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1. 发明授权

US08535290B2 Apparatus and methods for clot dissolution 有权
公开(公告)号：US08535290B2
公开(公告)日：2013-09-17
申请号：US13548338
申请日：2012-07-13
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

2. 发明申请

US20120283699A1 APPARATUS AND METHODS FOR CLOT DISSOLUTION 有权
标题翻译：装置解决方案的装置和方法
公开(公告)号：US20120283699A1
公开(公告)日：2012-11-08
申请号：US13548338
申请日：2012-07-13
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M25/00 , A61M1/00 , A61M25/10
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

3. 发明授权

US07763010B2 Apparatus and methods for clot dissolution 有权
标题翻译：用于凝块溶解的装置和方法
公开(公告)号：US07763010B2
公开(公告)日：2010-07-27
申请号：US10142005
申请日：2002-05-08
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

4. 发明授权

US06929633B2 Apparatus and methods for clot dissolution 有权
标题翻译：用于凝块溶解的装置和方法
公开(公告)号：US06929633B2
公开(公告)日：2005-08-16
申请号：US10278735
申请日：2002-10-21
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang , Jody Maria Cimbalo , Stephen Leeflang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang , Jody Maria Cimbalo , Stephen Leeflang
IPC分类号： A61B17/22 , A61M25/00 , A61M25/01 , A61M39/22 , A61M31/00
CPC分类号： A61B17/320758 , A61B17/22 , A61B17/22004 , A61B2017/00685 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084 , A61B2017/320716 , A61B2017/320766 , A61M25/0021 , A61M25/007 , A61M25/0075 , A61M25/0105 , A61M39/22 , A61M2025/1052
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, agitate the clot and agent, and aspirate broken-up clot from the blood vessel. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，搅动凝块和药剂的能力的导管，以及从血管中抽出破碎的凝块来实现凝块破裂和溶解。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

5. 发明授权

US08241241B2 Apparatus and methods for clot dissolution 有权
标题翻译：用于凝块溶解的装置和方法
公开(公告)号：US08241241B2
公开(公告)日：2012-08-14
申请号：US12816347
申请日：2010-06-15
申请人： Michael A. Evans , Denise Demarias , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarias , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61B17/20
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

6. 发明申请

US20110046542A1 APPARATUS AND METHODS FOR CLOT DISSOLUTION 有权
标题翻译：装置解决方案的装置和方法
公开(公告)号：US20110046542A1
公开(公告)日：2011-02-24
申请号：US12816347
申请日：2010-06-15
申请人： Michael A. Evans , Denise Demarias , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarias , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61B17/22 , A61M25/00 , A61M25/10 , A61M25/09
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

7. 发明授权

US09242068B2 Spirally conformable infusion catheter 有权
标题翻译：螺旋状输液导管
公开(公告)号：US09242068B2
公开(公告)日：2016-01-26
申请号：US12505191
申请日：2009-07-17
申请人： Michael Thai , Thomas Chien , Kelvin Ning , Robert Mcrae
发明人： Michael Thai , Thomas Chien , Kelvin Ning , Robert Mcrae
IPC分类号： A61M25/00 , A61M25/01
CPC分类号： A61M25/0021 , A61M25/003 , A61M25/007 , A61M25/0102 , A61M2025/0024 , A61M2025/0037 , A61M2025/0057 , A61M2025/0063
摘要： An infusion catheter includes a catheter body having a proximal end, a distal end, and two or more lumens extending therethrough. The infusion catheter also includes an infusion tube having a proximal end, a distal end, and one or more ports disposed therethrough. The first lumen of the catheter body is in fluid communication with the lumen of the infusion tube. A central member has a distal end connected to the distal end of the infusion tube, a proximal end, and a proximal portion slidably received in the second lumen of the catheter body. The infusion tube is disposed relative to the central member such that axial advancement of the central member relative to the catheter body radially collapses the infusion tube over the central member and axial retraction of the central member relative to the catheter body radially expands the infusion tube about the central member.
摘要翻译：输液导管包括具有近端，远端和延伸穿过其中的两个或多个腔的导管体。输注导管还包括具有近端，远端以及通过其设置的一个或多个端口的输液管。导管体的第一腔与输液管的内腔流体连通。中心构件具有连接到输注管的远端的远端，近端和可滑动地容纳在导管体的第二腔中的近端部分。输液管相对于中心构件设置，使得中心构件相对于导管主体的轴向前进径向地将输注管塌陷在中心构件上方，并且中心构件相对于导管主体的轴向缩回使输液管径向扩张约中央成员。

8. 发明授权

US09486345B2 Methods and systems for placement of a stent adjacent an ostium 有权
标题翻译：支架邻近口腔放置支架的方法和系统
公开(公告)号：US09486345B2
公开(公告)日：2016-11-08
申请号：US11969021
申请日：2008-01-03
申请人： Kelvin Ning , Richard Scott Rader
发明人： Kelvin Ning , Richard Scott Rader
IPC分类号： A61F2/06 , A61F2/958 , A61F2/954 , A61F2/82
CPC分类号： A61F2/958 , A61F2/954 , A61F2002/821
摘要： The present invention provides for treatment of ostial occlusions through placement of scaffold in a side-branch adjacent the ostium.
摘要翻译：本发明通过将支架放置在邻近口的侧支中来提供口腔闭塞的治疗。

9. 发明申请

US20100016832A1 SPIRALLY CONFORMABLE INFUSION CATHETER 有权
标题翻译：螺旋输入管
公开(公告)号：US20100016832A1
公开(公告)日：2010-01-21
申请号：US12505191
申请日：2009-07-17
申请人： Michael Thai , Thomas Chien , Kelvin Ning , Robert Mcrae
发明人： Michael Thai , Thomas Chien , Kelvin Ning , Robert Mcrae
IPC分类号： A61M5/14 , A61M25/00 , A61M25/09 , A61M25/098
CPC分类号： A61M25/0021 , A61M25/003 , A61M25/007 , A61M25/0102 , A61M2025/0024 , A61M2025/0037 , A61M2025/0057 , A61M2025/0063
摘要： An infusion catheter includes a catheter body having a proximal end, a distal end, and two or more lumens extending therethrough. The infusion catheter also includes an infusion tube having a proximal end, a distal end, and one or more ports disposed therethrough. The first lumen of the catheter body is in fluid communication with the lumen of the infusion tube. A central member has a distal end connected to the distal end of the infusion tube, a proximal end, and a proximal portion slidably received in the second lumen of the catheter body. The infusion tube is disposed relative to the central member such that axial advancement of the central member relative to the catheter body radially collapses the infusion tube over the central member and axial retraction of the central member relative to the catheter body radially expands the infusion tube about the central member.
摘要翻译：输液导管包括具有近端，远端和延伸穿过其中的两个或多个腔的导管体。输注导管还包括具有近端，远端以及通过其设置的一个或多个端口的输液管。导管体的第一腔与输液管的内腔流体连通。中心构件具有连接到输注管的远端的远端，近端和可滑动地容纳在导管体的第二腔中的近端部分。输液管相对于中心构件设置，使得中心构件相对于导管主体的轴向前进径向地将输注管塌陷在中心构件上方，并且中心构件相对于导管主体的轴向缩回使输液管径向扩张约中央成员。

10. 发明申请

US20090177259A1 METHODS AND SYSTEMS FOR PLACEMENT OF A STENT ADJACENT AN OSTIUM 有权
标题翻译：用于放置固定相的静电场的方法和系统
公开(公告)号：US20090177259A1
公开(公告)日：2009-07-09
申请号：US11969021
申请日：2008-01-03
申请人： Kelvin Ning , Richard Scott Rader
发明人： Kelvin Ning , Richard Scott Rader
IPC分类号： A61F2/06 , A61M31/00
CPC分类号： A61F2/958 , A61F2/954 , A61F2002/821
摘要： The present invention provides for treatment of ostial occlusions through placement of scaffold in a side-branch adjacent the ostium.
摘要翻译：本发明通过将支架放置在邻近口的侧支中来提供口腔闭塞的治疗。

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