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    • 5. 发明申请
    • Cable insulation system with flexibility, high temperature deformation resistance, and reduced degree of stickiness
    • 电缆绝缘系统具有柔韧性,耐高温变形性,粘度降低
    • US20060169477A1
    • 2006-08-03
    • US10564142
    • 2004-07-22
    • Laurence Gross
    • Laurence Gross
    • H01B3/44
    • H01B3/441C08L23/0815C08L2203/202C08L2666/02
    • The present invention is a cable comprising one or more electrical conductors or a core of one or more electrical conductors and having each conductor or core being surrounded by a layer of insulation. The insulation comprises an olefinic polymer, having a density in the range of 0.880 to 0.915 grams per cubic centimeter, a melting temperature of at least 115 degrees Celsius, a melt index in the range of 0.5 to 10 grams per 10 minutes, a crystallization-analysis-soluble fraction in 1,2,4-trichlorobenzene at 30 degrees Celsius of less than 35 weight percent, and a polydispersity index of at least 3.5. Alternatively, the insulation layer has an 1% secant flexural modulus at ambient of less than 15,000 psi and a dynamic elastic modulus at 150 degrees Celsius of at least 4×107 dyne/square centimeter.
    • 本发明是一种电缆,其包括一个或多个电导体或一个或多个电导体的芯,并且每个导体或芯被绝缘层包围。 绝缘体包含烯属聚合物,其密度在0.880至0.915克/立方厘米的范围内,熔融温度至少为115摄氏度,熔体指数在0.5至10克/ 10分钟的范围内, 在30摄氏度的1,2,4-三氯苯中的分析可溶级分小于35重量%,多分散指数至少为3.5。 或者,绝缘层在小于15,000psi的环境下具有1%的正割弯曲模量,并且在150摄氏度下具有至少4×10 7达因/平方厘米的动态弹性模量。
    • 6. 发明授权
    • Tricyclic dicarbonyl derivatives
    • 三环二羰基衍生物
    • US5688803A
    • 1997-11-18
    • US737240
    • 1996-11-15
    • Bernd ButtelmannThierry GodelLaurence GrossMarie-Paule Heitz NeidhartClaus RiemerRene Wyler
    • Bernd ButtelmannThierry GodelLaurence GrossMarie-Paule Heitz NeidhartClaus RiemerRene Wyler
    • A61K31/4353A61K31/445A61K31/505A61P3/08A61P9/00A61P9/08A61P9/10A61P17/00A61P25/00A61P25/04A61P25/18A61P25/20A61P25/24A61P25/26A61P25/28A61P39/02C07D233/56C07D471/04C07D487/04C07D491/048C07D498/04
    • C07D471/04C07D487/04
    • Compounds of general formula (Ia), (Ib) and (II), wherein R.sup.1 and R.sup.2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino, halogen, cyano or R.sup.3 R.sup.4 NS(O).sub.2 -- and R.sup.3 and R.sup.4 signify lower alkyl, and R.sup.2 can additionally signify morpholino or thiomorpholino, a 5- or 6-membered heterocycle with 1-3N atoms optionally substituted by lower alkyl, hydroxy, amino or the group --CH.sub.2 NHCH.sub.3, a bicyclic heterocycle with 1-3N atoms or a group --NR.sup.5 R.sup.6 or --OR.sup.5 in which R.sup.5 and R.sup.6 can be the same or different and signify hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, amino-lower alkyl or lower alkylamino-lower alkyl, and X in formula (II) signifies --CH.dbd.CH--, --CH.dbd.N--, --NH--, --CO-- or --O--, as well as pharmaceutically usable salts of compounds of general formula (Ia), (Ib) and (II). They can be used for the treatment or prevention of illnesses, especially for the treatment or prevention of ischemia, hypoglycaemia, hypoxia, cerebral vascular spasms, spasticity, trauma, hemorrhagia, infection (viral, bacterial, amoebic, prional), epileptic seizures, autoimmune diseases, withdrawal symptoms, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, intoxications, olivoponto-cerebellar atrophy, spinal cord injuries, schizophrenia, depressions, anxiety states, dependence, pains,autism and mental retardation.
    • PCT No.PCT / EP95 / 01856 Sec。 371日期1996年11月15日 102(e)日期1996年11月15日PCT提交1995年5月16日PCT公布。 出版物WO95 / 32205 (Ia)通式(Ia),(Ib)和(II)的化合物,其中R 1和R 2各自独立地表示氢,低级 烷基,低级烷氧基,硝基,三氟甲基,氨基,卤素,氰基或R3R4NS(O)2-,R3和R4表示低级烷基,R2可另外表示吗啉或硫代吗啉代,具有1-3N的5-或6-元杂环 任选被低级烷基,羟基,氨基或基团-CH 2 NHCH 3取代的原子,具有1-3N原子的二环杂环或-NR5R6基或-OR5,其中R5和R6可以相同或不同,表示氢,低级烷基, 羟基 - 低级烷基,低级烷氧基 - 低级烷基,氨基 - 低级烷基或低级烷基氨基 - 低级烷基,式(II)中的X表示-CH = CH-, - CH = N - , - NH - , - CO-或 -O-,以及通式(Ia),(Ib)和(II)的化合物的药学上可用的盐。 它们可用于治疗或预防疾病,特别是治疗或预防缺血,低血糖,缺氧,脑血管痉挛,痉挛,创伤,出血,感染(病毒,细菌,阿米巴,定性),癫痫发作,自身免疫 疾病,戒断症状,​​阿尔茨海默病,帕金森病,肌萎缩性侧索硬化,亨廷顿病,中毒,橄榄体 - 小脑萎缩,脊髓损伤,精神分裂症,沮丧,焦虑状态,依赖性,疼痛,自闭症和智力迟钝。