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1. 发明授权

US5310650A Method and device for improved reaction kinetics in nucleic acid hybridizations 失效
标题翻译：用于改善核酸杂交反应动力学的方法和装置
公开(公告)号：US5310650A
公开(公告)日：1994-05-10
申请号：US925322
申请日：1992-08-04
申请人： Michael E. McMahon , Julian Gordon
发明人： Michael E. McMahon , Julian Gordon
IPC分类号： B01L3/00 , C12Q1/68 , C12Q1/70 , G01N30/38 , G01N30/60 , G01N30/92 , G01N33/558 , G01N37/00
CPC分类号： G01N33/558 , B01L3/5023 , C12Q1/6834 , C12Q1/6876 , C12Q1/689 , C12Q1/701 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , G01N30/38 , G01N30/6065 , G01N30/92 , Y10S435/81
摘要： The present invention relates to methods and test strips for performing nucleic acid hybridizations on a porous chromatographic material having the capacity for rapid chromatographic solvent transport of non-immobilized reagents and reactive solution components by means of a selected chromatographic solvent. The strip includes a first end or contact site, at which chromatographic solvent transport begins, a second end, at which chromatographic solvent transport ends, and at least one zone positioned between the first and second ends. The zone is impregnated with a capture nucleotide sequence which is immobilized against solvent transport and which is capable of hybridization with a complementary nucleotide sequence or probe so as to render it immobilized in the capture zone. The strip may further include a probe zone between the first end and the capture zone, wherein a labeled probe is impregnated such that it is mobilized by the solvent and transported to the capture zone where hybridization can occur. Interfering sample components and unhybridized nucleic acids are cleared from the capture zone by chromatographic solvent transport to form an inherent wash.
摘要翻译：本发明涉及用于在多孔层析材料上进行核酸杂交的方法和测试条，该多孔层析材料具有通过选择的色谱溶剂快速色谱溶剂转运非固定化试剂和反应溶液组分的能力。条带包括开始色谱溶剂转移的第一端或接触位置，色谱溶剂输送结束的第二端和位于第一端和第二端之间的至少一个区。该区域被捕获核苷酸序列浸渍，该捕获核苷酸序列固定化以抵抗溶剂转运并且能够与互补核苷酸序列或探针杂交，以使其固定在捕获区中。条带还可以包括在第一端和捕获区之间的探针区，其中标记的探针被浸渍，使得其被溶剂移动并被运送到可以发生杂交的捕获区。干扰样品组分和未杂交的核酸通过色谱溶剂转移从捕获区域中清除，形成固有的洗涤液。

2. 发明授权

US4960691A Chromatographic test strip for determining ligands or receptors 失效
标题翻译：用于测定配体或受体的色谱测试条
公开(公告)号：US4960691A
公开(公告)日：1990-10-02
申请号：US912878
申请日：1986-09-29
申请人： Julian Gordon , Michael E. McMahon , Shanfun Ching
发明人： Julian Gordon , Michael E. McMahon , Shanfun Ching
IPC分类号： G01N33/50 , B01L3/00 , G01N30/38 , G01N30/60 , G01N30/92 , G01N33/543 , G01N33/558 , G01N37/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/084 , G01N30/38 , G01N30/6065 , G01N30/92 , Y10S435/805 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： A test strip for analysis of analytes such as antigens, antibodies or polynucleotides employs a chromatographic medium and a solvent capable of transporting reagents and/or sample. Reagents are selected and disposed on the medium such that a labeled (first) reagent arrives at the detection (third) zone only after analyte is immobilized there and non-reactive sample componets have been transported beyond the detection zone. This sequential arrival is accomplished by the relative mobility of the reagent or sample; or by the site relationship of the zones. Preferably, the site relationship of the sample (second) zone and the label (first) zone is such that a plurality of pathways guide the sample and labeled reagent and any subsequent reagents to the detection zone in the recited order. Single and multiple pathway devices are disclosed.
摘要翻译：用于分析抗原，抗体或多核苷酸的分析物的测试条使用色谱介质和能够运送试剂和/或样品的溶剂。选择试剂并置于培养基上，使标记的（第一）试剂只有在分析物被固定在那里后才到达检测（第3）区域，而非反应性样品组分已经被运送到超出检测区域。这种连续到达是通过试剂或样品的相对迁移率来实现的; 或通过区域的站点关系。优选地，样品（第二）区域和标签（第一）区域的位置关系使得多个途径以所述顺序将样品和标记的试剂和任何后续的试剂引导到检测区。公开了单通道和多通路装置。

3. 发明授权

US08095597B2 Method and system of automating data capture from electronic correspondence 有权
标题翻译：从电子通信自动化数据采集的方法和系统
公开(公告)号：US08095597B2
公开(公告)日：2012-01-10
申请号：US09846741
申请日：2001-05-01
申请人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
发明人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , G06F17/2705 , G06F17/30876 , G06Q10/107 , G06Q40/12 , H04L51/14 , H04L67/306
摘要： A method and system of automating capture of electronic data provide a user with an effective universal Internet identity and e-mail address, comprehensive e-mail filtering and forwarding services, and e-receipt identification and data extraction. Detailed user e-mail preferences data stored at a central server may be selectively altered such that incoming correspondence is redirected in accordance with the user's preferences. Computer program code at the central server parses incoming e-mail header information and data content, selectively extracts data from identified types of correspondence, and forwards extracted data in accordance with user preferences data. Additional computer program code may manipulate the extracted data in accordance with format requirements and display the manipulated data to a user in a desired format.
摘要翻译：自动捕获电子数据的方法和系统为用户提供有效的通用互联网身份和电子邮件地址，全面的电子邮件过滤和转发服务，以及电子收据识别和数据提取。可以选择性地改变存储在中央服务器处的详细用户电子邮件偏好数据，使得根据用户偏好重定向传入对应。中央服务器上的计算机程序代码解析输入的电子邮件头信息和数据内容，从识别的对应类型中选择性地提取数据，并根据用户偏好数据转发提取的数据。附加的计算机程序代码可以根据格式要求来操纵所提取的数据，并以期望的格式将操纵的数据显示给用户。

4. 发明申请

US20060029963A1 Reagents and methods useful for detecting diseases of the breast 审中-公开
标题翻译：用于检测乳腺疾病的试剂和方法
公开(公告)号：US20060029963A1
公开(公告)日：2006-02-09
申请号：US11201347
申请日：2005-08-10
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , John Russell , Stephen Stroupe
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C07K14/47 , C07K16/3015 , C12Q2600/136 , C12Q2600/156
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS325 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to SB325-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS325 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
摘要翻译：描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为BS325并从乳腺组织转录。这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。还提供了特异性结合SB325编码的多肽或蛋白质的抗体，以及预防组织特异性BS325多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。

5. 发明申请

US20050191633A1 Reagents and methods useful for detecting diseases of the breast 审中-公开
标题翻译：用于检测乳腺疾病的试剂和方法
公开(公告)号：US20050191633A1
公开(公告)日：2005-09-01
申请号：US10719144
申请日：2003-11-21
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS274 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS274-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS274 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases
摘要翻译：描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BS274并从乳腺组织转录。这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。还提供了特异性结合BS274编码的多肽或蛋白质的抗体，以及预防组织特异性BS274多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤

6. 发明申请

US20050181401A1 Reagents and methods useful for detecting diseases of the prostate 审中-公开
公开(公告)号：US20050181401A1
公开(公告)日：2005-08-18
申请号：US11043675
申请日：2005-01-26
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： C07K14/47 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS116 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS116 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

7. 发明授权

US06867016B1 Reagents and methods useful for detecting diseases of the gastrointestinal tract 失效
标题翻译：用于检测胃肠道疾病的试剂和方法
公开(公告)号：US06867016B1
公开(公告)日：2005-03-15
申请号：US09052855
申请日：1998-03-31
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Stephen D. Stroupe
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N15/00
CPC分类号： C07K16/3046 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译：描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为CS141并从胃肠道组织转录。这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。还提供了特异性结合CS141编码的多肽或蛋白质的抗体以及预防组织特异性CS141多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。

8. 发明授权

US06465181B2 Reagents and methods useful for detecting diseases of the prostate 失效
标题翻译：用于检测前列腺疾病的试剂和方法
公开(公告)号：US06465181B2
公开(公告)日：2002-10-15
申请号：US09276600
申请日：1999-03-25
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Julian Gordon , Edward N. Granados , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Julian Gordon , Edward N. Granados , John C. Russell , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： G01N33/57434 , A61K38/00 , C07K14/4748 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PCIGF and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PCIGF-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PCIGF polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译：描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，称为PCIGF并从前列腺组织转录。这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。还提供了特异性结合PCIGF编码的多肽或蛋白质的抗体，以及预防组织特异性PCIGF多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。

9. 发明授权

US6068978A Apparatus and method for transfer of a fluid sample 失效
标题翻译：用于转移流体样品的装置和方法
公开(公告)号：US6068978A
公开(公告)日：2000-05-30
申请号：US859552
申请日：1997-05-20
申请人： Peter Zaun , Stanley R. Bouma , Julian Gordon , John J. Kotlarik , Natalie A. Solomon
发明人： Peter Zaun , Stanley R. Bouma , Julian Gordon , John J. Kotlarik , Natalie A. Solomon
IPC分类号： B01L3/00 , B01L7/00 , B01L99/00 , C12N15/09 , C12Q1/68 , G01N1/00 , G01N35/00
CPC分类号： B01L7/52 , B01L3/502 , G01N2035/00237 , G01N2035/00366 , G01N2035/00376 , G01N2035/00752 , G01N35/1095 , Y10S435/808
摘要： Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection chamber to form the reaction/detection unit. A first heating element of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.
摘要翻译：提供了扩增和检测核酸的方法，装置，装置和试剂盒。该装置是与反应/检测单元结合操作的一层或两层热循环装置。将样品装载到装置的反应室中，然后将其与检测室配合以形成反应/检测单元。热循环装置的第一加热元件将所需的温度施加到反应/检测装置以扩增样品中的靶核酸。然后将反应混合物通过第二加热元件转移到检测室，并将扩增的靶核酸固定在检测室中的载体上。微处理器控制独立于第一元件施加的热量来控制由第二元件施加的热量。与该装置相关的检测系统检测并分析固定的扩增的核酸靶。图像被捕获并数字化并进行统计分析以提高该方法的准确性。

10. 发明授权

US5780308A Calibration reagents for semiquanitative binding assays and devices 失效
标题翻译：用于半定量结合测定和装置的校准试剂
公开(公告)号：US5780308A
公开(公告)日：1998-07-14
申请号：US854785
申请日：1997-05-12
申请人： ShanFun Ching , Julian Gordon
发明人： ShanFun Ching , Julian Gordon
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/558
CPC分类号： G01N33/558 , G01N33/54366 , Y10S435/97 , Y10S435/971
摘要： The novel analytical devices and methods of the present invention involve a semiquantitative specific binding assay method for the detection of the presence of at least a predetermined minimum concentration of an analyte in the test sample. A calibration reagent is present at a concentration sufficient to inhibit the formation of a detectable analyte complex unless a predetermined minimum concentration of analyte is present in the test sample.
摘要翻译：本发明的新型分析装置和方法涉及用于检测测试样品中至少预定最小浓度的分析物的存在的半定量特异性结合测定方法。校准试剂以足以抑制可检测分析物复合物的形成的浓度存在，除非在测试样品中存在预定的最小浓度的分析物。

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