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1. 发明授权

US06088570A Method and apparatus employing delay elements in multiple diversity paths of a wireless system repeater translator to allow for selective diversity and automatic level control in a time-division multiple access system 有权
标题翻译：在无线系统中继器转换器的多个分集路径中采用延迟元件的方法和装置，以允许时分多址系统中的选择性分集和自动电平控制
公开(公告)号：US06088570A
公开(公告)日：2000-07-11
申请号：US198485
申请日：1998-11-24
申请人： Michael A. Komara , Thomas R. Schmutz , Jeffrey W. Smith , Stephen J. Foley
发明人： Michael A. Komara , Thomas R. Schmutz , Jeffrey W. Smith , Stephen J. Foley
IPC分类号： H04B7/005 , H04B7/08 , H04B7/15
CPC分类号： H04B7/2606 , H04B7/0802 , H04B7/15542 , H04W52/42 , H04B7/0828
摘要： In a conventional Time Division Multiple Access (TDMA) wireless system, the specified distance between a mobile unit and the base transceiver system (BTS) cannot exceed predetermined distances because of time slot synchronization constraints. Furthermore, varying distances between mobile units and the BTS, as well as Rayleigh fading, caused by destructive interference effects between direct and reflected signals, create extreme signal strength variations in the initial uplink signal from the mobile stations. The use of spatially-diverse antennas for receiving uplink signals provides diversity gain and mitigates deep fades. Furthermore, selecting the stronger of the spatially-diverse uplink signals mitigates deep fades and reduces frequency usage in the backhaul frequency band. In this approach to extending TDMA system coverage, in-band translator components are located in the center of remote cells which would normally contain a base transceiver system (BTS). The in-band translators include delay elements to implement slot-by-slot selective spatial diversity and automatic level control in a predictive feedforward fashion. The selective diversity mitigates deep Rayleigh fades, while the dynamic automatic level control drastically reduces the uplink backhaul dynamic range to allow for greater backhaul distances. Predictive feedforward automatic level control also eliminates overload and saturation of the backhaul high power amplifier, normally caused by wide variations in uplink power levels.
摘要翻译：在传统的时分多址（TDMA）无线系统中，由于时隙同步约束，移动单元与基站收发器系统（BTS）之间的指定距离不能超过预定距离。此外，移动单元与BTS之间的距离变化以及由直接和反射信号之间的相互干扰影响引起的瑞利衰落造成来自移动台的初始上行链路信号的极端信号强度变化。使用空间多样的天线来接收上行链路信号提供分集增益并减轻深度衰落。此外，选择较强的空间多样化的上行链路信号可以减轻深度衰落，并减少回程频带中的频率使用。在这种扩展TDMA系统覆盖的方法中，带内转换器组件位于通常包含基站收发器系统（BTS）的远程小区的中心。带内转换器包括以预定的前馈方式实现逐时隙选择性空间分集和自动电平控制的延迟元件。选择性分集减轻了瑞利衰落深度，而动态自动电平控制大大降低了上行链路回程动态范围，从而允许更大的回程距离。预测前馈自动电平控制还消除了回程高功率放大器的过载和饱和，通常由上行链路功率电平的宽泛变化引起。

2. 发明授权

US06487187B1 Random access control channel gain control and time slot recovery for remote in-band translator in time division multiple access wireless system 有权
标题翻译：用于时分多址无线系统的远程带内转换器的随机存取控制信道增益控制和时隙恢复
公开(公告)号：US06487187B1
公开(公告)日：2002-11-26
申请号：US09198808
申请日：1998-11-24
申请人： Thomas R. Schmutz , Michael A. Komara , Roger L. Overton , Jeffrey W. Smith , David D. Coons , Jeffrey R. Nuckols
发明人： Thomas R. Schmutz , Michael A. Komara , Roger L. Overton , Jeffrey W. Smith , David D. Coons , Jeffrey R. Nuckols
IPC分类号： H04B7212
CPC分类号： H04B7/2656 , H04W16/26 , H04W52/325
摘要： In a conventional Time Division Multiple Access (TDMA) wireless system, the specified distance between a mobile unit and the base transceiver system (BTS) cannot exceed predetermined distances because of time slot synchronization constraints. Furthermore, the varying distances between mobile units and the BTS create timing differences in the random access control channel (RACCH) bursts in the initial uplink signal from the mobile stations. In this approach to extending TDMA system coverage, in-band translator components are located in the center of remote cells which would normally contain a base transceiver system. The in-band translators include a loop back circuit that permits a host BTS to measure the backhaul propagation time delay by sending test access signals between the host BTS and the distant in-band translators. After backhaul timing delay is compensated in the BTS, then the in-band translator uses downlink time slot recovery to synchronize slot-by-slot uplink diversity selection and automatic level control. Recovery of timing bursts on downlink from the BTS allows for determination of burst, frame, and multiframe timing for downlink and uplink in the in-band translator. Processing allows for pre-determination of which uplink time slots that the RAACH signal can appear from the mobile unit. This method allows for automatic level control during RAACH bursts in addition to normal uplink bursts.
摘要翻译：在传统的时分多址（TDMA）无线系统中，由于时隙同步约束，移动单元与基站收发器系统（BTS）之间的指定距离不能超过预定距离。此外，移动单元和BTS之间的变化的距离在来自移动台的初始上行链路信号中在随机接入控制信道（RACCH）突发中产生定时差。在这种扩展TDMA系统覆盖的方法中，带内转换器组件位于通常包含基站收发器系统的远程小区的中心。带内转换器包括回送电路，其允许主机BTS通过在主机BTS和远端带内转换器之间发送测试接入信号来测量回程传播时间延迟。在BTS中补偿回程定时延迟后，带内转换器使用下行链路时隙恢复来同步逐个时隙上行链路分集选择和自动电平控制。来自BTS的下行链路上的定时突发的恢复允许确定下行链路和上行链路的突发，帧和多帧定时带内翻译器。处理允许预先确定RAACH信号可以从移动单元出现哪些上行链路时隙。该方法允许除了正常的上行链路突发之外的RAACH突发期间的自动电平控制。

3. 发明授权

US08712475B2 Method to calibrate RF paths of an FHOP adaptive base station 有权
标题翻译：校准FHOP自适应基站的RF路径的方法
公开(公告)号：US08712475B2
公开(公告)日：2014-04-29
申请号：US13350489
申请日：2012-01-13
申请人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
发明人： John R. Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
IPC分类号： H04B1/38
CPC分类号： H04B7/0848 , H04B17/21
摘要： A base transceiver station including a transceiver unit is provided. A method of calibration uses a transceiver unit to receive an RF signal, measure a calibration value, and transmit the measured value. The calibration value is used to determine weighting parameters to compensate for relative RF path phase delay and amplitude variation.
摘要翻译：提供了包括收发器单元的基站收发器。校准方法使用收发器单元来接收RF信号，测量校准值并传输测量值。校准值用于确定加权参数以补偿相对RF路径相位延迟和幅度变化。

4. 发明授权

US07935785B2 Selective substrates for matrix metalloproteinases 失效
标题翻译：基质金属蛋白酶的选择性底物
公开(公告)号：US07935785B2
公开(公告)日：2011-05-03
申请号：US12252160
申请日：2008-10-15
申请人： Jeffrey W. Smith , Emily I. Chen , Steven J. Kridel
发明人： Jeffrey W. Smith , Emily I. Chen , Steven J. Kridel
IPC分类号： C07K5/00 , C07K14/00
CPC分类号： A61K49/0021 , A61K47/64 , A61K49/0056 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0821 , C07K5/0823 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/1024 , C07K7/06 , C07K7/08 , C12Q1/37
摘要： The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selective substrate polypeptides contain SEQ ID NOS:28-35, and MT1-MMP selective substrate polypeptide contain SEQ ID NOS:36-40. In addition, the invention provides a method of preferentially directing a moiety to a site of MMP-2 activity by administering to a subject an effective amount of an isolated MMP-2 selective substrate polypeptide containing SEQ ID NOS:45-47 linked to a moiety. Also provided is a method of preferentially directing a moiety to a site of MMP-9 activity by administering to a subject an effective amount of an isolated MMP-9 selective substrate polypeptide containing SEQ ID NO:44 linked to a moiety, and preferentially directing a moiety to a site of MT1-MMP activity by administering to a subject an effective amount of an isolated MT1-MMP selective substrate polypeptide containing SEQ ID NOS:36-40 linked to a moiety.
摘要翻译：本发明提供分离的MMP-2，MMP-9和MT1-MMP选择性底物多肽或功能肽模拟物。选择性底物多肽包含以下序列：MMP-2选择性底物多肽含有SEQ ID NO：1-27，含有SEQ ID NO：28-35的MMP-9选择性底物多肽，并且含有SEQ ID NOS的MT1-MMP选择性底物多肽：36-40。此外，本发明提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：45-47的分离的MMP-2选择性底物多肽来优先将部分定向到MMP-2活性位点的方法。还提供了通过向受试者施用有效量的与部分连接的含有SEQ ID NO：44的分离的MMP-9选择性底物多肽，优先将一部分连接至部分MMP-9活性部位的方法，通过向受试者施用有效量的与部分连接的含有SEQ ID NO：36-40的分离的MT1-MMP选择性底物多肽，从而部分到MT1-MMP活性的位点。

5. 发明授权

US07643852B2 Method to calibrate RF paths of an FHOP adaptive base station 有权
标题翻译：校准FHOP自适应基站的RF路径的方法
公开(公告)号：US07643852B2
公开(公告)日：2010-01-05
申请号：US11333193
申请日：2006-01-17
申请人： John Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
发明人： John Noll , Jeffrey W. Smith , Shannon Tomarchio , Brady Gaughan
IPC分类号： H04B1/38
CPC分类号： H04B7/0848 , H04B17/21
摘要： A method for calibration of RF paths of a frequency hopping adaptive base transceiver station is provided. The method of calibration calibrates a wireless cellular telecommunication system with a frequency hopping adaptive base transceiver station including an adaptive antenna array with two or more RF traffic transceiver apparatus chains. The wireless cellular telecommunication system communicates with mobile units on a frequencies defined by a hop list. The method of calibration includes the step of periodically interrupting a frequency hopping process of the frequency hopping adaptive base transceiver station while calls are in progress. The method of calibration further includes the step of calibrating an antenna transmit path for a RF traffic transceiver apparatus chain at a frequency selected to include one or more frequencies in the hop list to determine a set of weighting parameters for the antenna transmit path at the one or more frequencies. A self-calibrating frequency hopping adaptive base transceiver station is also provided.
摘要翻译：提供了一种用于校准跳频自适应基站的射频路径的方法。校准方法使用包括具有两个或更多个RF业务收发器设备链的自适应天线阵列的跳频自适应基站收发器校准无线蜂窝电信系统。无线蜂窝电信系统在跳频列表定义的频率上与移动单元进行通信。校准方法包括在呼叫进行期间周期性地中断跳频自适应基站收发机的跳频过程的步骤。校准方法还包括校准用于RF业务收发器设备链的天线发射路径的步骤，该频率被选择为包括跳频列表中的一个或多个频率，以确定一个天线发射路径的一组加权参数或更多的频率。还提供了自校准跳频自适应基站收发台。

6. 发明申请

US20090042922A1 NOVEL BELACTOSIN DERIVATIVES AS THERAPEUTIC AGENTS/BIOLOGICAL PROBES AND THEIR SYNTHESIS 失效
标题翻译：新型BELACTOSIN衍生物作为治疗药物/生物探针及其合成
公开(公告)号：US20090042922A1
公开(公告)日：2009-02-12
申请号：US11775154
申请日：2007-07-09
申请人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
发明人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
IPC分类号： A61K31/365 , C07D305/08 , A61K31/4375 , A61P35/00 , C07D491/16
CPC分类号： C07D407/12 , C07D305/12
摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.
摘要翻译：披露了双乳糖蛋白衍生物及其合成。在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

7. 发明申请

US20090005307A1 Compositions and Methods for Detection of Colorectal Cancer 审中-公开
标题翻译：用于检测结肠直肠癌的组合物和方法
公开(公告)号：US20090005307A1
公开(公告)日：2009-01-01
申请号：US11992279
申请日：2006-09-21
申请人： Jeffrey W. Smith , Changming Fang
发明人： Jeffrey W. Smith , Changming Fang
IPC分类号： A61K38/17 , C12N15/12 , C07H21/00 , C12N15/79 , C07K16/18 , A61P35/00 , C12Q1/68 , G01N33/574 , C12N15/11 , C12N5/10
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
摘要翻译：我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

8. 外观设计

USD395960S Reclining theatre seat 失效
公开(公告)号：USD395960S
公开(公告)日：1998-07-14
申请号：US68284
申请日：1997-03-26
申请人： Jeffrey W. Smith
设计人： Jeffrey W. Smith

9. 发明授权

US08563248B2 Compositions and methods for detection of colorectal cancer 失效
标题翻译：用于检测结肠直肠癌的组合物和方法
公开(公告)号：US08563248B2
公开(公告)日：2013-10-22
申请号：US12959349
申请日：2010-12-02
申请人： Jeffrey W. Smith , Changming Fang
发明人： Jeffrey W. Smith , Changming Fang
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： We have identified a new variant of ileal bile acid binding protein (IBABP), designated IBABP-L, which is a biomarker for colorectal cancer. The transcript for IBABP-L arises from an alternative start site and includes three exons that are absent in IBABP. IBABP-L also shares part of a fourth exon with IBABP. The protein encoded by IBABP-L contains a deduced 49 residue N-terminal sequence that is not found in the IBABP protein. The present invention provides methods for diagnosing colorectal cancer and other compositions and methods based on this discovery.
摘要翻译：我们已经确定了回肠胆汁酸结合蛋白（IBABP）的新变体，称为IBABP-L，其是结肠直肠癌的生物标志物。 IBABP-L的成绩单来自替代起始位点，并且包括IBABP中缺少的三个外显子。 IBABP-L还与IBABP共享第四外显子的一部分。由IBABP-L编码的蛋白质含有在IBABP蛋白中未发现的49个残基的N-末端序列。本发明提供了用于诊断结肠直肠癌的方法以及基于该发现的其它组合物和方法。

10. 发明授权

US08119653B2 Belactosin derivatives as therapeutic agents/biological probes and their synthesis 失效
标题翻译：贝米松星衍生物作为治疗剂/生物探针及其合成
公开(公告)号：US08119653B2
公开(公告)日：2012-02-21
申请号：US11775154
申请日：2007-07-09
申请人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
发明人： Daniel Romo , Sung Wook Cho , Jeffrey W. Smith , Robyn D. Richardson
IPC分类号： A61K31/436 , C07D221/18
CPC分类号： C07D407/12 , C07D305/12
摘要： Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.
摘要翻译：披露了双乳糖蛋白衍生物及其合成。在某些实施方案中，本发明的化合物表现出抗癌，抗病毒，抗生素和/或自身免疫治疗能力。通常，本文公开的合成方法允许在多个位置引入各种取代基以及容易地引入β-内酯环部分。在优选实施方案中，合成步骤包括串联的Mukaiyama醛醇内酯反应。还公开了证明一些衍生物作为蛋白酶体抑制剂的效用的数据。

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