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1. 发明申请

US20100169990A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20100169990A1
公开(公告)日：2010-07-01
申请号：US12650873
申请日：2009-12-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Grace Chen , Mark Prince
IPC分类号： A01K67/00 , C12N5/00
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

2. 发明授权

US07723112B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US07723112B2
公开(公告)日：2010-05-25
申请号：US11591019
申请日：2006-10-31
申请人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
发明人： Michael F. Clarke , Tim Hoey , Xinhao Wang , Scott Dylla , Austin Gurney , Piero Dalerba , Mark Prince , Grace Chen
IPC分类号： G01N33/53
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

3. 发明授权

US07939263B2 Compositions and methods for treating and diagnosing cancer 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US07939263B2
公开(公告)日：2011-05-10
申请号：US12512655
申请日：2009-07-30
申请人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
发明人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
IPC分类号： C12Q1/68
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译：本发明涉及用于治疗，表征和诊断癌症的组合物和方法。特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。

4. 发明申请

US20110183866A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20110183866A1
公开(公告)日：2011-07-28
申请号：US13077380
申请日：2011-03-31
申请人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
发明人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译：本发明涉及用于治疗，表征和诊断癌症的组合物和方法。特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。

5. 发明申请

US20100093556A1 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 有权
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：US20100093556A1
公开(公告)日：2010-04-15
申请号：US12512655
申请日：2009-07-30
申请人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
发明人： Michael F. Clarke , Xinhao Wang , John A. Lewicki , Austin L. Gurney
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： G01N33/6887 , C12N5/0693 , C12N5/0695 , C12N2501/58 , C12Q1/6886 , G01N33/57484 , G01N2333/705
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
摘要翻译：本发明涉及用于治疗，表征和诊断癌症的组合物和方法。特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱和特征，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌标记。更具体地，本发明鉴定了可用于癌症和癌症转移的诊断，表征和治疗的癌症干细胞的两个概况。本发明还提供用于诊断和治疗癌症的多种试剂如干细胞基因特征。

6. 发明授权

US08148147B2 Compositions and methods for treating and diagnosing pancreatic cancer 有权
标题翻译：用于治疗和诊断胰腺癌的组合物和方法
公开(公告)号：US08148147B2
公开(公告)日：2012-04-03
申请号：US12019339
申请日：2008-01-24
申请人： Diane M. Simeone , Michael F. Clarke
发明人： Diane M. Simeone , Michael F. Clarke
IPC分类号： C12N5/071 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0695 , A01K2267/0331
摘要： The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.
摘要翻译：本发明涉及肿瘤学领域，并提供用于诊断和治疗胰腺癌的新型组合物和方法。特别地，本发明提供了可用于实体瘤的研究，诊断和治疗的胰腺癌干细胞。

7. 发明申请

US20120027685A1 DETERMINING THE CAPABILITY OF A TEST COMPOUND TO AFFECT SOLID TUMOR STEM CELLS 有权
标题翻译：测定化合物对固体肿瘤干细胞的影响的能力
公开(公告)号：US20120027685A1
公开(公告)日：2012-02-02
申请号：US13241701
申请日：2011-09-23
申请人： Michael F. Clarke , Scott J. Dylla , Sanjeev Satyal
发明人： Michael F. Clarke , Scott J. Dylla , Sanjeev Satyal
IPC分类号： A61K49/00
CPC分类号： G01N33/5011 , A01K67/0271 , A61K2039/505 , A61K2039/5152 , A61K2039/5158 , B82Y30/00 , C12N5/0695 , C12N2501/42 , C12N2503/00 , C12N2503/02 , G01N33/5088 , G01N33/57492
摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.
摘要翻译：建立的实体瘤内的一小部分细胞具有干细胞的特性。这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力的细胞和产生新肿瘤的能力。因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤细胞从原发性肿瘤建立肿瘤。这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

8. 发明申请

US20100255471A1 Single cell gene expression for diagnosis, prognosis and identification of drug targets 有权
标题翻译：单细胞基因表达用于诊断，预后和鉴定药物靶标
公开(公告)号：US20100255471A1
公开(公告)日：2010-10-07
申请号：US12657457
申请日：2010-01-20
申请人： Michael F. Clarke , Stephen R. Quake , Piero D. Dalerba , Huiping Liu , Anne Leyrat , Tomer Kalisky , Maximilian Diehn
发明人： Michael F. Clarke , Stephen R. Quake , Piero D. Dalerba , Huiping Liu , Anne Leyrat , Tomer Kalisky , Maximilian Diehn
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/5023 , G01N33/57484 , G01N2800/52
摘要： Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and/or pathways in disease-state cells.
摘要翻译：通过分析从单细胞分析获得的一组基因的表达，为疾病的诊断和预后提供方法。分类允许优化治疗，确定是否进行特定治疗，以及如何优化剂量，治疗选择等。单细胞分析还提供了鉴定和开发针对疾病状态细胞中的突变和/或途径的疗法。

9. 发明申请

US20080194022A1 Isolation and use of solid tumor stem cells 审中-公开
标题翻译：实体肿瘤干细胞的分离和使用
公开(公告)号：US20080194022A1
公开(公告)日：2008-08-14
申请号：US11788489
申请日：2007-04-20
申请人： Michael F. Clarke , Sean J. Morrison , Max S. Wicha , Muhammad Al-Hajj
发明人： Michael F. Clarke , Sean J. Morrison , Max S. Wicha , Muhammad Al-Hajj
IPC分类号： C12N5/06
CPC分类号： C12N5/0693 , C12N5/0695 , C12N2503/00 , G01N33/5011 , G01N33/57492
摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumors in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells.We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.
摘要翻译：建立的实体瘤内的一小部分细胞具有干细胞的特性。这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力的细胞和产生新肿瘤的能力。因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤从原发肿瘤中建立肿瘤。这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

10. 发明申请

US20080178305A1 Isolation And Use Of Solid Tumor Stem Cells 有权
标题翻译：实体肿瘤干细胞的分离和使用
公开(公告)号：US20080178305A1
公开(公告)日：2008-07-24
申请号：US11776935
申请日：2007-07-12
申请人： Michael F. Clarke , Scott J. Dylla , Sanjeev Satyal
发明人： Michael F. Clarke , Scott J. Dylla , Sanjeev Satyal
IPC分类号： A01K67/027 , C12Q1/02 , G01N33/574
CPC分类号： G01N33/5011 , A01K67/0271 , A61K2039/505 , A61K2039/5152 , A61K2039/5158 , B82Y30/00 , C12N5/0695 , C12N2501/42 , C12N2503/00 , C12N2503/02 , G01N33/5088 , G01N33/57492
摘要： A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.
摘要翻译：建立的实体瘤内的一小部分细胞具有干细胞的特性。这些实体肿瘤干细胞产生更多的肿瘤干细胞和肿瘤中大部分已经失去广泛增殖能力的细胞和产生新肿瘤的能力。因此，实体肿瘤异质性反映了由固体肿瘤干细胞产生的肿瘤细胞后代的存在。我们已经开发了异种移植模型，其中我们已经能够通过在严重免疫缺陷小鼠的乳腺中注射肿瘤细胞从原发性肿瘤建立肿瘤。这些异种移植物测定使我们能够进行生物学和分子测定来表征克隆型实体瘤干细胞。我们还发现证据强烈地暗示Notch途径，特别是Notch 4，作为致癌过程的中心途径。

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