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1. 发明申请

US20140253519A1 EXPANDABLE DIAMETER STYLUS 审中-公开
标题翻译：可扩展的直径STYLUS
公开(公告)号：US20140253519A1
公开(公告)日：2014-09-11
申请号：US13789898
申请日：2013-03-08
申请人： Michael David , Sean P. O'Neal
发明人： Michael David , Sean P. O'Neal
IPC分类号： G06F3/0354
CPC分类号： G06F3/03545
摘要： In accordance with the present disclosure, an expandable diameter stylus and related systems and methods are described herein. The expandable diameter stylus may comprise an elongated body and a writing surface disposed on an end of the elongated body. The expandable diameter stylus may also include a variable diameter grip proximate to the writing surface. In certain embodiments the variable diameter grip may have a first diameter when the expandable diameter stylus is positioned within a stylus garage of a portable computing system. The variable diameter grip may have a second diameter, larger than the first diameter, when the stylus is removed from the stylus garage for use as an input device.
摘要翻译：根据本公开，本文描述了可扩展直径触针及相关系统和方法。可扩展直径触针可以包括细长主体和设置在细长主体的端部上的书写表面。可扩展直径的触针还可以包括靠近书写表面的可变直径的手柄。在某些实施例中，当可扩展直径的触针位于便携式计算系统的触针车库内时，可变直径的手柄可以具有第一直径。当将触针从触针车库中取出以用作输入装置时，可变直径手柄可以具有大于第一直径的第二直径。

2. 发明授权

US08883155B2 Methods for treating hematopoietic malignancies 有权
标题翻译：造血恶性肿瘤治疗方法
公开(公告)号：US08883155B2
公开(公告)日：2014-11-11
申请号：US12919708
申请日：2009-01-22
申请人： Michael David , Irene Munk Pedersen
发明人： Michael David , Irene Munk Pedersen
IPC分类号： A61K39/395 , A61K38/17 , C07K16/24 , C07K16/30
CPC分类号： C12Q1/6886 , A61K31/52 , A61K38/1793 , A61K39/39558 , A61K45/06 , C07K16/241 , C07K16/3061 , C12Q2600/178 , G01N33/57426 , G01N2333/916 , A61K2300/00
摘要： The present invention relates to methods for treating neoplasias in a mammalian subject. In particular, the invention provides methods for treating lymphomas, including forms of non-Hodgkin lymphoma. In one embodiment, these methods involve reducing tumor necrosis factor signaling.
摘要翻译：本发明涉及在哺乳动物受试者中治疗肿瘤的方法。特别地，本发明提供了治疗淋巴瘤的方法，包括非霍奇金淋巴瘤的形式。在一个实施方案中，这些方法涉及减少肿瘤坏死因子信号传导。

3. 发明授权

US08455553B2 Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease and transplant rejection 有权
标题翻译：预防和治疗炎性疾病，自身免疫性疾病和移植排斥反应的方法和组合物
公开(公告)号：US08455553B2
公开(公告)日：2013-06-04
申请号：US13293876
申请日：2011-11-10
申请人： Michael David
发明人： Michael David
IPC分类号： A61K31/09 , A61P29/00
CPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/135 , A61K31/70 , A61K31/7028 , A61K31/704
摘要： The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compound of any one of Formulae A-E. The invention's methods are useful for the prevention, amelioration, and treatment of autoimmune disease, inflammatory disease, and/or transplant rejection.
摘要翻译：本发明提供了通过向有需要的受试者施用药学有效量的式A-E中任一种的纯化化合物来减少自身免疫疾病，炎性疾病和/或移植排斥的一种或多种症状的组合物和方法。本发明的方法可用于预防，改善和治疗自身免疫性疾病，炎性疾病和/或移植排斥反应。

4. 发明申请

US20130086705A1 COMPOSITIONS AND METHODS FOR REDUCING AND DETECTING VIRAL INFECTION 审中-公开
标题翻译：用于减少和检测病毒感染的组合物和方法
公开(公告)号：US20130086705A1
公开(公告)日：2013-04-04
申请号：US13624153
申请日：2012-09-21
申请人： Michael David , Manqing Li
发明人： Michael David , Manqing Li
IPC分类号： C12N5/07
CPC分类号： C12N5/06 , A01K2217/075 , A01K2267/0337 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , G01N33/5023 , G01N2333/16 , G01N2500/10 , G01N2800/50
摘要： The invention provides methods and compositions for screening candidate compounds for activity in altering the level of expression of Schlafen (Slfn) in cells, tissues and animals. The invention also provides methods and compositions for screening candidate compounds for activity in altering the level of virus infection. The invention further provides methods and compositions for screening candidate compounds for altering the level of expression of virus proteins without substantially unfaltering the level of expression of cellular proteins. The invention additionally provides methods and compositions for diagnosing the risk and/or susceptibility to virus infection. The invention also provides transgenic non-human animals, and transgenic cells, comprising a mutant Schlafen (Slfn) gene, such as a knockout mutation. These invention's compositions and methods are useful as models for virus infection, and for screening candidate prophylactic and/or therapeutic anti-viral compounds.
摘要翻译：本发明提供用于筛选候选化合物以改变细胞，组织和动物中Schlafen（Slfn）表达水平的活性的方法和组合物。本发明还提供了用于筛选候选化合物用于改变病毒感染水平的活性的方法和组合物。本发明进一步提供用于筛选候选化合物以改变病毒蛋白质表达水平而基本上不改变细胞蛋白质表达水平的方法和组合物。本发明另外提供用于诊断病毒感染的风险和/或易感性的方法和组合物。本发明还提供转基因非人动物和转基因细胞，其包含突变型Schlafen（Slfn）基因，例如敲除突变。这些发明的组合物和方法可用作病毒感染的模型，并用于筛选候选的预防和/或治疗性抗病毒化合物。

5. 发明授权

US07971904B2 Rollover protection system 有权
标题翻译：翻转保护系统
公开(公告)号：US07971904B2
公开(公告)日：2011-07-05
申请号：US11471005
申请日：2006-06-20
申请人： Michael David
发明人： Michael David
IPC分类号： B60R21/013
CPC分类号： B60R21/13
摘要： A rollover protection system for an off road vehicle includes a pair of lower legs, each lower leg having an arced portion and a horizontal portion connected to the vehicle frame. The upper section of the rollover protection system is pivotably connected to the lower legs, so that it may pivot to a lowered position in which the upper section fits around the rear mounted engine and is within the rear dimensions of the vehicle.
摘要翻译：用于越野车辆的翻车保护系统包括一对下腿，每个小腿具有弧形部分和连接到车架的水平部分。翻车保护系统的上部可枢转地连接到下腿，使得其可以枢转到下部位置，在该下部位置上部分配置在后部安装的发动机周围并且在车辆的后部尺寸内。

6. 发明申请

US20100010047A1 Isotopically substituted proton pump inhibitors 审中-公开
标题翻译：同位素替代质子泵抑制剂
公开(公告)号：US20100010047A1
公开(公告)日：2010-01-14
申请号：US12461985
申请日：2009-08-31
申请人： Bernhard Kohl , Bernd MÜLLER , Dieter Haag , Wolfgang-Alexander Simon , Karl Zech , Michael David , Oliver Von Richter , Felix Huth
发明人： Bernhard Kohl , Bernd MÜLLER , Dieter Haag , Wolfgang-Alexander Simon , Karl Zech , Michael David , Oliver Von Richter , Felix Huth
IPC分类号： A61K31/4439 , C07D401/02 , A61P1/00
CPC分类号： C07D401/12 , C07D471/04
摘要： The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
摘要翻译：本发明涉及式1和式10的化合物和包含这些化合物的组合物以及通过施用这些化合物治疗胃肠道疾病的方法。

7. 发明授权

US07004533B2 Composite floor for utility vehicle 有权
公开(公告)号：US07004533B2
公开(公告)日：2006-02-28
申请号：US09945540
申请日：2001-08-29
申请人： John Raymond Arthur , Daniel James Knight , Michael David , Russell William Strong , Mohamad El-Zein
发明人： John Raymond Arthur , Daniel James Knight , Michael David , Russell William Strong , Mohamad El-Zein
IPC分类号： B62D33/077
CPC分类号： B62D25/20 , B62D25/16 , B62D29/04 , B62D33/0617 , B62D49/00
摘要： For a compact tractor, a composite molded plastic floor and fender structure is supported on a chassis of the vehicle. The floor and fender structure includes a foot supporting region, a seat supporting region and two fenders all formed of a composite RIM plastic material. The unitary floor and fender structure simplifies manufacture of the tractor as well as providing a lightweight, durable structure.

8. 发明授权

US06481131B2 LED illuminated plaque 失效
标题翻译： LED照明斑块
公开(公告)号：US06481131B2
公开(公告)日：2002-11-19
申请号：US09823686
申请日：2001-03-31
申请人： Amanda Gianotti , Michael David , Wayne Kirchner
发明人： Amanda Gianotti , Michael David , Wayne Kirchner
IPC分类号： G09F1318
CPC分类号： G02B6/0036 , G02B6/0031 , G02B6/006 , G02B6/0068 , Y10S362/812
摘要： An aesthetically striking memento comprising an edge-lit translucent panel having an inscribed design, and a free-standing compact base unit with integral LED edge-lighting system. The compact base unit includes an LED light source for reflecting light upward into the translucent panel. The plaque generally comprises an acrylic panel inscribed with a reverse design on its rear face with text, logos and/or graphics and which seats within a recessed cavity in the compact base unit. A reflective material lines the floor of the cavity and surrounds a series of LEDs spaced lengthwise along the slot at the bottom of the cavity. An integral battery or A/C power receptacle provides power to the LEDs through a switch located in the compact base unit. When illuminated, the LEDs emit light upward into the translucent acrylic panel. The light is reflected forwardly from the inwardly-inscribed design and outward to a viewer, thereby accentuating the inscribed indicia carried on the panel.
摘要翻译：一种美观醒目的纪念品，包括具有内雕设计的边缘光亮的半透明面板，以及具有集成LED边缘照明系统的独立式紧凑型基座单元。紧凑型基座单元包括用于将光向上反射到半透明面板中的LED光源。斑块通常包括在其背面上刻有逆向设计的丙烯酸树脂板，其具有文字，标识和/或图形，并且位于紧凑型基座单元中的凹腔内。反射材料沿空腔的地板排列并且围绕沿着空腔底部的狭槽沿长度方向间隔开的一系列LED。集成电池或A / C电源插座通过位于紧凑型基座单元中的开关为LED供电。当照明时，LED将向上发射到透明的丙烯酸面板中。光从向内刻录的设计向前反射并向外反射到观看者，从而强调面板上携带的刻录标记。

9. 发明授权

US07717219B2 Unitary rear frame for mounting engine, hydrostatic transmission, and other components to mower 有权
标题翻译：用于安装发动机，静液压传动装置和其他部件的整体式后架
公开(公告)号：US07717219B2
公开(公告)日：2010-05-18
申请号：US11759363
申请日：2007-06-07
申请人： Michael David
发明人： Michael David
IPC分类号： B60K5/12
CPC分类号： A01D34/64
摘要： A unitary rear frame mounting an engine and hydrostatic transmissions to the rear of a ZTR mower is disclosed. The unitary rear frame includes a lower mounting surface supporting the engine, an upper mounting surface above and forward of the lower mounting surface; a wall extending between the upper and lower mounting surfaces; and a pair of integral side panels depending downwardly from the upper mounting surface and extending forwardly of the wall. Each side panel may have a side pocket for mounting a hydrostatic transmission thereto.
摘要翻译：公开了将发动机和静液压传动装置安装在ZTR割草机后部的整体式后框架。整体后框架包括支撑发动机的下安装表面，下安装表面上方和前方的上安装表面; 在所述上安装表面和所述下安装表面之间延伸的壁; 以及从上安装表面向下延伸并在壁的前方延伸的一对整体的侧板。每个侧板可以具有用于安装静液压传动装置的侧袋。

10. 发明授权

US07601737B2 Isotopically substituted proton pump inhibitors 失效
标题翻译：同位素替代质子泵抑制剂
公开(公告)号：US07601737B2
公开(公告)日：2009-10-13
申请号：US12000376
申请日：2007-12-12
申请人： Bernhard Kohl , Bernd Müller , Dieter Haag , Wolfgang-Alexander Simon , Karl Zech , Michael David , Oliver Von Richter , Felix Huth
发明人： Bernhard Kohl , Bernd Müller , Dieter Haag , Wolfgang-Alexander Simon , Karl Zech , Michael David , Oliver Von Richter , Felix Huth
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D401/12 , C07D471/04
摘要： The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
摘要翻译：本发明涉及式1和式10的化合物和包含这些化合物的组合物以及通过施用这些化合物治疗胃肠道疾病的方法。

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