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1. 发明授权

US06366801B1 Pharmaceutically enhanced low-energy radiosurgery 失效
标题翻译：药物强化低能放射外科手术
公开(公告)号：US06366801B1
公开(公告)日：2002-04-02
申请号：US09550498
申请日：2000-04-14
申请人： Webster C. Cash, Jr. , Michael D. Weil
发明人： Webster C. Cash, Jr. , Michael D. Weil
IPC分类号： A61B600
CPC分类号： A61N5/10 , A61K41/0085 , A61K49/006 , A61K49/0461 , A61N2005/1091 , A61N2005/1098
摘要： Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements from these contrast agents, even small quantities, leads to a major dose increase in target tissue. When combined with in vivo calibration of the amount of contrast agent, the procedure is quick, accurate, and safe. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue, up to 10:1.
摘要翻译：专为x射线诊断开发的造影剂可提供剂量增强的放射治疗和放射外科手术。来自这些造影剂的重元素甚至少量的存在导致靶组织中主要的剂量增加。结合造影剂量的体内校准时，手术快速，准确，安全。该技术还可以与诸如聚焦X射线的其它技术结合使用，以进一步提高治疗比。通过优化设备，可以在健康组织中达到非常大的剂量比例，达到10：1。

2. 发明申请

US20210401288A1 Non-Invasive Convergent Heating Treatment 有权
公开(公告)号：US20210401288A1
公开(公告)日：2021-12-30
申请号：US17359869
申请日：2021-06-28
申请人： Michael D. Weil
发明人： Michael D. Weil
IPC分类号： A61B5/00 , A61B5/0507 , A61N5/02 , A61B5/05 , A61N1/40 , A61N5/06 , A61N1/28 , A61B8/08 , A61N7/02 , A61G15/02 , A61N5/01 , A61G13/02 , A61B8/00 , A61N5/04 , A61N1/20
摘要： The invention relates to medical therapy of detrimental lesions. A system treats with non-invasive arrays of non-ionizing energy-radiation sources. The external sources focus energy dose distribution to a selected volume in a body. Energy output is directed towards a pathologic location and quenched around other sites or healthy tissue. Beam aiming is done without source movement. Targeted, volumetrically discrete energy deposition can beneficially manipulate lesions within the body. The purpose of the focused and enhanced energy deposition is to repair or disable pathologic physiology or structures, nerve pathways, extracellular fluid, and misfolded proteins. Locally augmented energy is used to enhance immunity, release pharmaceutical compounds from energy-sensitive vesicles and reconfigure or eliminate misfolded proteins and their aggregates. Targeted tissue may have enhanced sensitivity to received energy via a non-ionizing-radiation, treatment-localizing agent. This system optimizes delivery of non-ionizing, non-ablating electromagnetic or mechanical energy, degrading or repairing an abnormality upon interaction with it.

3. 发明授权

US6125295A Pharmaceutically enhanced low-energy radiosurgery 失效
标题翻译：药物强化低能放射外科手术
公开(公告)号：US6125295A
公开(公告)日：2000-09-26
申请号：US140981
申请日：1998-08-27
申请人： Webster C. Cash, Jr. , Michael D. Weil
发明人： Webster C. Cash, Jr. , Michael D. Weil
IPC分类号： A61K41/00 , A61N5/10 , A61B6/00
CPC分类号： A61N5/10 , A61K41/0085 , A61N2005/1091 , A61N2005/1098
摘要： Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements from these contrast agents, even small quantities, leads to a major dose increase in target tissue. When combined with in vivo calibration of the amount of contrast agent, the procedure is quick, accurate, and safe. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue up to 10:1.
摘要翻译：专为x射线诊断开发的造影剂可提供剂量增强的放射治疗和放射外科手术。来自这些造影剂的重元素甚至少量的存在导致靶组织中主要的剂量增加。结合造影剂量的体内校准时，手术快速，准确，安全。该技术还可以与诸如聚焦X射线的其它技术结合使用，以进一步提高治疗比。通过设备的优化，可以在健康组织中达到非常大的剂量比例，达到10：1。

4. 发明公开

US20240245931A1 GRADIENT OPTIMIZED RADIAL TREATMENT (GORT) 审中-公开
公开(公告)号：US20240245931A1
公开(公告)日：2024-07-25
申请号：US18099668
申请日：2023-01-20
申请人： Michael D. Weil
发明人： Michael D. Weil
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1067 , A61N5/1084 , A61N2005/005
摘要： The present invention relates to the field of medical therapy of lesions detrimental to a body. The system is capable of treatment with a non-invasive, ionizing kV energy radiation source. Locally focused energy can be used to definitively treat, or as an adjuvant to enhance immune modulators, to eliminate tumors. Distributed external beam entry points produce a significant advantageous dose profile at depth as intersecting beams accumulate in a narrow focus to treat a selected volume. Targeted disease may have enhanced sensitivity to the radiation by taking up an ionizing-radiation, treatment-localizing agent. This increases the effectiveness of an energy dose in the lesion. The pattern of beam output is effectively directed towards a desired location and kV x-rays traveling towards undesired locations, such as healthy tissue, are quenched. Targeting a lesion within the body with volumetrically discrete energy dose deposition can beneficially impact harmful lesions. Aiming the beam at a pathologic target is done while moving an x-ray source mechanically around a patient to distribute surface dose. The purpose of the focused energy deposition is to destroy and disable pathologic physiology, such as malignant masses. More specifically this invention relates to a system, which optimizes delivery of ionizing kV beams to a lesion alone or one containing treatment-localizing agents in higher concentration than the surrounding normal tissues. Thereby an optimal delivery of ionizing radiation becomes more destructive to a mass of abnormal cells upon interaction with the targeted site.

5. 发明授权

US08243877B2 Dual-use radiation system 有权
标题翻译：双用途辐射系统
公开(公告)号：US08243877B2
公开(公告)日：2012-08-14
申请号：US11853999
申请日：2007-09-12
申请人： Michael D. Weil
发明人： Michael D. Weil
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61B6/032 , A61B6/06 , A61B6/481 , A61N2005/1091 , A61N2005/1098
摘要： The present invention relates to the field of medical imaging and therapy of lesions that are detrimental to the body. The system is capable of both imaging and treatment with the same kilovoltage radiation source. Dual-use collimators produce a wide beam, which is not a pencil beam or a fan beam, to image and treat a target that has an enhanced radiation cross-section after taking up contrast agent containing a high-Z element. This results in increased radiation dose in the lesion. Furthermore, the significant drop in intensity of a low-energy radiation beam traveling through tissue is surmounted by continually aiming the beam at the target while moving it around the patient. Wide detectors opposing the radiation source permit the imaging and measurement of contrast in the target. More specifically this invention relates to a system, which optimizes delivery of kilovoltage x-rays to a lesion containing contrast agents in higher concentration than the surrounding normal tissues. Thereby subsequent delivery of radiation becomes cytotoxic upon interaction with the contrast.
摘要翻译：本发明涉及对身体有害的病变的医学成像和治疗领域。该系统能够使用相同的千伏辐射源进行成像和处理。在使用含有高Z元素的造影剂后，双重使用的准直仪产生不是笔形光束或扇形光束的宽光束，以成像和处理具有增强的辐射截面的靶。这导致病变中辐射剂量的增加。此外，穿过组织的低能量辐射束的强度的显着下降通过在将梁移动到患者周围的目标处不断瞄准目标而被克服。与辐射源相对的宽检测器允许成像和测量目标中的对比度。更具体地，本发明涉及一种系统，该系统优化将千伏X射线输送到比周围正常组织更高浓度的含有造影剂的病变的输送。因此随后的辐射递送在与对比度相互作用时变成细胞毒性。

6. 发明授权

US08709380B1 Targeting agents for enhancing radiation therapy 有权
标题翻译：用于增强放射治疗的靶向剂
公开(公告)号：US08709380B1
公开(公告)日：2014-04-29
申请号：US11671222
申请日：2007-02-05
申请人： Michael D. Weil , Kevin N. Morris , Rainer M. Malzbender
发明人： Michael D. Weil , Kevin N. Morris , Rainer M. Malzbender
IPC分类号： A61K51/00 , A61M36/14 , A61K49/04 , A61K41/00 , A61K9/00
CPC分类号： A61K49/04 , A61K41/0038 , A61K47/6929
摘要： Targeting agents are provided that have an affinity for aberrant cells and tissues. These agents are comprised of chelates, ligands, and/or particles combined with high atomic weight elements so that treatment with ionizing electromagnetic radiation (X-rays, or Gamma rays) results in a higher dose to aberrant cells and tissues than other cells and tissues of a host. The invention further provide methods to enhance the tumor to normal tissue damage ratio by concentrating agents with high atomic number elements to the site of the tumor prior to administering radiotherapy. The result is greater therapeutic efficacy with fewer side effects. These compounds also permit diagnostic uses in combination with the therapeutic use.
摘要翻译：提供了对异常细胞和组织具有亲和力的靶向剂。这些试剂由与高原子量元素结合的螯合物，配体和/或颗粒组成，使得用电离电磁辐射（X射线或γ射线）治疗导致比其他细胞和组织更高的异常细胞和组织的剂量的主机。本发明还提供了在施用放射治疗之前通过具有高原子序数元素的浓缩剂将肿瘤增强至肿瘤部位的方法。结果是治疗效果更好，副作用较少。这些化合物还可以与治疗用途结合使用诊断用途。

7. 发明申请

US20130035682A1 Noninvasive Nerve Ablation 审中-公开
标题翻译：无创神经消融
公开(公告)号：US20130035682A1
公开(公告)日：2013-02-07
申请号：US13565788
申请日：2012-08-02
申请人： Michael D. Weil
发明人： Michael D. Weil
IPC分类号： A61B18/18
CPC分类号： A61N5/103 , A61B18/18 , A61B2018/00434 , A61B2018/00577 , A61B2090/3954 , A61N2005/1055 , A61N2005/1087
摘要： The present invention relates to the field of medical imaging and therapy of nerve lesions that are detrimental to the body. The method incorporates both identifying imaging for localization and treatment with a radiation source. Clear images of individual nerve structures are fused to conventional images for accurate treatment planning with noninvasive ablating beams. This results in increased radiation dose in the lesion. Furthermore, neither endovascular intervention nor additional internally introduced reference points are needed. More specifically this invention relates to a method for optimizing delivery of ablating beams to a lesion compared to the surrounding normal tissues without invasive techniques.
摘要翻译：本发明涉及对身体有害的神经损伤的医学成像和治疗领域。该方法结合了用于定位和用辐射源处理的识别成像。将单个神经结构的清晰图像融合到常规图像中，以用无创消融束进行准确的治疗计划。这导致病变中辐射剂量的增加。此外，既不需要血管内干预也不需要额外的内部引用参考点。更具体地，本发明涉及一种用于与没有侵入性技术的周围正常组织相比，将消融束优化给病变的方法。

8. 发明申请

US20080063142A1 Dual-Use Radiation System 有权
标题翻译：双用途辐射系统
公开(公告)号：US20080063142A1
公开(公告)日：2008-03-13
申请号：US11853999
申请日：2007-09-12
申请人： Michael D. Weil
发明人： Michael D. Weil
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61B6/032 , A61B6/06 , A61B6/481 , A61N2005/1091 , A61N2005/1098
摘要： The present invention relates to the field of medical imaging and therapy of lesions that are detrimental to the body. The system is capable of both imaging and treatment with the same kilovoltage radiation source. Dual-use collimators produce a wide beam, which is not a pencil beam or a fan beam, to image and treat a target that has an enhanced radiation cross-section after taking up contrast agent containing a high-Z element. This results in increased radiation dose in the lesion. Furthermore, the significant drop in intensity of a low-energy radiation beam traveling through tissue is surmounted by continually aiming the beam at the target while moving it around the patient. Wide detectors opposing the radiation source permit the imaging and measurement of contrast in the target. More specifically this invention relates to a system, which optimizes delivery of kilovoltage x-rays to a lesion containing contrast agents in higher concentration than the surrounding normal tissues. Thereby subsequent delivery of radiation becomes cytotoxic upon interaction with the contrast.
摘要翻译：本发明涉及对身体有害的病变的医学成像和治疗领域。该系统能够使用相同的千伏辐射源进行成像和处理。在使用含有高Z元素的造影剂后，双重使用的准直仪产生不是笔形光束或扇形光束的宽光束，以成像和处理具有增强的辐射截面的靶。这导致病变中辐射剂量的增加。此外，穿过组织的低能量辐射束的强度的显着下降通过在将梁移动到患者周围的目标处不断瞄准目标而被克服。与辐射源相对的宽检测器允许成像和测量目标中的对比度。更具体地，本发明涉及一种系统，该系统优化将千伏X射线输送到比周围正常组织更高浓度的含有造影剂的病变的输送。因此随后的辐射递送在与对比度相互作用时变成细胞毒性。

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