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1. 发明申请

US20080096844A1 Novel inhibitors of chymase 有权
标题翻译：糜酶的新型抑制剂
公开(公告)号：US20080096844A1
公开(公告)日：2008-04-24
申请号：US11975235
申请日：2007-10-18
申请人： Michael Greco , Michael Hawkins , Lawrence De Garavilla , Eugene Powell , Bruce Maryanoff
发明人： Michael Greco , Michael Hawkins , Lawrence De Garavilla , Eugene Powell , Bruce Maryanoff
IPC分类号： A61K31/665 , A61P11/00 , C07F9/02
CPC分类号： C07F9/65517
摘要： The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders.
摘要翻译：本发明涉及式（I）的化合物或其对映体，非对映异构体，多晶型物或其药学上可接受的盐以及制备所述化合物及其组合物，中间体及其衍生物的方法，以及用于治疗炎性或丝氨酸蛋白酶介导的病症的方法。

2. 发明申请

US20050176769A1 Novel inhibitors of chymase 有权
标题翻译：糜酶的新型抑制剂
公开(公告)号：US20050176769A1
公开(公告)日：2005-08-11
申请号：US11037938
申请日：2005-01-18
申请人： Michael Hawkins , Michael Greco , Eugene Powell , Lawrence de Garavilla , Bruce Maryanoff
发明人： Michael Hawkins , Michael Greco , Eugene Powell , Lawrence de Garavilla , Bruce Maryanoff
IPC分类号： A61K31/165 , A61K31/381 , A61K31/4436 , A61K31/453 , A61K31/662 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/655 , C07F9/6553 , C07F9/6558 , C07F9/6561 , C07F9/6571 , C07D49/02
CPC分类号： C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译：本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。

3. 发明授权

US07872044B2 Inhibitors of chymase 有权
标题翻译：胃促胰酶抑制剂
公开(公告)号：US07872044B2
公开(公告)日：2011-01-18
申请号：US11975235
申请日：2007-10-18
申请人： Michael Greco , Michael Hawkins , Eugene Powell , Bruce E. Maryanoff
发明人： Michael Greco , Michael Hawkins , Eugene Powell , Bruce E. Maryanoff
IPC分类号： A61K31/343 , C07D307/87 , C07F9/28
CPC分类号： C07F9/65517
摘要： The present invention is directed to a compound of Formula (I): or an enantiomer, diastereomer, polymorph or pharmaceutically acceptable salt thereof and methods for preparing said compounds and compositions, intermediates and derivatives thereof, and methods for treating inflammatory or serine protease mediated disorders.
摘要翻译：本发明涉及式（I）的化合物或其对映体，非对映异构体，多晶型物或其药学上可接受的盐以及制备所述化合物及其组合物，中间体及其衍生物的方法，以及用于治疗炎性或丝氨酸蛋白酶介导的病症的方法。

4. 发明申请

US20120302641A1 BIPHENYL DERIVATIVES USEFUL AS GLUCAGON RECEPTOR ANTAGONISTS 有权
标题翻译：二苯乙烯衍生物作为GLUCAGON受体拮抗剂有用
公开(公告)号：US20120302641A1
公开(公告)日：2012-11-29
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/197 , A61P13/12 , A61P3/04 , C07C237/36 , A61P3/10
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

5. 发明申请

US20210078139A1 Locking Pliers with Modular Tool Insert 有权
公开(公告)号：US20210078139A1
公开(公告)日：2021-03-18
申请号：US16574040
申请日：2019-09-17
申请人： Michael Greco
发明人： Michael Greco
IPC分类号： B25B7/22 , B25B7/12 , B25B7/02
摘要： This invention is a set of locking pliers which includes a modular locking system to allow for tool inserts to be secured between the jaws of the pliers.

6. 发明申请

US20160157973A1 APPARATUS FOR INTEGRATED TOOTHBRUSH AND FLOSS 审中-公开
标题翻译：一体化牙刷和血管的装置
公开(公告)号：US20160157973A1
公开(公告)日：2016-06-09
申请号：US14563321
申请日：2014-12-08
申请人： Michael Greco
发明人： Michael Greco
IPC分类号： A61C15/04 , A46B15/00
CPC分类号： A61C15/048 , A46B15/0073 , A46B2200/1066
摘要： An integrated apparatus includes a toothbrush having a first end and a second end. Between the first and the second end of the toothbrush includes a head, a middle body and a lower body; the head being towards the first end, the lower body towards the second end. The middle body placed between the head and the lower body providing grip area for the apparatus. A plurality of bristles placed above the head of the toothbrush towards the first end. The lower body further includes a contour section, and a floss receptacle section. A floss assembly includes of a floss body and a floss, the floss assembly configured to attach to the floss receptacle section of the toothbrush. The contour section has an upper edge and a lower edge.
摘要翻译：一种集成的装置包括具有第一端和第二端的牙刷。在牙刷的第一端和第二端之间包括头部，中部本体和下部本体; 头部朝向第一端，下体朝向第二端。放置在头部和下部本体之间的中间体为设备提供抓握区域。多个刷毛放置在牙刷的头部上方朝向第一端。下体还包括轮廓部分和牙线容器部分。牙线组件包括牙线体和牙线，所述牙线组件构造成附接到牙刷的牙线容器部分。轮廓部分具有上边缘和下边缘。

7. 发明授权

US11292106B2 Locking pliers with modular tool insert 有权
公开(公告)号：US11292106B2
公开(公告)日：2022-04-05
申请号：US16574040
申请日：2019-09-17
申请人： Michael Greco
发明人： Michael Greco
IPC分类号： B25B7/22 , B25B7/02 , B25B7/12 , B26B5/00 , B26B11/00
摘要： This invention is a set of locking pliers which includes a modular locking system to allow for tool inserts to be secured between the jaws of the pliers.

8. 发明授权

US09045389B2 Biphenyl derivatives useful as glucagon receptor antagonists 有权
标题翻译：可用作胰高血糖素受体拮抗剂的联苯衍生物
公开(公告)号：US09045389B2
公开(公告)日：2015-06-02
申请号：US13478568
申请日：2012-05-23
申请人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
发明人： Devraj Chakravarty , Michael Greco , Brian Shook , Guozhang Xu , Rui Zhang
IPC分类号： A61K31/166 , C07C229/52 , C07C237/36
CPC分类号： C07C237/36
摘要： The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.
摘要翻译：本发明涉及联苯衍生物，含有它们的药物组合物及其在治疗和/或预防通过拮抗一种或多种胰高血糖素受体，包括例如代谢性疾病如II型糖尿病和肥胖症而改善的病症和病症中的用途。

9. 发明授权

US08474458B1 Ergonomic chin support for medical headgear 失效
标题翻译：符合人体工程学的下巴支持医疗头饰
公开(公告)号：US08474458B1
公开(公告)日：2013-07-02
申请号：US12589855
申请日：2009-10-29
申请人： Mitchell W. Yadven , Michael Greco
发明人： Mitchell W. Yadven , Michael Greco
IPC分类号： A61M11/00
CPC分类号： A61M16/0694 , A61M16/0605 , A61M16/0683
摘要： An ergonomic chin support is designed for use in combination with medical headgear. The headgear has flexible straps adapted for locating a ventilation interface on a patient. The ergonomic chin support comprises a generally arcuate and substantially rigid chin cradle. First and second substantially rigid extensions are formed at opposite ends of the chin cradle, and are adapted for being pulled by respective straps of the headgear to urge the chin cradle against the mandible of the patient. Retaining posts are provided for retaining the ergonomic chin support at a fixed location along respective lengths of the straps.
摘要翻译：符合人体工程学的下巴支撑设计用于与医疗头带组合使用。头带具有适于在患者身上定位通气界面的柔性带。符合人体工程学的下巴支撑件包括大致弓形且基本上刚性的下巴支架。第一和第二基本上刚性的延伸部形成在下巴支架的相对端处，并且适于被头带的相应带拉动，以将下巴托架推压抵靠患者的下颌骨。提供保持柱用于沿着带的相应长度将固定位置保持在人体工程学的下巴支撑上。

10. 发明授权

US5842467A Metered dose inhaler and ambulatory manual breathing unit combination 失效
标题翻译：计量吸入器和手动呼吸单元组合
公开(公告)号：US5842467A
公开(公告)日：1998-12-01
申请号：US665942
申请日：1996-06-19
申请人： Michael Greco
发明人： Michael Greco
IPC分类号： A61M15/00 , A61M16/00 , A61M11/00 , A62B9/02
CPC分类号： A61M16/0078 , A61M15/0088 , A61M15/0086 , A61M15/009
摘要： The use of a large ambulatory manual breathing unit in combination with a metered dose medication inhaler for delivering medication to a patient, who is either breathing spontaneously or non-spontaneously. The large bag or reservoir of the breathing unit is used to insure minimization of size and homogeneous disbursement of the particles of medication. For non-spontaneous patient breathing, the reservoir's contents are disbursed into the patient by manually or mechanically squeezing the bag, after which the bag returns to its original shape and volume. At one or the other end of the bag, a typical metered dose inhalator is mounted in a manner to disburse the medication into the bag, and directly in line therewith, through an adaptor. The metered dose inhaler collar, into which the inhaler fits, when the inhaler is not in use, is capped.
摘要翻译：使用大型手动呼吸单元与计量剂量药物吸入器结合，用于向患者自发或非自发呼吸的患者输送药物。呼吸单元的大袋或储存器用于确保药物颗粒的尺寸和均匀支付的最小化。对于非自发的患者呼吸，通过手动或机械挤压袋子将储存器的内容物分发到患者中，之后袋返回其原始形状和体积。在袋的一个或另一端，典型的计量剂量吸入器以将药物分发到袋中并且直接与其直接通过适配器的方式安装。当吸入器不使用时，吸入器配合的计量吸入器套管被盖住。

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