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1. 外观设计

USD643506S1 Water treatment system 有权
标题翻译：水处理系统
公开(公告)号：USD643506S1
公开(公告)日：2011-08-16
申请号：US29365272
申请日：2010-07-07
申请人： Michael E. Miles , Terry L. Lautzenheiser , Karlis Vecziedins , Karen J. Vanderkooi , David Fry
设计人： Michael E. Miles , Terry L. Lautzenheiser , Karlis Vecziedins , Karen J. Vanderkooi , David Fry

2. 发明申请

US20070135351A1 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof 失效
标题翻译：神经肽-2受体（Y-2R）激动剂及其用途
公开(公告)号：US20070135351A1
公开(公告)日：2007-06-14
申请号：US11607230
申请日：2006-12-01
申请人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Fry , Wajiha Khan , Anish Konkar , Cristina Rondinone , Joseph Swistok , Rebecca Taub , Jefferson Tilley
发明人： Karin Conde-Knape , Waleed Danho , George Ehrlich , Nader Fotouhi , David Fry , Wajiha Khan , Anish Konkar , Cristina Rondinone , Joseph Swistok , Rebecca Taub , Jefferson Tilley
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/57545 , A61K38/00 , A61K47/60
摘要： Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
摘要翻译：本文提供了式（I）的神经肽-2受体激动剂：以及其药学上可接受的盐，衍生物和片段，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗疾病，例如肥胖症和糖尿病。

3. 发明申请

US20060190582A1 Maintaining building serviceability information for geographic locations 审中-公开
标题翻译：维护地理位置的建筑物可用性信息
公开(公告)号：US20060190582A1
公开(公告)日：2006-08-24
申请号：US11283439
申请日：2005-11-18
申请人： David Fry , William Prescott
发明人： David Fry , William Prescott
IPC分类号： G06F15/173
CPC分类号： G06Q10/00 , H04L67/18
摘要： Systems and methods are disclosed for maintaining building serviceability information for geographic locations. The disclosed systems and methods may include receiving a request for communication services information for a geographic location, wherein a user enters location information specific to the geographic location into a communications service management system. Furthermore, the disclosed systems and methods may include receiving medium information about the geographic location from the communications service management system and determining which communications services are currently provided to the geographic location. Moreover, the disclosed systems and methods may include displaying the communications services that are currently provided to the geographic location to the user.
摘要翻译：公开了用于维护地理位置的建筑物可使用性信息的系统和方法。所公开的系统和方法可以包括接收对于地理位置的通信服务信息的请求，其中用户将特定于地理位置的位置信息输入到通信服务管理系统中。此外，所公开的系统和方法可以包括从通信服务管理系统接收关于地理位置的介质信息，并确定当前提供给地理位置的通信服务。此外，所公开的系统和方法可以包括将当前提供给地理位置的通信服务显示给用户。

4. 发明授权

US5749096A Helmet with high performance head and face protection utilizing complementary materials 失效
标题翻译：头盔采用高性能的头部和脸部保护，利用补充材料
公开(公告)号：US5749096A
公开(公告)日：1998-05-12
申请号：US270633
申请日：1994-07-01
申请人： Jeffrey K. Fergason , David Fry , Stephen M. Brunnell
发明人： Jeffrey K. Fergason , David Fry , Stephen M. Brunnell
IPC分类号： A61F9/06 , B29C65/70 , A42B3/00
CPC分类号： B29C65/70 , A61F9/06 , A61F9/061 , A61F9/067 , B29C66/71 , B29C66/7212 , B29C66/7394
摘要： A structure formed of a composite material and a support material, the support material being integrally coupled to the composite material by an insert molding process to form an integral structure, and protective head gear, such as a welding helmet, welding shield, hard hat, etc. using such structure. A method for making a structure using sheet-like composite material includes adhering to the composite material a relatively rigid support member or frame by insert molding directly to the composite material.
摘要翻译：由复合材料和支撑材料形成的结构，所述支撑材料通过嵌件模制工艺整体地联接到所述复合材料以形成整体结构，以及保护性头盔，例如焊接头盔，焊接护罩，硬帽，使用这种结构。使用片状复合材料制造结构的方法包括通过直接将复合材料嵌入成型将复合材料粘附到相对刚性的支撑构件或框架上。

5. 发明授权

US5073222A Method of adhering holograms to textile wearing apparel 失效
标题翻译：将全息图粘贴到纺织品服装上的方法
公开(公告)号：US5073222A
公开(公告)日：1991-12-17
申请号：US543093
申请日：1990-06-25
申请人： David Fry
发明人： David Fry
IPC分类号： D06Q1/00 , G03C11/14
CPC分类号： D06Q1/00 , G03C11/14 , Y10T156/108 , Y10T428/24868
摘要： A method of adhering articles to textile wearing apparel involving the steps of laminating a precut article having an upper surface and a lower surface between a clear polyester coating and an adhesive scrim backing to envelope the article and protect it from moisture and scuffing, cutting margins away from the laminated article to form an enveloped article, and applying the enveloped article to wearing apparel at a temperature of approximately 270.degree. F. to 300.degree. F., under a pressure of approximately 30 psi to 50 psi for a period of approximately 8 seconds to 15 seconds. The article becomes firmly adhered to the wearing apparel and remains impervious to moisture after repeated machine washing and drying cycles.
摘要翻译：一种将制品粘附到纺织品服装上的方法，包括以下步骤：将具有上表面和下表面的预切割物品层压在透明聚酯涂层和粘合剂稀松布背衬之间以包封物品并保护其免受潮湿和磨损，切割边缘从层压制品中形成包封的制品，并在大约30psi至50psi的压力下在约270°F至300°F的温度下将包封的物品施加到服装上约8秒的时间至15秒。该物品在重复的机器洗涤和干燥循环后变得牢固地粘附在服装上并且保持不透湿。

6. 发明授权

US06455534B2 Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family 失效
标题翻译：能够抑制表皮生长因子受体家族酪氨酸激酶的双环化合物
公开(公告)号：US06455534B2
公开(公告)日：2002-09-24
申请号：US09824606
申请日：2001-04-02
申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
发明人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
IPC分类号： A61K31519
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D495/04
摘要： Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where: one of A or E is nitrogen, with remaining atoms carbon; X=O, S, NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.
摘要翻译：通过用有效抑制量治疗有需要的哺乳动物，描述了化合物和抑制表皮生长因子受体酪氨酸激酶的方法，其中：A或E中的一个是氮，其余的原子碳 ; X = O，S，NH或NR7，使得R7 =低级烷基（1-4个碳原子），OH，NH2，低级烷氧基（1-4个碳原子）或低级单烷基氨基（1-4个碳原子）。其他术语在说明书中描述。

7. 发明授权

US06265410B1 Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family 失效
标题翻译：能够抑制表皮生长因子受体家族酪氨酸激酶的双环化合物
公开(公告)号：US06265410B1
公开(公告)日：2001-07-24
申请号：US09191163
申请日：1998-11-13
申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
发明人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
IPC分类号： A61K31519
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D495/04
摘要： Described are compositions and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where: any two continguous positions in positions A-E taken together can be a single heteroatom selected from the group consisting of nitrogen, oxygen or sulfur, in which case the other two remaining atoms must be carbon; the remaining substituents are disclosed in the specification
摘要翻译：描述了通过以有效抑制量治疗需要其的哺乳动物治疗式II化合物来抑制表皮生长因子受体酪氨酸激酶的组合物和方法：其中：一起位置AE中的任何两个相对位置可以是选自氮，氧或硫的单个杂原子，其中另外两个剩余的原子必须是碳; 剩余的取代基在说明书中公开

8. 发明授权

US6084095A Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family 失效
标题翻译：能够抑制表皮生长因子受体家族酪氨酸激酶的取代的吡啶并[3,2-d]嘧啶
公开(公告)号：US6084095A
公开(公告)日：2000-07-04
申请号：US811797
申请日：1997-03-06
申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
发明人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson
IPC分类号： C07D487/04 , A61K31/495 , A61K31/4985 , A61K31/505 , A61K31/519 , A61K31/525 , A61P1/00 , A61P13/02 , A61P15/00 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/00 , C07D471/04 , C07D471/14 , C07D473/34 , C07D487/02 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D495/04
摘要： Novel 4-substituted amino pyrido [3,2-d]pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.
摘要翻译：本发明描述了新型的4-取代氨基吡啶并[3,2-d]嘧啶抑制剂，其酪氨酸激酶表皮生长因子受体家族及其药物组合物可用于治疗增殖性疾病如癌症，滑膜血管us入侵在关节炎，牛皮癣，血管再狭窄和血管发生中，另外可用于治疗胰腺炎和肾脏疾病以及避孕药。

9. 发明授权

US06596726B1 Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family 失效
标题翻译：能抑制表皮生长因子受体家族酪氨酸激酶的三环化合物
公开(公告)号：US06596726B1
公开(公告)日：2003-07-22
申请号：US08811803
申请日：1997-03-06
申请人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson , Howard Daniel Hollis Showalter
发明人： Alexander James Bridges , William Alexander Denny , David Fry , Alan Kraker , Robert Frederick Meyer , Gordon William Rewcastle , Andrew Mark Thompson , Howard Daniel Hollis Showalter
IPC分类号： A61K31505
CPC分类号： C07D471/04 , C07D239/70 , C07D471/14 , C07D473/34 , C07D487/04 , C07D491/04 , C07D491/14 , C07D495/04 , C07D513/04 , C07D513/14
摘要： Described are compounds of the following formula and a method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of the formula: wherein the formula terms are described in the specification and wherein the members in the aforementioned structure are defined in the specification.
摘要翻译：描述了下式的化合物和抑制表皮生长因子的方法：通过以有效抑制量治疗有需要的哺乳动物，下式的化合物：其中式术语在说明书中描述，其中成员上述结构在说明书中定义。

10. 发明授权

US4956040A Method of adhering holograms to textile wearing apparel 失效
标题翻译：将全息图粘贴到纺织品服装上的方法
公开(公告)号：US4956040A
公开(公告)日：1990-09-11
申请号：US214396
申请日：1988-07-01
申请人： David Fry
发明人： David Fry
IPC分类号： D06Q1/00 , G03C11/14
CPC分类号： D06Q1/00 , G03C11/14 , Y10T156/108 , Y10T428/24868
摘要： A method for adhering holograms to textile wearing apparel involving the steps of laminating a precut hologram between a clear polyester coating and an adhesive scrim backing to envelope the hologram and protect it from moisture and scuffing, cutting margins away from the laminated hologram to form an enveloped hologram, and applying the enveloped hologram to wearing apparel at a temperature of approximately 270.degree. to 300.degree. F. under a pressure of approximately 30 to 50 psi for a period of approximately 8 to 15 seconds. The hologram becomes firmly adhered to the wearing apparel and remains impervious to moisture after repeated machine washing and drying cycles.
摘要翻译：一种将全息图粘附到纺织品服装上的方法，包括以下步骤：在透明聚酯涂层和粘合剂稀松布背衬之间层压预切割全息图以包围全息图并保护其免受潮湿和磨损，从而切割离开层叠全息图的边缘以形成包络全息图，并且在大约270至300°F的温度下，在大约30至50psi的压力下将包封的全息图涂覆到服装上约8至15秒的时间。全息图在重复洗涤和干燥循环后变得牢固地粘附在服装上并且保持不透湿。

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