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1. 发明授权

US08916187B2 Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same 有权
标题翻译：聚（酰胺）和聚（酯 - 酰胺）聚合物和药物递送颗粒和含有它们的涂层
公开(公告)号：US08916187B2
公开(公告)日：2014-12-23
申请号：US13221767
申请日：2011-08-30
申请人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
发明人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC分类号： A61F2/02 , A61L31/16 , C08G69/44 , C08G69/48 , A61L31/10 , C08L77/12
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
摘要翻译：本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。

2. 发明授权

US08765162B2 Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same 有权
公开(公告)号：US08765162B2
公开(公告)日：2014-07-01
申请号：US12165173
申请日：2008-06-30
申请人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
发明人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC分类号： A61F2/02
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.

3. 发明申请

US20110311596A1 POLY(AMIDE) AND POLY(ESTER-AMIDE) POLYMERS AND DRUG DELIVERY PARTICLES AND COATINGS CONTAINING SAME 有权
标题翻译：聚（酰胺）和聚（酰胺）聚合物和药物递送颗粒和包含它们的涂料
公开(公告)号：US20110311596A1
公开(公告)日：2011-12-22
申请号：US13221767
申请日：2011-08-30
申请人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
发明人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC分类号： A61K9/14 , A61K47/34 , A61K31/436 , A61K31/675 , B82Y5/00
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
摘要翻译：本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。

4. 发明申请

US20090324671A1 Poly(Amide) And Poly(Ester-Amide) Polymers And Drug Delivery Particles And Coatings Containing Same 有权
标题翻译：聚（酰胺）和聚（酯 - 酰胺）聚合物和药物递送颗粒和包含它们的涂料
公开(公告)号：US20090324671A1
公开(公告)日：2009-12-31
申请号：US12165173
申请日：2008-06-30
申请人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
发明人： Michael Huy Ngo , Mikael O. Trollsas , Thierry Glauser , Jinping Wan , Bozena Zofia Maslanka
IPC分类号： A61L27/54 , A61L27/34 , C08G69/02
CPC分类号： C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要： The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
摘要翻译：本发明涉及聚（酰胺）和聚（酯 - 酰胺）聚合物，包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。

5. 发明申请

US20080200377A1 POLYMER PARTICLES 审中-公开
标题翻译：聚合物颗粒
公开(公告)号：US20080200377A1
公开(公告)日：2008-08-21
申请号：US11676175
申请日：2007-02-16
申请人： Mikael O. Trollsas , Thierry Glauser , Michael Ngo , Jinping Wan
发明人： Mikael O. Trollsas , Thierry Glauser , Michael Ngo , Jinping Wan
IPC分类号： A61K47/48 , A61K47/30 , A61K48/00 , A61P35/00 , A61P29/00 , A61K38/17
CPC分类号： A61K9/0019 , A61K9/5031 , A61K47/34
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution comprising particles comprising a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid, wherein the activated diamine comprises a product of a diol and an amino acid. A method including combining a treatment agent and a polymeric product of at least one activated diamine and at least one activated dicarboxylic acid; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译：一种包含适于引入血管的溶液的组合物，其包含包含至少一种活化二胺和至少一种活化二羧酸的处理剂和聚合物的颗粒。一种包括将输送装置引入血管的方法; 并将溶液引入血管中，所述溶液包含包含至少一种活化二胺和至少一种活化二羧酸的处理剂和聚合物的颗粒，其中所述活化二胺包括二醇和氨基酸的产物。一种方法，包括将处理剂和至少一种活化二胺和至少一种活化的二羧酸的聚合物组合; 以及形成适于通过血管输送的组合颗粒。

6. 发明申请

US20100323019A1 Microparticles for the treatment of disease 审中-公开
标题翻译：微粒治疗疾病
公开(公告)号：US20100323019A1
公开(公告)日：2010-12-23
申请号：US12806790
申请日：2010-08-19
申请人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
发明人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
IPC分类号： A61K9/14 , A61K38/18 , A61K33/26 , A61K31/517 , A61K31/41 , A61K31/436 , A61P13/12 , A61P3/10
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031
摘要： Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
摘要翻译：公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。

7. 发明授权

US09119787B2 Microparticles for the treatment of disease 有权
标题翻译：微粒治疗疾病
公开(公告)号：US09119787B2
公开(公告)日：2015-09-01
申请号：US12806790
申请日：2010-08-19
申请人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
发明人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
IPC分类号： A61K9/16 , A61K9/50 , A61K9/00
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031
摘要： Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
摘要翻译：公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。

8. 发明申请

US20090297621A1 Microparticles For The Treatment Of Disease 审中-公开
标题翻译：微粒治疗疾病
公开(公告)号：US20090297621A1
公开(公告)日：2009-12-03
申请号：US12132562
申请日：2008-06-03
申请人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
发明人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
IPC分类号： A61K9/14 , A61K39/395 , A61K31/7048 , A61K31/517
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031
摘要： Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
摘要翻译：公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。

9. 发明授权

US09173890B2 Sustained release of Apo A-I mimetic peptides and methods of treatment 有权
标题翻译：持续释放Apo A-I模拟肽和治疗方法
公开(公告)号：US09173890B2
公开(公告)日：2015-11-03
申请号：US11946028
申请日：2007-11-27
申请人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
发明人： Katsuyuki Murase , Jinping Wan , John Stankus , Dariush Davalian , Florian Ludwig
IPC分类号： A61K38/00 , A61K31/661 , A61K9/14 , A61K38/10 , A61K38/17 , A61P3/00 , A61K9/00 , A61K9/127 , A61K9/16 , A61K9/51
CPC分类号： A61K31/661 , A61K9/0019 , A61K9/0024 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K38/17
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.
摘要翻译：一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质胆固醇运输。包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

10. 发明申请

US20090081299A1 SUSTAINED RELEASE OF APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
公开(公告)号：US20090081299A1
公开(公告)日：2009-03-26
申请号：US11946029
申请日：2007-11-27
申请人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
发明人： Syed F. A. Hossainy , Jinping Wan , Dariush Davalian , Florian Ludwig , Katsuyuki Murase
IPC分类号： A61K9/14 , A61K38/00 , A61K38/10 , A61P3/00 , A61K38/17 , A61K31/661
CPC分类号： A61K31/661 , A61K9/1647 , A61K9/5084 , A61K38/00
摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

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