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1. 发明授权

US06296852B1 Recombinant avian adenovirus vector 失效
标题翻译：重组禽腺病毒载体
公开(公告)号：US06296852B1
公开(公告)日：2001-10-02
申请号：US09272032
申请日：1999-03-18
申请人： Michael A. Johnson , Christopher T. Prideaux , Richard J. McCoy , John W. Lowenthal
发明人： Michael A. Johnson , Christopher T. Prideaux , Richard J. McCoy , John W. Lowenthal
IPC分类号： A61K3912
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C12N15/86 , C12N2710/10222 , C12N2710/10234 , C12N2710/10243 , C12N2710/16334 , C12N2720/10034 , C12N2760/18134 , C12N2770/20034
摘要： This invention relates to a recombinant vector comprising a recombinant avian adenovirus incorporating, and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinate of infectious bursal disease virus. The invention further relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting poultry from disease.
摘要翻译：本发明涉及包含重组禽类腺病毒的重组载体，其包含并能够表达至少一个异源核苷酸序列。核苷酸序列优选为编码传染性法氏囊病病毒抗原决定簇的核苷酸序列。本发明还涉及重组载体的生产方法，基于载体的疫苗的制备方法，给药策略和保护家禽免受疾病的方法。

2. 发明授权

US06642032B2 Uses of avian interferon gamma (IFN-&ggr;) 失效
标题翻译：使用禽类干扰素γ（IFN-γ）
公开(公告)号：US06642032B2
公开(公告)日：2003-11-04
申请号：US09443218
申请日：1999-11-19
申请人： John W. Lowenthal , Michael A. Johnson , Terri E. O'Neil , Jennifer J. York
发明人： John W. Lowenthal , Michael A. Johnson , Terri E. O'Neil , Jennifer J. York
IPC分类号： C12P1934
CPC分类号： C07K14/57 , A61K38/00 , A61K39/00 , A61K39/39 , C07K14/465 , C07K14/555 , C07K16/249
摘要： The present invention provides compositions comprising recombinant avian IFN-&ggr; polypeptides and methods using said recombinant avian IFN-&ggr; polypeptides and compositions to enhance the immune responses of birds, and to enhance growth and/or prevent weight loss in birds. The present invention is particularly useful in the prophylactic and therapeutic treatment of birds against coccidiosis and the causative agent thereof.
摘要翻译：本发明提供了包含重组禽IFN-γ多肽的组合物，以及使用所述重组禽类IFN-γ多肽和组合物增强鸟类免疫应答并增强鸟类生长和/或防止体重减轻的方法。本发明特别可用于预防和治疗鸟类抗球虫病及其致病因子。

3. 发明授权

US07785602B2 Recombinant porcine adenovirus vector 失效
标题翻译：重组猪腺病毒载体
公开(公告)号：US07785602B2
公开(公告)日：2010-08-31
申请号：US12197056
申请日：2008-08-22
申请人： Michael A. Johnson , Jeffrey Michael Hammond , Richard J. McCoy , Michael G. Sheppard
发明人： Michael A. Johnson , Jeffrey Michael Hammond , Richard J. McCoy , Michael G. Sheppard
IPC分类号： A61K39/12 , A61K39/295 , C12N15/861 , C12N7/01
CPC分类号： C07K14/005 , A61K39/00 , C07K14/535 , C12N15/86 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.
摘要翻译：本发明涉及包含重组猪腺病毒的重组载体，其稳定并入并能够表达至少一个异源核苷酸序列。核苷酸序列优选是编码猪霍乱病毒或伪狂犬病病毒的抗原决定簇的核苷酸序列。本发明涉及重组载体的生产方法，基于载体的疫苗的制备方法，给药策略和保护猪免于疾病的方法。

4. 发明授权

US07473428B2 Recombinant porcine adenovirus vector 失效
标题翻译：重组猪腺病毒载体
公开(公告)号：US07473428B2
公开(公告)日：2009-01-06
申请号：US11387026
申请日：2006-03-22
申请人： Michael A. Johnson , Jeffrey Hammond , Richard J. McCoy , Michael G. Sheppard
发明人： Michael A. Johnson , Jeffrey Hammond , Richard J. McCoy , Michael G. Sheppard
IPC分类号： A61K39/235 , A61K39/295
CPC分类号： C07K14/005 , A61K39/00 , C07K14/535 , C12N15/86 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.
摘要翻译：本发明涉及包含重组猪腺病毒的重组载体，其稳定并入并能够表达至少一个异源核苷酸序列。核苷酸序列优选是编码猪霍乱病毒或伪狂犬病病毒的抗原决定簇的核苷酸序列。本发明涉及重组载体的生产方法，基于载体的疫苗的制备方法，给药策略和保护猪免于疾病的方法。

5. 发明申请

US20090226485A1 Recombinant Porcine Adenovirus Vector 失效
标题翻译：重组猪腺病毒载体
公开(公告)号：US20090226485A1
公开(公告)日：2009-09-10
申请号：US12197056
申请日：2008-08-22
申请人： Michael A. Johnson , Jeffrey Michael Hammond , Richard J. McCoy , Michael G. Sheppard
发明人： Michael A. Johnson , Jeffrey Michael Hammond , Richard J. McCoy , Michael G. Sheppard
IPC分类号： A61K39/12 , C12N15/00 , C12P21/00
CPC分类号： C07K14/005 , A61K39/00 , C07K14/535 , C12N15/86 , C12N2710/10343 , C12N2770/24322 , C12N2770/24334
摘要： This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The nucleotide sequence is preferably one which encodes an antigenic determinant of Hog Cholera Virus or Pseudorabies virus. The further invention relates to a method of production of recombinant vectors, to methods of preparation of vaccines based on the vectors, to administration strategies and to methods of protecting pigs from disease.
摘要翻译：本发明涉及包含重组猪腺病毒的重组载体，其稳定并入并能够表达至少一个异源核苷酸序列。核苷酸序列优选是编码猪霍乱病毒或伪狂犬病病毒的抗原决定簇的核苷酸序列。本发明涉及重组载体的生产方法，基于载体的疫苗的制备方法，给药策略和保护猪免于疾病的方法。

6. 发明授权

US09840591B2 Method of preparing benzoxazine-thiol polymers films 有权
公开(公告)号：US09840591B2
公开(公告)日：2017-12-12
申请号：US13813306
申请日：2011-08-02
申请人： Ilya Gorodisher , Michael A. Johnson
发明人： Ilya Gorodisher , Michael A. Johnson
IPC分类号： B29C39/16 , C08G75/14 , C08G73/06 , C08J5/18 , B29K79/00 , B29K81/00 , B29K105/24
CPC分类号： C08G75/14 , B29C39/16 , B29K2079/00 , B29K2081/00 , B29K2105/243 , C08G73/06 , C08J5/18 , C08J2379/02 , Y02P20/582
摘要： A process for preparing benzoxazine-thiol polymer film is described comprising forming a rolling bank of a curable composition comprising a polybenzoxazine and a polythiol, wherein the rolling bank contacts first and second carrier substrates; passing the first and second substrates with the curable composition therebetween through a nip; and at least partially curing the curable composition to provide the corresponding polymeric layer. The compositions are useful in coating, sealants, adhesive and many other applications.

7. 发明申请

US20160310826A1 PROCESS AND TOOL FOR APPLICATION OF WAX ONTO WATERSPORT BOARDS 审中-公开
标题翻译： WAX应用于水上船的工艺和工具
公开(公告)号：US20160310826A1
公开(公告)日：2016-10-27
申请号：US15134961
申请日：2016-04-21
申请人： Elise Thieler , Michael A. Johnson
发明人： Elise Thieler , Michael A. Johnson
IPC分类号： A63C11/08 , B63B35/79
CPC分类号： A63C11/08 , A47L13/02 , B63B35/79 , B63B35/85
摘要： A process and tool for the application of wax onto watersport boards including, but not limited to, surfboards, longboards, foam top boards, skim boards, standup paddle boards, boogie boards, wake skateboards, and wake surfboards. The process includes shredding wax with the use of a handheld grating device having a cutting blade with grating holes. The process further includes distributing the grated wax fragments onto the surface of the watersport board while continuing to rub the wax over the cutting blade of the grating device and layering the grated wax fragments over areas of the board surface where grip is needed, and then gently pressing the wax fragments onto the surface of the board to create a texture for ideal grip and traction needed to stand on and control the watersport board. One or more scraper edges on the grating device allow for removal of the wax from the board surface.
摘要翻译：包括但不限于冲浪板，长板，泡沫顶板，滑板，立式板，倒钩板，尾翼滑板和尾巴冲浪板等在水上运动板上应用蜡的过程和工具。该方法包括使用具有带有光栅孔的切割刀片的手持式光栅装置来切碎蜡。该方法还包括将磨碎的蜡碎片分配到水口板的表面上，同时继续将蜡擦拭在光栅装置的切割刀片上，并将磨碎的蜡碎片在需要握持的板表面的区域上分层，然后轻轻地将蜡片压在板的表面上，以形成理想的抓地力和牵引力所需的纹理，并且控制水上滑板。光栅装置上的一个或多个刮刀边缘允许从板表面去除蜡。

8. 发明授权

US08618202B2 Polymer blends including surface-modified nanoparticles and methods of making the same 有权
标题翻译：包括表面改性纳米颗粒的聚合物共混物及其制备方法
公开(公告)号：US08618202B2
公开(公告)日：2013-12-31
申请号：US11722850
申请日：2005-12-22
申请人： Jimmie R. Baran, Jr. , Michael A. Johnson , James D. Laperre
发明人： Jimmie R. Baran, Jr. , Michael A. Johnson , James D. Laperre
IPC分类号： C08K3/18 , C08K3/22
CPC分类号： C08K9/06 , C08K9/04 , C08L21/00 , C09J11/04
摘要： The present invention relates to the use of surface-modified nanoparticles to alter the morphology and microstructure of polymer blends. The addition of surface modified nanoparticles to polymer blends comprised of immiscible polymers facilitates the uniform distribution of the dispersed phase of the polymer blend. In an embodiment, the present invention relates to a polymer blend comprising (1) a continuous phase comprising at least one polymer, monomer or oligomer, and a plurality of surface-modified nanoparticles, having a particle diameter of less than about 100 nanometers, distributed in the continuous polymer phase; and (2) a dispersed phase comprising at least one polymer, monomer or oligomer, wherein the continuous polymer phase and the dispersed polymer phase are immiscible.
摘要翻译：本发明涉及使用表面改性的纳米粒子来改变聚合物共混物的形态和微结构。将表面改性纳米粒子加入由不混溶聚合物组成的聚合物共混物有助于聚合物共混物的分散相的均匀分布。在一个实施方案中，本发明涉及一种聚合物共混物，其包含（1）包含至少一种聚合物，单体或低聚物的连续相和具有小于约100纳米的粒径的多个表面改性的纳米颗粒，分布在连续聚合物相中; 和（2）包含至少一种聚合物，单体或低聚物的分散相，其中连续聚合物相和分散的聚合物相是不混溶的。

9. 发明授权

US08163544B2 Methods and compositions for increasing tissue tropism of recombinant adenoviral vectors 失效
标题翻译：用于增加重组腺病毒载体的组织嗜性的方法和组合物
公开(公告)号：US08163544B2
公开(公告)日：2012-04-24
申请号：US12373772
申请日：2007-07-27
申请人： Jeffrey Hammond , Michael A. Johnson
发明人： Jeffrey Hammond , Michael A. Johnson
IPC分类号： C12N15/861 , A61K39/12 , A01N63/00
CPC分类号： C12N15/86 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N2710/10343 , C12N2710/10345 , C12N2710/10371 , C12N2810/6018
摘要： Methods are provide to allow for the preparation of adenoviral vectors with altered tropism. Compositions comprising such vectors and methods of use thereof also are provided.
摘要翻译：提供了允许制备具有改变的嗜性的腺病毒载体的方法。还提供了包含这些载体的组合物及其使用方法。

10. 发明授权

US07802518B2 Fuze mounting assemblies for penetrator weapons 有权
标题翻译： Fuze安装组件穿透武器
公开(公告)号：US07802518B2
公开(公告)日：2010-09-28
申请号：US12434839
申请日：2009-05-04
申请人： Stanley N. Schwantes , Bradley M. Biggs , Michael A. Johnson
发明人： Stanley N. Schwantes , Bradley M. Biggs , Michael A. Johnson
IPC分类号： C06C7/00 , F42C19/06 , F42C9/14
CPC分类号： F42C19/02 , F42C1/10
摘要： A fuze mounting assembly for a penetrating, the fuze mounting assembly includes a fuze well and a fuze. The fuze includes an integral flange for securing to the fuze well.
摘要翻译：用于穿透的引信安装组件，引信安装组件包括引信井和引信。引信包括用于固定到引信的整体法兰。

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