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1. 发明授权

US08065180B2 System for clinical trial subject compliance 有权
标题翻译：临床试验系统符合标准
公开(公告)号：US08065180B2
公开(公告)日：2011-11-22
申请号：US09825533
申请日：2001-04-02
申请人： Michael Hufford , David Peterson , Jean A. Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean A. Paty , Saul Shiffman
IPC分类号： G06Q10/00
CPC分类号： G06F19/366 , G06F19/00 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明还可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

2. 发明授权

US08433605B2 System for clinical trial subject compliance 有权
公开(公告)号：US08433605B2
公开(公告)日：2013-04-30
申请号：US13399150
申请日：2012-02-17
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
IPC分类号： G06Q10/00
CPC分类号： G06F19/366 , G06F19/00 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.

3. 发明授权

US08145519B2 System for clinical trial subject compliance 有权
标题翻译：临床试验系统符合标准
公开(公告)号：US08145519B2
公开(公告)日：2012-03-27
申请号：US13211133
申请日：2011-08-16
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
IPC分类号： G06Q10/00
CPC分类号： G06F19/366 , G06F19/00 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明还可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

4. 发明申请

US20130006671A1 Clinical Monitoring Device With Time Shifting Capability 有权
标题翻译：具有时间移位能力的临床监测装置
公开(公告)号：US20130006671A1
公开(公告)日：2013-01-03
申请号：US13603035
申请日：2012-09-04
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
IPC分类号： G06Q50/24
CPC分类号： G06F19/36 , G06F19/00 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H40/63
摘要： The present invention is designed to develop research protocols for clinical trials. The invention can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

5. 发明申请

US20140108032A1 CLINICAL MONITORING DEVICE WITH TIME SHIFTING CAPABILITY 审中-公开
标题翻译：具有时间转移能力的临床监测装置
公开(公告)号：US20140108032A1
公开(公告)日：2014-04-17
申请号：US13953503
申请日：2013-07-29
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
IPC分类号： G06F19/00
CPC分类号： G06F19/36 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H40/63
摘要： The present invention is designed to develop research protocols for clinical trials. The invention can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

6. 发明申请

US20130268287A1 SYSTEM FOR CLINICAL TRIAL SUBJECT COMPLIANCE 审中-公开
标题翻译：临床试验依从性系统
公开(公告)号：US20130268287A1
公开(公告)日：2013-10-10
申请号：US13801853
申请日：2013-03-13
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
IPC分类号： G06F19/00
CPC分类号： G16H10/20 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明还可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

7. 发明授权

US08533029B2 Clinical monitoring device with time shifting capability 有权
标题翻译：具有时移能力的临床监测装置
公开(公告)号：US08533029B2
公开(公告)日：2013-09-10
申请号：US13603035
申请日：2012-09-04
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman , Jonathan McClelland , Kevin Dennis O'Keefe
IPC分类号： G06Q10/00
CPC分类号： G06F19/36 , G06F19/00 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H40/63
摘要： The present invention is designed to develop research protocols for clinical trials. The invention can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

8. 发明申请

US20120239414A1 System for Clinical Trial Subject Compliance 有权
公开(公告)号：US20120239414A1
公开(公告)日：2012-09-20
申请号：US13399150
申请日：2012-02-17
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
IPC分类号： G06Q50/22
CPC分类号： G06F19/366 , G06F19/00 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.

9. 发明申请

US20120029940A1 System for Clinical Trial Subject Compliance 有权
标题翻译：临床试验标准制度
公开(公告)号：US20120029940A1
公开(公告)日：2012-02-02
申请号：US13211133
申请日：2011-08-16
申请人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
发明人： Michael Hufford , David Peterson , Jean Paty , Saul Shiffman
IPC分类号： G06Q50/00
CPC分类号： G06F19/366 , G06F19/00 , G06F19/325 , G06Q10/0639 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/40 , G16H50/20
摘要： The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol. The invention further provides evaluability data related to subject performance in the clinical trial. According to an alternative embodiment of the invention, a portable electronic device is used to query and collect data from the subject.
摘要翻译：本发明旨在开发用于临床试验的研究方案。本发明还可以跟踪和增强主体符合研究协议。本发明还提供了与临床试验中的受试者表现相关的可评估性数据。根据本发明的替代实施例，使用便携式电子设备来查询和收集来自对象的数据。

10. 发明授权

US07415447B2 Apparatus and method for prediction and management of participant compliance in clinical research 有权
标题翻译：临床研究参与者依从性预测与管理的装置及方法
公开(公告)号：US07415447B2
公开(公告)日：2008-08-19
申请号：US11324504
申请日：2006-01-03
申请人： Saul Shiffman , Michael R. Hufford , Jean A. Paty
发明人： Saul Shiffman , Michael R. Hufford , Jean A. Paty
IPC分类号： G06F17/00 , G06N5/00 , G06N5/02
CPC分类号： G06Q90/00 , G06F19/00 , G06Q10/04 , G16H10/20 , G16H40/20
摘要： A system for developing and implementing empirically derived algorithms to generate decision rules to determine participant noncompliance and fraud with research protocols in clinical trials allows for the identification of complex patterns of variables that detect or predict participant noncompliance and fraud with research protocol, including performance and enrollment goals, in the clinical trial. The data may be used to overall predict the performance of any participant in a clinical trial, allowing selection of participants that tend to produce useful, high-quality results. The present invention can also be used to monitor participant compliance with the research protocol and goals to determine preferred actions to be performed. Optionally, the invention may provide a spectrum of noncompliance, from minor noncompliance needing only corrective feedback, to significant noncompliance requiring participant removal from the clinical trial or from future clinical trials. The algorithms and decision rules can also be domain-specific, such as detecting non-compliance or fraud among subjects in a cardiovascular drug trial, or demographically specific, such as taking into account gender, age or location, which provides for algorithms and decision rules to be optimized for the specific sample of participants being studied.
摘要翻译：用于开发和实施经验派生算法以生成决策规则以确定临床试验中的研究协议的参与者违规和欺诈的系统允许通过研究方案来识别检测或预测参与者违规和欺诈的复杂变量模式，包括绩效和注册目标，在临床试验。数据可用于总体预测临床试验中任何参与者的表现，允许选择倾向于产生有用的高质量结果的参与者。本发明还可以用于监视参与者遵守研究协议和目标以确定要执行的优选动作。任选地，本发明可以从仅需要纠正反馈的轻微不合规性到要求参与者从临床试验或未来临床试验中移除的重大不合规提供一系列不合规。算法和决策规则也可以是域特定的，例如在心血管药物试验中检测受试者的不合规或欺诈，或人口统计特异性，例如考虑性别，年龄或位置，其提供算法和决策规则针对正在研究的参与者的具体样本进行优化。

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