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1. 发明申请

US20070122466A1 Sphingomyelin liposomes for the treatment of hyperactive bladder disorders 有权
标题翻译：鞘磷脂脂质体用于治疗膀胱过动症
公开(公告)号：US20070122466A1
公开(公告)日：2007-05-31
申请号：US11546025
申请日：2006-10-11
申请人： Michael Chancellor , Pradeep Tyagi , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
发明人： Michael Chancellor , Pradeep Tyagi , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/1272 , Y02A50/469
摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysftunction.
摘要翻译：本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍作为有需要的动物或人类的间质性膀胱炎（IC）。还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。特别地，为了治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍，提供了香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送。

2. 发明申请

US20070003610A1 Application of lipid vehicles and use for drug delivery 审中-公开
标题翻译：脂质载体的应用和用于药物输送
公开(公告)号：US20070003610A1
公开(公告)日：2007-01-04
申请号：US11438912
申请日：2006-05-22
申请人： Michael Chancellor , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
发明人： Michael Chancellor , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
IPC分类号： A61K39/08 , A61K9/127 , A61K31/16 , A61K48/00
CPC分类号： A61K9/127 , A61K9/0034
摘要： The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.
摘要翻译：本发明涉及用于施用基于脂质的载体以治疗各种疾病（包括膀胱炎症，感染，功能障碍和癌症）的组合物和方法。在各个方面，本发明的组合物和方法可用于向膀胱，泌尿生殖道，胃肠系统，肺系统和其它器官或身体系统延长递送药物，例如抗生素，疼痛治疗和抗癌剂。特别地，本发明涉及用于治疗膀胱病症（包括疼痛，炎症，失禁和排尿功能障碍）的香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送。进一步相关的是单独使用这些载体或与抗体（例如尿布隆蛋白抗体）联合以改善脂质体附着持续时间并提供长期膀胱内药物递送平台的方法。本发明具体涉及可用于靶向用于药物，肽，多肽或核酸递送的特异性受体的抗体包被的脂质体。在一个特定方面，本发明涉及用抗神经生长因子（NGF）受体和含有NGF反义核酸的抗体包被的脂质体，其用作神经源性膀胱功能障碍的治疗。

3. 发明申请

US20060276531A1 Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia 审中-公开
标题翻译：代理治疗膀胱刺激症状伴有良性前列腺增生
公开(公告)号：US20060276531A1
公开(公告)日：2006-12-07
申请号：US11503067
申请日：2006-08-14
申请人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William de Groat , Naoki Yoshimura , Adrian Sculptoreanu
发明人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William de Groat , Naoki Yoshimura , Adrian Sculptoreanu
IPC分类号： A61K31/381
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.
摘要翻译：本发明提供了一种用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K + / O通道开放活性的化合物或以及用于治疗伴有良性前列腺增生的膀胱刺激症状的筛选剂的方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

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