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1. 发明授权

US6036654A Multi-lumen, multi-parameter catheter 失效
标题翻译：多腔多参数导管
公开(公告)号：US6036654A
公开(公告)日：2000-03-14
申请号：US311477
申请日：1994-09-23
申请人： Michael D. Quinn , Jaime Siman , Mark L. Yelderman
发明人： Michael D. Quinn , Jaime Siman , Mark L. Yelderman
IPC分类号： A61B5/00 , A61B5/028 , A61B5/02
CPC分类号： A61B5/6852 , A61B5/028 , A61B5/1459
摘要： A multi-lumen catheter capable of measuring cardiac output continuously, mixed venous oxygen saturation as well as other hemodynamic parameters. The catheter is also capable of undertaking therapeutic operations such as drug infusion and cardiac pacing. The catheter includes optical fibers for coupling to an external oximeter, an injectate port and thermistor for bolus thermodilution measurements, a heating element for inputting a heat signal and for coupling to an external processor for continuously measuring cardiac output, and a distal lumen for measuring pressure, withdrawing blood, guidewire passage or drug infusion. In a preferred embodiment, the catheter includes a novel lumen configuration permitting an additional infusion lumen for either fast drug infusion or cardiac pacing.
摘要翻译：可以连续测量心输出量的多腔导管，混合静脉血氧饱和度以及其他血液动力学参数。导管还能够进行治疗操作，例如药物输注和心脏起搏。导管包括用于耦合到外部血氧计的光纤，用于推注热稀释测量的注射端口和热敏电阻，用于输入热信号并耦合到外部处理器以连续测量心输出量的加热元件，以及用于测量压力的远端内腔，抽血，导丝通过或药物输注。在优选实施例中，导管包括允许另外的输注腔用于快速药物输注或心脏起搏的新型管腔构型。

2. 发明授权

US06273875B1 Medical devices having improved antimicrobial/antithrombogenic properties 有权
标题翻译：具有改善的抗微生物/抗血栓形成特性的医疗装置
公开(公告)号：US06273875B1
公开(公告)日：2001-08-14
申请号：US09135873
申请日：1998-08-17
申请人： Jaime Siman , Jeff Dove
发明人： Jaime Siman , Jeff Dove
IPC分类号： A61M2500
CPC分类号： A61L27/54 , A61L29/16 , A61L31/16 , A61L33/0011 , A61L33/0023 , A61L2300/102 , A61L2300/236 , A61L2300/404 , A61L2300/42 , A61N1/05
摘要： An enhanced antimicrobial antithrombogenic medical device is formed by using an oligodynamic metal and a noble metal with a polymer, and forming the mixture into a device. By using low concentrations of conductive polymers or ionophoric compounds, non-conductive, or highly plasticized polymers can be likewise blended into an iontophoretic-capable composition. The surface of the device may be treated with a solvent to remove the top surface of the polymer and create surface voids in the composition in order to expose previously encapsulated iontophoretic materials. This surface treatment results in a larger reaction area of the iontophoretic capable composition that produces larger yields of bacteriostatic oligodynamic ions for a longer duration thereby increasing the antimicrobial effectiveness of the composition. The surface of the antimicrobial composition may be treated with an anticoagulant such as heparin or heparin complexed with a quaternary ammonium salt for an added bacteriostatic effect.
摘要翻译：通过使用低聚物金属和贵金属与聚合物形成增强的抗微生物抗血栓形成的医疗装置，并将该混合物形成装置。通过使用低浓度的导电聚合物或离子化合物，可以将非导电或高度增塑的聚合物同样地混合到具有离子电渗能力的组合物中。可以用溶剂处理装置的表面以除去聚合物的顶表面，并在组合物中产生表面空隙，以暴露先前包封的离子电渗材料。这种表面处理导致离子电渗能力组合物的较大的反应面积产生更长时间的较高产量的抑菌性低分子动力学离子，从而提高组合物的抗微生物效能。抗微生物组合物的表面可以用抗凝血剂如肝素或与季铵盐络合的肝素进行治疗以增加抑菌作用。

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