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1. 发明授权

US06284917B1 Method for hydrogenating benzene polycarboxylic acids or derivatives thereof by using a catalyst containing macropores 有权
公开(公告)号：US06284917B1
公开(公告)日：2001-09-04
申请号：US09581843
申请日：2000-06-19
申请人： Melanie Brunner , Arnd Böttcher , Boris Breitscheidel , Klaus Halbritter , Jochem Henkelmann , Lucien Thil , Rolf Pinkos
发明人： Melanie Brunner , Arnd Böttcher , Boris Breitscheidel , Klaus Halbritter , Jochem Henkelmann , Lucien Thil , Rolf Pinkos
IPC分类号： C07C6974
CPC分类号： C08K5/12 , C07C51/36 , C07C67/303 , C07C69/75 , C07C2601/14 , C07C61/09
摘要： A process for hydrogenating a benzenepolycarboxylic acid or a derivative thereof or a mixture of two or more thereof by bringing the benzenepolycarboxylic acid or the derivative thereof or the mixture of two or more thereof into contact with a hydrogen-containing gas is carried out in the presence of a catalyst which comprises as active metal at least one metal of transition group VIII of the Periodic Table alone or together with at least one metal of transition group I or VII of the periodic table applied to a support which contains macropores with the proviso that if dimethyl terephthalate is hydrogenated, the hydrogenation using a catalyst which comprises as active metal ruthenium either alone or together with at least one metal of transition group I, VII or VIII of the Periodic Table applied to a support, where the support has a mean pore diameter of at least 50 nm and a BET surface area of at most 30 m2/g and the amount of the active metal is from 0.01 to 30% by weight, based on the total weight of the catalyst, and the ratio of the surface areas of the active metal and the catalyst support is less than 0.05, and/or a catalyst which comprises as active metal ruthenium either alone or together with at least one metal of transition group I, VII or VIII of the Periodic Table in an amount of from 0.01 to 30% by weight, based on the total weight of the catalyst, applied to a support, where from 10 to 50% of the pore volume of the support is formed by macropores having a pore diameter in the range from 50 nm to 10,000 nm and from 50 to 90% of the pore volume of the support is formed by mesopores having a pore diameter in the range from 2 to 50 nm, where the sum of the pore volumes adds up to 100%, is excluded, and novel hydrogenation products, obtainable by hydrogenating benzenepolycarboxylic acid (derivatives) as well as their use as plasticizers in plastics.

2. 发明授权

US06888021B2 Hydrogenation of benzenepolycarboxylic acids or derivatives thereof using a catalyst containing macropores 有权
标题翻译：使用含有大孔的催化剂氢化苯多元羧酸或其衍生物
公开(公告)号：US06888021B2
公开(公告)日：2005-05-03
申请号：US09879456
申请日：2001-06-13
申请人： Melanie Brunner , Arnd Böttcher , Boris Breitscheidel , Klaus Halbritter , Jochem Henkelmann , Lucien Thil , Rolf Pinkos
发明人： Melanie Brunner , Arnd Böttcher , Boris Breitscheidel , Klaus Halbritter , Jochem Henkelmann , Lucien Thil , Rolf Pinkos
IPC分类号： B01J23/46 , C07B61/00 , C07C51/36 , C07C61/08 , C07C61/09 , C07C67/303 , C07C69/75 , C08K5/12 , C07C69/74 , C07C69/66 , C08K5/09
CPC分类号： C08K5/12 , C07C51/36 , C07C67/303 , C07C69/75 , C07C2601/14 , C07C61/09
摘要： A process for producing plasticizers in which a phthalic acid having the CAS Nos. 111381-89-6, 111381-90-9, 111381-91-0, 68515-44-6, 68515-45-7 and 3648-20-7, the formed plasticizers and a method of increasing the plasticity of a plastic product.
摘要翻译：一种生产增塑剂的方法，其中具有CAS号111381-89-6,111381-90-9,111381-91-0,68515-44-6,68515-45-7和3648-20-7的邻苯二甲酸，形成的增塑剂和增加塑料制品的可塑性的方法。

3. 发明授权

US07208545B1 Selected cyclohexane -1,3-and -1,4-dicarboxylic acid esters 有权
标题翻译：选择的环己烷-1,3和-1,4-二羧酸酯
公开(公告)号：US07208545B1
公开(公告)日：2007-04-24
申请号：US09959380
申请日：2000-06-09
申请人： Melanie Brunner , Lucien Thil , Boris Breitscheidel
发明人： Melanie Brunner , Lucien Thil , Boris Breitscheidel
IPC分类号： C08K5/12 , C07C69/74
CPC分类号： C08K5/12 , B01J23/40 , B01J23/462 , B01J35/10 , C07C67/303 , C07C69/75
摘要： Selected cyclohexane-1,3- and -1,4-dicarboxylic acid esters are described, as is their use as plasticizers in plastics and their preparation by hydrogenation of the corresponding isophthalic or terephthalic esters by bringing one or more of these isophthalic or terephthalic esters into contact with a hydrogen-containing gas in the presence of a catalyst which comprises, as active metal, at least one metal of the 8th transition group of the Periodic Table on its own or together with at least one metal of the 1st or 7th transition group of the Periodic Table, applied to a support, which comprises using a support having micropores.
摘要翻译：描述了选择的环己烷-1,3-和-1,4-二羧酸酯，它们在塑料中作为增塑剂的用途，以及通过使这些间苯二甲酸或对苯二甲酸酯中的一种或多种与对苯二甲酸或对苯二酸酯氢化制备在催化剂存在下与含氢气体接触，该催化剂包含作为活性金属的元素周期表第8族过渡基团中的至少一种金属或与第一或第七转变体中的至少一种金属包括使用具有微孔的载体的元素周期表。

4. 发明授权

US06583286B1 Method for hydrogenating unsaturated heterocyclic compounds 有权
标题翻译：氢化不饱和杂环化合物的方法
公开(公告)号：US06583286B1
公开(公告)日：2003-06-24
申请号：US09743895
申请日：2001-01-17
申请人： Arnd Böttcher , Melanie Brunner , Jochem Henkelmann , Heinz Rütter , Boris Breitscheidel
发明人： Arnd Böttcher , Melanie Brunner , Jochem Henkelmann , Heinz Rütter , Boris Breitscheidel
IPC分类号： C07P21102
CPC分类号： C07D295/023 , C07B35/02
摘要： A process for hydrogenating an unsaturated heterocyclic compound or a mixture of two or more thereof by contacting the unsaturated heterocyclic compounder the mixture of two or more thereof with a hydrogen-containing gas in the presence of a catalyst comprising as active metal at least one metal from transition group VIII of the Periodic Table, applied to a support, wherein the support has macropores.
摘要翻译：在不饱和杂环化合物的两种或更多种的混合物与含氢气体的存在下，在催化剂存在下使不饱和杂环化合物或其两种或多种的混合物氢化的方法，所述催化剂包含作为活性金属的至少一种金属，过渡组VIII的周期表，应用于载体，其中载体具有大孔。

5. 发明授权

US06177598B1 Preparation of sugar alcohols 失效
标题翻译：制备糖醇
公开(公告)号：US06177598B1
公开(公告)日：2001-01-23
申请号：US09283866
申请日：1999-04-01
申请人： Melanie Brunner , Boris Breitscheidel , Jochem Henkelmann , Arnd Böttcher
发明人： Melanie Brunner , Boris Breitscheidel , Jochem Henkelmann , Arnd Böttcher
IPC分类号： C07C29141
CPC分类号： C07C29/132 , C07C31/26
摘要： A process for the hydrogenation of a sugar or a mixture of two or more thereof comprises the following step: Bringing the sugar or the mixture of two or more thereof into contact with hydrogen in the presence of specific catalysts to give a sugar alcohol or a mixture of two or more thereof, wherein the catalyst comprises at least one metal of transition group VIII of the Periodic Table, either alone or together with at least one metal of transition group I or VII of the Periodic Table.
摘要翻译：糖或其两种或多种的混合物的氢化方法包括以下步骤：在特定催化剂存在下，使糖或其两种或多种的混合物与氢接触以得到糖醇或混合物其中所述催化剂包含元素周期表中至少一种第Ⅷ族过渡金属，单独或与元素周期表中至少一种过渡族I或Ⅶ族金属一起。

6. 发明授权

US6130360A Hydrogenation of alkinols using a catalyst containing macropores 失效
标题翻译：使用含有大孔的催化剂氢化烷醇
公开(公告)号：US6130360A
公开(公告)日：2000-10-10
申请号：US207622
申请日：1998-12-09
申请人： Arnd Bottcher , Melanie Brunner , Jochem Henkelmann , Heinz Rutter
发明人： Arnd Bottcher , Melanie Brunner , Jochem Henkelmann , Heinz Rutter
IPC分类号： C07C29/17 , C07C27/00
CPC分类号： C07C29/172
摘要： An alkinol or mixture of two or more thereof is hydrogenated by bringing the alkinol or the mixture of two or more thereof into contact with a hydrogen-containing gas in the presence of a catalyst comprising as active metal at least one metal of transition group VIII of the Periodic Table, either alone or together with at least one metal of transition group I or VII of the Periodic Table, applied to a support, wherein the support contains macropores.
摘要翻译：通过使烯醇或其两种或多种的混合物在含有活性金属的催化剂存在下与含氢气体接触来氢化烯醇或其混合物，所述催化剂包含至少一种第单体或与周期表中的至少一种过渡组I或VII的金属一起施加到载体上，其中载体含有大孔。

7. 发明授权

US06242653B1 Process for the preparation of &agr;-diketones from ketols or ketals from ketols 失效
标题翻译：从酮基酮或酮缩酮制备α-二酮的方法
公开(公告)号：US06242653B1
公开(公告)日：2001-06-05
申请号：US09377732
申请日：1999-08-19
申请人： Werner Aquila , Jörg Botzem , Melanie Brunner , Hartwig Fuchs , Wolfgang Krause , Klaus Pandl , Ulrich Schäfer-Lüderssen
发明人： Werner Aquila , Jörg Botzem , Melanie Brunner , Hartwig Fuchs , Wolfgang Krause , Klaus Pandl , Ulrich Schäfer-Lüderssen
IPC分类号： C07C4529
CPC分类号： C07C45/39 , C07C45/515 , C07C49/12 , C07C49/175 , C07C49/517
摘要： The process for the preparation of carbonyl compounds of the formula I where R1 and R2 are a hydrocarbon radical, or R1 and R2 together are an unsubstituted or substituted alkylene group, and X is=O or two alkoxy groups, comprises oxidizing alcohols of the formula II where R1 to R2 and X are as defined above, with oxygen in the gaseous phase a) at temperatures of from 270 to 600° C. on silver coated catalysts which comprise an abrasion-resistant coating of metallic silver on a core of inert support material, or b) at temperatures of from 450 to 750° C. on silver crystals and/or copper crystals having a particle size of from 0.1 to 2.5 mm for a residence time of at most 0.1 second. Also claimed is an advantageous overall process for the preparation of &agr;-diketones, preferably diacetal, from the corresponding ketone, in particular methyl ethyl ketone, via the carbonyl compounds of the formula I where X is two alkoxy groups.
摘要翻译：制备式I的羰基化合物的方法，其中R 1和R 2是烃基，或者R 1和R 2一起是未取代或取代的亚烷基，并且X是= O或两个烷氧基，包括氧化式II的醇，其中R 1 在含有惰性载体材料芯上的金属银的耐磨涂层的银涂覆的催化剂上，在温度为270-600℃的温度下，R2和X如上定义，在气相中为氧）在450至750℃的温度下，在银晶体和/或具有0.1至2.5mm的粒度的铜晶体上，停留时间至多为0.1秒。还要求保护的是制备α 二酮，优选二缩醛，通过其中X是两个烷氧基的式I的羰基化合物从相应的酮，特别是甲基乙基酮中获得。

8. 发明申请

US20070148241A1 Use of an intermediate for controlling the release profile of an oral formulation of a medicament 审中-公开
标题翻译：使用中间体来控制药物的口服制剂的释放曲线
公开(公告)号：US20070148241A1
公开(公告)日：2007-06-28
申请号：US11506382
申请日：2006-08-18
申请人： Michael Braun , Klaus Neuer , Thomas Beckert , Carmen Heinz , Melanie Brunner
发明人： Michael Braun , Klaus Neuer , Thomas Beckert , Carmen Heinz , Melanie Brunner
IPC分类号： A61K9/24
CPC分类号： A61K9/5073 , A61K9/5026 , A61K9/5047
摘要： A swellable intermediate layer that includes a swellable material selected from the group of starch, starch derivatives such as pregelatinised starch, sodium carboxyethyl starch, sodium starch gycolate, cellulose, cellulose ethers such as HPMC, HPC, HEC MC, sodium carboxymethyl cellulose, carrageenans, aginates, pectins, xanthanes and their derivatives, guar gum, tragacanth, polyvinyl pyrrolidones and mixtures thereof, in a delayed-release, solid pharmaceutical formulation for peroral use. The formulation has a substrate containing an active substance, the swellable intermediate layer and a retarding coating layer for the adjustment of a release profile for the active substance which essentially permits complete release near the end.
摘要翻译：包括选自淀粉，淀粉衍生物如预胶化淀粉，羧乙基淀粉，淀粉羟基淀粉酸钠，纤维素，纤维素醚如HPMC，HPC，HEC MC，羧甲基纤维素钠，角叉菜胶等的可溶胀材料的可溶胀中间层，碱性，果胶，黄原胶及其衍生物，瓜尔胶，黄蓍胶，聚乙烯吡咯烷酮及其混合物，用于口服使用的延迟释放固体药物制剂。制剂具有含有活性物质，可溶胀中间层和用于调节活性物质的释放曲线的延迟涂层的基材，其基本上允许在末端附近完全释放。

9. 发明授权

US06297407B1 Method for producing alkyne diols 失效
标题翻译：炔二醇的制备方法
公开(公告)号：US06297407B1
公开(公告)日：2001-10-02
申请号：US09744437
申请日：2001-01-24
申请人： Alois Kindler , Melanie Brunner , Christian Tragut , Jochem Henkelmann
发明人： Alois Kindler , Melanie Brunner , Christian Tragut , Jochem Henkelmann
IPC分类号： C07C3118
CPC分类号： C07C29/42 , C07C33/042 , C07C33/044
摘要： The invention relates to a method for producing alkyne diols by reacting ketones with acetylenic hydrocarbons in an organic solvent in the presence of a base which contains potassium alcoholates of primary and/or secondary alcohols. The alkyne diols are produced while forming adducts which precipitate out of the reaction mixture and which are comprised of alkyne monoalcohols and/or alkyne diols and a base. The stoichiometries of the reaction partners are selected such that gelatinous adducts are formed which comprise a spherical surface, whereby the reaction mixture remains agitable during the entire reaction.
摘要翻译：本发明涉及一种在含有伯醇和/或仲醇的醇钾的碱存在下，通过酮与炔烃在有机溶剂中反应制备炔烃的方法。产生炔二醇，同时形成从反应混合物中沉淀的加合物，其由炔一醇和/或炔二醇和碱组成。选择反应伴侣的化学计量，使得形成包含球形表面的凝胶状加合物，由此在整个反应期间反应混合物保持敏感。

10. 发明授权

US06346629B1 Method for producing butyrolactones 失效
标题翻译：丁内酯的制备方法
公开(公告)号：US06346629B1
公开(公告)日：2002-02-12
申请号：US09700426
申请日：2000-11-15
申请人： Melanie Brunner , Ralf-Thomas Rahn , Udo Rheude , Jochem Henkelmann
发明人： Melanie Brunner , Ralf-Thomas Rahn , Udo Rheude , Jochem Henkelmann
IPC分类号： C07D30702
CPC分类号： C07D315/00
摘要： Process for producing butyrolactones of the general formula I where R1 and R2 are each hydrogen, alkyl, hydroxyalkyl, substituted or unsubstituted aryl or substituted or unsubstituted trialkylsilyl, by reacting alkynes of the general formula II where R1 and R2 are each as defined above, with carbon monoxide and water in the presence of a rhodium catalyst under pressures from 20 to 300 bar and hydrogenating the unhydrogenated 2(5H)-furanone intermediates comprises a) reacting the carbonylation reaction mixture with hydrogen at from 150 to 250° C. and from 100 to 300 bar, b) removing the precipitated catalyst and returning it into the carbonylation reaction, and c) subjecting the catalyst-free reaction mixture to a distillation to recover the butyrolactone.
摘要翻译：制备通式I的丁内酯的方法，其中R 1和R 2各自为氢，烷基，羟基烷基，取代或未取代的芳基或取代或未取代的三烷基甲硅烷基，其中通式II的炔烃其中R 1和R 2各自如上所定义，与一氧化碳和铑催化剂存在下的水，在20-300巴的压力下氢化未氢化的2（5H） - 呋喃酮中间体包括：a）使羰基化反应混合物与氢在150-250℃和100-300巴条件下反应，b）除去沉淀的催化剂并将其返回到羰基化反应中，和c）使无催化剂反应混合物进行蒸馏以回收丁内酯。

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