED IMAGE ANALYSIS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：自动图像分析用于磁共振成像
公开(公告)号：US20150015253A1
公开(公告)日：2015-01-15
申请号：US14248998
申请日：2014-04-09
申请人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
发明人： Susumu Mori , Michael I. Miller , Jiangyang Zhang , Kenichi Oishi
IPC分类号： G01R33/56
CPC分类号： G01R33/56 , G01R33/5608 , G01R33/56341 , G06T7/0012 , G06T7/11 , G06T7/30 , G06T2207/10088 , G06T2207/30016
摘要： A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.
摘要翻译：一种磁共振成像（MRI）系统，包括：磁共振成像扫描器，被配置为产生用于从观察对象形成软组织区域的至少一个磁共振图像的多个信号，其中所述至少一个磁共振图像提供至少一个积分特征以促进自动分割; 信号处理系统，与所述磁共振成像扫描器通信以接收所述多个信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元包含与所述软组织区域对应的至少一个模板，其中所述信号处理系统适于处理从所述磁共振成像扫描器接收的所述多个信号通过利用所述至少一个模板和所述至少一个积分特征来自动执行观察对象的软组织区域的分割。

8. 发明授权

US08838201B2 Atlas-based analysis for image-based anatomic and functional data of organism 有权
标题翻译：基于图像的生物体解剖学和功能数据分析
公开(公告)号：US08838201B2
公开(公告)日：2014-09-16
申请号：US13703859
申请日：2011-06-22
申请人： Susumu Mori , Andreia V. Faria , Michael I. Miller , Kenichi Oishi
发明人： Susumu Mori , Andreia V. Faria , Michael I. Miller , Kenichi Oishi
IPC分类号： A61B5/05 , G06T7/00 , A61B6/00 , A61B5/055 , G06K9/20 , G01R33/56 , A61B6/03
CPC分类号： G06K9/2054 , A61B5/055 , A61B6/03 , A61B6/5217 , G01R33/5608 , G06T7/11 , G06T7/149 , G06T2207/10072 , G06T2207/20128 , G06T2207/30016
摘要： A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one anatomical substructure and more than one constituent tissue type; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit is configured to store a parcellation atlas comprising spatial information of the at least one substructure in the tissue region, wherein the signal processing system is adapted to: reconstruct an image of the tissue region based on the imaging signal; parcellate, based on the parcellation atlas, the at least one anatomical substructure in the image; segment the more than one constituent tissue types in the image; and automatically identify, in the image, a portion of the at least one anatomical substructure that correspond to one of the more than one constituent tissue type.
摘要翻译：一种非侵入性成像系统，包括适于从观察对象的组织区域产生成像信号的成像扫描器，所述组织区域具有至少一个解剖学亚结构和多于一种构成组织类型; 与成像扫描仪通信的信号处理系统，以从成像扫描仪接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元被配置为存储包括所述组织区域中的所述至少一个子结构的空间信息的分割图集，其中所述信号处理系统适于：重构基于成像信号的组织区域的图像; 基于分割图谱分析图像中的至少一个解剖学亚结构; 在图像中分割多个组成组织类型; 并且在所述图像中自动识别所述至少一个解剖学亚结构的对应于多于一种构成组织类型之一的部分。

9. 发明申请

US20140181754A1 SYSTEM FOR A THREE-DIMENSIONAL INTERFACE AND DATABASE 审中-公开
标题翻译：三维接口和数据库系统
公开(公告)号：US20140181754A1
公开(公告)日：2014-06-26
申请号：US14129552
申请日：2012-06-28
申请人： Susumu Mori , Michael I. Miller
发明人： Susumu Mori , Michael I. Miller
IPC分类号： G06F3/0484 , G06F3/0481
CPC分类号： G06F3/04842 , G06F3/04815 , G06F16/444 , G06F16/48 , G06T19/00 , G06T2210/41 , G16H50/50
摘要： An embodiment in accordance with the present invention provides a system and method for a three-dimensional interface for interacting with a database. The three-dimensional interface can include an interactive three-dimensional atlas depicting an element of anatomy, machine, device, or other object. Given the three-dimensional nature of the atlas, a user can zoom in on particular areas to view them with more specificity. Different structural points of the anatomy are labeled with names or coordinates, such that the user can select one of the structural points and search a database for information related to that specific structural point. The user can also use specific keywords to search with respect to the specific structural point selected. The three-dimensional interface and atlas are displayed to the user on a computing device that can either house the database within its memory or alternately communicate with the database over a network.
摘要翻译：根据本发明的实施例提供了一种用于与数据库进行交互的三维界面的系统和方法。三维界面可以包括描绘解剖结构，机器，装置或其他对象的元件的交互式三维图集。鉴于地图集的三维性质，用户可以放大特定区域以更具体地查看它们。解剖结构的不同结构点用名称或坐标标记，使得用户可以选择结构点之一并搜索数据库以获得与该特定结构点相关的信息。用户还可以使用特定关键词来搜索所选择的特定结构点。三维界面和图集在计算设备上显示给用户，该计算设备可以将数据库存储在其存储器内，或者通过网络交替地与数据库通信。

10. 发明申请

US20130223716A1 IMAGE SEARCH ENGINE 有权
标题翻译：图像搜索引擎
公开(公告)号：US20130223716A1
公开(公告)日：2013-08-29
申请号：US13824853
申请日：2011-10-25
申请人： Susumu Mori , Michael I. Miller , Kenichi Oishi , Andreia V. Faria
发明人： Susumu Mori , Michael I. Miller , Kenichi Oishi , Andreia V. Faria
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , A61B5/0013 , A61B5/055 , A61B6/032 , A61B6/501 , A61B6/56 , A61B8/56 , A61B8/565 , G06F17/30247 , G06F19/00 , G06F19/321 , G16H50/70
摘要： An embodiment of the current invention includes a non-invasive imaging system, comprising: an imaging scanner suitable to generate an image representing a tissue region of a subject under observation, the tissue region having at least one substructure and the image comprising a plurality of image voxels; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit is configured to store: an atlas comprising spatial information of the at least one substructure in the tissue region, and a database comprising a plurality of pre-stored medical images representing the tissue region, and wherein the signal processing system is adapted to: identify, based on the atlas and for each of the at least one substructure, a corresponding portion of image voxels in the image; provide a computed quantification of the corresponding portion of image voxels for each of the at least one substructure of the tissue region by performing spatial filtering on the image; and search the database to provide at least one selected medical image from the plurality of pre-stored medical images, the at least one selected medical image having a corresponding quantification that is substantially similar to the computed quantification.
摘要翻译：本发明的一个实施例包括一种非侵入性成像系统，包括：成像扫描仪，其适于产生表示观察对象的组织区域的图像，所述组织区域具有至少一个子结构，并且所述图像包括多个图像体素与成像扫描仪通信的信号处理系统，以从成像扫描仪接收成像信号; 以及与所述信号处理系统通信的数据存储单元，其中所述数据存储单元被配置为存储：包括所述组织区域中的所述至少一个子结构的空间信息的图集，以及包括多个预先存储的医疗表示组织区域的图像，并且其中所述信号处理系统适于：基于所述图集并且针对所述至少一个子结构中的每一个识别所述图像中的图像体素的相应部分; 通过对图像执行空间滤波来提供组织区域的至少一个子结构中的每一个的图像体素的相应部分的计算定量; 并且搜索所述数据库以从所述多个预先存储的医学图像中提供至少一个所选择的医学图像，所述至少一个所选择的医学图像具有与所计算的定量基本相似的相应量化。

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